#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99383 uniprotkb:P38217 intact:EBI-11783|uniprotkb:Q02741|ensemblfungi:YOL123W|uniprotkb:D6W1U5 intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:hrp1_yeast(display_long)|uniprotkb:YOL123W(locus name)|uniprotkb:HRP1(gene name)|psi-mi:HRP1(display_short)|uniprotkb:NAB4(gene name synonym)|uniprotkb:NAB5(gene name synonym)|uniprotkb:Cleavage factor IB(gene name synonym) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707484|imex:IM-9192-1|dip:DIP-2793E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YOL123W(gene)|ensemblfungi:YOL123W_mRNA(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034155|interpro:IPR034156|interpro:IPR035979|rcsb pdb:2CJK|rcsb pdb:2KM8|go:"GO:0005737"(cytoplasm)|refseq:NP_014518.1|sgd:S000005483|dip:DIP-1371N ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:1B231069437B093D crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:8EWzxKR7UWoJhDGSB/0C2d0Qn6k559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:hb9qa5KK8pKl0xxzx+I7bxECRhI false sufficient binding region:494-534|mutation disrupting interaction strength:519-519,516-516,512-513|mutation disrupting interaction:529-529|mutation disrupting interaction strength:532-532|mutation disrupting interaction strength:532-532|mutation disrupting interaction strength:532-532 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99383 uniprotkb:P38217 intact:EBI-11783|uniprotkb:Q02741|ensemblfungi:YOL123W|uniprotkb:D6W1U5 intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:hrp1_yeast(display_long)|uniprotkb:YOL123W(locus name)|uniprotkb:HRP1(gene name)|psi-mi:HRP1(display_short)|uniprotkb:NAB4(gene name synonym)|uniprotkb:NAB5(gene name synonym)|uniprotkb:Cleavage factor IB(gene name synonym) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707517|imex:IM-9192-17|dip:DIP-2793E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YOL123W(gene)|ensemblfungi:YOL123W_mRNA(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034155|interpro:IPR034156|interpro:IPR035979|rcsb pdb:2CJK|rcsb pdb:2KM8|go:"GO:0005737"(cytoplasm)|refseq:NP_014518.1|sgd:S000005483|dip:DIP-1371N ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:1B231069437B093D crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:8EWzxKR7UWoJhDGSB/0C2d0Qn6k559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:hb9qa5KK8pKl0xxzx+I7bxECRhI false sufficient binding region:494-534|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q00916 uniprotkb:P38217 intact:EBI-724|uniprotkb:D6VVM3|ensemblfungi:YIL061C intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:ru17_yeast(display_long)|uniprotkb:YIL061C(locus name)|uniprotkb:SNP1(gene name)|psi-mi:SNP1(display_short)|uniprotkb:U1 small nuclear ribonucleoprotein SNP1(gene name synonym) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707559|imex:IM-9192-8|dip:DIP-59350E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_012203.1|sgd:S000001323|dip:DIP-663N|mint:Q00916|ensemblfungi:YIL061C(gene)|ensemblfungi:YIL061C_mRNA(transcript)|go:"GO:0000243"(commitment complex)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003729"(mRNA binding)|go:"GO:0005685"(U1 snRNP)|go:"GO:0017069"(snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR022023|interpro:IPR034143|interpro:IPR035979|rcsb pdb:5ZWN|rcsb pdb:6G90|rcsb pdb:6N7P|rcsb pdb:6N7R|rcsb pdb:6N7X ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:7D9E47BE66FE1EB8 crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:U9mfzw792DuNErqlM1vuG+QDjzE559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:ajR5gcg5MpohL5VPcP/qVEimhF0 false binding-associated region:1-42|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04821 uniprotkb:P38217 intact:EBI-4237|uniprotkb:D6VYV4|ensemblfungi:YLR310C intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:cdc25_yeast(display_long)|uniprotkb:CDC25(gene name)|psi-mi:CDC25(display_short)|uniprotkb:CTN1(gene name synonym)|uniprotkb:YLR310C(locus name)|uniprotkb:L2142.6(orf name) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707580|imex:IM-9192-4|dip:DIP-59353E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_013413.1|sgd:S000004301|dip:DIP-2261N|mint:P04821|ensemblfungi:YLR310C(gene)|ensemblfungi:YLR310C_mRNA(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001452(Src homology-3)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR019804|interpro:IPR023578|interpro:IPR036028|interpro:IPR036964|reactome:R-SCE-354192|reactome:R-SCE-392517|reactome:R-SCE-416482 ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:CA90053435C85465 crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:odGMmVuh+nvSK5Z37n++BP0jW5E559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:0ZwdEooE6uQFt6sAcd+zxy7MfZY false binding-associated region:774-823|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03497 uniprotkb:P38217 intact:EBI-18285|uniprotkb:D3DKQ8|ensemblfungi:YHL007C intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:ste20_yeast(display_long)|uniprotkb:STE20(gene name)|psi-mi:STE20(display_short)|uniprotkb:YHL007C(locus name) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707601|imex:IM-9192-9|dip:DIP-59357E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_011856.1|sgd:S000000999|ensemblfungi:YHL007C(gene)|ensemblfungi:YHL007C_mRNA(transcript)|go:"GO:0000011"(vacuole inheritance)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000131"(incipient cellular bud site)|go:"GO:0000282"(cellular bud site selection)|go:"GO:0000750"(pheromone-dependent signal transduction involved in conjugation with cellular fusion)|go:"GO:0001402"(signal transduction involved in filamentous growth)|reactome:R-SCE-389359|interpro:IPR036936|reactome:R-SCE-5627123|reactome:R-SCE-5687128|reactome:R-SCE-9013405|reactome:R-SCE-9013406|rcsb pdb:2KYM|rcsb pdb:2LCS|rcsb pdb:2RQW|reactome:R-SCE-2029482|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0001403"(invasive growth in response to glucose limitation)|go:"GO:0003729"(mRNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007118"(budding cell apical bud growth)|go:"GO:0007121"(bipolar cellular bud site selection)|go:"GO:0007124"(pseudohyphal growth)|go:"GO:0007232"(osmosensory signaling pathway via Sho1 osmosensor)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035376"(sterol import)|go:"GO:0035404"(histone-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043332"(mating projection tip)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044025"("histone kinase activity (H2B-S14 specific)")|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|dip:DIP-712N|mint:Q03497 ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:69C1C12F5B87733C crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:ammX6PwJCeyVjNxJ2UJUBrZt9mM559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:dSH8hfTqAxp+ZdNbiVIRdMADhHQ false binding-associated region:226-275|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92973 uniprotkb:Q99383 intact:EBI-286693|intact:EBI-1760498|uniprotkb:Q92957|uniprotkb:Q92975|intact:EBI-1965561|uniprotkb:B4DVC6|ensembl:ENSP00000336712 intact:EBI-11783|uniprotkb:Q02741|ensemblfungi:YOL123W|uniprotkb:D6W1U5 psi-mi:tnpo1_human(display_long)|uniprotkb:TRN(gene name synonym)|uniprotkb:TNPO1(gene name)|psi-mi:TNPO1(display_short)|uniprotkb:KPNB2(gene name synonym)|uniprotkb:MIP1(gene name synonym)|uniprotkb:Importin beta-2(gene name synonym)|uniprotkb:Karyopherin beta-2(gene name synonym)|uniprotkb:M9 region interaction protein(gene name synonym) psi-mi:hrp1_yeast(display_long)|uniprotkb:YOL123W(locus name)|uniprotkb:HRP1(gene name)|psi-mi:HRP1(display_short)|uniprotkb:NAB4(gene name synonym)|uniprotkb:NAB5(gene name synonym)|uniprotkb:Cleavage factor IB(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707538|imex:IM-9192-7|dip:DIP-59347E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002261.3|refseq:NP_694858.1|refseq:XP_005248557.1|dip:DIP-29335N|ensembl:ENSG00000083312(gene)|ensembl:ENST00000337273(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|mint:Q92973|rcsb pdb:1QBK|rcsb pdb:2H4M|rcsb pdb:2OT8|rcsb pdb:2QMR|rcsb pdb:2Z5J|rcsb pdb:2Z5K|rcsb pdb:2Z5M|rcsb pdb:2Z5N|rcsb pdb:2Z5O|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:4JLQ|rcsb pdb:4OO6|rcsb pdb:5J3V|rcsb pdb:5TQC|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:7CYL|reactome:R-HSA-450513|reactome:R-HSA-5620924|reactome:R-HSA-9615933 ensemblfungi:YOL123W(gene)|ensemblfungi:YOL123W_mRNA(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034155|interpro:IPR034156|interpro:IPR035979|rcsb pdb:2CJK|rcsb pdb:2KM8|go:"GO:0005737"(cytoplasm)|refseq:NP_014518.1|sgd:S000005483|dip:DIP-1371N psi-mi:"MI:0465"(dip) - crc64:1B231069437B093D full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:n8Q3n1rmTiJAp6f8DBcBV6j6lac9606 rogid:8EWzxKR7UWoJhDGSB/0C2d0Qn6k559292 rigid:pDu/fC8r7XMTq6yNCOKHQ9MO0oA false - glutathione s tranferase tag:n-n|binding-associated region:494-534 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P32505 uniprotkb:P38217 intact:EBI-11770|ensemblfungi:YGL122C|uniprotkb:D6VU26 intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:nab2_yeast(display_long)|uniprotkb:YGL122C(locus name)|uniprotkb:NAB2(gene name)|psi-mi:NAB2(display_short) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707622|imex:IM-9192-10|dip:DIP-10563E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YGL122C(gene)|ensemblfungi:YGL122C_mRNA(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008312"(7S RNA binding)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0033204"(ribonuclease P RNA binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0046872"(metal ion binding)|go:"GO:1900152"(negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR021083|interpro:IPR040366|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|interpro:IPR041044|interpro:IPR043094|rcsb pdb:2JPS|rcsb pdb:2LHN|rcsb pdb:2V75|rcsb pdb:3LCN|rcsb pdb:3ZJ1|rcsb pdb:3ZJ2|rcsb pdb:4JLQ|rcsb pdb:5L2L|refseq:NP_011393.3|sgd:S000003090|mint:P32505|dip:DIP-1331N ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:40335C3D4658DD91 crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:tNdhCVVTRYjqg7BES5wD2Gg4rjw559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:6oMegkNSGiCRpCksgV5vy3ZJIvY false sufficient binding region:201-251|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92973 uniprotkb:P32505 intact:EBI-286693|intact:EBI-1760498|uniprotkb:Q92957|uniprotkb:Q92975|intact:EBI-1965561|uniprotkb:B4DVC6|ensembl:ENSP00000336712 intact:EBI-11770|ensemblfungi:YGL122C|uniprotkb:D6VU26 psi-mi:tnpo1_human(display_long)|uniprotkb:TRN(gene name synonym)|uniprotkb:TNPO1(gene name)|psi-mi:TNPO1(display_short)|uniprotkb:KPNB2(gene name synonym)|uniprotkb:MIP1(gene name synonym)|uniprotkb:Importin beta-2(gene name synonym)|uniprotkb:Karyopherin beta-2(gene name synonym)|uniprotkb:M9 region interaction protein(gene name synonym) psi-mi:nab2_yeast(display_long)|uniprotkb:YGL122C(locus name)|uniprotkb:NAB2(gene name)|psi-mi:NAB2(display_short) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707643|imex:IM-9192-5|dip:DIP-59348E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002261.3|refseq:NP_694858.1|refseq:XP_005248557.1|dip:DIP-29335N|ensembl:ENSG00000083312(gene)|ensembl:ENST00000337273(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|mint:Q92973|rcsb pdb:1QBK|rcsb pdb:2H4M|rcsb pdb:2OT8|rcsb pdb:2QMR|rcsb pdb:2Z5J|rcsb pdb:2Z5K|rcsb pdb:2Z5M|rcsb pdb:2Z5N|rcsb pdb:2Z5O|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:4JLQ|rcsb pdb:4OO6|rcsb pdb:5J3V|rcsb pdb:5TQC|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:7CYL|reactome:R-HSA-450513|reactome:R-HSA-5620924|reactome:R-HSA-9615933 ensemblfungi:YGL122C(gene)|ensemblfungi:YGL122C_mRNA(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008312"(7S RNA binding)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0033204"(ribonuclease P RNA binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0046872"(metal ion binding)|go:"GO:1900152"(negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR021083|interpro:IPR040366|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|interpro:IPR041044|interpro:IPR043094|rcsb pdb:2JPS|rcsb pdb:2LHN|rcsb pdb:2V75|rcsb pdb:3LCN|rcsb pdb:3ZJ1|rcsb pdb:3ZJ2|rcsb pdb:4JLQ|rcsb pdb:5L2L|refseq:NP_011393.3|sgd:S000003090|mint:P32505|dip:DIP-1331N psi-mi:"MI:0465"(dip) - crc64:40335C3D4658DD91 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:n8Q3n1rmTiJAp6f8DBcBV6j6lac9606 rogid:tNdhCVVTRYjqg7BES5wD2Gg4rjw559292 rigid:qesTABDy8Dpd22iKFoey1+GZmJA false - glutathione s tranferase tag:n-n|binding-associated region:201-251 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P53919 uniprotkb:P38217 intact:EBI-28887|uniprotkb:B0KZR2|uniprotkb:B0KZS1|uniprotkb:B0KZT9|uniprotkb:B0KZZ3|uniprotkb:B0L002|uniprotkb:D6W159|ensemblfungi:YNL124W intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:naf1_yeast(display_long)|uniprotkb:YNL124W(locus name)|uniprotkb:N1888(orf name)|uniprotkb:NAF1(gene name)|psi-mi:NAF1(display_short)|uniprotkb:Nuclear assembly factor 1(gene name synonym) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707664|imex:IM-9192-15|dip:DIP-59351E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005068|refseq:NP_014275.3|dip:DIP-4345N|ensemblfungi:YNL124W(gene)|ensemblfungi:YNL124W_mRNA(transcript)|go:"GO:0000493"(box H/ACA snoRNP assembly)|go:"GO:0001522"(pseudouridine synthesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0006364"(rRNA processing)|go:"GO:0042254"(ribosome biogenesis)|interpro:IPR007504(Gar1 protein RNA-binding region)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR038664|interpro:IPR040309|rcsb pdb:2V3M ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:5A496278070F6255 crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:9ZtegpRDLFL25BUqw4ke9qJ393Q559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:z+WRZcZEvtVAAb2Ye0SZZZL/djI false binding-associated region:269-318|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P10080 uniprotkb:P38217 intact:EBI-18146|uniprotkb:D3DKT4|ensemblfungi:YHL034C intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:ssbp1_yeast(display_long)|uniprotkb:YHL034C(locus name)|uniprotkb:SBP1(gene name)|psi-mi:SBP1(display_short)|uniprotkb:SSBR1(gene name synonym)|uniprotkb:SSB1(gene name synonym) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707685|imex:IM-9192-11|dip:DIP-59354E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0017148"(negative regulation of translation)|refseq:NP_011829.1|sgd:S000001026|go:"GO:0032055"(negative regulation of translation in response to stress)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|ensemblfungi:YHL034C(gene)|ensemblfungi:YHL034C_mRNA(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0010494"(cytoplasmic stress granule)|dip:DIP-6824N|mint:P10080 ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:FF740B206DDE5EC8 crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:8AgAdyv7G/nPzGOhgIq2XwqvXt4559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:/VEnTBNcWqXOmkWh0MSMGDCTMKA false binding-associated region:138-187|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P52272 uniprotkb:P38217 intact:EBI-486809|uniprotkb:Q9Y492|uniprotkb:Q15584|uniprotkb:Q8WZ44|uniprotkb:Q96H56|uniprotkb:Q9BWL9|intact:EBI-28985795|ensembl:ENSP00000325376 intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:hnrpm_human(display_long)|uniprotkb:HNRNPM(gene name)|psi-mi:HNRNPM(display_short)|uniprotkb:HNRPM(gene name synonym)|uniprotkb:NAGR1(gene name synonym) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707706|imex:IM-9192-6|dip:DIP-59345E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005959.2|refseq:NP_112480.2|ensembl:ENSG00000099783(gene)|ensembl:ENST00000325495(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042382"(paraspeckles)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071014"(post-mRNA release spliceosomal complex)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000815"(regulation of mRNA stability involved in response to oxidative stress)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR024666|interpro:IPR024667|interpro:IPR034990|interpro:IPR035979|mint:P52272|rcsb pdb:2DGV|rcsb pdb:2DH9|rcsb pdb:2DO0|rcsb pdb:2OT8|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|dip:DIP-29336N|ensembl:ENSP00000325376|ensembl:ENST00000348943|ensembl:ENSP00000325732 ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) - crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:5FnCgrz0xltEkgw3yh70KP2jz5g9606 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:z9jdmiqo8AecvW3knnj2V10xhQs false binding-associated region:41-70|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P41896 uniprotkb:P38217 intact:EBI-18916|uniprotkb:D6VUE2|ensemblfungi:YGR005C intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:t2fb_yeast(display_long)|uniprotkb:YGR005C(locus name)|uniprotkb:TFG2(gene name)|psi-mi:TFG2(display_short)|uniprotkb:TFIIF-beta(gene name synonym)|uniprotkb:TFIIF medium subunit(gene name synonym)|uniprotkb:Transcription factor G 54 kDa subunit(gene name synonym) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707727|imex:IM-9192-12|dip:DIP-12451E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YGR005C(gene)|ensemblfungi:YGR005C_mRNA(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001111"(promoter clearance from RNA polymerase II promoter)|go:"GO:0001174"(transcriptional start site selection at RNA polymerase II promoter)|go:"GO:0003677"(DNA binding)|go:"GO:0005674"(transcription factor TFIIF complex)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|rcsb pdb:5FMF|rcsb pdb:5FYW|rcsb pdb:5FZ5|rcsb pdb:5OQJ|rcsb pdb:5OQM|rcsb pdb:5SVA|rcsb pdb:6GYK|rcsb pdb:6GYL|rcsb pdb:6GYM|rcsb pdb:7O4I|rcsb pdb:7O4J|rcsb pdb:7O72|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|interpro:IPR003196(Transcription initiation factor IIF, beta subunit)|rcsb pdb:7O73|rcsb pdb:7O75|reactome:R-SCE-113418|reactome:R-SCE-674695|reactome:R-SCE-6796648|reactome:R-SCE-6807505|reactome:R-SCE-72086|reactome:R-SCE-73776|reactome:R-SCE-73779|reactome:R-SCE-75953|reactome:R-SCE-75955|reactome:R-SCE-76042|reactome:R-SCE-77075|reactome:R-SCE-9018519|interpro:IPR011039(Transcription Factor IIF, Rap30/Rap74, interaction)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040450|interpro:IPR040504|rcsb pdb:4V1N|rcsb pdb:4V1O|sgd:S000003237|refseq:NP_011519.3|dip:DIP-1152N|mint:P41896 ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:DDDA895446BBF26F crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:v+bk6NVZDN+wXpCa+37sl26PrR4559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:1Wdz1hnjTtc4czxWyz7cQxeq+08 false sufficient binding region:165-214|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P09232 uniprotkb:P38217 intact:EBI-13925|uniprotkb:D3DLJ0|ensemblfungi:YEL060C intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:prtb_yeast(display_long)|uniprotkb:YEL060C(locus name)|uniprotkb:PRB1(gene name)|psi-mi:PRB1(display_short)|uniprotkb:Vacuolar protease B(gene name synonym)|uniprotkb:Proteinase YSCB(gene name synonym) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707748|imex:IM-9192-16|dip:DIP-59352E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010854.1|sgd:S000000786|ensemblfungi:YEL060C(gene)|ensemblfungi:YEL060C_mRNA(transcript)|go:"GO:0000324"(fungal-type vacuole)|go:"GO:0000328"(fungal-type vacuole lumen)|go:"GO:0000425"(pexophagy)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007039"(protein catabolic process in the vacuole)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0030435"(sporulation resulting in formation of a cellular spore)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR010259(Proteinase inhibitor I9, subtilisin propeptide)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR022398|interpro:IPR023827|interpro:IPR023828|interpro:IPR034193|interpro:IPR036852|interpro:IPR037045|mint:P09232|dip:DIP-2544N ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:C346C2B1C7DDDC48 crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:+kInWJvx1g70dvHuATf0HPj4SxE559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:IBNvrSbei19v4b/KN8d9W7ZYBzE false binding-associated region:125-174|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03063 uniprotkb:P38217 intact:EBI-29752|uniprotkb:D6W3W5|ensemblfungi:YPL049C intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:dig1_yeast(display_long)|uniprotkb:DIG1(gene name)|psi-mi:DIG1(display_short)|uniprotkb:Regulator of sterile twelve 1(gene name synonym)|uniprotkb:Regulator of STE12 protein 1(gene name synonym)|uniprotkb:RST1(gene name synonym)|uniprotkb:P7102.02(orf name)|uniprotkb:YPL049C(locus name) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707769|imex:IM-9192-13|dip:DIP-59355E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005970|refseq:NP_015276.1|dip:DIP-1291N|mint:Q03063|ensemblfungi:YPL049C(gene)|ensemblfungi:YPL049C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046020"(negative regulation of transcription from RNA polymerase II promoter by pheromones)|go:"GO:1900240"(negative regulation of phenotypic switching)|go:"GO:1990526"(Ste12p-Dig1p-Dig2p complex)|go:"GO:1990527"(Tec1p-Ste12p-Dig1p complex)|go:"GO:2000218"(negative regulation of invasive growth in response to glucose limitation)|go:"GO:2000221"(negative regulation of pseudohyphal growth) ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:2D27F9878BFADD30 crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:Qt+hpsHdt+kIqMB+GKG4AYKLgOQ559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:wj72uzgnjkctiAIw5m/5dQzFwXw false binding-associated region:66-115|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P32505 uniprotkb:P38217 intact:EBI-11770|ensemblfungi:YGL122C|uniprotkb:D6VU26 intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:nab2_yeast(display_long)|uniprotkb:YGL122C(locus name)|uniprotkb:NAB2(gene name)|psi-mi:NAB2(display_short) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707832|imex:IM-9192-2|dip:DIP-10563E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YGL122C(gene)|ensemblfungi:YGL122C_mRNA(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008312"(7S RNA binding)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0033204"(ribonuclease P RNA binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0046872"(metal ion binding)|go:"GO:1900152"(negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR021083|interpro:IPR040366|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|interpro:IPR041044|interpro:IPR043094|rcsb pdb:2JPS|rcsb pdb:2LHN|rcsb pdb:2V75|rcsb pdb:3LCN|rcsb pdb:3ZJ1|rcsb pdb:3ZJ2|rcsb pdb:4JLQ|rcsb pdb:5L2L|refseq:NP_011393.3|sgd:S000003090|mint:P32505|dip:DIP-1331N ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:40335C3D4658DD91 crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:tNdhCVVTRYjqg7BES5wD2Gg4rjw559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:6oMegkNSGiCRpCksgV5vy3ZJIvY false sufficient binding region:201-251|mutation disrupting interaction:219-219,218-218,217-217,216-216|mutation disrupting interaction strength:229-229,226-226,222-222,218-219|mutation disrupting interaction:235-235|mutation disrupting interaction:236-236|mutation disrupting interaction:239-239,238-238,235-235|mutation disrupting interaction:239-239,238-238,222-222|mutation disrupting interaction:239-239,238-238|mutation disrupting interaction strength:239-239|mutation disrupting interaction strength:239-239|mutation disrupting interaction strength:239-239|mutation disrupting interaction strength:239-239 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P32611 uniprotkb:P38217 intact:EBI-22374|uniprotkb:D3DLK0|ensemblfungi:YEL050C intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:rml2_yeast(display_long)|uniprotkb:RML2(gene name)|psi-mi:RML2(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein uL2m(gene name synonym)|uniprotkb:SYGP-ORF37(orf name)|uniprotkb:YEL050C(locus name) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707811|imex:IM-9192-3|dip:DIP-59349E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_010864.3|sgd:S000000776|dip:DIP-6812N|mint:P32611|ensemblfungi:YEL050C(gene)|ensemblfungi:YEL050C_mRNA(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0016740"(transferase activity)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR002171(Ribosomal protein L2)|interpro:IPR005880(Ribosomal protein L2, bacterial-type)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR014726(Ribosomal protein L2, domain 3)|interpro:IPR022666|interpro:IPR022669|interpro:IPR022671|rcsb pdb:3J6B|rcsb pdb:5MRC|rcsb pdb:5MRE|rcsb pdb:5MRF ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:6AD955FF61C24923 crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:1UYPCP3+0uEnbmBfVaDhu8YxPLQ559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:LZmIn6b/5g26jLQBZDCCEwHn5dc false sufficient binding region:74-123|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P35637 uniprotkb:P38217 intact:EBI-400434|uniprotkb:Q9H4A8|ensembl:ENSP00000254108 intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:fus_human(display_long)|uniprotkb:FUS(gene name)|psi-mi:FUS(display_short)|uniprotkb:TLS(gene name synonym)|uniprotkb:Oncogene FUS(gene name synonym)|uniprotkb:Oncogene TLS(gene name synonym)|uniprotkb:Translocated in liposarcoma protein(gene name synonym)|uniprotkb:POMp75(gene name synonym)|uniprotkb:75 kDa DNA-pairing protein(gene name synonym) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707790|imex:IM-9192-18|dip:DIP-59346E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001164105.1|refseq:NP_004951.1|ensembl:ENSG00000089280(gene)|ensembl:ENST00000254108(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P35637|rcsb pdb:2LA6|rcsb pdb:2LCW|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:5W3N|rcsb pdb:5XRR|rcsb pdb:5XSG|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:6BWZ|rcsb pdb:6BXV|rcsb pdb:6BZP|rcsb pdb:6G99|rcsb pdb:6GBM|rcsb pdb:6KJ1|rcsb pdb:6KJ2|rcsb pdb:6KJ3|rcsb pdb:6KJ4|rcsb pdb:6SNJ|rcsb pdb:6XFM|rcsb pdb:7CYL|reactome:R-HSA-72163|dip:DIP-29857N ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) - crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:HUP4fGXQyJnm5CFTuwjTpiucZOc9606 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:u1ScjGHNXEC9Q6cVSEYYvUE37LY false binding-associated region:476-526|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P38333 uniprotkb:P38217 intact:EBI-6482|uniprotkb:D6VQP3|ensemblfungi:YBR247C intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:enp1_yeast(display_long)|uniprotkb:ENP1(gene name)|psi-mi:ENP1(display_short)|uniprotkb:MEG1(gene name synonym)|uniprotkb:YBR247C(locus name)|uniprotkb:YBR1635(orf name) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707890|imex:IM-9192-14|dip:DIP-12436E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_009806.3|sgd:S000000451|mint:P38333|dip:DIP-6612N|ensemblfungi:YBR247C(gene)|ensemblfungi:YBR247C_mRNA(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0030688"(preribosome, small subunit precursor)|interpro:IPR007955(Bystin)|rcsb pdb:5WLC|rcsb pdb:5WWO|rcsb pdb:5WYJ|rcsb pdb:6EML|rcsb pdb:6FAI|rcsb pdb:6KE6|rcsb pdb:6LQP|rcsb pdb:6LQQ|rcsb pdb:6LQR|rcsb pdb:6LQS|rcsb pdb:6LQU|rcsb pdb:6LQV|rcsb pdb:6RBD|rcsb pdb:6Y7C|rcsb pdb:6ZQA|rcsb pdb:6ZQB|rcsb pdb:6ZQC|rcsb pdb:6ZQD|rcsb pdb:6ZQE|rcsb pdb:6ZQF|rcsb pdb:6ZQG|rcsb pdb:7AJT|rcsb pdb:7AJU|reactome:R-SCE-6791226 ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:399A415131294637 crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:hRWEGOAGLPtihuRsJqQDpZyNtcE559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:eqjbFAA+2URIWpnN3RbhAcRMMp4 false binding-associated region:1-27|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q12386 uniprotkb:P38217 intact:EBI-2967|uniprotkb:D6W2J7|ensemblfungi:YOR141C intact:EBI-9152|ensemblfungi:YBR017C|uniprotkb:D6VQ19 psi-mi:arp8_yeast(display_long)|uniprotkb:ARP8(gene name)|psi-mi:ARP8(display_short)|uniprotkb:YOR3348C(orf name)|uniprotkb:YOR141C(locus name) psi-mi:imb2_yeast(display_long)|uniprotkb:KAP104(gene name)|psi-mi:KAP104(display_short)|uniprotkb:YBR017C(locus name)|uniprotkb:YBR0224(orf name)|uniprotkb:Karyopherin subunit beta-2(gene name synonym)|uniprotkb:Karyopherin-104(gene name synonym)|uniprotkb:Importin-104(gene name synonym)|uniprotkb:Transportin(gene name synonym) psi-mi:"MI:0096"(pull down) Süel et al. (2008) pubmed:18532879|doi:10.1371/journal.pbio.0060137|imex:IM-9192 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15707911|imex:IM-9192-19|dip:DIP-59356E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014784.1|sgd:S000005667|dip:DIP-6706N|mint:Q12386|ensemblfungi:YOR141C(gene)|ensemblfungi:YOR141C_mRNA(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031011"(Ino80 complex)|go:"GO:0043044"|interpro:IPR004000(Actin/actin-like)|interpro:IPR027668|interpro:IPR043129|rcsb pdb:4AM6|rcsb pdb:4AM7|rcsb pdb:5NBN ensemblfungi:YBR017C(gene)|ensemblfungi:YBR017C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|reactome:R-SCE-450513|go:"GO:0005934"(cellular bud tip)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010458"(exit from mitosis)|go:"GO:0051028"(mRNA transport)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|refseq:NP_009573.1|sgd:S000000221|dip:DIP-1399N|mint:P38217 psi-mi:"MI:0465"(dip) crc64:8174851B6B077A19 crc64:E8010A477D1FC0B5 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:Fc4e07dK0jlFdmua36/7VcyUTa0559292 rogid:2qmHUziyz8MZ4Q1/M4VcdD186Y4559292 rigid:6YdQECL2NYa9zwhSA2D13pBJCyw false binding-associated region:114-163|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)