#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P11346 uniprotkb:P11346 intact:EBI-664624|uniprotkb:Q9W4Z3|uniprotkb:Q8I086|uniprotkb:Q8I0D9|uniprotkb:Q8ISE1|uniprotkb:Q8ISE2|uniprotkb:Q8ISE3|uniprotkb:Q9NEH9|uniprotkb:A8JUV5|uniprotkb:Q0KHW7|ensemblmetazoa:FBpp0070385|ensemblmetazoa:FBpp0310458 intact:EBI-664624|uniprotkb:Q9W4Z3|uniprotkb:Q8I086|uniprotkb:Q8I0D9|uniprotkb:Q8ISE1|uniprotkb:Q8ISE2|uniprotkb:Q8ISE3|uniprotkb:Q9NEH9|uniprotkb:A8JUV5|uniprotkb:Q0KHW7|ensemblmetazoa:FBpp0070385|ensemblmetazoa:FBpp0310458 psi-mi:kraf1_drome(display_long)|uniprotkb:Raf(gene name)|psi-mi:Raf(display_short)|uniprotkb:Protein pole-hole(gene name synonym)|uniprotkb:ph(gene name synonym)|uniprotkb:phl(gene name synonym)|uniprotkb:CG2845(orf name) psi-mi:kraf1_drome(display_long)|uniprotkb:Raf(gene name)|psi-mi:Raf(display_short)|uniprotkb:Protein pole-hole(gene name synonym)|uniprotkb:ph(gene name synonym)|uniprotkb:phl(gene name synonym)|uniprotkb:CG2845(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xia et al. (2008) pubmed:18494562|doi:10.1371/journal.pbio.0060128|imex:IM-9157 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15703221|imex:IM-9157-6|dip:DIP-59256E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_525047.1|flybase:FBgn0003079|refseq:NP_001096867.3|dip:DIP-29769N|ensemblmetazoa:FBgn0003079(gene)|ensemblmetazoa:FBtr0070401(transcript)|ensemblmetazoa:FBtr0344007(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0002168"(instar larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007369"(gastrulation)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007552"(metamorphosis)|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|reactome:R-DME-1295596|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-432553|reactome:R-DME-5621575|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5675482 refseq:NP_525047.1|flybase:FBgn0003079|refseq:NP_001096867.3|dip:DIP-29769N|ensemblmetazoa:FBgn0003079(gene)|ensemblmetazoa:FBtr0070401(transcript)|ensemblmetazoa:FBtr0344007(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0002168"(instar larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007369"(gastrulation)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007552"(metamorphosis)|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|reactome:R-DME-1295596|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-432553|reactome:R-DME-5621575|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5675482 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/05 2017/08/10 rogid:rbvsd7+5RvYrFoXyonEM6Li84hM7227 rogid:rbvsd7+5RvYrFoXyonEM6Li84hM7227 rigid:YYZA3DRlnBJJB6Fb2YWOY0lcVE4 false binding-associated region:1-367|ha tag:n-n binding-associated region:368-739|mutation disrupting interaction:510-510|v5 tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P00528 uniprotkb:P11346 intact:EBI-87092|uniprotkb:A4V1H7|uniprotkb:O18372|uniprotkb:Q9VZA2|ensemblmetazoa:FBpp0073177|ensemblmetazoa:FBpp0099944|ensemblmetazoa:FBpp0099946|ensemblmetazoa:FBpp0099947|ensemblmetazoa:FBpp0099948|ensemblmetazoa:FBpp0291750|ensemblmetazoa:FBpp0293526|ensemblmetazoa:FBpp0293527 intact:EBI-664624|uniprotkb:Q9W4Z3|uniprotkb:Q8I086|uniprotkb:Q8I0D9|uniprotkb:Q8ISE1|uniprotkb:Q8ISE2|uniprotkb:Q8ISE3|uniprotkb:Q9NEH9|uniprotkb:A8JUV5|uniprotkb:Q0KHW7|ensemblmetazoa:FBpp0070385|ensemblmetazoa:FBpp0310458 psi-mi:src64_drome(display_long)|uniprotkb:Src64B(gene name)|psi-mi:Src64B(display_short)|uniprotkb:Src1(gene name synonym)|uniprotkb:CG7524(orf name) psi-mi:kraf1_drome(display_long)|uniprotkb:Raf(gene name)|psi-mi:Raf(display_short)|uniprotkb:Protein pole-hole(gene name synonym)|uniprotkb:ph(gene name synonym)|uniprotkb:phl(gene name synonym)|uniprotkb:CG2845(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xia et al. (2008) pubmed:18494562|doi:10.1371/journal.pbio.0060128|imex:IM-9157 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15703275|imex:IM-9157-5|dip:DIP-59254E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-DME-1251985|reactome:R-DME-1253288|reactome:R-DME-1257604|reactome:R-DME-1295596|reactome:R-DME-1433557|reactome:R-DME-177929|reactome:R-DME-180292|reactome:R-DME-186763|reactome:R-DME-2454202|reactome:R-DME-354192|reactome:R-DME-373753|reactome:R-DME-1227986|reactome:R-DME-375165|reactome:R-DME-3928662|reactome:R-DME-3928663|reactome:R-DME-3928664|reactome:R-DME-3928665|reactome:R-DME-399954|reactome:R-DME-399955|reactome:R-DME-399956|reactome:R-DME-418592|reactome:R-DME-418594|reactome:R-DME-430116|reactome:R-DME-432142|reactome:R-DME-4420097|reactome:R-DME-456926|reactome:R-DME-5621575|reactome:R-DME-5663220|reactome:R-DME-5673000|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-6798695|reactome:R-DME-6811558|reactome:R-DME-69231|reactome:R-DME-8934903|reactome:R-DME-8941858|reactome:R-DME-9009391|reactome:R-DME-9013407|reactome:R-DME-9027276|reactome:R-DME-9027284|reactome:R-DME-418885|reactome:R-DME-912631|ensemblmetazoa:FBgn0262733(gene)|ensemblmetazoa:FBtr0073321(transcript)|ensemblmetazoa:FBtr0100504(transcript)|ensemblmetazoa:FBtr0100505(transcript)|ensemblmetazoa:FBtr0100507(transcript)|ensemblmetazoa:FBtr0100508(transcript)|ensemblmetazoa:FBtr0302594(transcript)|ensemblmetazoa:FBtr0304989(transcript)|ensemblmetazoa:FBtr0304990(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007300"(ovarian nurse cell to oocyte transport)|go:"GO:0007301"(female germline ring canal formation)|go:"GO:0007349"(cellularization)|go:"GO:0007411"(axon guidance)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007616"(long-term memory)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008302"(female germline ring canal formation, actin assembly)|go:"GO:0008335"(female germline ring canal stabilization)|go:"GO:0016319"(mushroom body development)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030708"(germarium-derived female germ-line cyst encapsulation)|go:"GO:0030723"(ovarian fusome organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0036058"(filtration diaphragm assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0045172"(germline ring canal)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045874"(positive regulation of sevenless signaling pathway)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048477"(oogenesis)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0120176"(positive regulation of torso signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0030717"(oocyte karyosome formation)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|refseq:NP_001014561.1|refseq:NP_001014562.1|refseq:NP_001014563.1|refseq:NP_001014564.1|refseq:NP_001189051.1|refseq:NP_524934.2|flybase:FBgn0262733|refseq:NP_001246628.1|refseq:NP_001246629.1|dip:DIP-17438N refseq:NP_525047.1|flybase:FBgn0003079|refseq:NP_001096867.3|dip:DIP-29769N|ensemblmetazoa:FBgn0003079(gene)|ensemblmetazoa:FBtr0070401(transcript)|ensemblmetazoa:FBtr0344007(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0002168"(instar larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007369"(gastrulation)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007552"(metamorphosis)|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|reactome:R-DME-1295596|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-432553|reactome:R-DME-5621575|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5675482 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/05 2017/08/10 rogid:o3ytx+aAkV5m40RrH4wV+CJapqs7227 rogid:rbvsd7+5RvYrFoXyonEM6Li84hM7227 rigid:FB+g6x9tqUmsVmBURDXXZwEU1Ek false - sufficient binding region:1-367|v5 tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q24324 uniprotkb:P11346 intact:EBI-671282|ensemblmetazoa:FBpp0071248|uniprotkb:Q8ISE0|uniprotkb:Q9W360 intact:EBI-664624|uniprotkb:Q9W4Z3|uniprotkb:Q8I086|uniprotkb:Q8I0D9|uniprotkb:Q8ISE1|uniprotkb:Q8ISE2|uniprotkb:Q8ISE3|uniprotkb:Q9NEH9|uniprotkb:A8JUV5|uniprotkb:Q0KHW7|ensemblmetazoa:FBpp0070385|ensemblmetazoa:FBpp0310458 psi-mi:dsor1_drome(display_long)|uniprotkb:Dsor1(gene name)|psi-mi:Dsor1(display_short)|uniprotkb:CG15793(orf name) psi-mi:kraf1_drome(display_long)|uniprotkb:Raf(gene name)|psi-mi:Raf(display_short)|uniprotkb:Protein pole-hole(gene name synonym)|uniprotkb:ph(gene name synonym)|uniprotkb:phl(gene name synonym)|uniprotkb:CG2845(orf name) psi-mi:"MI:0424"(protein kinase assay) Xia et al. (2008) pubmed:18494562|doi:10.1371/journal.pbio.0060128|imex:IM-9157 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15703296|imex:IM-9157-7|dip:DIP-59255E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0010269(gene)|ensemblmetazoa:FBtr0071313(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|refseq:NP_511098.1|flybase:FBgn0010269|refseq:NP_001285044.1|dip:DIP-29770N|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019900"(kinase binding)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-110056|reactome:R-DME-112411|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|reactome:R-DME-445144|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499 refseq:NP_525047.1|flybase:FBgn0003079|refseq:NP_001096867.3|dip:DIP-29769N|ensemblmetazoa:FBgn0003079(gene)|ensemblmetazoa:FBtr0070401(transcript)|ensemblmetazoa:FBtr0344007(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0002168"(instar larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007369"(gastrulation)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007552"(metamorphosis)|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|reactome:R-DME-1295596|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-432553|reactome:R-DME-5621575|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5675482 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:FsIuc6ILmQjnAJmLsgb17lwXMU07227 rogid:rbvsd7+5RvYrFoXyonEM6Li84hM7227 rigid:hhwlNXGA0yislHmqux9SCe1Tyro false glutathione s tranferase tag:n-n mutation increasing interaction:510-510|v5 tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P00528 uniprotkb:P11346 intact:EBI-87092|uniprotkb:A4V1H7|uniprotkb:O18372|uniprotkb:Q9VZA2|ensemblmetazoa:FBpp0073177|ensemblmetazoa:FBpp0099944|ensemblmetazoa:FBpp0099946|ensemblmetazoa:FBpp0099947|ensemblmetazoa:FBpp0099948|ensemblmetazoa:FBpp0291750|ensemblmetazoa:FBpp0293526|ensemblmetazoa:FBpp0293527 intact:EBI-664624|uniprotkb:Q9W4Z3|uniprotkb:Q8I086|uniprotkb:Q8I0D9|uniprotkb:Q8ISE1|uniprotkb:Q8ISE2|uniprotkb:Q8ISE3|uniprotkb:Q9NEH9|uniprotkb:A8JUV5|uniprotkb:Q0KHW7|ensemblmetazoa:FBpp0070385|ensemblmetazoa:FBpp0310458 psi-mi:src64_drome(display_long)|uniprotkb:Src64B(gene name)|psi-mi:Src64B(display_short)|uniprotkb:Src1(gene name synonym)|uniprotkb:CG7524(orf name) psi-mi:kraf1_drome(display_long)|uniprotkb:Raf(gene name)|psi-mi:Raf(display_short)|uniprotkb:Protein pole-hole(gene name synonym)|uniprotkb:ph(gene name synonym)|uniprotkb:phl(gene name synonym)|uniprotkb:CG2845(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xia et al. (2008) pubmed:18494562|doi:10.1371/journal.pbio.0060128|imex:IM-9157 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15703320|imex:IM-9157-3|dip:DIP-59254E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-DME-1251985|reactome:R-DME-1253288|reactome:R-DME-1257604|reactome:R-DME-1295596|reactome:R-DME-1433557|reactome:R-DME-177929|reactome:R-DME-180292|reactome:R-DME-186763|reactome:R-DME-2454202|reactome:R-DME-354192|reactome:R-DME-373753|reactome:R-DME-1227986|reactome:R-DME-375165|reactome:R-DME-3928662|reactome:R-DME-3928663|reactome:R-DME-3928664|reactome:R-DME-3928665|reactome:R-DME-399954|reactome:R-DME-399955|reactome:R-DME-399956|reactome:R-DME-418592|reactome:R-DME-418594|reactome:R-DME-430116|reactome:R-DME-432142|reactome:R-DME-4420097|reactome:R-DME-456926|reactome:R-DME-5621575|reactome:R-DME-5663220|reactome:R-DME-5673000|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-6798695|reactome:R-DME-6811558|reactome:R-DME-69231|reactome:R-DME-8934903|reactome:R-DME-8941858|reactome:R-DME-9009391|reactome:R-DME-9013407|reactome:R-DME-9027276|reactome:R-DME-9027284|reactome:R-DME-418885|reactome:R-DME-912631|ensemblmetazoa:FBgn0262733(gene)|ensemblmetazoa:FBtr0073321(transcript)|ensemblmetazoa:FBtr0100504(transcript)|ensemblmetazoa:FBtr0100505(transcript)|ensemblmetazoa:FBtr0100507(transcript)|ensemblmetazoa:FBtr0100508(transcript)|ensemblmetazoa:FBtr0302594(transcript)|ensemblmetazoa:FBtr0304989(transcript)|ensemblmetazoa:FBtr0304990(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007300"(ovarian nurse cell to oocyte transport)|go:"GO:0007301"(female germline ring canal formation)|go:"GO:0007349"(cellularization)|go:"GO:0007411"(axon guidance)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007616"(long-term memory)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008302"(female germline ring canal formation, actin assembly)|go:"GO:0008335"(female germline ring canal stabilization)|go:"GO:0016319"(mushroom body development)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030708"(germarium-derived female germ-line cyst encapsulation)|go:"GO:0030723"(ovarian fusome organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0036058"(filtration diaphragm assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0045172"(germline ring canal)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045874"(positive regulation of sevenless signaling pathway)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048477"(oogenesis)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0120176"(positive regulation of torso signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0030717"(oocyte karyosome formation)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|refseq:NP_001014561.1|refseq:NP_001014562.1|refseq:NP_001014563.1|refseq:NP_001014564.1|refseq:NP_001189051.1|refseq:NP_524934.2|flybase:FBgn0262733|refseq:NP_001246628.1|refseq:NP_001246629.1|dip:DIP-17438N refseq:NP_525047.1|flybase:FBgn0003079|refseq:NP_001096867.3|dip:DIP-29769N|ensemblmetazoa:FBgn0003079(gene)|ensemblmetazoa:FBtr0070401(transcript)|ensemblmetazoa:FBtr0344007(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0002168"(instar larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007369"(gastrulation)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007552"(metamorphosis)|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|reactome:R-DME-1295596|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-432553|reactome:R-DME-5621575|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5675482 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/05 2017/08/10 rogid:o3ytx+aAkV5m40RrH4wV+CJapqs7227 rogid:rbvsd7+5RvYrFoXyonEM6Li84hM7227 rigid:FB+g6x9tqUmsVmBURDXXZwEU1Ek false v5 tag:c-c - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q24324 uniprotkb:P11346 intact:EBI-671282|ensemblmetazoa:FBpp0071248|uniprotkb:Q8ISE0|uniprotkb:Q9W360 intact:EBI-664624|uniprotkb:Q9W4Z3|uniprotkb:Q8I086|uniprotkb:Q8I0D9|uniprotkb:Q8ISE1|uniprotkb:Q8ISE2|uniprotkb:Q8ISE3|uniprotkb:Q9NEH9|uniprotkb:A8JUV5|uniprotkb:Q0KHW7|ensemblmetazoa:FBpp0070385|ensemblmetazoa:FBpp0310458 psi-mi:dsor1_drome(display_long)|uniprotkb:Dsor1(gene name)|psi-mi:Dsor1(display_short)|uniprotkb:CG15793(orf name) psi-mi:kraf1_drome(display_long)|uniprotkb:Raf(gene name)|psi-mi:Raf(display_short)|uniprotkb:Protein pole-hole(gene name synonym)|uniprotkb:ph(gene name synonym)|uniprotkb:phl(gene name synonym)|uniprotkb:CG2845(orf name) psi-mi:"MI:0424"(protein kinase assay) Xia et al. (2008) pubmed:18494562|doi:10.1371/journal.pbio.0060128|imex:IM-9157 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15703339|imex:IM-9157-1|dip:DIP-59255E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0010269(gene)|ensemblmetazoa:FBtr0071313(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|refseq:NP_511098.1|flybase:FBgn0010269|refseq:NP_001285044.1|dip:DIP-29770N|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019900"(kinase binding)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-110056|reactome:R-DME-112411|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|reactome:R-DME-445144|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499 refseq:NP_525047.1|flybase:FBgn0003079|refseq:NP_001096867.3|dip:DIP-29769N|ensemblmetazoa:FBgn0003079(gene)|ensemblmetazoa:FBtr0070401(transcript)|ensemblmetazoa:FBtr0344007(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0002168"(instar larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007369"(gastrulation)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007552"(metamorphosis)|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|reactome:R-DME-1295596|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-432553|reactome:R-DME-5621575|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5675482 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:FsIuc6ILmQjnAJmLsgb17lwXMU07227 rogid:rbvsd7+5RvYrFoXyonEM6Li84hM7227 rigid:hhwlNXGA0yislHmqux9SCe1Tyro false glutathione s tranferase tag:n-n sufficient binding region:368-739|v5 tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P00528 uniprotkb:P11346 intact:EBI-87092|uniprotkb:A4V1H7|uniprotkb:O18372|uniprotkb:Q9VZA2|ensemblmetazoa:FBpp0073177|ensemblmetazoa:FBpp0099944|ensemblmetazoa:FBpp0099946|ensemblmetazoa:FBpp0099947|ensemblmetazoa:FBpp0099948|ensemblmetazoa:FBpp0291750|ensemblmetazoa:FBpp0293526|ensemblmetazoa:FBpp0293527 intact:EBI-664624|uniprotkb:Q9W4Z3|uniprotkb:Q8I086|uniprotkb:Q8I0D9|uniprotkb:Q8ISE1|uniprotkb:Q8ISE2|uniprotkb:Q8ISE3|uniprotkb:Q9NEH9|uniprotkb:A8JUV5|uniprotkb:Q0KHW7|ensemblmetazoa:FBpp0070385|ensemblmetazoa:FBpp0310458 psi-mi:src64_drome(display_long)|uniprotkb:Src64B(gene name)|psi-mi:Src64B(display_short)|uniprotkb:Src1(gene name synonym)|uniprotkb:CG7524(orf name) psi-mi:kraf1_drome(display_long)|uniprotkb:Raf(gene name)|psi-mi:Raf(display_short)|uniprotkb:Protein pole-hole(gene name synonym)|uniprotkb:ph(gene name synonym)|uniprotkb:phl(gene name synonym)|uniprotkb:CG2845(orf name) psi-mi:"MI:0424"(protein kinase assay) Xia et al. (2008) pubmed:18494562|doi:10.1371/journal.pbio.0060128|imex:IM-9157 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15703249|imex:IM-9157-4|dip:DIP-59254E - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-DME-1251985|reactome:R-DME-1253288|reactome:R-DME-1257604|reactome:R-DME-1295596|reactome:R-DME-1433557|reactome:R-DME-177929|reactome:R-DME-180292|reactome:R-DME-186763|reactome:R-DME-2454202|reactome:R-DME-354192|reactome:R-DME-373753|reactome:R-DME-1227986|reactome:R-DME-375165|reactome:R-DME-3928662|reactome:R-DME-3928663|reactome:R-DME-3928664|reactome:R-DME-3928665|reactome:R-DME-399954|reactome:R-DME-399955|reactome:R-DME-399956|reactome:R-DME-418592|reactome:R-DME-418594|reactome:R-DME-430116|reactome:R-DME-432142|reactome:R-DME-4420097|reactome:R-DME-456926|reactome:R-DME-5621575|reactome:R-DME-5663220|reactome:R-DME-5673000|reactome:R-DME-5673001|reactome:R-DME-5674135|reactome:R-DME-6798695|reactome:R-DME-6811558|reactome:R-DME-69231|reactome:R-DME-8934903|reactome:R-DME-8941858|reactome:R-DME-9009391|reactome:R-DME-9013407|reactome:R-DME-9027276|reactome:R-DME-9027284|reactome:R-DME-418885|reactome:R-DME-912631|ensemblmetazoa:FBgn0262733(gene)|ensemblmetazoa:FBtr0073321(transcript)|ensemblmetazoa:FBtr0100504(transcript)|ensemblmetazoa:FBtr0100505(transcript)|ensemblmetazoa:FBtr0100507(transcript)|ensemblmetazoa:FBtr0100508(transcript)|ensemblmetazoa:FBtr0302594(transcript)|ensemblmetazoa:FBtr0304989(transcript)|ensemblmetazoa:FBtr0304990(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007300"(ovarian nurse cell to oocyte transport)|go:"GO:0007301"(female germline ring canal formation)|go:"GO:0007349"(cellularization)|go:"GO:0007411"(axon guidance)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007616"(long-term memory)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008302"(female germline ring canal formation, actin assembly)|go:"GO:0008335"(female germline ring canal stabilization)|go:"GO:0016319"(mushroom body development)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030046"(parallel actin filament bundle assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030708"(germarium-derived female germ-line cyst encapsulation)|go:"GO:0030723"(ovarian fusome organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0036058"(filtration diaphragm assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0045172"(germline ring canal)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045874"(positive regulation of sevenless signaling pathway)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048477"(oogenesis)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0120176"(positive regulation of torso signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0030717"(oocyte karyosome formation)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|refseq:NP_001014561.1|refseq:NP_001014562.1|refseq:NP_001014563.1|refseq:NP_001014564.1|refseq:NP_001189051.1|refseq:NP_524934.2|flybase:FBgn0262733|refseq:NP_001246628.1|refseq:NP_001246629.1|dip:DIP-17438N refseq:NP_525047.1|flybase:FBgn0003079|refseq:NP_001096867.3|dip:DIP-29769N|ensemblmetazoa:FBgn0003079(gene)|ensemblmetazoa:FBtr0070401(transcript)|ensemblmetazoa:FBtr0344007(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0002168"(instar larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007369"(gastrulation)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007552"(metamorphosis)|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|reactome:R-DME-1295596|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-432553|reactome:R-DME-5621575|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5675482 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:o3ytx+aAkV5m40RrH4wV+CJapqs7227 rogid:rbvsd7+5RvYrFoXyonEM6Li84hM7227 rigid:FB+g6x9tqUmsVmBURDXXZwEU1Ek false glutathione s tranferase tag:n-n binding-associated region:368-739|mutation disrupting interaction:510-510|his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q24324 uniprotkb:P11346 intact:EBI-671282|ensemblmetazoa:FBpp0071248|uniprotkb:Q8ISE0|uniprotkb:Q9W360 intact:EBI-664624|uniprotkb:Q9W4Z3|uniprotkb:Q8I086|uniprotkb:Q8I0D9|uniprotkb:Q8ISE1|uniprotkb:Q8ISE2|uniprotkb:Q8ISE3|uniprotkb:Q9NEH9|uniprotkb:A8JUV5|uniprotkb:Q0KHW7|ensemblmetazoa:FBpp0070385|ensemblmetazoa:FBpp0310458 psi-mi:dsor1_drome(display_long)|uniprotkb:Dsor1(gene name)|psi-mi:Dsor1(display_short)|uniprotkb:CG15793(orf name) psi-mi:kraf1_drome(display_long)|uniprotkb:Raf(gene name)|psi-mi:Raf(display_short)|uniprotkb:Protein pole-hole(gene name synonym)|uniprotkb:ph(gene name synonym)|uniprotkb:phl(gene name synonym)|uniprotkb:CG2845(orf name) psi-mi:"MI:0424"(protein kinase assay) Xia et al. (2008) pubmed:18494562|doi:10.1371/journal.pbio.0060128|imex:IM-9157 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15703362|imex:IM-9157-2|dip:DIP-59255E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0010269(gene)|ensemblmetazoa:FBtr0071313(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000793"(condensed chromosome)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007430"(terminal branching, open tracheal system)|refseq:NP_511098.1|flybase:FBgn0010269|refseq:NP_001285044.1|dip:DIP-29770N|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019900"(kinase binding)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-DME-110056|reactome:R-DME-112411|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|reactome:R-DME-445144|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499 refseq:NP_525047.1|flybase:FBgn0003079|refseq:NP_001096867.3|dip:DIP-29769N|ensemblmetazoa:FBgn0003079(gene)|ensemblmetazoa:FBtr0070401(transcript)|ensemblmetazoa:FBtr0344007(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0002168"(instar larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007362"(terminal region determination)|go:"GO:0007369"(gastrulation)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007430"(terminal branching, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007472"(wing disc morphogenesis)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007552"(metamorphosis)|go:"GO:0008069"(dorsal/ventral axis specification, ovarian follicular epithelium)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0035171"(lamellocyte differentiation)|go:"GO:0035309"(wing and notum subfield formation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042051"(compound eye photoreceptor development)|go:"GO:0042386"(hemocyte differentiation)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046530"(photoreceptor cell differentiation)|go:"GO:0046534"(positive regulation of photoreceptor cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR029071|reactome:R-DME-1295596|reactome:R-DME-170968|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-392517|reactome:R-DME-430116|reactome:R-DME-432553|reactome:R-DME-5621575|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5674499|reactome:R-DME-5675221|reactome:R-DME-5675482 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:FsIuc6ILmQjnAJmLsgb17lwXMU07227 rogid:rbvsd7+5RvYrFoXyonEM6Li84hM7227 rigid:hhwlNXGA0yislHmqux9SCe1Tyro false glutathione s tranferase tag:n-n mutation increasing interaction:510-510 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)