#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q91ZE9 uniprotkb:Q07440 intact:EBI-708032|uniprotkb:Q8BUK0|ensembl:ENSMUSP00000159051 intact:EBI-707754|ensembl:ENSMUSP00000096086 psi-mi:bmf_mouse(display_long)|uniprotkb:Bmf(gene name)|psi-mi:Bmf(display_short) psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Smits et al. (2008) pubmed:18462686|doi:10.1016/j.str.2008.02.009|imex:IM-9172 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15701440|imex:IM-9172-6|dip:DIP-59291E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_612186.2|refseq:XP_006498918.1|refseq:NP_001318150.1|dip:DIP-29806N|ensembl:ENSMUSG00000040093(gene)|ensembl:ENSMUST00000125860(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR028192|mint:Q91ZE9|rcsb pdb:2VOG|reactome:R-MMU-111453|reactome:R-MMU-139910 refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:TuX2CXkbIbnDcK+gYw7T0AyD5zo10090 rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090 rigid:4wC/JzrDXE1uZdsFJyPpm+x5Wuw false binding-associated region:126-152 binding-associated region:1-152 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99ML1 uniprotkb:Q07440 intact:EBI-727801|ensembl:ENSMUSP00000002152 intact:EBI-707754|ensembl:ENSMUSP00000096086 psi-mi:bbc3_mouse(display_long)|uniprotkb:Bbc3(gene name)|psi-mi:Bbc3(display_short)|uniprotkb:Puma(gene name synonym)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym) psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Smits et al. (2008) pubmed:18462686|doi:10.1016/j.str.2008.02.009|imex:IM-9172 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15701461|imex:IM-9172-1|dip:DIP-59290E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_573497.1|refseq:XP_006539640.1|refseq:XP_006539641.1|refseq:XP_006539642.1|refseq:XP_006539643.1|refseq:XP_006539644.1|refseq:XP_006539645.1|ensembl:ENSMUSG00000002083(gene)|ensembl:ENSMUST00000002152(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|rcsb pdb:2ROC|rcsb pdb:2VOF|go:"GO:0071456"(cellular response to hypoxia)|dip:DIP-29805N refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:lq0AaGSFPd/uPIBsgkCJrSkJzNM10090 rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090 rigid:211D1819TVadvvxGHw7hmAnODyk false binding-associated region:130-155 binding-associated region:1-152 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q91ZE9 uniprotkb:Q07440 intact:EBI-708032|uniprotkb:Q8BUK0|ensembl:ENSMUSP00000159051 intact:EBI-707754|ensembl:ENSMUSP00000096086 psi-mi:bmf_mouse(display_long)|uniprotkb:Bmf(gene name)|psi-mi:Bmf(display_short) psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Smits et al. (2008) pubmed:18462686|doi:10.1016/j.str.2008.02.009|imex:IM-9172 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15701525|imex:IM-9172-5|dip:DIP-59291E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_612186.2|refseq:XP_006498918.1|refseq:NP_001318150.1|dip:DIP-29806N|ensembl:ENSMUSG00000040093(gene)|ensembl:ENSMUST00000125860(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034644"(cellular response to UV)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043276"(anoikis)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR028192|mint:Q91ZE9|rcsb pdb:2VOG|reactome:R-MMU-111453|reactome:R-MMU-139910 refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:TuX2CXkbIbnDcK+gYw7T0AyD5zo10090 rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090 rigid:4wC/JzrDXE1uZdsFJyPpm+x5Wuw false binding-associated region:126-152 binding-associated region:1-152 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99ML1 uniprotkb:Q07440 intact:EBI-727801|ensembl:ENSMUSP00000002152 intact:EBI-707754|ensembl:ENSMUSP00000096086 psi-mi:bbc3_mouse(display_long)|uniprotkb:Bbc3(gene name)|psi-mi:Bbc3(display_short)|uniprotkb:Puma(gene name synonym)|uniprotkb:p53 up-regulated modulator of apoptosis(gene name synonym) psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Smits et al. (2008) pubmed:18462686|doi:10.1016/j.str.2008.02.009|imex:IM-9172 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15701547|imex:IM-9172-4|dip:DIP-59290E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_573497.1|refseq:XP_006539640.1|refseq:XP_006539641.1|refseq:XP_006539642.1|refseq:XP_006539643.1|refseq:XP_006539644.1|refseq:XP_006539645.1|ensembl:ENSMUSG00000002083(gene)|ensembl:ENSMUST00000002152(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032464"(positive regulation of protein homooligomerization)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|go:"GO:1901998"(toxin transport)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR031661|rcsb pdb:2ROC|rcsb pdb:2VOF|go:"GO:0071456"(cellular response to hypoxia)|dip:DIP-29805N refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:lq0AaGSFPd/uPIBsgkCJrSkJzNM10090 rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090 rigid:211D1819TVadvvxGHw7hmAnODyk false binding-associated region:130-155 binding-associated region:1-152 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70444 uniprotkb:Q07440 intact:EBI-783400|uniprotkb:Q99M39|ensembl:ENSMUSP00000004560|ensembl:ENSMUSP00000125731 intact:EBI-707754|ensembl:ENSMUSP00000096086 psi-mi:bid_mouse(display_long)|uniprotkb:p22 BID(gene name synonym)|uniprotkb:Bid(gene name)|psi-mi:Bid(display_short) psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Smits et al. (2008) pubmed:18462686|doi:10.1016/j.str.2008.02.009|imex:IM-9172 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15701569|imex:IM-9172-3|dip:DIP-59293E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031570.2|ensembl:ENSMUSG00000004446(gene)|ensembl:ENSMUST00000004560(transcript)|ensembl:ENSMUST00000160684(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002931"(response to ischemia)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|refseq:XP_006505472.1|refseq:XP_006505473.1|refseq:XP_006505474.1|dip:DIP-29808N|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR010479(BH3 interacting)|interpro:IPR020728|interpro:IPR036834|mint:P70444|rcsb pdb:1DDB|rcsb pdb:2VOI|reactome:R-MMU-111447|reactome:R-MMU-111452|reactome:R-MMU-111453|reactome:R-MMU-114294|reactome:R-MMU-75108 refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:wP7rDKvhdigb9+nzg+E2e6K+FY410090 rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090 rigid:woOMheufVU9CxP6H49lgJ0fq1K0 false binding-associated region:76-109 binding-associated region:1-152 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O08734 uniprotkb:Q07440 intact:EBI-822441|uniprotkb:E9QM21|uniprotkb:Q8C264|ensembl:ENSMUSP00000077757 intact:EBI-707754|ensembl:ENSMUSP00000096086 psi-mi:bak_mouse(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bak1(gene name)|psi-mi:Bak1(display_short)|uniprotkb:Bak(gene name synonym) psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Smits et al. (2008) pubmed:18462686|doi:10.1016/j.str.2008.02.009|imex:IM-9172 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15701503|imex:IM-9172-7|dip:DIP-59292E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031549.2|dip:DIP-29807N|ensembl:ENSMUSG00000057789(gene)|ensembl:ENSMUST00000078691(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|rcsb pdb:2VOH|rcsb pdb:5FMJ|rcsb pdb:5KTG|rcsb pdb:6MCY|reactome:R-MMU-111452|reactome:R-MMU-111457|reactome:R-MMU-5620971 refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:T7CFw0SsDVHa+bqgyJSxkaebDBc10090 rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090 rigid:NPUnAyt1ZCaP8y3ZJgyqAhKbsH4 false binding-associated region:64-89 binding-associated region:1-152 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70444 uniprotkb:Q07440 intact:EBI-783400|uniprotkb:Q99M39|ensembl:ENSMUSP00000004560|ensembl:ENSMUSP00000125731 intact:EBI-707754|ensembl:ENSMUSP00000096086 psi-mi:bid_mouse(display_long)|uniprotkb:p22 BID(gene name synonym)|uniprotkb:Bid(gene name)|psi-mi:Bid(display_short) psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Smits et al. (2008) pubmed:18462686|doi:10.1016/j.str.2008.02.009|imex:IM-9172 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15701482|imex:IM-9172-2|dip:DIP-59293E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031570.2|ensembl:ENSMUSG00000004446(gene)|ensembl:ENSMUST00000004560(transcript)|ensembl:ENSMUST00000160684(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002931"(response to ischemia)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|refseq:XP_006505472.1|refseq:XP_006505473.1|refseq:XP_006505474.1|dip:DIP-29808N|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR010479(BH3 interacting)|interpro:IPR020728|interpro:IPR036834|mint:P70444|rcsb pdb:1DDB|rcsb pdb:2VOI|reactome:R-MMU-111447|reactome:R-MMU-111452|reactome:R-MMU-111453|reactome:R-MMU-114294|reactome:R-MMU-75108 refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:wP7rDKvhdigb9+nzg+E2e6K+FY410090 rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090 rigid:woOMheufVU9CxP6H49lgJ0fq1K0 false binding-associated region:76-109 binding-associated region:1-152 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O08734 uniprotkb:Q07440 intact:EBI-822441|uniprotkb:E9QM21|uniprotkb:Q8C264|ensembl:ENSMUSP00000077757 intact:EBI-707754|ensembl:ENSMUSP00000096086 psi-mi:bak_mouse(display_long)|uniprotkb:Apoptosis regulator BAK(gene name synonym)|uniprotkb:Bak1(gene name)|psi-mi:Bak1(display_short)|uniprotkb:Bak(gene name synonym) psi-mi:b2la1_mouse(display_long)|uniprotkb:Protein BFL-1(gene name synonym)|uniprotkb:Hemopoietic-specific early response protein(gene name synonym)|uniprotkb:A1-A(gene name synonym)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:A1(gene name synonym)|uniprotkb:Bcl2a1a(gene name synonym)|uniprotkb:Bfl1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Smits et al. (2008) pubmed:18462686|doi:10.1016/j.str.2008.02.009|imex:IM-9172 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15701591|imex:IM-9172-8|dip:DIP-59292E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031549.2|dip:DIP-29807N|ensembl:ENSMUSG00000057789(gene)|ensembl:ENSMUST00000078691(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0002352"(B cell negative selection)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009620"(response to fungus)|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010225"(response to UV-C)|go:"GO:0010248"(establishment or maintenance of transmembrane electrochemical gradient)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0051087"(chaperone binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060068"(vagina development)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097145"(BAK complex)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1902262"(apoptotic process involved in blood vessel morphogenesis)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR026308|interpro:IPR036834|rcsb pdb:2VOH|rcsb pdb:5FMJ|rcsb pdb:5KTG|rcsb pdb:6MCY|reactome:R-MMU-111452|reactome:R-MMU-111457|reactome:R-MMU-5620971 refseq:NP_033872.1|dip:DIP-29804N|ensembl:ENSMUSG00000102037(gene)|ensembl:ENSMUST00000098485(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|rcsb pdb:2VOF|rcsb pdb:2VOG|rcsb pdb:2VOH|rcsb pdb:2VOI psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:T7CFw0SsDVHa+bqgyJSxkaebDBc10090 rogid:y0kYh4r1CGSfgjKaJRBD5FBTSK010090 rigid:NPUnAyt1ZCaP8y3ZJgyqAhKbsH4 false binding-associated region:64-89 binding-associated region:1-152 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)