#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Z111 uniprotkb:Q9Z111 intact:EBI-1173616 intact:EBI-1173616 psi-mi:ga45g_mouse(display_long)|uniprotkb:Gadd45g(gene name)|psi-mi:Gadd45g(display_short)|uniprotkb:Cr6(gene name synonym)|uniprotkb:Cytokine-responsive protein CR6(gene name synonym) psi-mi:ga45g_mouse(display_long)|uniprotkb:Gadd45g(gene name)|psi-mi:Gadd45g(display_short)|uniprotkb:Cr6(gene name synonym)|uniprotkb:Cytokine-responsive protein CR6(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Schrag et al. (2008) pubmed:18445651|doi:10.1073/pnas.0800086105|imex:IM-9264 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15699710|imex:IM-9264-1|dip:DIP-59508E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:3CG6|dip:DIP-29978N go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:3CG6|dip:DIP-29978N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:wZwE3DiGe4torrzISFHx5q2L8Pg10090 rogid:wZwE3DiGe4torrzISFHx5q2L8Pg10090 rigid:6w8nLphGemnfuDUGWbRGgZ9PEdw false mutation disrupting interaction:80-80|binding-associated region:16-159 mutation disrupting interaction:80-80|binding-associated region:16-159 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Z111 uniprotkb:Q9Z111 intact:EBI-1173616 intact:EBI-1173616 psi-mi:ga45g_mouse(display_long)|uniprotkb:Gadd45g(gene name)|psi-mi:Gadd45g(display_short)|uniprotkb:Cr6(gene name synonym)|uniprotkb:Cytokine-responsive protein CR6(gene name synonym) psi-mi:ga45g_mouse(display_long)|uniprotkb:Gadd45g(gene name)|psi-mi:Gadd45g(display_short)|uniprotkb:Cr6(gene name synonym)|uniprotkb:Cytokine-responsive protein CR6(gene name synonym) psi-mi:"MI:0038"(dynamic light scattering) Schrag et al. (2008) pubmed:18445651|doi:10.1073/pnas.0800086105|imex:IM-9264 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15699749|imex:IM-9264-3|dip:DIP-59508E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:3CG6|dip:DIP-29978N go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:3CG6|dip:DIP-29978N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:wZwE3DiGe4torrzISFHx5q2L8Pg10090 rogid:wZwE3DiGe4torrzISFHx5q2L8Pg10090 rigid:6w8nLphGemnfuDUGWbRGgZ9PEdw false mutation disrupting interaction:80-80|binding-associated region:16-159 mutation disrupting interaction:80-80|binding-associated region:16-159 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Z111 uniprotkb:Q9Z111 intact:EBI-1173616 intact:EBI-1173616 psi-mi:ga45g_mouse(display_long)|uniprotkb:Gadd45g(gene name)|psi-mi:Gadd45g(display_short)|uniprotkb:Cr6(gene name synonym)|uniprotkb:Cytokine-responsive protein CR6(gene name synonym) psi-mi:ga45g_mouse(display_long)|uniprotkb:Gadd45g(gene name)|psi-mi:Gadd45g(display_short)|uniprotkb:Cr6(gene name synonym)|uniprotkb:Cytokine-responsive protein CR6(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Schrag et al. (2008) pubmed:18445651|doi:10.1073/pnas.0800086105|imex:IM-9264 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15699771|imex:IM-9264-4|dip:DIP-59508E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:3CG6|dip:DIP-29978N go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:3CG6|dip:DIP-29978N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:wZwE3DiGe4torrzISFHx5q2L8Pg10090 rogid:wZwE3DiGe4torrzISFHx5q2L8Pg10090 rigid:6w8nLphGemnfuDUGWbRGgZ9PEdw false binding-associated region:16-159 binding-associated region:16-159 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Z111 uniprotkb:Q9Z111 intact:EBI-1173616 intact:EBI-1173616 psi-mi:ga45g_mouse(display_long)|uniprotkb:Gadd45g(gene name)|psi-mi:Gadd45g(display_short)|uniprotkb:Cr6(gene name synonym)|uniprotkb:Cytokine-responsive protein CR6(gene name synonym) psi-mi:ga45g_mouse(display_long)|uniprotkb:Gadd45g(gene name)|psi-mi:Gadd45g(display_short)|uniprotkb:Cr6(gene name synonym)|uniprotkb:Cytokine-responsive protein CR6(gene name synonym) psi-mi:"MI:0016"(circular dichroism) Schrag et al. (2008) pubmed:18445651|doi:10.1073/pnas.0800086105|imex:IM-9264 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15699731|imex:IM-9264-2|dip:DIP-59508E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:3CG6|dip:DIP-29978N go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:3CG6|dip:DIP-29978N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:wZwE3DiGe4torrzISFHx5q2L8Pg10090 rogid:wZwE3DiGe4torrzISFHx5q2L8Pg10090 rigid:6w8nLphGemnfuDUGWbRGgZ9PEdw false binding-associated region:16-159 binding-associated region:16-159 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Z111 uniprotkb:Q9Z111 intact:EBI-1173616 intact:EBI-1173616 psi-mi:ga45g_mouse(display_long)|uniprotkb:Gadd45g(gene name)|psi-mi:Gadd45g(display_short)|uniprotkb:Cr6(gene name synonym)|uniprotkb:Cytokine-responsive protein CR6(gene name synonym) psi-mi:ga45g_mouse(display_long)|uniprotkb:Gadd45g(gene name)|psi-mi:Gadd45g(display_short)|uniprotkb:Cr6(gene name synonym)|uniprotkb:Cytokine-responsive protein CR6(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Schrag et al. (2008) pubmed:18445651|doi:10.1073/pnas.0800086105|imex:IM-9264 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15699789|imex:IM-9264-5|dip:DIP-59508E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:3CG6|dip:DIP-29978N go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:3CG6|dip:DIP-29978N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:wZwE3DiGe4torrzISFHx5q2L8Pg10090 rogid:wZwE3DiGe4torrzISFHx5q2L8Pg10090 rigid:6w8nLphGemnfuDUGWbRGgZ9PEdw false mutation disrupting interaction:80-80|binding-associated region:16-159 mutation disrupting interaction:80-80|binding-associated region:16-159 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)