#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q80Z64-1 uniprotkb:Q8BX22 intact:EBI-15699014|ensembl:ENSMUSP00000012540 intact:EBI-2312582|uniprotkb:A2AV00|uniprotkb:Q6S7E8|uniprotkb:Q6S7E9|uniprotkb:Q7TST6|ensembl:ENSMUSP00000029061 psi-mi:q80z64-1(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym) psi-mi:sall4_mouse(display_long)|uniprotkb:Sall4(gene name)|psi-mi:Sall4(display_short)|uniprotkb:Zinc finger protein SALL4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2008) pubmed:18436640|doi:10.1073/pnas.0802288105|imex:IM-9233 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15699025|imex:IM-9233-8|dip:DIP-59420E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2312517(isoform-parent)|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript) refseq:NP_780512.2|refseq:NP_958797.2|refseq:NP_958798.2|dip:DIP-29926N|ensembl:ENSMUSG00000027547(gene)|ensembl:ENSMUST00000029061(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0001843"(neural tube closure)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009888"(tissue development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021915"(neural tube development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8BX22|reactome:R-MMU-8943724 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:84RTcgupqeb0ypojGiwpAezUWVw10090 rigid:Hc3pfddk98IdNKlcE6QfugikmcI false flag tag:?-? v5 tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q80Z64-1 uniprotkb:Q80Z64-1 intact:EBI-15699014|ensembl:ENSMUSP00000012540 intact:EBI-15699014|ensembl:ENSMUSP00000012540 psi-mi:q80z64-1(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym) psi-mi:q80z64-1(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2008) pubmed:18436640|doi:10.1073/pnas.0802288105|imex:IM-9233 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15699048|imex:IM-9233-5|dip:DIP-59422E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2312517(isoform-parent)|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript) intact:EBI-2312517(isoform-parent)|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rigid:qCnKonARWUMHU8oIrifXpK6xdkI false v5 tag:?-?|sufficient binding region:156-305 flag tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9CU65 uniprotkb:Q80Z64-1 intact:EBI-2312762|uniprotkb:Q3UUZ8|uniprotkb:Q3UXK7|uniprotkb:Q80XP0|uniprotkb:B2RUS2|ensembl:ENSMUSP00000022511 intact:EBI-15699014|ensembl:ENSMUSP00000012540 psi-mi:zmym2_mouse(display_long)|uniprotkb:Zmym2(gene name)|psi-mi:Zmym2(display_short)|uniprotkb:Zfp198(gene name synonym)|uniprotkb:Znf198(gene name synonym)|uniprotkb:Zinc finger protein 198(gene name synonym) psi-mi:q80z64-1(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2008) pubmed:18436640|doi:10.1073/pnas.0802288105|imex:IM-9233 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15699075|imex:IM-9233-7|dip:DIP-59424E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006519728.1|refseq:NP_083774.2|refseq:XP_017171710.1|dip:DIP-29928N|ensembl:ENSMUSG00000021945(gene)|ensembl:ENSMUST00000022511(transcript)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016605"(PML body)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|interpro:IPR010507(Zinc finger, MYM-type)|interpro:IPR011017(TRASH)|interpro:IPR021893|mint:Q9CU65 intact:EBI-2312517(isoform-parent)|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:gIm0LYQWUamVGDkVsYWlgKrzePw10090 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rigid:A+9csT1WdplpUDSTtzOxpeoGkrw false v5 tag:c-c flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7TSZ8 uniprotkb:Q80Z64-1 intact:EBI-5691985|uniprotkb:Q80X97|uniprotkb:Q9CZ72|ensembl:ENSMUSP00000001975 intact:EBI-15699014|ensembl:ENSMUSP00000012540 psi-mi:nacc1_mouse(display_long)|uniprotkb:Nacc1(gene name)|psi-mi:Nacc1(display_short)|uniprotkb:Btbd14b(gene name synonym)|uniprotkb:Nac1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein 14B(gene name synonym) psi-mi:q80z64-1(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2008) pubmed:18436640|doi:10.1073/pnas.0802288105|imex:IM-9233 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15699098|imex:IM-9233-6|dip:DIP-59426E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_080064.3|refseq:XP_006531355.1|refseq:XP_006531356.1|refseq:XP_006531357.1|dip:DIP-29930N|ensembl:ENSMUSG00000001910(gene)|ensembl:ENSMUST00000001975(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030054"(cell junction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018379|mint:Q7TSZ8 intact:EBI-2312517(isoform-parent)|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:Mp3o/oidyfj6U+OTJwTb2WP4Q3Y10090 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rigid:REc9mEzB2WLH/UgLj3AXThAF+j0 false v5 tag:c-c flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q61066 uniprotkb:Q80Z64-1 intact:EBI-2312665|uniprotkb:O09068|uniprotkb:O09147|ensembl:ENSMUSP00000026036 intact:EBI-15699014|ensembl:ENSMUSP00000012540 psi-mi:nr0b1_mouse(display_long)|uniprotkb:Nr0b1(gene name)|psi-mi:Nr0b1(display_short)|uniprotkb:Ahch(gene name synonym)|uniprotkb:Dax1(gene name synonym)|uniprotkb:Nuclear receptor DAX-1(gene name synonym) psi-mi:q80z64-1(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2008) pubmed:18436640|doi:10.1073/pnas.0802288105|imex:IM-9233 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15699121|imex:IM-9233-3|dip:DIP-59425E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031456.1|dip:DIP-29929N|ensembl:ENSMUSG00000025056(gene)|ensembl:ENSMUST00000026036(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007530"(sex determination)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008406"(gonad development)|go:"GO:0008584"(male gonad development)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030238"(male sex determination)|go:"GO:0030325"(adrenal gland development)|go:"GO:0032448"(DNA hairpin binding)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050682"(AF-2 domain binding)|go:"GO:0060008"(Sertoli cell differentiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR025900|interpro:IPR033544|interpro:IPR035500|mint:Q61066|rcsb pdb:3F5C|reactome:R-MMU-383280 intact:EBI-2312517(isoform-parent)|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:I9visL2LIOpphOt23lKwCwCtulA10090 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rigid:C1A4m7INcJxLUfuYanuRpE1DPsE false v5 tag:c-c flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q80Z64-1 uniprotkb:Q80Z64-1 intact:EBI-15699014|ensembl:ENSMUSP00000012540 intact:EBI-15699014|ensembl:ENSMUSP00000012540 psi-mi:q80z64-1(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym) psi-mi:q80z64-1(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2008) pubmed:18436640|doi:10.1073/pnas.0802288105|imex:IM-9233 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15699144|imex:IM-9233-9|dip:DIP-59422E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2312517(isoform-parent)|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript) intact:EBI-2312517(isoform-parent)|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rigid:qCnKonARWUMHU8oIrifXpK6xdkI false v5 tag:?-? flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P20263 uniprotkb:Q80Z64-1 intact:EBI-1606219|uniprotkb:Q63843|ensembl:ENSMUSP00000025271 intact:EBI-15699014|ensembl:ENSMUSP00000012540 psi-mi:po5f1_mouse(display_long)|uniprotkb:Pou5f1(gene name)|psi-mi:Pou5f1(display_short)|uniprotkb:Oct-3(gene name synonym)|uniprotkb:Oct-4(gene name synonym)|uniprotkb:Otf-3(gene name synonym)|uniprotkb:Otf3(gene name synonym)|uniprotkb:Octamer-binding transcription factor 3(gene name synonym)|uniprotkb:NF-A3(gene name synonym)|uniprotkb:Octamer-binding protein 3(gene name synonym)|uniprotkb:Octamer-binding protein 4(gene name synonym) psi-mi:q80z64-1(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2008) pubmed:18436640|doi:10.1073/pnas.0802288105|imex:IM-9233 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15699169|imex:IM-9233-1|dip:DIP-59427E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038661.2|ensembl:ENSMUSG00000024406(gene)|ensembl:ENSMUST00000025271(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0001824"(blastocyst development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009786"(regulation of asymmetric cell division)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019955"(cytokine binding)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0005730"(nucleolus)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060795"(cell fate commitment involved in formation of primary germ layer)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0005737"(cytoplasm)|go:"GO:0070974"(POU domain binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090081"(regulation of heart induction by regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090308"(regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000327(POU-specific)|go:"GO:0005739"(mitochondrion)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|interpro:IPR013847(POU)|interpro:IPR015585(POU domain class 5)|interpro:IPR017970|rcsb pdb:1OCP|rcsb pdb:3L1P|rcsb pdb:6HT5|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-29931N intact:EBI-2312517(isoform-parent)|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:AA1LwlLApjnKYcDk+3DoqicIRlk10090 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rigid:XJNSNcJHKJWFdYspGYfsBtVyiOw false v5 tag:c-c flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99LI5 uniprotkb:Q80Z64-1 intact:EBI-2312719|uniprotkb:Q3U063|uniprotkb:Q4FK52|ensembl:ENSMUSP00000039003|ensembl:ENSMUSP00000107677 intact:EBI-15699014|ensembl:ENSMUSP00000012540 psi-mi:zn281_mouse(display_long)|uniprotkb:Znf281(gene name)|psi-mi:Znf281(display_short)|uniprotkb:Zfp281(gene name synonym) psi-mi:q80z64-1(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wang et al. (2008) pubmed:18436640|doi:10.1073/pnas.0802288105|imex:IM-9233 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15699192|imex:IM-9233-4|dip:DIP-59423E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001153723.1|refseq:NP_808311.1|dip:DIP-29927N|ensembl:ENSMUSG00000041483(gene)|ensembl:ENSMUST00000047734(transcript)|ensembl:ENSMUST00000112046(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q99LI5 intact:EBI-2312517(isoform-parent)|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:UX8iqhzIg2wktQ6TTjRVftIXybE10090 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rigid:Qg02MP4uIQ2hxNFNMfmSwboGRCc false v5 tag:c-c flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q80Z64 uniprotkb:Q80Z64 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 intact:EBI-2312517|uniprotkb:Q6SMR1|uniprotkb:Q7TN85|ensembl:ENSMUSP00000012540 psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:nanog_mouse(display_long)|uniprotkb:Nanog(gene name)|psi-mi:Nanog(display_short)|uniprotkb:Ecat4(gene name synonym)|uniprotkb:Enk(gene name synonym)|uniprotkb:Homeobox transcription factor Nanog(gene name synonym)|uniprotkb:Early embryo specific expression NK-type homeobox protein(gene name synonym)|uniprotkb:ES cell-associated protein 4(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Wang et al. (2008) pubmed:18436640|doi:10.1073/pnas.0802288105|imex:IM-9233 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15699215|imex:IM-9233-2|dip:DIP-59422E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 refseq:NP_001276757.1|refseq:NP_001276759.1|refseq:NP_001276760.1|refseq:NP_082292.1|refseq:XP_006506714.1|dip:DIP-29932N|ensembl:ENSMUSG00000012396(gene)|ensembl:ENSMUST00000012540(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001010"(RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008406"(gonad development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010033"(response to organic substance)|go:"GO:0010454"(negative regulation of cell fate commitment)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017145"(stem cell division)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042664"(negative regulation of endodermal cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043697"(cell dedifferentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000035"(regulation of stem cell division)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:Q80Z64|rcsb pdb:2VI6 psi-mi:"MI:0465"(dip) - - dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2013-09-28|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rogid:v8TDhd7PZnOKFS3djxouMHxftPs10090 rigid:P9n7I7xHPwM4TWlvz0tgkEY2BBA false - - - 0 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)