#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q24145 uniprotkb:Q9W0A0 intact:EBI-3403861|ensemblmetazoa:FBpp0086382|uniprotkb:Q26299|uniprotkb:Q9V7K5 intact:EBI-107028|intact:EBI-7607984|intact:MINT-7555415|uniprotkb:Q1EC80|uniprotkb:Q9W0A1|uniprotkb:M9NEX8|ensemblmetazoa:FBpp0072681 psi-mi:shark_drome(display_long)|uniprotkb:Shark(gene name)|psi-mi:Shark(display_short)|uniprotkb:Tk7(gene name synonym)|uniprotkb:CG18247(orf name) psi-mi:drpr_drome(display_long)|uniprotkb:drpr(gene name)|psi-mi:drpr(display_short)|uniprotkb:Megf10(gene name synonym)|uniprotkb:CG2086(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ziegenfuss et al. (2008) pubmed:18432193|doi:10.1038/nature06901|imex:IM-18001 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15698744|imex:IM-18001-1|dip:DIP-189600E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0015295(gene)|ensemblmetazoa:FBtr0087244(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007391"(dorsal closure)|go:"GO:0007394"(dorsal closure, elongation of leading edge cells)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045087"(innate immune response)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046843"(dorsal appendage formation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR020683|interpro:IPR035061|interpro:IPR036770|interpro:IPR036860|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007306"(eggshell chorion assembly)|dip:DIP-59843N|flybase:FBgn0015295|refseq:NP_524743.2 flybase:FBgn0027594|refseq:NP_001246549.1|refseq:NP_728660.2|refseq:NP_477450.1|dip:DIP-19640N|ensemblmetazoa:FBgn0027594(gene)|ensemblmetazoa:FBtr0072799(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008345"(larval locomotory behavior)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0030424"(axon)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0048678"(response to axon injury)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0098794"(postsynapse)|go:"GO:1904396"(regulation of neuromuscular junction development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR011489(EMI)|interpro:IPR013032(EGF-like region, conserved site)|mint:Q9W0A0|reactome:R-DME-114608|reactome:R-DME-159763|reactome:R-DME-159782|reactome:R-DME-381426|reactome:R-DME-8957275 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/05 2017/08/10 rogid:X+orgumEhXjW4daomputG2HXBvw7227 rogid:sMOnCoVjKUNhd8J7lu2LMZqvke47227 rigid:wOuUryHIrzSl7jSPOVXrSU/yXDc false myc tag:n-n mutation decreasing interaction:949-949|ha tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q24145 uniprotkb:Q9W0A0 intact:EBI-3403861|ensemblmetazoa:FBpp0086382|uniprotkb:Q26299|uniprotkb:Q9V7K5 intact:EBI-107028|intact:EBI-7607984|intact:MINT-7555415|uniprotkb:Q1EC80|uniprotkb:Q9W0A1|uniprotkb:M9NEX8|ensemblmetazoa:FBpp0072681 psi-mi:shark_drome(display_long)|uniprotkb:Shark(gene name)|psi-mi:Shark(display_short)|uniprotkb:Tk7(gene name synonym)|uniprotkb:CG18247(orf name) psi-mi:drpr_drome(display_long)|uniprotkb:drpr(gene name)|psi-mi:drpr(display_short)|uniprotkb:Megf10(gene name synonym)|uniprotkb:CG2086(orf name) psi-mi:"MI:0018"(two hybrid) Ziegenfuss et al. (2008) pubmed:18432193|doi:10.1038/nature06901|imex:IM-18001 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15698768|imex:IM-18001-2|dip:DIP-189600E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0015295(gene)|ensemblmetazoa:FBtr0087244(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007391"(dorsal closure)|go:"GO:0007394"(dorsal closure, elongation of leading edge cells)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045087"(innate immune response)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046843"(dorsal appendage formation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR020683|interpro:IPR035061|interpro:IPR036770|interpro:IPR036860|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007306"(eggshell chorion assembly)|dip:DIP-59843N|flybase:FBgn0015295|refseq:NP_524743.2 flybase:FBgn0027594|refseq:NP_001246549.1|refseq:NP_728660.2|refseq:NP_477450.1|dip:DIP-19640N|ensemblmetazoa:FBgn0027594(gene)|ensemblmetazoa:FBtr0072799(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008345"(larval locomotory behavior)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0030424"(axon)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0048678"(response to axon injury)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0098794"(postsynapse)|go:"GO:1904396"(regulation of neuromuscular junction development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR011489(EMI)|interpro:IPR013032(EGF-like region, conserved site)|mint:Q9W0A0|reactome:R-DME-114608|reactome:R-DME-159763|reactome:R-DME-159782|reactome:R-DME-381426|reactome:R-DME-8957275 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:X+orgumEhXjW4daomputG2HXBvw7227 rogid:sMOnCoVjKUNhd8J7lu2LMZqvke47227 rigid:wOuUryHIrzSl7jSPOVXrSU/yXDc false binding-associated region:10-468 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q24145 uniprotkb:Q9W0A0 intact:EBI-3403861|ensemblmetazoa:FBpp0086382|uniprotkb:Q26299|uniprotkb:Q9V7K5 intact:EBI-107028|intact:EBI-7607984|intact:MINT-7555415|uniprotkb:Q1EC80|uniprotkb:Q9W0A1|uniprotkb:M9NEX8|ensemblmetazoa:FBpp0072681 psi-mi:shark_drome(display_long)|uniprotkb:Shark(gene name)|psi-mi:Shark(display_short)|uniprotkb:Tk7(gene name synonym)|uniprotkb:CG18247(orf name) psi-mi:drpr_drome(display_long)|uniprotkb:drpr(gene name)|psi-mi:drpr(display_short)|uniprotkb:Megf10(gene name synonym)|uniprotkb:CG2086(orf name) psi-mi:"MI:0018"(two hybrid) Ziegenfuss et al. (2008) pubmed:18432193|doi:10.1038/nature06901|imex:IM-18001 taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15698787|imex:IM-18001-3|dip:DIP-189600E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblmetazoa:FBgn0015295(gene)|ensemblmetazoa:FBtr0087244(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0007391"(dorsal closure)|go:"GO:0007394"(dorsal closure, elongation of leading edge cells)|go:"GO:0030154"(cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045087"(innate immune response)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046843"(dorsal appendage formation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR020683|interpro:IPR035061|interpro:IPR036770|interpro:IPR036860|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007306"(eggshell chorion assembly)|dip:DIP-59843N|flybase:FBgn0015295|refseq:NP_524743.2 flybase:FBgn0027594|refseq:NP_001246549.1|refseq:NP_728660.2|refseq:NP_477450.1|dip:DIP-19640N|ensemblmetazoa:FBgn0027594(gene)|ensemblmetazoa:FBtr0072799(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0008345"(larval locomotory behavior)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0030424"(axon)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048190"(wing disc dorsal/ventral pattern formation)|go:"GO:0048678"(response to axon injury)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0098794"(postsynapse)|go:"GO:1904396"(regulation of neuromuscular junction development)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR011489(EMI)|interpro:IPR013032(EGF-like region, conserved site)|mint:Q9W0A0|reactome:R-DME-114608|reactome:R-DME-159763|reactome:R-DME-159782|reactome:R-DME-381426|reactome:R-DME-8957275 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:X+orgumEhXjW4daomputG2HXBvw7227 rogid:sMOnCoVjKUNhd8J7lu2LMZqvke47227 rigid:wOuUryHIrzSl7jSPOVXrSU/yXDc false binding-associated region:10-468 mutation disrupting interaction:949-949|mutation decreasing interaction:934-934 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)