#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O42569	uniprotkb:Q91813	intact:EBI-15695825|uniprotkb:O73690|uniprotkb:Q6DFL8	intact:EBI-15695802|uniprotkb:Q6DDZ3|uniprotkb:Q91811|uniprotkb:Q91812	psi-mi:sox2_xenla(display_long)|uniprotkb:sox2(gene name)|psi-mi:sox2(display_short)|uniprotkb:"SRY (sex determining region Y)-box 2"(gene name synonym)	psi-mi:otx2a_xenla(display_long)|uniprotkb:otx2-a(gene name)|psi-mi:otx2-a(display_short)|uniprotkb:Orthodenticle 2-A(gene name synonym)|uniprotkb:Orthodenticle-A-like protein A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Danno et al. (2008)	pubmed:18385377|doi:10.1073/pnas.0710954105|imex:IM-9209	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695869|imex:IM-9209-5|dip:DIP-59383E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|refseq:NP_001081691.1|refseq:XP_018121173.1|dip:DIP-29886N	go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001356(Homeobox)|interpro:IPR003022(Transcription factor Otx2)|interpro:IPR003025(Transcription factor Otx)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013851(Transcription factor Otx, C-terminal)|interpro:IPR017970|refseq:NP_001084160.1|refseq:XP_018087427.1	psi-mi:"MI:0465"(dip)	-	crc64:AEB2F2948D51F6D4	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:sHzSdjM0mzrYHdBXWjTorbTFJTA8355	rogid:/h3MgQQA9Re4drZqvoxMgfNYcVk8355	rigid:c5BD5hbAk1xKt6zuDiUTZ94LA+M	false	ha tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O42569	uniprotkb:Q91813	intact:EBI-15695825|uniprotkb:O73690|uniprotkb:Q6DFL8	intact:EBI-15695802|uniprotkb:Q6DDZ3|uniprotkb:Q91811|uniprotkb:Q91812	psi-mi:sox2_xenla(display_long)|uniprotkb:sox2(gene name)|psi-mi:sox2(display_short)|uniprotkb:"SRY (sex determining region Y)-box 2"(gene name synonym)	psi-mi:otx2a_xenla(display_long)|uniprotkb:otx2-a(gene name)|psi-mi:otx2-a(display_short)|uniprotkb:Orthodenticle 2-A(gene name synonym)|uniprotkb:Orthodenticle-A-like protein A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Danno et al. (2008)	pubmed:18385377|doi:10.1073/pnas.0710954105|imex:IM-9209	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695846|imex:IM-9209-4|dip:DIP-59383E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|refseq:NP_001081691.1|refseq:XP_018121173.1|dip:DIP-29886N	go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001356(Homeobox)|interpro:IPR003022(Transcription factor Otx2)|interpro:IPR003025(Transcription factor Otx)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013851(Transcription factor Otx, C-terminal)|interpro:IPR017970|refseq:NP_001084160.1|refseq:XP_018087427.1	psi-mi:"MI:0465"(dip)	-	crc64:AEB2F2948D51F6D4	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:sHzSdjM0mzrYHdBXWjTorbTFJTA8355	rogid:/h3MgQQA9Re4drZqvoxMgfNYcVk8355	rigid:c5BD5hbAk1xKt6zuDiUTZ94LA+M	false	ha tag:n-n	glutathione s tranferase tag:n-n|sufficient binding region:38-100	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O42569	uniprotkb:Q91813	intact:EBI-15695825|uniprotkb:O73690|uniprotkb:Q6DFL8	intact:EBI-15695802|uniprotkb:Q6DDZ3|uniprotkb:Q91811|uniprotkb:Q91812	psi-mi:sox2_xenla(display_long)|uniprotkb:sox2(gene name)|psi-mi:sox2(display_short)|uniprotkb:"SRY (sex determining region Y)-box 2"(gene name synonym)	psi-mi:otx2a_xenla(display_long)|uniprotkb:otx2-a(gene name)|psi-mi:otx2-a(display_short)|uniprotkb:Orthodenticle 2-A(gene name synonym)|uniprotkb:Orthodenticle-A-like protein A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Danno et al. (2008)	pubmed:18385377|doi:10.1073/pnas.0710954105|imex:IM-9209	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695913|imex:IM-9209-1|dip:DIP-59383E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|refseq:NP_001081691.1|refseq:XP_018121173.1|dip:DIP-29886N	go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001356(Homeobox)|interpro:IPR003022(Transcription factor Otx2)|interpro:IPR003025(Transcription factor Otx)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013851(Transcription factor Otx, C-terminal)|interpro:IPR017970|refseq:NP_001084160.1|refseq:XP_018087427.1	psi-mi:"MI:0465"(dip)	-	crc64:AEB2F2948D51F6D4	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:sHzSdjM0mzrYHdBXWjTorbTFJTA8355	rogid:/h3MgQQA9Re4drZqvoxMgfNYcVk8355	rigid:c5BD5hbAk1xKt6zuDiUTZ94LA+M	false	ha tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O42569	uniprotkb:Q91813	intact:EBI-15695825|uniprotkb:O73690|uniprotkb:Q6DFL8	intact:EBI-15695802|uniprotkb:Q6DDZ3|uniprotkb:Q91811|uniprotkb:Q91812	psi-mi:sox2_xenla(display_long)|uniprotkb:sox2(gene name)|psi-mi:sox2(display_short)|uniprotkb:"SRY (sex determining region Y)-box 2"(gene name synonym)	psi-mi:otx2a_xenla(display_long)|uniprotkb:otx2-a(gene name)|psi-mi:otx2-a(display_short)|uniprotkb:Orthodenticle 2-A(gene name synonym)|uniprotkb:Orthodenticle-A-like protein A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Danno et al. (2008)	pubmed:18385377|doi:10.1073/pnas.0710954105|imex:IM-9209	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695890|imex:IM-9209-2|dip:DIP-59383E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|refseq:NP_001081691.1|refseq:XP_018121173.1|dip:DIP-29886N	go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001356(Homeobox)|interpro:IPR003022(Transcription factor Otx2)|interpro:IPR003025(Transcription factor Otx)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013851(Transcription factor Otx, C-terminal)|interpro:IPR017970|refseq:NP_001084160.1|refseq:XP_018087427.1	psi-mi:"MI:0465"(dip)	-	crc64:AEB2F2948D51F6D4	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:sHzSdjM0mzrYHdBXWjTorbTFJTA8355	rogid:/h3MgQQA9Re4drZqvoxMgfNYcVk8355	rigid:c5BD5hbAk1xKt6zuDiUTZ94LA+M	false	glutathione s tranferase tag:n-n|sufficient binding region:64-114	myc tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O42569	uniprotkb:Q91813	intact:EBI-15695825|uniprotkb:O73690|uniprotkb:Q6DFL8	intact:EBI-15695802|uniprotkb:Q6DDZ3|uniprotkb:Q91811|uniprotkb:Q91812	psi-mi:sox2_xenla(display_long)|uniprotkb:sox2(gene name)|psi-mi:sox2(display_short)|uniprotkb:"SRY (sex determining region Y)-box 2"(gene name synonym)	psi-mi:otx2a_xenla(display_long)|uniprotkb:otx2-a(gene name)|psi-mi:otx2-a(display_short)|uniprotkb:Orthodenticle 2-A(gene name synonym)|uniprotkb:Orthodenticle-A-like protein A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Danno et al. (2008)	pubmed:18385377|doi:10.1073/pnas.0710954105|imex:IM-9209	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695934|imex:IM-9209-3|dip:DIP-59383E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|refseq:NP_001081691.1|refseq:XP_018121173.1|dip:DIP-29886N	go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR001356(Homeobox)|interpro:IPR003022(Transcription factor Otx2)|interpro:IPR003025(Transcription factor Otx)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013851(Transcription factor Otx, C-terminal)|interpro:IPR017970|refseq:NP_001084160.1|refseq:XP_018087427.1	psi-mi:"MI:0465"(dip)	-	crc64:AEB2F2948D51F6D4	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:sHzSdjM0mzrYHdBXWjTorbTFJTA8355	rogid:/h3MgQQA9Re4drZqvoxMgfNYcVk8355	rigid:c5BD5hbAk1xKt6zuDiUTZ94LA+M	false	glutathione s tranferase tag:n-n|sufficient binding region:35-114	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)