#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Z1W4	uniprotkb:Q62849	intact:EBI-8571260|ensembl:ENSMUSP00000026408|uniprotkb:Q9QX55|intact:MINT-2842224|uniprotkb:Q9R221	intact:EBI-15695608|ensembl:ENSRNOP00000023677	psi-mi:gdf11_mouse(display_long)|uniprotkb:Gdf11(gene name)|psi-mi:Gdf11(display_short)|uniprotkb:Bmp11(gene name synonym)|uniprotkb:Bone morphogenetic protein 11(gene name synonym)	psi-mi:pcsk7_rat(display_long)|uniprotkb:Pcsk7(gene name)|psi-mi:Pcsk7(display_short)|uniprotkb:Pc7(gene name synonym)|uniprotkb:Prohormone convertase 7(gene name synonym)|uniprotkb:Proprotein convertase 7(gene name synonym)|uniprotkb:Subtilisin/kexin-like protease PC7(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Essalmani et al. (2008)	pubmed:18378898|doi:10.1073/pnas.0709428105|imex:IM-9221	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695635|imex:IM-9221-3|dip:DIP-59401E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025352(gene)|ensembl:ENSMUST00000026408(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0021512"(spinal cord anterior/posterior patterning)|go:"GO:0031016"(pancreas development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048469"(cell maturation)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:Q9Z1W4|refseq:NP_034402.1|dip:DIP-29907N	ensembl:ENSRNOG00000017478(gene)|ensembl:ENSRNOT00000023677(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0008233"(peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030173"(integral component of Golgi membrane)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR002884(Proprotein convertase, P)|interpro:IPR008979(Galactose-binding like)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR022398|interpro:IPR023828|interpro:IPR032815|interpro:IPR034182|interpro:IPR036852|interpro:IPR038466|dip:DIP-29905N|refseq:NP_062119.1|rgd:3275	psi-mi:"MI:0465"(dip)	comment:mint|function:Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:dnG5VIkRh1k9mmPHVcikm7kIgXY10090	rogid:Ehd/faaVjBL0ZWc0KL/rUU+xZ5810116	rigid:YZajcK3S8M1BcMJJoKcj8cV0xiU	false	binding-associated region:290-301|mutation increasing interaction:297-297	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Z1W4	uniprotkb:P09958	intact:EBI-8571260|ensembl:ENSMUSP00000026408|uniprotkb:Q9QX55|intact:MINT-2842224|uniprotkb:Q9R221	intact:EBI-1056807|uniprotkb:Q14336|uniprotkb:Q6LBS3|uniprotkb:Q9UCZ5|ensembl:ENSP00000268171|ensembl:ENSP00000483552|ensembl:ENSP00000484952|ensembl:ENSP00000506143	psi-mi:gdf11_mouse(display_long)|uniprotkb:Gdf11(gene name)|psi-mi:Gdf11(display_short)|uniprotkb:Bmp11(gene name synonym)|uniprotkb:Bone morphogenetic protein 11(gene name synonym)	psi-mi:furin_human(display_long)|uniprotkb:FURIN(gene name)|psi-mi:FURIN(display_short)|uniprotkb:FUR(gene name synonym)|uniprotkb:PACE(gene name synonym)|uniprotkb:PCSK3(gene name synonym)|uniprotkb:Paired basic amino acid residue-cleaving enzyme(gene name synonym)|uniprotkb:Dibasic-processing enzyme(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Essalmani et al. (2008)	pubmed:18378898|doi:10.1073/pnas.0709428105|imex:IM-9221	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695679|imex:IM-9221-4|dip:DIP-59402E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025352(gene)|ensembl:ENSMUST00000026408(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0021512"(spinal cord anterior/posterior patterning)|go:"GO:0031016"(pancreas development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048469"(cell maturation)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:Q9Z1W4|refseq:NP_034402.1|dip:DIP-29907N	refseq:NP_002560.1|refseq:NP_001276752.1|refseq:NP_001276753.1|go:"GO:0097341"(zymogen inhibition)|go:"GO:1901394"(positive regulation of transforming growth factor beta1 activation)|go:"GO:1990000"(amyloid fibril formation)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR002884(Proprotein convertase, P)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR022398|interpro:IPR023827|interpro:IPR023828|interpro:IPR032815|interpro:IPR034182|interpro:IPR036852|interpro:IPR038466|mint:P09958|rcsb pdb:4OMC|rcsb pdb:4OMD|rcsb pdb:4RYD|rcsb pdb:4Z2A|rcsb pdb:5JMO|rcsb pdb:5JXG|rcsb pdb:5JXH|rcsb pdb:5JXI|rcsb pdb:5JXJ|rcsb pdb:5MIM|rcsb pdb:6A8Y|rcsb pdb:6EQV|rcsb pdb:6EQW|rcsb pdb:6EQX|rcsb pdb:6HLB|rcsb pdb:6HLD|rcsb pdb:6HLE|rcsb pdb:6HZA|rcsb pdb:6HZB|rcsb pdb:6HZC|rcsb pdb:6HZD|rcsb pdb:6YD2|rcsb pdb:6YD3|rcsb pdb:6YD4|rcsb pdb:6YD7|reactome:R-HSA-1181150|reactome:R-HSA-1442490|reactome:R-HSA-1566948|reactome:R-HSA-1592389|go:"GO:0090472"(dibasic protein processing)|reactome:R-HSA-159782|reactome:R-HSA-167060|reactome:R-HSA-171286|reactome:R-HSA-186797|reactome:R-HSA-1912420|reactome:R-HSA-2173789|reactome:R-HSA-5210891|reactome:R-HSA-6809371|reactome:R-HSA-8963889|reactome:R-HSA-9662834|reactome:R-HSA-9679191|reactome:R-HSA-9694614|reactome:R-HSA-977225|ensembl:ENSG00000140564(gene)|ensembl:ENST00000268171(transcript)|ensembl:ENST00000610579(transcript)|ensembl:ENST00000618099(transcript)|ensembl:ENST00000680053(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002020"(protease binding)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008233"(peptidase activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0016486"(peptide hormone processing)|go:"GO:0019058"(viral life cycle)|go:"GO:0019082"(viral protein processing)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031638"(zymogen activation)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032902"(nerve growth factor production)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032940"(secretion by cell)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0043043"(peptide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051004"(regulation of lipoprotein lipase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0070062"(extracellular exosome)|dip:DIP-29904N	psi-mi:"MI:0465"(dip)	comment:mint|function:Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:dnG5VIkRh1k9mmPHVcikm7kIgXY10090	rogid:fARxF82aRgmZAfcuuw1QgDBKjCU9606	rigid:RW1zXEsdNwEaVgQoR6v89xf+vyg	false	binding-associated region:290-301|mutation increasing interaction:297-297	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Z1W4	uniprotkb:P29122-1	intact:EBI-8571260|ensembl:ENSMUSP00000026408|uniprotkb:Q9QX55|intact:MINT-2842224|uniprotkb:Q9R221	intact:EBI-9640355|ensembl:ENSP00000482760	psi-mi:gdf11_mouse(display_long)|uniprotkb:Gdf11(gene name)|psi-mi:Gdf11(display_short)|uniprotkb:Bmp11(gene name synonym)|uniprotkb:Bone morphogenetic protein 11(gene name synonym)	psi-mi:p29122-1(display_long)|uniprotkb:PCSK6(gene name)|psi-mi:PCSK6(display_short)|uniprotkb:PACE4(gene name synonym)|uniprotkb:Paired basic amino acid cleaving enzyme 4(gene name synonym)|uniprotkb:Subtilisin-like proprotein convertase 4(gene name synonym)|uniprotkb:Subtilisin/kexin-like protease PACE4(gene name synonym)|uniprotkb:PACE4(isoform synonym)	psi-mi:"MI:0435"(protease assay)	Essalmani et al. (2008)	pubmed:18378898|doi:10.1073/pnas.0709428105|imex:IM-9221	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695657|imex:IM-9221-2|dip:DIP-59399E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025352(gene)|ensembl:ENSMUST00000026408(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0021512"(spinal cord anterior/posterior patterning)|go:"GO:0031016"(pancreas development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048469"(cell maturation)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:Q9Z1W4|refseq:NP_034402.1|dip:DIP-29907N	ensembl:ENSG00000140479(gene)|ensembl:ENST00000611716(transcript)|intact:EBI-2683528(isoform-parent)	psi-mi:"MI:0465"(dip)	comment:mint|function:Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:dnG5VIkRh1k9mmPHVcikm7kIgXY10090	rogid:Xh7YAAyyc+G8pX8aiioRKS4PB/Y9606	rigid:gy5/BJES1akzWa6OqunVfeJm4+I	false	binding-associated region:290-301|mutation increasing interaction:297-297	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Z1W4	uniprotkb:P41413-2	intact:EBI-8571260|ensembl:ENSMUSP00000026408|uniprotkb:Q9QX55|intact:MINT-2842224|uniprotkb:Q9R221	intact:EBI-15695701|ensembl:ENSRNOP00000016164	psi-mi:gdf11_mouse(display_long)|uniprotkb:Gdf11(gene name)|psi-mi:Gdf11(display_short)|uniprotkb:Bmp11(gene name synonym)|uniprotkb:Bone morphogenetic protein 11(gene name synonym)	psi-mi:p41413-2(display_long)|uniprotkb:Proprotein convertase 5(gene name synonym)|uniprotkb:Proprotein convertase 6(gene name synonym)|uniprotkb:Subtilisin/kexin-like protease PC5(gene name synonym)|uniprotkb:Short(isoform synonym)|uniprotkb:Pcsk5(gene name)|psi-mi:Pcsk5(display_short)	psi-mi:"MI:0435"(protease assay)	Essalmani et al. (2008)	pubmed:18378898|doi:10.1073/pnas.0709428105|imex:IM-9221	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695710|imex:IM-9221-1|dip:DIP-59400E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025352(gene)|ensembl:ENSMUST00000026408(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0021512"(spinal cord anterior/posterior patterning)|go:"GO:0031016"(pancreas development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048469"(cell maturation)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:Q9Z1W4|refseq:NP_034402.1|dip:DIP-29907N	ensembl:ENSRNOG00000012036(gene)|ensembl:ENSRNOT00000016164(transcript)|intact:EBI-16354733(isoform-parent)	psi-mi:"MI:0465"(dip)	comment:mint|function:Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:dnG5VIkRh1k9mmPHVcikm7kIgXY10090	rogid:2wWyJIPlgnhUfGfaOwwmV2Z3v/U10116	rigid:XHhKx6NgkDMGghFz3y3UCkpChQI	false	binding-associated region:290-301|mutation increasing interaction:297-297	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)