#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UNG2 uniprotkb:Q9UNG2 intact:EBI-15672281|ensembl:ENSP00000385470|uniprotkb:A9IQG8|uniprotkb:O95852|uniprotkb:Q6ISV1 intact:EBI-15672281|ensembl:ENSP00000385470|uniprotkb:A9IQG8|uniprotkb:O95852|uniprotkb:Q6ISV1 psi-mi:tnf18_human(display_long)|uniprotkb:TNFSF18(gene name)|psi-mi:TNFSF18(display_short)|uniprotkb:AITRL(gene name synonym)|uniprotkb:GITRL(gene name synonym)|uniprotkb:TL6(gene name synonym)|uniprotkb:UNQ149/PRO175(orf name)|uniprotkb:Activation-inducible TNF-related ligand(gene name synonym)|uniprotkb:Glucocorticoid-induced TNF-related ligand(gene name synonym) psi-mi:tnf18_human(display_long)|uniprotkb:TNFSF18(gene name)|psi-mi:TNFSF18(display_short)|uniprotkb:AITRL(gene name synonym)|uniprotkb:GITRL(gene name synonym)|uniprotkb:TL6(gene name synonym)|uniprotkb:UNQ149/PRO175(orf name)|uniprotkb:Activation-inducible TNF-related ligand(gene name synonym)|uniprotkb:Glucocorticoid-induced TNF-related ligand(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Zhou et al. (2008) pubmed:18378892|doi:10.1073/pnas.0711350105|imex:IM-9207 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15695481|imex:IM-9207-4|dip:DIP-59379E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120337(gene)|ensembl:ENST00000404377(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2000508"(regulation of dendritic cell chemotaxis)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR042380|rcsb pdb:2Q1M|rcsb pdb:2R30|rcsb pdb:2R32|rcsb pdb:3B93|rcsb pdb:3B94|rcsb pdb:7KHD|reactome:R-HSA-5669034|refseq:NP_005083.2|dip:DIP-29882N ensembl:ENSG00000120337(gene)|ensembl:ENST00000404377(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2000508"(regulation of dendritic cell chemotaxis)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR042380|rcsb pdb:2Q1M|rcsb pdb:2R30|rcsb pdb:2R32|rcsb pdb:3B93|rcsb pdb:3B94|rcsb pdb:7KHD|reactome:R-HSA-5669034|refseq:NP_005083.2|dip:DIP-29882N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:LGPRpjFhwtGs0lOxYY3OOk4ixkE9606 rogid:LGPRpjFhwtGs0lOxYY3OOk4ixkE9606 rigid:wJjGUMtrqQrYag3EUQLU2k83iqA false binding-associated region:50-177 binding-associated region:50-177 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNG2 uniprotkb:Q9UNG2 intact:EBI-15672281|ensembl:ENSP00000385470|uniprotkb:A9IQG8|uniprotkb:O95852|uniprotkb:Q6ISV1 intact:EBI-15672281|ensembl:ENSP00000385470|uniprotkb:A9IQG8|uniprotkb:O95852|uniprotkb:Q6ISV1 psi-mi:tnf18_human(display_long)|uniprotkb:TNFSF18(gene name)|psi-mi:TNFSF18(display_short)|uniprotkb:AITRL(gene name synonym)|uniprotkb:GITRL(gene name synonym)|uniprotkb:TL6(gene name synonym)|uniprotkb:UNQ149/PRO175(orf name)|uniprotkb:Activation-inducible TNF-related ligand(gene name synonym)|uniprotkb:Glucocorticoid-induced TNF-related ligand(gene name synonym) psi-mi:tnf18_human(display_long)|uniprotkb:TNFSF18(gene name)|psi-mi:TNFSF18(display_short)|uniprotkb:AITRL(gene name synonym)|uniprotkb:GITRL(gene name synonym)|uniprotkb:TL6(gene name synonym)|uniprotkb:UNQ149/PRO175(orf name)|uniprotkb:Activation-inducible TNF-related ligand(gene name synonym)|uniprotkb:Glucocorticoid-induced TNF-related ligand(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Zhou et al. (2008) pubmed:18378892|doi:10.1073/pnas.0711350105|imex:IM-9207 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15695499|imex:IM-9207-2|dip:DIP-59379E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120337(gene)|ensembl:ENST00000404377(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2000508"(regulation of dendritic cell chemotaxis)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR042380|rcsb pdb:2Q1M|rcsb pdb:2R30|rcsb pdb:2R32|rcsb pdb:3B93|rcsb pdb:3B94|rcsb pdb:7KHD|reactome:R-HSA-5669034|refseq:NP_005083.2|dip:DIP-29882N ensembl:ENSG00000120337(gene)|ensembl:ENST00000404377(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2000508"(regulation of dendritic cell chemotaxis)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR042380|rcsb pdb:2Q1M|rcsb pdb:2R30|rcsb pdb:2R32|rcsb pdb:3B93|rcsb pdb:3B94|rcsb pdb:7KHD|reactome:R-HSA-5669034|refseq:NP_005083.2|dip:DIP-29882N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:LGPRpjFhwtGs0lOxYY3OOk4ixkE9606 rogid:LGPRpjFhwtGs0lOxYY3OOk4ixkE9606 rigid:wJjGUMtrqQrYag3EUQLU2k83iqA false binding-associated region:50-177 binding-associated region:50-177 - 0 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y5U5 uniprotkb:Q9Y5U5 intact:EBI-3962532|ensembl:ENSP00000368570|uniprotkb:B1AME1|uniprotkb:O95851|uniprotkb:Q5U0I4|uniprotkb:Q9NYJ9 intact:EBI-3962532|ensembl:ENSP00000368570|uniprotkb:B1AME1|uniprotkb:O95851|uniprotkb:Q5U0I4|uniprotkb:Q9NYJ9 psi-mi:tnr18_human(display_long)|uniprotkb:TNFRSF18(gene name)|psi-mi:TNFRSF18(display_short)|uniprotkb:AITR(gene name synonym)|uniprotkb:Activation-inducible TNFR family receptor(gene name synonym)|uniprotkb:GITR(gene name synonym)|uniprotkb:Glucocorticoid-induced TNFR-related protein(gene name synonym)|uniprotkb:UNQ319/PRO364(orf name) psi-mi:tnr18_human(display_long)|uniprotkb:TNFRSF18(gene name)|psi-mi:TNFRSF18(display_short)|uniprotkb:AITR(gene name synonym)|uniprotkb:Activation-inducible TNFR family receptor(gene name synonym)|uniprotkb:GITR(gene name synonym)|uniprotkb:Glucocorticoid-induced TNFR-related protein(gene name synonym)|uniprotkb:UNQ319/PRO364(orf name) psi-mi:"MI:0030"(cross-linking study) Zhou et al. (2008) pubmed:18378892|doi:10.1073/pnas.0711350105|imex:IM-9207 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15695517|imex:IM-9207-6|dip:DIP-59380E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000186891(gene)|ensembl:ENST00000379268(transcript)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045785"(positive regulation of cell adhesion)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022318|interpro:IPR034018|rcsb pdb:7KHD|reactome:R-HSA-5669034|reactome:R-HSA-8877330|refseq:NP_683699.1|refseq:NP_683700.1|refseq:NP_004186.1|dip:DIP-29883N ensembl:ENSG00000186891(gene)|ensembl:ENST00000379268(transcript)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045785"(positive regulation of cell adhesion)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022318|interpro:IPR034018|rcsb pdb:7KHD|reactome:R-HSA-5669034|reactome:R-HSA-8877330|refseq:NP_683699.1|refseq:NP_683700.1|refseq:NP_004186.1|dip:DIP-29883N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:Gym2+LrgO9wVfXnM8tBK96CtJjY9606 rogid:Gym2+LrgO9wVfXnM8tBK96CtJjY9606 rigid:tsJqXaciGa/Tvm/+kHewropBcp0 false binding-associated region:26-162 binding-associated region:26-162 - 0 psi-mi:"MI:0815"(confirmation by molecular weight) psi-mi:"MI:0815"(confirmation by molecular weight) uniprotkb:Q9UNG2 uniprotkb:Q9UNG2 intact:EBI-15672281|ensembl:ENSP00000385470|uniprotkb:A9IQG8|uniprotkb:O95852|uniprotkb:Q6ISV1 intact:EBI-15672281|ensembl:ENSP00000385470|uniprotkb:A9IQG8|uniprotkb:O95852|uniprotkb:Q6ISV1 psi-mi:tnf18_human(display_long)|uniprotkb:TNFSF18(gene name)|psi-mi:TNFSF18(display_short)|uniprotkb:AITRL(gene name synonym)|uniprotkb:GITRL(gene name synonym)|uniprotkb:TL6(gene name synonym)|uniprotkb:UNQ149/PRO175(orf name)|uniprotkb:Activation-inducible TNF-related ligand(gene name synonym)|uniprotkb:Glucocorticoid-induced TNF-related ligand(gene name synonym) psi-mi:tnf18_human(display_long)|uniprotkb:TNFSF18(gene name)|psi-mi:TNFSF18(display_short)|uniprotkb:AITRL(gene name synonym)|uniprotkb:GITRL(gene name synonym)|uniprotkb:TL6(gene name synonym)|uniprotkb:UNQ149/PRO175(orf name)|uniprotkb:Activation-inducible TNF-related ligand(gene name synonym)|uniprotkb:Glucocorticoid-induced TNF-related ligand(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Zhou et al. (2008) pubmed:18378892|doi:10.1073/pnas.0711350105|imex:IM-9207 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15695537|imex:IM-9207-5|dip:DIP-59379E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120337(gene)|ensembl:ENST00000404377(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2000508"(regulation of dendritic cell chemotaxis)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR042380|rcsb pdb:2Q1M|rcsb pdb:2R30|rcsb pdb:2R32|rcsb pdb:3B93|rcsb pdb:3B94|rcsb pdb:7KHD|reactome:R-HSA-5669034|refseq:NP_005083.2|dip:DIP-29882N ensembl:ENSG00000120337(gene)|ensembl:ENST00000404377(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2000508"(regulation of dendritic cell chemotaxis)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR042380|rcsb pdb:2Q1M|rcsb pdb:2R30|rcsb pdb:2R32|rcsb pdb:3B93|rcsb pdb:3B94|rcsb pdb:7KHD|reactome:R-HSA-5669034|refseq:NP_005083.2|dip:DIP-29882N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:LGPRpjFhwtGs0lOxYY3OOk4ixkE9606 rogid:LGPRpjFhwtGs0lOxYY3OOk4ixkE9606 rigid:wJjGUMtrqQrYag3EUQLU2k83iqA false binding-associated region:50-177 binding-associated region:50-177 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNG2 uniprotkb:Q9UNG2 intact:EBI-15672281|ensembl:ENSP00000385470|uniprotkb:A9IQG8|uniprotkb:O95852|uniprotkb:Q6ISV1 intact:EBI-15672281|ensembl:ENSP00000385470|uniprotkb:A9IQG8|uniprotkb:O95852|uniprotkb:Q6ISV1 psi-mi:tnf18_human(display_long)|uniprotkb:TNFSF18(gene name)|psi-mi:TNFSF18(display_short)|uniprotkb:AITRL(gene name synonym)|uniprotkb:GITRL(gene name synonym)|uniprotkb:TL6(gene name synonym)|uniprotkb:UNQ149/PRO175(orf name)|uniprotkb:Activation-inducible TNF-related ligand(gene name synonym)|uniprotkb:Glucocorticoid-induced TNF-related ligand(gene name synonym) psi-mi:tnf18_human(display_long)|uniprotkb:TNFSF18(gene name)|psi-mi:TNFSF18(display_short)|uniprotkb:AITRL(gene name synonym)|uniprotkb:GITRL(gene name synonym)|uniprotkb:TL6(gene name synonym)|uniprotkb:UNQ149/PRO175(orf name)|uniprotkb:Activation-inducible TNF-related ligand(gene name synonym)|uniprotkb:Glucocorticoid-induced TNF-related ligand(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Zhou et al. (2008) pubmed:18378892|doi:10.1073/pnas.0711350105|imex:IM-9207 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15695555|imex:IM-9207-3|dip:DIP-59379E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120337(gene)|ensembl:ENST00000404377(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2000508"(regulation of dendritic cell chemotaxis)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR042380|rcsb pdb:2Q1M|rcsb pdb:2R30|rcsb pdb:2R32|rcsb pdb:3B93|rcsb pdb:3B94|rcsb pdb:7KHD|reactome:R-HSA-5669034|refseq:NP_005083.2|dip:DIP-29882N ensembl:ENSG00000120337(gene)|ensembl:ENST00000404377(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2000508"(regulation of dendritic cell chemotaxis)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR042380|rcsb pdb:2Q1M|rcsb pdb:2R30|rcsb pdb:2R32|rcsb pdb:3B93|rcsb pdb:3B94|rcsb pdb:7KHD|reactome:R-HSA-5669034|refseq:NP_005083.2|dip:DIP-29882N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:LGPRpjFhwtGs0lOxYY3OOk4ixkE9606 rogid:LGPRpjFhwtGs0lOxYY3OOk4ixkE9606 rigid:wJjGUMtrqQrYag3EUQLU2k83iqA false binding-associated region:50-177 binding-associated region:50-177 - 0 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UNG2 uniprotkb:Q9Y5U5 intact:EBI-15672281|ensembl:ENSP00000385470|uniprotkb:A9IQG8|uniprotkb:O95852|uniprotkb:Q6ISV1 intact:EBI-3962532|ensembl:ENSP00000368570|uniprotkb:B1AME1|uniprotkb:O95851|uniprotkb:Q5U0I4|uniprotkb:Q9NYJ9 psi-mi:tnf18_human(display_long)|uniprotkb:TNFSF18(gene name)|psi-mi:TNFSF18(display_short)|uniprotkb:AITRL(gene name synonym)|uniprotkb:GITRL(gene name synonym)|uniprotkb:TL6(gene name synonym)|uniprotkb:UNQ149/PRO175(orf name)|uniprotkb:Activation-inducible TNF-related ligand(gene name synonym)|uniprotkb:Glucocorticoid-induced TNF-related ligand(gene name synonym) psi-mi:tnr18_human(display_long)|uniprotkb:TNFRSF18(gene name)|psi-mi:TNFRSF18(display_short)|uniprotkb:AITR(gene name synonym)|uniprotkb:Activation-inducible TNFR family receptor(gene name synonym)|uniprotkb:GITR(gene name synonym)|uniprotkb:Glucocorticoid-induced TNFR-related protein(gene name synonym)|uniprotkb:UNQ319/PRO364(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Zhou et al. (2008) pubmed:18378892|doi:10.1073/pnas.0711350105|imex:IM-9207 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15695573|imex:IM-9207-1|dip:DIP-59381E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000120337(gene)|ensembl:ENST00000404377(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:2000329"(negative regulation of T-helper 17 cell lineage commitment)|go:"GO:2000508"(regulation of dendritic cell chemotaxis)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR042380|rcsb pdb:2Q1M|rcsb pdb:2R30|rcsb pdb:2R32|rcsb pdb:3B93|rcsb pdb:3B94|rcsb pdb:7KHD|reactome:R-HSA-5669034|refseq:NP_005083.2|dip:DIP-29882N ensembl:ENSG00000186891(gene)|ensembl:ENST00000379268(transcript)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045785"(positive regulation of cell adhesion)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022318|interpro:IPR034018|rcsb pdb:7KHD|reactome:R-HSA-5669034|reactome:R-HSA-8877330|refseq:NP_683699.1|refseq:NP_683700.1|refseq:NP_004186.1|dip:DIP-29883N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:LGPRpjFhwtGs0lOxYY3OOk4ixkE9606 rogid:Gym2+LrgO9wVfXnM8tBK96CtJjY9606 rigid:TUItcdUlUiKQ1dPxd5c1EyvlzBs false binding-associated region:50-177 binding-associated region:26-162 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)