#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75695	uniprotkb:Q9D0J4	intact:EBI-7996807|uniprotkb:Q9NU67|uniprotkb:Q86XJ7|intact:MINT-5003911|ensembl:ENSP00000218340	intact:EBI-1033319|uniprotkb:Q9WUM1|ensembl:ENSMUSP00000025893	psi-mi:xrp2_human(display_long)|uniprotkb:RP2(gene name)|psi-mi:RP2(display_short)	psi-mi:arl2_mouse(display_long)|uniprotkb:Arl2(gene name)|psi-mi:Arl2(display_short)	psi-mi:"MI:0415"(enzymatic study)	Veltel et al. (2008)	pubmed:18376416|doi:10.1038/nsmb.1396|imex:IM-9642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695280|imex:IM-9642-2|dip:DIP-88377E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008846.2|dip:DIP-29024N|ensembl:ENSG00000102218(gene)|ensembl:ENST00000218340(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990075"(periciliary membrane compartment)|interpro:IPR006599(CARP motif)|interpro:IPR012945(Tubulin binding cofactor C)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR036223|interpro:IPR036850|interpro:IPR039093|mint:O75695|rcsb pdb:2BX6|rcsb pdb:3BH6|rcsb pdb:3BH7|reactome:R-HSA-5624138	refseq:NP_062696.2|ensembl:ENSMUSG00000024944(gene)|ensembl:ENSMUST00000025893(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007098"(centrosome cycle)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0015870"(acetylcholine transport)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|rcsb pdb:1KSG|rcsb pdb:1KSH|rcsb pdb:1KSJ|rcsb pdb:4GOK|reactome:R-MMU-83936|reactome:R-MMU-9648002|dip:DIP-36659N	psi-mi:"MI:0465"(dip)	comment:mint|function:Stimulates the GTPase activity of tubulin, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor for ARL3|function:"Defects in RP2 are the cause of retinitis pigmentosa type 2 (RP2) [MIM:312600]; also known as X-linked retinitis pigmentosa 2 (XLRP-2). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:34VzWqa5cV0XAIxDOCDGzd+1VPk9606	rogid:zb6s8gL3Fr5kyys6iB/rrgsj7qI10090	rigid:hCSR155BnqC+dYjLAml9FS/MWbs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75695	uniprotkb:Q9WUL7	intact:EBI-7996807|uniprotkb:Q9NU67|uniprotkb:Q86XJ7|intact:MINT-5003911|ensembl:ENSP00000218340	intact:EBI-6860857|ensembl:ENSMUSP00000026009	psi-mi:xrp2_human(display_long)|uniprotkb:RP2(gene name)|psi-mi:RP2(display_short)	psi-mi:arl3_mouse(display_long)|uniprotkb:Arl3(gene name)|psi-mi:Arl3(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Veltel et al. (2008)	pubmed:18376416|doi:10.1038/nsmb.1396|imex:IM-9642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695261|imex:IM-9642-7|dip:DIP-57025E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008846.2|dip:DIP-29024N|ensembl:ENSG00000102218(gene)|ensembl:ENST00000218340(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990075"(periciliary membrane compartment)|interpro:IPR006599(CARP motif)|interpro:IPR012945(Tubulin binding cofactor C)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR036223|interpro:IPR036850|interpro:IPR039093|mint:O75695|rcsb pdb:2BX6|rcsb pdb:3BH6|rcsb pdb:3BH7|reactome:R-HSA-5624138	go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:Q9WUL7|rcsb pdb:1FZQ|rcsb pdb:3BH6|rcsb pdb:3BH7|rcsb pdb:4GOJ|rcsb pdb:4ZI2|rcsb pdb:4ZI3|rcsb pdb:7OK7|reactome:R-MMU-5624138|ensembl:ENSMUSG00000025035(gene)|ensembl:ENSMUST00000026009(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001822"(kidney development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|refseq:NP_062692.1|dip:DIP-29025N	psi-mi:"MI:0465"(dip)	comment:mint|function:Stimulates the GTPase activity of tubulin, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor for ARL3|function:"Defects in RP2 are the cause of retinitis pigmentosa type 2 (RP2) [MIM:312600]; also known as X-linked retinitis pigmentosa 2 (XLRP-2). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:34VzWqa5cV0XAIxDOCDGzd+1VPk9606	rogid:Pv4G4Y6wahs2lvrFtlxPhmF23ew10090	rigid:nqPDZpQEaEBoZSrzLOWUp+wR69g	false	-	binding-associated region:17-177	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15814	uniprotkb:Q9WUL7	intact:EBI-15695297|ensembl:ENSP00000361967|uniprotkb:Q53Y43|uniprotkb:Q5T787	intact:EBI-6860857|ensembl:ENSMUSP00000026009	psi-mi:tbcc_human(display_long)|uniprotkb:TBCC(gene name)|psi-mi:TBCC(display_short)|uniprotkb:Tubulin-folding cofactor C(gene name synonym)	psi-mi:arl3_mouse(display_long)|uniprotkb:Arl3(gene name)|psi-mi:Arl3(display_short)	psi-mi:"MI:0415"(enzymatic study)	Veltel et al. (2008)	pubmed:18376416|doi:10.1038/nsmb.1396|imex:IM-9642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695329|imex:IM-9642-3|dip:DIP-88376E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000124659(gene)|ensembl:ENST00000372876(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007023"(post-chaperonin tubulin folding pathway)|go:"GO:0015631"(tubulin binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0051087"(chaperone binding)|interpro:IPR006599(CARP motif)|interpro:IPR012945(Tubulin binding cofactor C)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR027684|interpro:IPR031925|interpro:IPR038397|rcsb pdb:2L3L|rcsb pdb:2YUH|reactome:R-HSA-389977|dip:DIP-46388N|refseq:NP_003183.1	go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:Q9WUL7|rcsb pdb:1FZQ|rcsb pdb:3BH6|rcsb pdb:3BH7|rcsb pdb:4GOJ|rcsb pdb:4ZI2|rcsb pdb:4ZI3|rcsb pdb:7OK7|reactome:R-MMU-5624138|ensembl:ENSMUSG00000025035(gene)|ensembl:ENSMUST00000026009(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001822"(kidney development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|refseq:NP_062692.1|dip:DIP-29025N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:dqw7HuYqmACHWe/7j/P/KytvRcE9606	rogid:Pv4G4Y6wahs2lvrFtlxPhmF23ew10090	rigid:VSRTqhp2q0X54fXB8yqaYsRyalg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75695	uniprotkb:Q9WUL7	intact:EBI-7996807|uniprotkb:Q9NU67|uniprotkb:Q86XJ7|intact:MINT-5003911|ensembl:ENSP00000218340	intact:EBI-6860857|ensembl:ENSMUSP00000026009	psi-mi:xrp2_human(display_long)|uniprotkb:RP2(gene name)|psi-mi:RP2(display_short)	psi-mi:arl3_mouse(display_long)|uniprotkb:Arl3(gene name)|psi-mi:Arl3(display_short)	psi-mi:"MI:0415"(enzymatic study)	Veltel et al. (2008)	pubmed:18376416|doi:10.1038/nsmb.1396|imex:IM-9642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695346|imex:IM-9642-4|dip:DIP-57025E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008846.2|dip:DIP-29024N|ensembl:ENSG00000102218(gene)|ensembl:ENST00000218340(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990075"(periciliary membrane compartment)|interpro:IPR006599(CARP motif)|interpro:IPR012945(Tubulin binding cofactor C)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR036223|interpro:IPR036850|interpro:IPR039093|mint:O75695|rcsb pdb:2BX6|rcsb pdb:3BH6|rcsb pdb:3BH7|reactome:R-HSA-5624138	go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:Q9WUL7|rcsb pdb:1FZQ|rcsb pdb:3BH6|rcsb pdb:3BH7|rcsb pdb:4GOJ|rcsb pdb:4ZI2|rcsb pdb:4ZI3|rcsb pdb:7OK7|reactome:R-MMU-5624138|ensembl:ENSMUSG00000025035(gene)|ensembl:ENSMUST00000026009(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001822"(kidney development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|refseq:NP_062692.1|dip:DIP-29025N	psi-mi:"MI:0465"(dip)	comment:mint|function:Stimulates the GTPase activity of tubulin, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor for ARL3|function:"Defects in RP2 are the cause of retinitis pigmentosa type 2 (RP2) [MIM:312600]; also known as X-linked retinitis pigmentosa 2 (XLRP-2). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:34VzWqa5cV0XAIxDOCDGzd+1VPk9606	rogid:Pv4G4Y6wahs2lvrFtlxPhmF23ew10090	rigid:nqPDZpQEaEBoZSrzLOWUp+wR69g	false	mutation decreasing interaction:118-118|mutation decreasing interaction:177-177|mutation decreasing interaction:116-116|mutation decreasing interaction:138-138	mutation disrupting interaction:71-71	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P39110	uniprotkb:P46670	intact:EBI-4676|uniprotkb:D6VZW1|ensemblfungi:YMR138W	intact:EBI-4671|uniprotkb:Q08973|uniprotkb:D6W3D0|ensemblfungi:YPL241C	psi-mi:cin4_yeast(display_long)|uniprotkb:CIN4(gene name)|psi-mi:CIN4(display_short)|uniprotkb:GTP1(gene name synonym)|uniprotkb:UGX1(gene name synonym)|uniprotkb:YMR138W(locus name)|uniprotkb:YM9375.07(orf name)|uniprotkb:Chromosome instability protein 4(gene name synonym)	psi-mi:tbcc_yeast(display_long)|uniprotkb:CIN2(gene name)|psi-mi:CIN2(display_short)|uniprotkb:YPL241C(locus name)|uniprotkb:P1043(orf name)|uniprotkb:Tubulin-folding cofactor C(gene name synonym)|uniprotkb:Chromosome instability protein 2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Veltel et al. (2008)	pubmed:18376416|doi:10.1038/nsmb.1396|imex:IM-9642	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695397|imex:IM-9642-6|dip:DIP-88375E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013858.1|sgd:S000004746|dip:DIP-1256N|ensemblfungi:YMR138W(gene)|ensemblfungi:YMR138W_mRNA(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031116"(positive regulation of microtubule polymerization)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612	sgd:S000006162|refseq:NP_015083.1|dip:DIP-3960N|ensemblfungi:YPL241C(gene)|ensemblfungi:YPL241C_mRNA(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007023"(post-chaperonin tubulin folding pathway)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR027684|rcsb pdb:5CYA	psi-mi:"MI:0465"(dip)	crc64:CF30AF932A2D2566	crc64:CE9F2DB6B76997A8	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:r26dnyPZ4JIOIfPdBjXi1hF0wv4559292	rogid:GkWQgtzNx/qG+g12mPPUbTzul7U559292	rigid:S/P3ZgLoMw6gI+uVroCSG9uBrZ0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75695	uniprotkb:Q9WUL7	intact:EBI-7996807|uniprotkb:Q9NU67|uniprotkb:Q86XJ7|intact:MINT-5003911|ensembl:ENSP00000218340	intact:EBI-6860857|ensembl:ENSMUSP00000026009	psi-mi:xrp2_human(display_long)|uniprotkb:RP2(gene name)|psi-mi:RP2(display_short)	psi-mi:arl3_mouse(display_long)|uniprotkb:Arl3(gene name)|psi-mi:Arl3(display_short)	psi-mi:"MI:0071"(molecular sieving)	Veltel et al. (2008)	pubmed:18376416|doi:10.1038/nsmb.1396|imex:IM-9642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695378|imex:IM-9642-5|dip:DIP-57025E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008846.2|dip:DIP-29024N|ensembl:ENSG00000102218(gene)|ensembl:ENST00000218340(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990075"(periciliary membrane compartment)|interpro:IPR006599(CARP motif)|interpro:IPR012945(Tubulin binding cofactor C)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR036223|interpro:IPR036850|interpro:IPR039093|mint:O75695|rcsb pdb:2BX6|rcsb pdb:3BH6|rcsb pdb:3BH7|reactome:R-HSA-5624138	go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:Q9WUL7|rcsb pdb:1FZQ|rcsb pdb:3BH6|rcsb pdb:3BH7|rcsb pdb:4GOJ|rcsb pdb:4ZI2|rcsb pdb:4ZI3|rcsb pdb:7OK7|reactome:R-MMU-5624138|ensembl:ENSMUSG00000025035(gene)|ensembl:ENSMUST00000026009(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001822"(kidney development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|refseq:NP_062692.1|dip:DIP-29025N	psi-mi:"MI:0465"(dip)	comment:mint|function:Stimulates the GTPase activity of tubulin, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor for ARL3|function:"Defects in RP2 are the cause of retinitis pigmentosa type 2 (RP2) [MIM:312600]; also known as X-linked retinitis pigmentosa 2 (XLRP-2). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:34VzWqa5cV0XAIxDOCDGzd+1VPk9606	rogid:Pv4G4Y6wahs2lvrFtlxPhmF23ew10090	rigid:nqPDZpQEaEBoZSrzLOWUp+wR69g	false	-	binding-associated region:17-177	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75695	uniprotkb:Q9WUL7	intact:EBI-7996807|uniprotkb:Q9NU67|uniprotkb:Q86XJ7|intact:MINT-5003911|ensembl:ENSP00000218340	intact:EBI-6860857|ensembl:ENSMUSP00000026009	psi-mi:xrp2_human(display_long)|uniprotkb:RP2(gene name)|psi-mi:RP2(display_short)	psi-mi:arl3_mouse(display_long)|uniprotkb:Arl3(gene name)|psi-mi:Arl3(display_short)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Veltel et al. (2008)	pubmed:18376416|doi:10.1038/nsmb.1396|imex:IM-9642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15695414|imex:IM-9642-1|dip:DIP-57025E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008846.2|dip:DIP-29024N|ensembl:ENSG00000102218(gene)|ensembl:ENST00000218340(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990075"(periciliary membrane compartment)|interpro:IPR006599(CARP motif)|interpro:IPR012945(Tubulin binding cofactor C)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR036223|interpro:IPR036850|interpro:IPR039093|mint:O75695|rcsb pdb:2BX6|rcsb pdb:3BH6|rcsb pdb:3BH7|reactome:R-HSA-5624138	go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|interpro:IPR044612|mint:Q9WUL7|rcsb pdb:1FZQ|rcsb pdb:3BH6|rcsb pdb:3BH7|rcsb pdb:4GOJ|rcsb pdb:4ZI2|rcsb pdb:4ZI3|rcsb pdb:7OK7|reactome:R-MMU-5624138|ensembl:ENSMUSG00000025035(gene)|ensembl:ENSMUST00000026009(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001822"(kidney development)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042461"(photoreceptor cell development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|refseq:NP_062692.1|dip:DIP-29025N	psi-mi:"MI:0465"(dip)	comment:mint|function:Stimulates the GTPase activity of tubulin, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor for ARL3|function:"Defects in RP2 are the cause of retinitis pigmentosa type 2 (RP2) [MIM:312600]; also known as X-linked retinitis pigmentosa 2 (XLRP-2). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:34VzWqa5cV0XAIxDOCDGzd+1VPk9606	rogid:Pv4G4Y6wahs2lvrFtlxPhmF23ew10090	rigid:nqPDZpQEaEBoZSrzLOWUp+wR69g	false	mutation decreasing interaction:118-118|mutation decreasing interaction:138-138|mutation decreasing interaction:115-115|mutation decreasing interaction:116-116|mutation decreasing interaction:121-121,120-120|mutation decreasing interaction:29-29,28-28|sufficient binding region:2-30	mutation decreasing interaction:72-72|mutation decreasing interaction:168-168,164-164	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)