#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6PEC4 uniprotkb:G3V802 intact:EBI-919194|ensembl:ENSRNOP00000007676 intact:EBI-15694230|ensembl:ENSRNOP00000021156 psi-mi:skp1_rat(display_long)|uniprotkb:Skp1(gene name)|psi-mi:Skp1(display_short)|uniprotkb:Skp1a(gene name synonym)|uniprotkb:S-phase kinase-associated protein 1A(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:p19A(gene name synonym) psi-mi:g3v802_rat(display_long)|uniprotkb:Ccna2(gene name)|psi-mi:Ccna2(display_short)|uniprotkb:rCG_41610(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kan et al. (2008) pubmed:18356301|doi:10.1073/pnas.0706392105|imex:IM-9196 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15694292|imex:IM-9196-2|dip:DIP-59363E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1359648|refseq:NP_001007609.1|dip:DIP-29863N|ensembl:ENSRNOG00000005828(gene)|ensembl:ENSRNOT00000007676(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|reactome:R-RNO-1169091|reactome:R-RNO-1170546|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2565942|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5676590|reactome:R-RNO-68949|reactome:R-RNO-69231|reactome:R-RNO-8854050|reactome:R-RNO-8951664|reactome:R-RNO-917937|reactome:R-RNO-983168 ensembl:ENSRNOG00000015423(gene)|ensembl:ENSRNOT00000021156(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032355"(response to estradiol)|go:"GO:0033762"(response to glucagon)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090102"(cochlea development)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR032447|interpro:IPR036915|interpro:IPR039361|reactome:R-RNO-1538133|reactome:R-RNO-171319|reactome:R-RNO-174184|reactome:R-RNO-176408|reactome:R-RNO-187577|reactome:R-RNO-2559582|reactome:R-RNO-2559586|reactome:R-RNO-5689880|reactome:R-RNO-5693607|reactome:R-RNO-6804116|reactome:R-RNO-6804756|reactome:R-RNO-6804757|reactome:R-RNO-68911|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69273|reactome:R-RNO-69563|reactome:R-RNO-69656|refseq:NP_446154.3|rgd:621059 psi-mi:"MI:0465"(dip) - crc64:1E6DC38B643D0F19 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/05 2017/08/10 rogid:qGk720KMKAbBPguy2tmUOZsLxRQ10116 rogid:EYOZsZWSOLlAGAaqX3dC3HMTaR810116 rigid:tHTkz1Df/Oju4pn0ejhHN8RqM6g false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PEC4 uniprotkb:Q64315 intact:EBI-919194|ensembl:ENSRNOP00000007676 intact:EBI-15694309|ensembl:ENSRNOP00000000628|ensembl:ENSRNOP00000072242 psi-mi:skp1_rat(display_long)|uniprotkb:Skp1(gene name)|psi-mi:Skp1(display_short)|uniprotkb:Skp1a(gene name synonym)|uniprotkb:S-phase kinase-associated protein 1A(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:p19A(gene name synonym) psi-mi:q64315_rat(display_long)|uniprotkb:Cdkn1a(gene name)|psi-mi:Cdkn1a(display_short)|uniprotkb:cip1(gene name synonym)|uniprotkb:WAF1(gene name synonym)|uniprotkb:rCG_61102(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kan et al. (2008) pubmed:18356301|doi:10.1073/pnas.0706392105|imex:IM-9196 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15694391|imex:IM-9196-5|dip:DIP-59361E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1359648|refseq:NP_001007609.1|dip:DIP-29863N|ensembl:ENSRNOG00000005828(gene)|ensembl:ENSRNOT00000007676(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|reactome:R-RNO-1169091|reactome:R-RNO-1170546|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2565942|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5676590|reactome:R-RNO-68949|reactome:R-RNO-69231|reactome:R-RNO-8854050|reactome:R-RNO-8951664|reactome:R-RNO-917937|reactome:R-RNO-983168 ensembl:ENSRNOG00000000521(gene)|ensembl:ENSRNOT00000000628(transcript)|ensembl:ENSRNOT00000091731(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010033"(response to organic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000278"(regulation of DNA biosynthetic process)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029841|reactome:R-RNO-187577|reactome:R-RNO-198323|reactome:R-RNO-2559582|reactome:R-RNO-2559586|reactome:R-RNO-6804116|reactome:R-RNO-69202|reactome:R-RNO-69231|reactome:R-RNO-69563|reactome:R-RNO-69656|reactome:R-RNO-8852276|reactome:R-RNO-9616222|dip:DIP-29867N|refseq:NP_542960.1|refseq:XP_006256190.1|rgd:69328 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/05 2017/08/10 rogid:qGk720KMKAbBPguy2tmUOZsLxRQ10116 rogid:XSg4Hx4AktYY930UZ8tgJdb/TPU10116 rigid:fUDhZyHmyw9yGKvc9m6Y24Le7Wg false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PEC4 uniprotkb:G3V802 intact:EBI-919194|ensembl:ENSRNOP00000007676 intact:EBI-15694230|ensembl:ENSRNOP00000021156 psi-mi:skp1_rat(display_long)|uniprotkb:Skp1(gene name)|psi-mi:Skp1(display_short)|uniprotkb:Skp1a(gene name synonym)|uniprotkb:S-phase kinase-associated protein 1A(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:p19A(gene name synonym) psi-mi:g3v802_rat(display_long)|uniprotkb:Ccna2(gene name)|psi-mi:Ccna2(display_short)|uniprotkb:rCG_41610(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kan et al. (2008) pubmed:18356301|doi:10.1073/pnas.0706392105|imex:IM-9196 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15694391|imex:IM-9196-5|dip:DIP-59361E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1359648|refseq:NP_001007609.1|dip:DIP-29863N|ensembl:ENSRNOG00000005828(gene)|ensembl:ENSRNOT00000007676(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|reactome:R-RNO-1169091|reactome:R-RNO-1170546|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2565942|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5676590|reactome:R-RNO-68949|reactome:R-RNO-69231|reactome:R-RNO-8854050|reactome:R-RNO-8951664|reactome:R-RNO-917937|reactome:R-RNO-983168 ensembl:ENSRNOG00000015423(gene)|ensembl:ENSRNOT00000021156(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032355"(response to estradiol)|go:"GO:0033762"(response to glucagon)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090102"(cochlea development)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR032447|interpro:IPR036915|interpro:IPR039361|reactome:R-RNO-1538133|reactome:R-RNO-171319|reactome:R-RNO-174184|reactome:R-RNO-176408|reactome:R-RNO-187577|reactome:R-RNO-2559582|reactome:R-RNO-2559586|reactome:R-RNO-5689880|reactome:R-RNO-5693607|reactome:R-RNO-6804116|reactome:R-RNO-6804756|reactome:R-RNO-6804757|reactome:R-RNO-68911|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69273|reactome:R-RNO-69563|reactome:R-RNO-69656|refseq:NP_446154.3|rgd:621059 psi-mi:"MI:0465"(dip) - crc64:1E6DC38B643D0F19 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/05 2017/08/10 rogid:qGk720KMKAbBPguy2tmUOZsLxRQ10116 rogid:EYOZsZWSOLlAGAaqX3dC3HMTaR810116 rigid:fUDhZyHmyw9yGKvc9m6Y24Le7Wg false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PEC4 uniprotkb:P39949 intact:EBI-919194|ensembl:ENSRNOP00000007676 intact:EBI-847441|uniprotkb:O09138 psi-mi:skp1_rat(display_long)|uniprotkb:Skp1(gene name)|psi-mi:Skp1(display_short)|uniprotkb:Skp1a(gene name synonym)|uniprotkb:S-phase kinase-associated protein 1A(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:p19A(gene name synonym) psi-mi:ccne1_rat(display_long)|uniprotkb:Ccne1(gene name)|psi-mi:Ccne1(display_short)|uniprotkb:Ccne(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kan et al. (2008) pubmed:18356301|doi:10.1073/pnas.0706392105|imex:IM-9196 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15694391|imex:IM-9196-5|dip:DIP-59361E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1359648|refseq:NP_001007609.1|dip:DIP-29863N|ensembl:ENSRNOG00000005828(gene)|ensembl:ENSRNOT00000007676(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|reactome:R-RNO-1169091|reactome:R-RNO-1170546|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2565942|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5676590|reactome:R-RNO-68949|reactome:R-RNO-69231|reactome:R-RNO-8854050|reactome:R-RNO-8951664|reactome:R-RNO-917937|reactome:R-RNO-983168 rgd:2294|dip:DIP-29865N|reactome:R-RNO-9706019|reactome:R-RNO-1538133|reactome:R-RNO-187577|reactome:R-RNO-2559586|reactome:R-RNO-6804116|reactome:R-RNO-69017|reactome:R-RNO-69200|reactome:R-RNO-69202|reactome:R-RNO-69563|reactome:R-RNO-8849470|reactome:R-RNO-69231|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001889"(liver development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014074"(response to purine-containing compound)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034097"(response to cytokine)|go:"GO:0042493"|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051597"(response to methylmercury)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/05 2017/08/10 rogid:qGk720KMKAbBPguy2tmUOZsLxRQ10116 rogid:cIuMb9EezhAJInRNR/7hUa3WTq410116 rigid:fUDhZyHmyw9yGKvc9m6Y24Le7Wg false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PEC4 uniprotkb:P39949 intact:EBI-919194|ensembl:ENSRNOP00000007676 intact:EBI-847441|uniprotkb:O09138 psi-mi:skp1_rat(display_long)|uniprotkb:Skp1(gene name)|psi-mi:Skp1(display_short)|uniprotkb:Skp1a(gene name synonym)|uniprotkb:S-phase kinase-associated protein 1A(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:p19A(gene name synonym) psi-mi:ccne1_rat(display_long)|uniprotkb:Ccne1(gene name)|psi-mi:Ccne1(display_short)|uniprotkb:Ccne(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kan et al. (2008) pubmed:18356301|doi:10.1073/pnas.0706392105|imex:IM-9196 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15694410|imex:IM-9196-1|dip:DIP-59364E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1359648|refseq:NP_001007609.1|dip:DIP-29863N|ensembl:ENSRNOG00000005828(gene)|ensembl:ENSRNOT00000007676(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|reactome:R-RNO-1169091|reactome:R-RNO-1170546|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2565942|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5676590|reactome:R-RNO-68949|reactome:R-RNO-69231|reactome:R-RNO-8854050|reactome:R-RNO-8951664|reactome:R-RNO-917937|reactome:R-RNO-983168 rgd:2294|dip:DIP-29865N|reactome:R-RNO-9706019|reactome:R-RNO-1538133|reactome:R-RNO-187577|reactome:R-RNO-2559586|reactome:R-RNO-6804116|reactome:R-RNO-69017|reactome:R-RNO-69200|reactome:R-RNO-69202|reactome:R-RNO-69563|reactome:R-RNO-8849470|reactome:R-RNO-69231|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0001889"(liver development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014074"(response to purine-containing compound)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034097"(response to cytokine)|go:"GO:0042493"|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051301"(cell division)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051597"(response to methylmercury)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/05 2017/08/10 rogid:qGk720KMKAbBPguy2tmUOZsLxRQ10116 rogid:cIuMb9EezhAJInRNR/7hUa3WTq410116 rigid:eWRnHUwYdBC6+tpsVQA2UylMqKI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PEC4 uniprotkb:D3ZRK7 intact:EBI-919194|ensembl:ENSRNOP00000007676 intact:EBI-15694427|ensembl:ENSRNOP00000032177|ensembl:ENSRNOP00000071363 psi-mi:skp1_rat(display_long)|uniprotkb:Skp1(gene name)|psi-mi:Skp1(display_short)|uniprotkb:Skp1a(gene name synonym)|uniprotkb:S-phase kinase-associated protein 1A(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:p19A(gene name synonym) psi-mi:d3zrk7_rat(display_long)|uniprotkb:Cdc6(gene name)|psi-mi:Cdc6(display_short)|uniprotkb:Cdc6_predicted(gene name synonym)|uniprotkb:rCG_34910(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kan et al. (2008) pubmed:18356301|doi:10.1073/pnas.0706392105|imex:IM-9196 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15694472|imex:IM-9196-3|dip:DIP-59362E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1359648|refseq:NP_001007609.1|dip:DIP-29863N|ensembl:ENSRNOG00000005828(gene)|ensembl:ENSRNOT00000007676(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|reactome:R-RNO-1169091|reactome:R-RNO-1170546|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2565942|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5676590|reactome:R-RNO-68949|reactome:R-RNO-69231|reactome:R-RNO-8854050|reactome:R-RNO-8951664|reactome:R-RNO-917937|reactome:R-RNO-983168 reactome:R-RNO-176187|reactome:R-RNO-68689|reactome:R-RNO-68827|reactome:R-RNO-68867|reactome:R-RNO-68949|reactome:R-RNO-68962|reactome:R-RNO-69017|ensembl:ENSRNOG00000027787(gene)|ensembl:ENSRNOT00000038228(transcript)|ensembl:ENSRNOT00000081424(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0019900"(kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0072686"(mitotic spindle)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR016314(Cell division control, Cdc6)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|interpro:IPR041083|refseq:NP_001101768.1|refseq:XP_006247416.1|rgd:1309157 psi-mi:"MI:0465"(dip) - crc64:DB442EA93D249296 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:qGk720KMKAbBPguy2tmUOZsLxRQ10116 rogid:cmeJjhqP2lG6WF/leGK0umlTbIE10116 rigid:VHteAHaFMT+0djawarY6YgwDAwk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PEC4 uniprotkb:D3ZRK7 intact:EBI-919194|ensembl:ENSRNOP00000007676 intact:EBI-15694427|ensembl:ENSRNOP00000032177|ensembl:ENSRNOP00000071363 psi-mi:skp1_rat(display_long)|uniprotkb:Skp1(gene name)|psi-mi:Skp1(display_short)|uniprotkb:Skp1a(gene name synonym)|uniprotkb:S-phase kinase-associated protein 1A(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:p19A(gene name synonym) psi-mi:d3zrk7_rat(display_long)|uniprotkb:Cdc6(gene name)|psi-mi:Cdc6(display_short)|uniprotkb:Cdc6_predicted(gene name synonym)|uniprotkb:rCG_34910(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kan et al. (2008) pubmed:18356301|doi:10.1073/pnas.0706392105|imex:IM-9196 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15694489|imex:IM-9196-4|dip:DIP-59362E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1359648|refseq:NP_001007609.1|dip:DIP-29863N|ensembl:ENSRNOG00000005828(gene)|ensembl:ENSRNOT00000007676(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|reactome:R-RNO-1169091|reactome:R-RNO-1170546|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2565942|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5676590|reactome:R-RNO-68949|reactome:R-RNO-69231|reactome:R-RNO-8854050|reactome:R-RNO-8951664|reactome:R-RNO-917937|reactome:R-RNO-983168 reactome:R-RNO-176187|reactome:R-RNO-68689|reactome:R-RNO-68827|reactome:R-RNO-68867|reactome:R-RNO-68949|reactome:R-RNO-68962|reactome:R-RNO-69017|ensembl:ENSRNOG00000027787(gene)|ensembl:ENSRNOT00000038228(transcript)|ensembl:ENSRNOT00000081424(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0019900"(kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0072686"(mitotic spindle)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR016314(Cell division control, Cdc6)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|interpro:IPR041083|refseq:NP_001101768.1|refseq:XP_006247416.1|rgd:1309157 psi-mi:"MI:0465"(dip) - crc64:DB442EA93D249296 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:qGk720KMKAbBPguy2tmUOZsLxRQ10116 rogid:cmeJjhqP2lG6WF/leGK0umlTbIE10116 rigid:VHteAHaFMT+0djawarY6YgwDAwk false - his tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)