#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15303	intact:EBI-4399559	intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2	dip:DIP-24261N	psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sundvall et al. (2008)	pubmed:18334649|doi:10.1073/pnas.0708333105|imex:IM-9189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15692848|imex:IM-9189-5|dip:DIP-59335E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	-	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/15	rogid:B6LYhMaoSj5IT6caAnj1n262+H49606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:lm8X8SeXs4DKeBB7P3XUVJTEvYo	false	-	flag tag:0-0	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15303	uniprotkb:Q96J02-2	intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2	intact:EBI-6672198|intact:EBI-7544716|intact:MINT-148307|intact:EBI-6955089|ensembl:ENSP00000363998	psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)	psi-mi:q96j02-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Sundvall et al. (2008)	pubmed:18334649|doi:10.1073/pnas.0708333105|imex:IM-9189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15692823|imex:IM-9189-4|dip:DIP-59336E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N	intact:EBI-1564678(isoform-parent)|uniprotkb:Q96J02-2(isoform-parent)|ensembl:ENSG00000078747(gene)|ensembl:ENST00000374864(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:B6LYhMaoSj5IT6caAnj1n262+H49606	rogid:HHkvsPLgjre0eg8ceEn788Hszck9606	rigid:JxxiuE8bONHrZyRsrAFIReg/TTI	false	ha tag:n-n	tag:?-?|sufficient binding region:285-350	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q15303	intact:EBI-4399559	intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2	dip:DIP-24261N	psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sundvall et al. (2008)	pubmed:18334649|doi:10.1073/pnas.0708333105|imex:IM-9189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15693000|dip:DIP-59335E|imex:IM-9189-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	-	no-uniprot-update:	dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2013-08-05|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/15	rogid:B6LYhMaoSj5IT6caAnj1n262+H49606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:lm8X8SeXs4DKeBB7P3XUVJTEvYo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15303	uniprotkb:Q96J02-2	intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2	intact:EBI-6672198|intact:EBI-7544716|intact:MINT-148307|intact:EBI-6955089|ensembl:ENSP00000363998	psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)	psi-mi:q96j02-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sundvall et al. (2008)	pubmed:18334649|doi:10.1073/pnas.0708333105|imex:IM-9189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15692933|imex:IM-9189-8|dip:DIP-59336E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N	intact:EBI-1564678(isoform-parent)|uniprotkb:Q96J02-2(isoform-parent)|ensembl:ENSG00000078747(gene)|ensembl:ENST00000374864(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/10	rogid:B6LYhMaoSj5IT6caAnj1n262+H49606	rogid:HHkvsPLgjre0eg8ceEn788Hszck9606	rigid:JxxiuE8bONHrZyRsrAFIReg/TTI	false	mutation disrupting interaction:1056-1056|mutation disrupting interaction:1054-1054	myc tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15303-3	intact:EBI-4399559	intact:EBI-15692884|ensembl:ENSP00000403204	dip:DIP-24261N	psi-mi:q15303-3(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sundvall et al. (2008)	pubmed:18334649|doi:10.1073/pnas.0708333105|imex:IM-9189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15692960|dip:DIP-59337E|imex:IM-9189-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000178568(gene)|ensembl:ENST00000436443(transcript)|intact:EBI-80371(isoform-parent)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	isoform-comment:"Proteolytical processing generates E4ICD2 (s80Cyt2)."	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/15	rogid:tihSFhq62QpeGDL37ksesIgwDaQ9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:wkdkJIup1OqNqocYCApepIs4GHY	false	-	flag tag:0-0	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15303	uniprotkb:Q96J02-2	intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2	intact:EBI-6672198|intact:EBI-7544716|intact:MINT-148307|intact:EBI-6955089|ensembl:ENSP00000363998	psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)	psi-mi:q96j02-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sundvall et al. (2008)	pubmed:18334649|doi:10.1073/pnas.0708333105|imex:IM-9189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15692979|imex:IM-9189-2|dip:DIP-59336E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N	intact:EBI-1564678(isoform-parent)|uniprotkb:Q96J02-2(isoform-parent)|ensembl:ENSG00000078747(gene)|ensembl:ENST00000374864(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/10	rogid:B6LYhMaoSj5IT6caAnj1n262+H49606	rogid:HHkvsPLgjre0eg8ceEn788Hszck9606	rigid:JxxiuE8bONHrZyRsrAFIReg/TTI	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15303-3	uniprotkb:Q96J02-2	intact:EBI-15692884|ensembl:ENSP00000403204	intact:EBI-6672198|intact:EBI-7544716|intact:MINT-148307|intact:EBI-6955089|ensembl:ENSP00000363998	psi-mi:q15303-3(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)	psi-mi:q96j02-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sundvall et al. (2008)	pubmed:18334649|doi:10.1073/pnas.0708333105|imex:IM-9189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15692895|dip:DIP-59339E|imex:IM-9189-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000178568(gene)|ensembl:ENST00000436443(transcript)|intact:EBI-80371(isoform-parent)	intact:EBI-1564678(isoform-parent)|uniprotkb:Q96J02-2(isoform-parent)|ensembl:ENSG00000078747(gene)|ensembl:ENST00000374864(transcript)	psi-mi:"MI:0465"(dip)	isoform-comment:"Proteolytical processing generates E4ICD2 (s80Cyt2)."	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/10	rogid:tihSFhq62QpeGDL37ksesIgwDaQ9606	rogid:HHkvsPLgjre0eg8ceEn788Hszck9606	rigid:7fdeC2TCG2my52OHAv46CAbuAQ0	false	-	myc tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15303	intact:EBI-4399559	intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2	dip:DIP-24261N	psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sundvall et al. (2008)	pubmed:18334649|doi:10.1073/pnas.0708333105|imex:IM-9189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15692867|dip:DIP-59338E|imex:IM-9189-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	-	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/15	rogid:B6LYhMaoSj5IT6caAnj1n262+H49606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:lm8X8SeXs4DKeBB7P3XUVJTEvYo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15303	intact:EBI-4399559	intact:EBI-80371|ensembl:ENSP00000342235|uniprotkb:Q2M1W1|uniprotkb:Q59EW4|uniprotkb:B7ZLE3|uniprotkb:B7ZLD7|uniprotkb:B7ZLE2	dip:DIP-24261N	psi-mi:erbb4_human(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sundvall et al. (2008)	pubmed:18334649|doi:10.1073/pnas.0708333105|imex:IM-9189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15692916|imex:IM-9189-3|dip:DIP-59335E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0021551"(central nervous system morphogenesis)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0007416"(synapse assembly)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0007507"(heart development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0007595"(lactation)|go:"GO:0043235"(receptor complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072046"(establishment of planar polarity involved in nephron morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR032778|interpro:IPR036941|mint:Q15303|rcsb pdb:2AHX|rcsb pdb:2L2T|rcsb pdb:2LCX|rcsb pdb:2R4B|rcsb pdb:3BBT|rcsb pdb:3BBW|rcsb pdb:3BCE|rcsb pdb:3U2P|rcsb pdb:3U7U|rcsb pdb:3U9U|reactome:R-HSA-1227986|reactome:R-HSA-1236394|reactome:R-HSA-1250196|reactome:R-HSA-1250342|reactome:R-HSA-1250347|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-1253288|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-9018519|reactome:R-HSA-9620244|reactome:R-HSA-9664565|reactome:R-HSA-9665686|ensembl:ENSG00000178568(gene)|ensembl:ENST00000342788(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|ensembl:ENSP00000342235|ensembl:ENST00000436443|ensembl:ENSP00000403204|refseq:NP_001036064.1|refseq:NP_005226.1|refseq:XP_005246433.1|refseq:XP_005246434.1|dip:DIP-29650N	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	-	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/15	rogid:B6LYhMaoSj5IT6caAnj1n262+H49606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:lm8X8SeXs4DKeBB7P3XUVJTEvYo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15303-3	intact:EBI-4399559	intact:EBI-15692884|ensembl:ENSP00000403204	dip:DIP-24261N	psi-mi:q15303-3(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sundvall et al. (2008)	pubmed:18334649|doi:10.1073/pnas.0708333105|imex:IM-9189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15693020|dip:DIP-59335E|imex:IM-9189-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000178568(gene)|ensembl:ENST00000436443(transcript)|intact:EBI-80371(isoform-parent)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	isoform-comment:"Proteolytical processing generates E4ICD2 (s80Cyt2)."	no-uniprot-update:	dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2013-08-05|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/15	rogid:tihSFhq62QpeGDL37ksesIgwDaQ9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:wkdkJIup1OqNqocYCApepIs4GHY	false	-	flag tag:0-0	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15303-3	uniprotkb:Q96J02-2	intact:EBI-15692884|ensembl:ENSP00000403204	intact:EBI-6672198|intact:EBI-7544716|intact:MINT-148307|intact:EBI-6955089|ensembl:ENSP00000363998	psi-mi:q15303-3(display_long)|uniprotkb:ERBB4(gene name)|psi-mi:ERBB4(display_short)|uniprotkb:HER4(gene name synonym)|uniprotkb:Proto-oncogene-like protein c-ErbB-4(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER4(gene name synonym)|uniprotkb:p180erbB4(gene name synonym)	psi-mi:q96j02-2(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sundvall et al. (2008)	pubmed:18334649|doi:10.1073/pnas.0708333105|imex:IM-9189	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15693042|dip:DIP-59336E|imex:IM-9189-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000178568(gene)|ensembl:ENST00000436443(transcript)|intact:EBI-80371(isoform-parent)	intact:EBI-1564678(isoform-parent)|uniprotkb:Q96J02-2(isoform-parent)|ensembl:ENSG00000078747(gene)|ensembl:ENST00000374864(transcript)	psi-mi:"MI:0465"(dip)	isoform-comment:"Proteolytical processing generates E4ICD2 (s80Cyt2)."	-	dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2013-08-05|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/10	rogid:tihSFhq62QpeGDL37ksesIgwDaQ9606	rogid:HHkvsPLgjre0eg8ceEn788Hszck9606	rigid:7fdeC2TCG2my52OHAv46CAbuAQ0	false	-	myc tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)