#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O05208	uniprotkb:O05207	intact:EBI-6430603	intact:EBI-9026762	psi-mi:top6a_sacsh(display_long)|uniprotkb:top6A(gene name)|psi-mi:top6A(display_short)|uniprotkb:Type II DNA topoisomerase VI subunit A(gene name synonym)	psi-mi:top6b_sacsh(display_long)|uniprotkb:top6B(gene name)|psi-mi:top6B(display_short)|uniprotkb:Type II DNA topoisomerase VI subunit B(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Graille et al. (2008)	pubmed:18334211|doi:10.1016/j.str.2007.12.020|imex:IM-9025	taxid:2286(sulsh)|taxid:2286(Sulfolobus shibatae)	taxid:2286(sulsh)|taxid:2286(Sulfolobus shibatae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15691892|imex:IM-9025-2|dip:DIP-58785E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005694"(chromosome)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR004085(DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388|rcsb pdb:2ZBK|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|dip:DIP-29417N	dip:DIP-29416N|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0042802"(identical protein binding)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005734(DNA topoisomerase VI, subunit B)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015320(DNA topoisomerase VI, subunit B, transducer)|interpro:IPR020568|interpro:IPR036890|rcsb pdb:1MU5|rcsb pdb:1MX0|rcsb pdb:1Z59|rcsb pdb:1Z5A|rcsb pdb:1Z5B|rcsb pdb:1Z5C|rcsb pdb:2HKJ|rcsb pdb:2ZBK	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:hTkomsuIxJaoM9W4yTeQVsQEmSA2286	rogid:bxfNiocOEI1pthPZNOM5aPKToko2286	rigid:1mTcn4RmHNL7DeiAtPyjUj7PHmY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O05208	uniprotkb:O05207	intact:EBI-6430603	intact:EBI-9026762	psi-mi:top6a_sacsh(display_long)|uniprotkb:top6A(gene name)|psi-mi:top6A(display_short)|uniprotkb:Type II DNA topoisomerase VI subunit A(gene name synonym)	psi-mi:top6b_sacsh(display_long)|uniprotkb:top6B(gene name)|psi-mi:top6B(display_short)|uniprotkb:Type II DNA topoisomerase VI subunit B(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Graille et al. (2008)	pubmed:18334211|doi:10.1016/j.str.2007.12.020|imex:IM-9025	taxid:2286(sulsh)|taxid:2286(Sulfolobus shibatae)	taxid:2286(sulsh)|taxid:2286(Sulfolobus shibatae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15691909|imex:IM-9025-1|dip:DIP-58785E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005694"(chromosome)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016889"(endodeoxyribonuclease activity, producing 3'-phosphomonoesters)|interpro:IPR002815(Spo11/DNA topoisomerase VI, subunit A)|interpro:IPR004085(DNA topoisomerase VI, subunit A)|interpro:IPR013049(Spo11/DNA topoisomerase VI, subunit A, N-terminal)|interpro:IPR034136|interpro:IPR036078|interpro:IPR036388|rcsb pdb:2ZBK|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|dip:DIP-29417N	dip:DIP-29416N|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0042802"(identical protein binding)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005734(DNA topoisomerase VI, subunit B)|interpro:IPR010979(Ribosomal protein S13-like, H2TH)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015320(DNA topoisomerase VI, subunit B, transducer)|interpro:IPR020568|interpro:IPR036890|rcsb pdb:1MU5|rcsb pdb:1MX0|rcsb pdb:1Z59|rcsb pdb:1Z5A|rcsb pdb:1Z5B|rcsb pdb:1Z5C|rcsb pdb:2HKJ|rcsb pdb:2ZBK	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:hTkomsuIxJaoM9W4yTeQVsQEmSA2286	rogid:bxfNiocOEI1pthPZNOM5aPKToko2286	rigid:1mTcn4RmHNL7DeiAtPyjUj7PHmY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)