#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:D2IYK1 uniprotkb:P43627 intact:EBI-22185450 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:d2iyk1_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941356|imex:IM-25668-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - no-uniprot-update: - figure legend:Fig 4A-1|comment:B4601 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/06 rogid:fP83ZIElCVzNBGh/OYTEubkiDVE9606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:X5+nqnbnNP2Q+m3YrsHz5vhciDs false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:V6DZ76 uniprotkb:P43627 intact:EBI-22185469 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:v6dz76_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941407|imex:IM-25668-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - no-uniprot-update: - figure legend:Fig 4A-2|comment:B7301 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/06 rogid:T1dm+/s19UaRYE0Bize82o9mdTE9606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:7Jley116ZZlOin2YZe0g+xzPiLY false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:D2IYK1 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-22185450 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:d2iyk1_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941415|imex:IM-25668-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" no-uniprot-update: figure legend:Fig 4A-3|comment:B4601 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/06 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:fP83ZIElCVzNBGh/OYTEubkiDVE9606 rigid:iRC5TTROG1M2iapcuRJrCMWznKA false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:V6DZ76 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-22185469 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:v6dz76_human(display_long)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941423|imex:IM-25668-61 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" no-uniprot-update: figure legend:Fig 4A-4|comment:B7301 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/06 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:T1dm+/s19UaRYE0Bize82o9mdTE9606 rigid:9VJeE704Aji+5a6l0o1awA9NpSg false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43626 uniprotkb:Q5D1W8 intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633 intact:EBI-22185978 psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym) psi-mi:q5d1w8_human(display_long)|uniprotkb:HLA-Cw(gene name)|psi-mi:HLA-Cw(display_short)|uniprotkb:HLA-C(gene name synonym)|uniprotkb:HLA-C*04 variant(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941430|imex:IM-25668-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint no-uniprot-update: figure legend:Fig 4A-5, 4B-20, 5|comment:C0401 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606 rogid:yuGQa+7WmFk+1cE4IFuEOwDi7JE9606 rigid:ltcxsVMSOdL8BhYhtqF3BOScm10 false variant:37-37,135-135|fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q5D1W8 uniprotkb:P43627 intact:EBI-22185978 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:q5d1w8_human(display_long)|uniprotkb:HLA-Cw(gene name)|psi-mi:HLA-Cw(display_short)|uniprotkb:HLA-C(gene name synonym)|uniprotkb:HLA-C*04 variant(gene name synonym) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941441|imex:IM-25668-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - no-uniprot-update: - figure legend:Fig 4B-21,5|comment:C0401 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:yuGQa+7WmFk+1cE4IFuEOwDi7JE9606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:uVvT1ehXFDAMxnOnNd8LaA5JNeM false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q7YNW6 uniprotkb:P43627 intact:EBI-22185999 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:q7ynw6_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw(gene name synonym) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941448|imex:IM-25668-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - no-uniprot-update: - figure legend:Fig 4B-1|comment:C0102 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:EO9aGeEq+nfzvV61ZQfswiC4aEQ9606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:o8/E+8BKJu8sEK6fCucik6uJ0ag false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:Q53YP1 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-13917186|uniprotkb:O62883|uniprotkb:O78060|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:P30503|uniprotkb:Q29743|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q9GIK8|uniprotkb:Q9TQB4 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:1c03_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLAC(gene name synonym)|uniprotkb:MHC class I antigen Cw*3(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941479|imex:IM-25668-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 go:"GO:0055038"(recycling endosome membrane)|uniprotkb:P10321(see-also)|rcsb pdb:1EFX|ensembl:ENST00000457903|ensembl:ENSP00000390851|ensembl:ENSG00000225691|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0009986"(cell surface)|go:"GO:0031901"(early endosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0046977"(TAP binding)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0045087"(innate immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR036179|interpro:IPR037055 - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" no-uniprot-update:|caution:"The protein could not be merged with EBI-1051396 because of some conflicts with the protein sequence (features which cannot be shifted)." figure legend:Fig 4B-4,5|comment:C0302, C0304 and C0303 alleles;all alleles showed similar binding.|comment:"I119L variant:dbSNP:rs1071649; Y140S variant dbSNP:rs713032; G115R variant dbSNP:rs1131122"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2017/03/02 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:JFeUsl+FLKQrUF6Miog4kKzX3aE9606 rigid:eAZI2fYd2Rmch8BHf86qsIX3DU8 false fc-igg tag:?-? variant:115-115|variant:140-140,119-119 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43627 uniprotkb:Q53YP1 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 intact:EBI-13917186|uniprotkb:O62883|uniprotkb:O78060|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:P30503|uniprotkb:Q29743|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q9GIK8|uniprotkb:Q9TQB4 psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:1c03_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLAC(gene name synonym)|uniprotkb:MHC class I antigen Cw*3(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941496|imex:IM-25668-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 go:"GO:0055038"(recycling endosome membrane)|uniprotkb:P10321(see-also)|rcsb pdb:1EFX|ensembl:ENST00000457903|ensembl:ENSP00000390851|ensembl:ENSG00000225691|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0009986"(cell surface)|go:"GO:0031901"(early endosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0046977"(TAP binding)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0045087"(innate immune response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050776"(regulation of immune response)|go:"GO:0060337"(type I interferon signaling pathway)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR036179|interpro:IPR037055 - - no-uniprot-update:|caution:"The protein could not be merged with EBI-1051396 because of some conflicts with the protein sequence (features which cannot be shifted)." figure legend:Fig 4A, 4B-3,5|comment:C0302, C0304 and C0303 alleles;all alleles showed similar binding.|comment:"I119L variant:dbSNP:rs1071649; Y140S variant dbSNP:rs713032; G115R variant dbSNP:rs1131122"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2017/03/02 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rogid:JFeUsl+FLKQrUF6Miog4kKzX3aE9606 rigid:gosW4BjrYM9wubj4pOZVG7cx7Zk false fc-igg tag:?-? variant:140-140,119-119|variant:115-115 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:Q7YNW6 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-22185999 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:q7ynw6_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941509|imex:IM-25668-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" no-uniprot-update: figure legend:Fig 4B-2,5|comment:C0102 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:EO9aGeEq+nfzvV61ZQfswiC4aEQ9606 rigid:y9I5jBairHF3rxOsm1rMa4H4C6E false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:Q5D1W8 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-22185978 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:q5d1w8_human(display_long)|uniprotkb:HLA-Cw(gene name)|psi-mi:HLA-Cw(display_short)|uniprotkb:HLA-C(gene name synonym)|uniprotkb:HLA-C*04 variant(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941526|imex:IM-25668-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" no-uniprot-update: figure legend:Fig 4B-22,5|comment:C0401 allele|comment:weak binding|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:yuGQa+7WmFk+1cE4IFuEOwDi7JE9606 rigid:S5YQuq1HEdx3JHuUq9ozFdLlS7A false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P10321 uniprotkb:P43627 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941534|imex:IM-25668-63 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - - - figure legend:Fig 4B-9,5|comment:C0702 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/10/18 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:tEcn7jCjufCLac8ZS+5utpD42r4 false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:P10321 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941551|imex:IM-25668-65 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" - figure legend:Fig 4B-10,5|comment:C0702 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/10/18 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:C9rNEX6KgOloPayGCJms4nYW+M4 false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:P10321 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941558|imex:IM-25668-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" - figure legend:Fig 4B-12,5|comment:C0801 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/10/18 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:C9rNEX6KgOloPayGCJms4nYW+M4 false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P10321 uniprotkb:P43627 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941594|imex:IM-25668-67 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - - - figure legend:Fig 4B-11,5|comment:C0801 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/10/18 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:tEcn7jCjufCLac8ZS+5utpD42r4 false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P10321 uniprotkb:P43627 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941601|imex:IM-25668-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - - - figure legend:Fig 4B-13,5|comment:C1402 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/10/18 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:tEcn7jCjufCLac8ZS+5utpD42r4 false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:P10321 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941608|imex:IM-25668-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" - figure legend:Fig 4B-14,5|comment:C1402 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/10/18 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:C9rNEX6KgOloPayGCJms4nYW+M4 false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:Q5RIP0 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-22185566 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:q5rip0_human(display_long)|uniprotkb:HLA-Cw(gene name)|psi-mi:HLA-Cw(display_short)|uniprotkb:HLA-C(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941615|imex:IM-25668-49 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" no-uniprot-update: figure legend:Fig 4B-25,5|comment:C0501 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:VBoY0c9Tj1Nqea02BLgSFK2hZKU9606 rigid:V9IC+N5ioOpBU56G+dxXslv+obw false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P10321 uniprotkb:P43627 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941623|imex:IM-25668-69 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - - - figure legend:Fig 4B-15,5|comment:C1601 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/10/18 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:tEcn7jCjufCLac8ZS+5utpD42r4 false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:P10321 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941630|imex:IM-25668-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" - figure legend:Fig 4B-16,5|comment:C1601 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/10/18 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 rigid:C9rNEX6KgOloPayGCJms4nYW+M4 false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43626 uniprotkb:Q7YQB1 intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633 intact:EBI-22185948 psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym) psi-mi:q7yqb1_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941651|imex:IM-25668-71 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint no-uniprot-update: figure legend:Fig 4B-17,5|comment:C0202 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606 rogid:spWpl8Jrn9iyCmtKQPBJ5sHOgxg9606 rigid:mDBeGs5FT/J5mu6onC/959qvYqU false variant:37-37,135-135|fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q7YQB1 uniprotkb:P43627 intact:EBI-22185948 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:q7yqb1_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw(gene name synonym) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941682|imex:IM-25668-73 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - no-uniprot-update: - figure legend:Fig 4B-1,5|comment:C0202 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:spWpl8Jrn9iyCmtKQPBJ5sHOgxg9606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:E2xQ9niR/Hl0Kgd0xKRiinyb/KY false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:Q7YQB1 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-22185948 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:q7yqb1_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941703|imex:IM-25668-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" no-uniprot-update: figure legend:Fig 4B-19,5|comment:C0202 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:spWpl8Jrn9iyCmtKQPBJ5sHOgxg9606 rigid:H5sGhsQJYnM5t+7LBtLJdOPJqF8 false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43626 uniprotkb:Q5RIP0 intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633 intact:EBI-22185566 psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym) psi-mi:q5rip0_human(display_long)|uniprotkb:HLA-Cw(gene name)|psi-mi:HLA-Cw(display_short)|uniprotkb:HLA-C(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941724|imex:IM-25668-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint no-uniprot-update: figure legend:Fig 4B-23,5|comment:C0501 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606 rogid:VBoY0c9Tj1Nqea02BLgSFK2hZKU9606 rigid:jq4xQIJMVGS3rl7uQTUst1QdT0g false fc-igg tag:?-?|variant:37-37,135-135 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q5RIP0 uniprotkb:P43627 intact:EBI-22185566 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:q5rip0_human(display_long)|uniprotkb:HLA-Cw(gene name)|psi-mi:HLA-Cw(display_short)|uniprotkb:HLA-C(gene name synonym) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941731|imex:IM-25668-51 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - no-uniprot-update: - figure legend:Fig 4B-24,5|comment:C0501 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:VBoY0c9Tj1Nqea02BLgSFK2hZKU9606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:1Kshwkj5elxWFoLN3dkcVZh2koo false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43626 uniprotkb:Q5QT33 intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633 intact:EBI-22185855|uniprotkb:K4MYM9 psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym) psi-mi:q5qt33_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:HLAC(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941738|imex:IM-25668-53 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint no-uniprot-update: figure legend:Fig 4B-26,5|comment:C0602 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606 rogid:FdIjvn4COE6bfc4ZdevQ4iIOEO89606 rigid:9C4M95xuNaxX1rPpYyFkJHIK0Ic false variant:37-37,135-135|fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q5QT33 uniprotkb:P43627 intact:EBI-22185855|uniprotkb:K4MYM9 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:q5qt33_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:HLAC(gene name synonym) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941745|imex:IM-25668-75 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - no-uniprot-update: - figure legend:Fig 4B-27,5|comment:C0602 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:FdIjvn4COE6bfc4ZdevQ4iIOEO89606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:lARdeMCY5+w733Emk9BMvTDwY34 false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:Q5QT33 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-22185855|uniprotkb:K4MYM9 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:q5qt33_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:HLAC(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941752|imex:IM-25668-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" no-uniprot-update: figure legend:Fig 4B-28,5|comment:C0602 allele;weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:FdIjvn4COE6bfc4ZdevQ4iIOEO89606 rigid:tpt7Szjpu9w7SdVcynkX0XOQ9as false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43626 uniprotkb:C1K0Y5 intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633 intact:EBI-22185877 psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym) psi-mi:c1k0y5_human(display_long)|uniprotkb:HLA-Cw(gene name)|psi-mi:HLA-Cw(display_short)|uniprotkb:HLA C(gene name synonym)|uniprotkb:HLA-C(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941759|imex:IM-25668-55 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint no-uniprot-update: figure legend:Fig 4B-29,5|comment:C1502 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606 rogid:FmgiDrbT1jmGhirg52ZtttwcSao9606 rigid:UotQXVC/deVA18fj8Hw7tabESZE false variant:37-37,135-135|fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:C1K0Y5 uniprotkb:P43627 intact:EBI-22185877 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:c1k0y5_human(display_long)|uniprotkb:HLA-Cw(gene name)|psi-mi:HLA-Cw(display_short)|uniprotkb:HLA C(gene name synonym)|uniprotkb:HLA-C(gene name synonym) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941766|imex:IM-25668-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - no-uniprot-update: - figure legend:Fig 4B-30,5|comment:C1502 allele;weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:FmgiDrbT1jmGhirg52ZtttwcSao9606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:5DiyvK91+4xAKsF/qDaqZySqrzA false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43626 uniprotkb:C9E8W1 intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633 intact:EBI-22185900|uniprotkb:K4MVL4 psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym) psi-mi:c9e8w1_human(display_long)|uniprotkb:HLA-Cw(gene name)|psi-mi:HLA-Cw(display_short)|uniprotkb:Cw*1701(gene name synonym)|uniprotkb:HLA-C(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941773|imex:IM-25668-37 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint no-uniprot-update: figure legend:Fig 4B-31,5|comment:C1701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606 rogid:vApxJ4VOGpVG6geycqTITtRbcvI9606 rigid:GUpsdw/v+mnt77XTlKbJB1MUJjE false variant:37-37,135-135|fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:C9E8W1 uniprotkb:P43627 intact:EBI-22185900|uniprotkb:K4MVL4 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 psi-mi:c9e8w1_human(display_long)|uniprotkb:HLA-Cw(gene name)|psi-mi:HLA-Cw(display_short)|uniprotkb:Cw*1701(gene name synonym)|uniprotkb:HLA-C(gene name synonym) psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941780|imex:IM-25668-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 - no-uniprot-update: - figure legend:Fig 4B-32,5|comment:C1701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:vApxJ4VOGpVG6geycqTITtRbcvI9606 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rigid:9f5vKzqMMo2dnQ1MNM+sckynv8w false - fc-igg tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:C9E8W1 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-22185900|uniprotkb:K4MVL4 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:c9e8w1_human(display_long)|uniprotkb:HLA-Cw(gene name)|psi-mi:HLA-Cw(display_short)|uniprotkb:Cw*1701(gene name synonym)|uniprotkb:HLA-C(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941787|imex:IM-25668-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" no-uniprot-update: figure legend:Fig 4B-33,5|comment:C1701 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:vApxJ4VOGpVG6geycqTITtRbcvI9606 rigid:r1KcpNqlGOWZiMM4IO3CKMAHwjM false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43626 uniprotkb:A0A142JA41 intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633 intact:EBI-22185924 psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym) psi-mi:a0a142ja41_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw*18GB(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941822|imex:IM-25668-57 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint no-uniprot-update: figure legend:Fig 4B-34,5|comment:C1802 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606 rogid:wQorUI5G9wOln6jjWYH/wWE8ynE9606 rigid:JfRSIXKiqD2gnxHOGIYl0WQFBHA false variant:37-37,135-135|fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43627 uniprotkb:A0A142JA41 intact:EBI-13941368|ensembl:ENSP00000480161|ensembl:ENSP00000481907|ensembl:ENSP00000482201|ensembl:ENSP00000482519|ensembl:ENSP00000483052|ensembl:ENSP00000483373|uniprotkb:C6EVR8|uniprotkb:Q14951 intact:EBI-22185924 psi-mi:ki2l2_human(display_long)|uniprotkb:KIR2DL2(gene name)|psi-mi:KIR2DL2(display_short)|uniprotkb:CD158B1(gene name synonym)|uniprotkb:NKAT6(gene name synonym)|uniprotkb:CD158 antigen-like family member B1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 6(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-43(gene name synonym) psi-mi:a0a142ja41_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw*18GB(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941831|imex:IM-25668-39 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000275407(gene)|ensembl:ENSG00000275546(gene)|ensembl:ENSG00000275914(gene)|ensembl:ENSG00000276011(gene)|ensembl:ENSG00000276731(gene)|ensembl:ENSG00000278731(gene)|ensembl:ENST00000611724(transcript)|ensembl:ENST00000613410(transcript)|ensembl:ENST00000616831(transcript)|ensembl:ENST00000618388(transcript)|ensembl:ENST00000618796(transcript)|ensembl:ENST00000619621(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EFX|rcsb pdb:2DL2|rcsb pdb:2DLI|rcsb pdb:6PA1|reactome:R-HSA-198933|refseq:NP_055034.2 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - - no-uniprot-update: figure legend:Fig 4B-35,5|comment:C1802 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:gDMFmGZrui8njGgXkU8jasY8EW09606 rogid:wQorUI5G9wOln6jjWYH/wWE8ynE9606 rigid:GF4pN9IbwItCCokocRCCjxwhpkk false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43628 uniprotkb:A0A142JA41 intact:EBI-8632435|ensembl:ENSP00000342215|ensembl:ENSP00000478136|ensembl:ENSP00000478657|ensembl:ENSP00000478848|ensembl:ENSP00000479121|ensembl:ENSP00000480087|ensembl:ENSP00000480464|ensembl:ENSP00000481159|ensembl:ENSP00000481237|ensembl:ENSP00000481355|ensembl:ENSP00000481478|ensembl:ENSP00000482830|ensembl:ENSP00000483192|ensembl:ENSP00000483419|ensembl:ENSP00000483551|ensembl:ENSP00000483883|ensembl:ENSP00000483975|ensembl:ENSP00000484459|ensembl:ENSP00000491264|ensembl:ENSP00000491273|ensembl:ENSP00000491452|ensembl:ENSP00000491955|ensembl:ENSP00000492356|ensembl:ENSP00000492856|intact:MINT-1523646|uniprotkb:Q14945|uniprotkb:Q9UM51|uniprotkb:P78402|uniprotkb:Q14944|uniprotkb:Q9UQ70|uniprotkb:O43472 intact:EBI-22185924 psi-mi:ki2l3_human(display_long)|uniprotkb:KIR2DL3(gene name)|psi-mi:KIR2DL3(display_short)|uniprotkb:KIRCL23(gene name synonym)|uniprotkb:NKAT2(gene name synonym)|uniprotkb:CD158B2(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 2(gene name synonym)|uniprotkb:NKAT2a(gene name synonym)|uniprotkb:NKAT2b(gene name synonym)|uniprotkb:p58 natural killer cell receptor clone CL-6(gene name synonym)|uniprotkb:p58.2 MHC class-I-specific NK receptor(gene name synonym)|uniprotkb:Killer inhibitory receptor cl 2-3(gene name synonym)|uniprotkb:KIR-023GB(gene name synonym)|uniprotkb:CD158 antigen-like family member B2(gene name synonym) psi-mi:a0a142ja41_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw*18GB(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941840|imex:IM-25668-59 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000243772(gene)|ensembl:ENSG00000273887(gene)|ensembl:ENSG00000274108(gene)|ensembl:ENSG00000274402(gene)|ensembl:ENSG00000274410(gene)|ensembl:ENSG00000274830(gene)|ensembl:ENSG00000274952(gene)|ensembl:ENSG00000275008(gene)|ensembl:ENSG00000275623(gene)|ensembl:ENSG00000275658(gene)|ensembl:ENSG00000276218(gene)|ensembl:ENSG00000276459(gene)|ensembl:ENSG00000276590(gene)|ensembl:ENSG00000277317(gene)|ensembl:ENSG00000277484(gene)|ensembl:ENSG00000277554(gene)|ensembl:ENSG00000277924(gene)|ensembl:ENSG00000278327(gene)|ensembl:ENSG00000283702(gene)|ensembl:ENSG00000283708(gene)|ensembl:ENSG00000283790(gene)|ensembl:ENSG00000284333(gene)|ensembl:ENSG00000284504(gene)|ensembl:ENSG00000284510(gene)|ensembl:ENST00000342376(transcript)|ensembl:ENST00000610407(transcript)|ensembl:ENST00000611207(transcript)|ensembl:ENST00000611369(transcript)|ensembl:ENST00000611821(transcript)|ensembl:ENST00000611990(transcript)|ensembl:ENST00000614792(transcript)|ensembl:ENST00000615091(transcript)|ensembl:ENST00000615739(transcript)|ensembl:ENST00000617150(transcript)|ensembl:ENST00000617242(transcript)|ensembl:ENST00000617404(transcript)|ensembl:ENST00000617593(transcript)|ensembl:ENST00000617790(transcript)|ensembl:ENST00000619702(transcript)|ensembl:ENST00000619995(transcript)|ensembl:ENST00000620549(transcript)|ensembl:ENST00000622644(transcript)|ensembl:ENST00000638813(transcript)|ensembl:ENST00000638851(transcript)|ensembl:ENST00000639089(transcript)|ensembl:ENST00000639101(transcript)|ensembl:ENST00000639176(transcript)|ensembl:ENST00000640485(transcript)|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1B6U|rcsb pdb:6PAG|reactome:R-HSA-198933|refseq:NP_056952.2 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint|function:"Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis" no-uniprot-update: figure legend:Fig 4B-36,5|comment:C1802 allele;weak interaction|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:cb3YfQFCC2N0Y8ePoGNwZ9HQyFY9606 rogid:wQorUI5G9wOln6jjWYH/wWE8ynE9606 rigid:5hHct0vLtSf7X6ujdkysejhAjpM false fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43626 uniprotkb:Q7YQB1 intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633 intact:EBI-22185948 psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym) psi-mi:q7yqb1_human(display_long)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short)|uniprotkb:HLA-Cw(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941850|imex:IM-25668-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint no-uniprot-update: figure legend:Fig 5|comment:C0202 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606 rogid:spWpl8Jrn9iyCmtKQPBJ5sHOgxg9606 rigid:mDBeGs5FT/J5mu6onC/959qvYqU false variant:37-37,135-135|fc-igg tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P43626 uniprotkb:Q5RIP0 intact:EBI-8684277|uniprotkb:Q6IST4|intact:MINT-8013645|uniprotkb:Q32WE6|uniprotkb:O43470|ensembl:ENSP00000478232|ensembl:ENSP00000478263|ensembl:ENSP00000479363|ensembl:ENSP00000482120|ensembl:ENSP00000484361|ensembl:ENSP00000484559|ensembl:ENSP00000291633 intact:EBI-22185566 psi-mi:ki2l1_human(display_long)|uniprotkb:KIR2DL1(gene name)|psi-mi:KIR2DL1(display_short)|uniprotkb:CD158 antigen-like family member A(gene name synonym)|uniprotkb:CD158A(gene name synonym)|uniprotkb:NKAT1(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 1(gene name synonym)|uniprotkb:p58 natural killer cell receptor clones CL-42/47.11(gene name synonym)|uniprotkb:p58.1 MHC class-I-specific NK receptor(gene name synonym) psi-mi:q5rip0_human(display_long)|uniprotkb:HLA-Cw(gene name)|psi-mi:HLA-Cw(display_short)|uniprotkb:HLA-C(gene name synonym) psi-mi:"MI:0004"(affinity chromatography technology) Moesta et al. (2008) pubmed:18322206|imex:IM-25668 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13941871|imex:IM-25668-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055033.2|ensembl:ENSG00000125498(gene)|ensembl:ENSG00000273794(gene)|ensembl:ENSG00000276625(gene)|ensembl:ENSG00000277833(gene)|ensembl:ENSG00000278495(gene)|ensembl:ENSG00000278738(gene)|ensembl:ENSG00000278821(gene)|ensembl:ENST00000291633(transcript)|ensembl:ENST00000611611(transcript)|ensembl:ENST00000615920(transcript)|ensembl:ENST00000617376(transcript)|ensembl:ENST00000618563(transcript)|ensembl:ENST00000620449(transcript)|ensembl:ENST00000622463(transcript)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1IM9|rcsb pdb:1NKR|reactome:R-HSA-198933 go:"GO:0016021"(integral component of membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0006955"(immune response)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR037055|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal) - comment:mint no-uniprot-update: figure legend:Fig 5|comment:C0501 allele|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/21 2019/11/07 rogid:8lycFqdUAUK1Ww2NpLHNFtFPlZ49606 rogid:VBoY0c9Tj1Nqea02BLgSFK2hZKU9606 rigid:jq4xQIJMVGS3rl7uQTUst1QdT0g false fc-igg tag:?-?|variant:37-37,135-135 - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)