#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P28223-1	uniprotkb:Q14416	intact:EBI-15573967|ensembl:ENSP00000437737	intact:EBI-10232876|uniprotkb:B0M0K7|uniprotkb:Q52MC6|uniprotkb:Q14CU5|uniprotkb:Q9H3N6|ensembl:ENSP00000378492	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:grm2_human(display_long)|uniprotkb:GRM2(gene name)|psi-mi:GRM2(display_short)|uniprotkb:GPRC1B(gene name synonym)|uniprotkb:MGLUR2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	González-Maeso et al. (2008)	pubmed:18297054|doi:10.1038/nature06612|imex:IM-17976	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15688359|imex:IM-17976-1|dip:DIP-189555E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	refseq:NP_000830.2|ensembl:ENSG00000164082(gene)|ensembl:ENST00000395052(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:Q14416|rcsb pdb:4XAQ|rcsb pdb:4XAS|rcsb pdb:5CNI|rcsb pdb:5CNJ|rcsb pdb:7E9G|rcsb pdb:7EPA|rcsb pdb:7EPB|rcsb pdb:7EPD|reactome:R-HSA-418594|rcsb pdb:5KZN|reactome:R-HSA-420499|rcsb pdb:5KZQ|refseq:XP_016861760.1|dip:DIP-59826N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rogid:rDxn3cvyuWTL9NE7fgI8RLY0Mts9606	rigid:e93mofot3aurY5hctdFJVxXZ5G0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28223-1	uniprotkb:Q14416	intact:EBI-15573967|ensembl:ENSP00000437737	intact:EBI-10232876|uniprotkb:B0M0K7|uniprotkb:Q52MC6|uniprotkb:Q14CU5|uniprotkb:Q9H3N6|ensembl:ENSP00000378492	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:grm2_human(display_long)|uniprotkb:GRM2(gene name)|psi-mi:GRM2(display_short)|uniprotkb:GPRC1B(gene name synonym)|uniprotkb:MGLUR2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	González-Maeso et al. (2008)	pubmed:18297054|doi:10.1038/nature06612|imex:IM-17976	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15688397|imex:IM-17976-3|dip:DIP-189555E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	refseq:NP_000830.2|ensembl:ENSG00000164082(gene)|ensembl:ENST00000395052(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:Q14416|rcsb pdb:4XAQ|rcsb pdb:4XAS|rcsb pdb:5CNI|rcsb pdb:5CNJ|rcsb pdb:7E9G|rcsb pdb:7EPA|rcsb pdb:7EPB|rcsb pdb:7EPD|reactome:R-HSA-418594|rcsb pdb:5KZN|reactome:R-HSA-420499|rcsb pdb:5KZQ|refseq:XP_016861760.1|dip:DIP-59826N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rogid:rDxn3cvyuWTL9NE7fgI8RLY0Mts9606	rigid:e93mofot3aurY5hctdFJVxXZ5G0	false	myc tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14416	uniprotkb:P28223-1	intact:EBI-10232876|uniprotkb:B0M0K7|uniprotkb:Q52MC6|uniprotkb:Q14CU5|uniprotkb:Q9H3N6|ensembl:ENSP00000378492	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:grm2_human(display_long)|uniprotkb:GRM2(gene name)|psi-mi:GRM2(display_short)|uniprotkb:GPRC1B(gene name synonym)|uniprotkb:MGLUR2(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	González-Maeso et al. (2008)	pubmed:18297054|doi:10.1038/nature06612|imex:IM-17976	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15688376|imex:IM-17976-2|dip:DIP-189555E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000830.2|ensembl:ENSG00000164082(gene)|ensembl:ENST00000395052(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:Q14416|rcsb pdb:4XAQ|rcsb pdb:4XAS|rcsb pdb:5CNI|rcsb pdb:5CNJ|rcsb pdb:7E9G|rcsb pdb:7EPA|rcsb pdb:7EPB|rcsb pdb:7EPD|reactome:R-HSA-418594|rcsb pdb:5KZN|reactome:R-HSA-420499|rcsb pdb:5KZQ|refseq:XP_016861760.1|dip:DIP-59826N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:rDxn3cvyuWTL9NE7fgI8RLY0Mts9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:e93mofot3aurY5hctdFJVxXZ5G0	false	yellow fluorescent protein tag:c-c	cyan fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14416	uniprotkb:P28223-1	intact:EBI-10232876|uniprotkb:B0M0K7|uniprotkb:Q52MC6|uniprotkb:Q14CU5|uniprotkb:Q9H3N6|ensembl:ENSP00000378492	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:grm2_human(display_long)|uniprotkb:GRM2(gene name)|psi-mi:GRM2(display_short)|uniprotkb:GPRC1B(gene name synonym)|uniprotkb:MGLUR2(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	González-Maeso et al. (2008)	pubmed:18297054|doi:10.1038/nature06612|imex:IM-17976	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15688418|imex:IM-17976-4|dip:DIP-189555E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000830.2|ensembl:ENSG00000164082(gene)|ensembl:ENST00000395052(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:Q14416|rcsb pdb:4XAQ|rcsb pdb:4XAS|rcsb pdb:5CNI|rcsb pdb:5CNJ|rcsb pdb:7E9G|rcsb pdb:7EPA|rcsb pdb:7EPB|rcsb pdb:7EPD|reactome:R-HSA-418594|rcsb pdb:5KZN|reactome:R-HSA-420499|rcsb pdb:5KZQ|refseq:XP_016861760.1|dip:DIP-59826N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:rDxn3cvyuWTL9NE7fgI8RLY0Mts9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:e93mofot3aurY5hctdFJVxXZ5G0	false	renilla luciferase protein tag:c-c	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)