#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8ML92	uniprotkb:Q8WXI2	intact:EBI-2563975|ensemblmetazoa:FBpp0086569	intact:EBI-1045119|uniprotkb:O94976|uniprotkb:Q5JPK4|uniprotkb:Q8WXI1|uniprotkb:B9EG83|uniprotkb:Q5JPN0|ensembl:ENSP00000368824|uniprotkb:B4DGR4|uniprotkb:B7ZLJ1|uniprotkb:E7ESA4	psi-mi:ave_drome(display_long)|uniprotkb:ave(gene name)|psi-mi:ave(display_short)|uniprotkb:CG30476(orf name)	psi-mi:cnkr2_human(display_long)|uniprotkb:CNKSR2(gene name)|psi-mi:CNKSR2(display_short)|uniprotkb:CNK2(gene name synonym)|uniprotkb:KIAA0902(gene name synonym)|uniprotkb:KSR2(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rajakulendran et al. (2008)	pubmed:18287031|doi:10.1073/pnas.0709705105|imex:IM-9103	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15686603|imex:IM-9103-3|dip:DIP-59203E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725413.1|flybase:FBgn0050476|ensemblmetazoa:FBgn0050476(gene)|ensemblmetazoa:FBtr0087439(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR039144|rcsb pdb:3BS5|rcsb pdb:3BS7|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|dip:DIP-29737N	refseq:NP_001162119.1|refseq:NP_055742.2|refseq:NP_001162118.1|refseq:NP_001162120.1|ensembl:ENSG00000149970(gene)|ensembl:ENST00000379510(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|rcsb pdb:2EAN|rcsb pdb:3BS5|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|ensembl:ENSP00000368824|ensembl:ENST00000425654|ensembl:ENSP00000397906|ensembl:ENST00000543067|ensembl:ENSP00000444633|ensembl:ENST00000642359|ensembl:ENSP00000496709|dip:DIP-29736N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:KFY1sGM+J+Bwi/LsJHiNvr5vutg7227	rogid:FEIgggNg8LMikG2NZ6LHRD3lKDw9606	rigid:BNE41F2QKrGJPcMhbNUSfScX+8k	false	binding-associated region:21-98|tag:n-n|mutation disrupting interaction:61-61,57-57|mutation decreasing interaction:61-61,57-57|mutation decreasing interaction:61-61	binding-associated region:5-84|mutation disrupting interaction:71-71,68-68|mutation decreasing interaction:71-71|mutation decreasing interaction:60-60|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7KNQ9	uniprotkb:Q8ML92	intact:EBI-111569|intact:EBI-2564001|ensemblmetazoa:FBpp0086117|ensemblmetazoa:FBpp0309189	intact:EBI-2563975|ensemblmetazoa:FBpp0086569	psi-mi:q7knq9_drome(display_long)|uniprotkb:cnk(gene name)|psi-mi:cnk(display_short)|uniprotkb:CNK(gene name synonym)|uniprotkb:Cnk(gene name synonym)|uniprotkb:Dmel\CG6556(gene name synonym)|uniprotkb:EC2-3(gene name synonym)|uniprotkb:EK2-3(gene name synonym)|uniprotkb:anon-WO0140519.129(gene name synonym)|uniprotkb:anon-WO0257455.27(gene name synonym)|uniprotkb:"l(2)k16314"(gene name synonym)|uniprotkb:sag(gene name synonym)|uniprotkb:CG6556(orf name)|uniprotkb:Dmel_CG6556(orf name)	psi-mi:ave_drome(display_long)|uniprotkb:ave(gene name)|psi-mi:ave(display_short)|uniprotkb:CG30476(orf name)	psi-mi:"MI:0096"(pull down)	Rajakulendran et al. (2008)	pubmed:18287031|doi:10.1073/pnas.0709705105|imex:IM-9103	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15686670|imex:IM-9103-4|dip:DIP-59204E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725671.1|refseq:NP_001286524.1|dip:DIP-29738N|flybase:FBgn0286070|ensemblmetazoa:FBgn0286070(gene)|ensemblmetazoa:FBtr0086962(transcript)|ensemblmetazoa:FBtr0340214(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|reactome:R-DME-5674135	refseq:NP_725413.1|flybase:FBgn0050476|ensemblmetazoa:FBgn0050476(gene)|ensemblmetazoa:FBtr0087439(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR039144|rcsb pdb:3BS5|rcsb pdb:3BS7|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|dip:DIP-29737N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:luUwzC5ziVQ0R3V3gskb0IrPiG47227	rogid:KFY1sGM+J+Bwi/LsJHiNvr5vutg7227	rigid:IvHIlrYkMNBaf9/GhXGQu8kwxQI	false	binding-associated region:2-549|mutation disrupting interaction:69-69,66-66	mutation decreasing interaction strength:57-57,61-61|tag:n-n|mutation disrupting interaction strength:61-61,57-57|mutation decreasing interaction:61-61	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8ML92	uniprotkb:Q8WXI2	intact:EBI-2563975|ensemblmetazoa:FBpp0086569	intact:EBI-1045119|uniprotkb:O94976|uniprotkb:Q5JPK4|uniprotkb:Q8WXI1|uniprotkb:B9EG83|uniprotkb:Q5JPN0|ensembl:ENSP00000368824|uniprotkb:B4DGR4|uniprotkb:B7ZLJ1|uniprotkb:E7ESA4	psi-mi:ave_drome(display_long)|uniprotkb:ave(gene name)|psi-mi:ave(display_short)|uniprotkb:CG30476(orf name)	psi-mi:cnkr2_human(display_long)|uniprotkb:CNKSR2(gene name)|psi-mi:CNKSR2(display_short)|uniprotkb:CNK2(gene name synonym)|uniprotkb:KIAA0902(gene name synonym)|uniprotkb:KSR2(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Rajakulendran et al. (2008)	pubmed:18287031|doi:10.1073/pnas.0709705105|imex:IM-9103	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15686704|imex:IM-9103-6|dip:DIP-59203E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725413.1|flybase:FBgn0050476|ensemblmetazoa:FBgn0050476(gene)|ensemblmetazoa:FBtr0087439(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR039144|rcsb pdb:3BS5|rcsb pdb:3BS7|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|dip:DIP-29737N	refseq:NP_001162119.1|refseq:NP_055742.2|refseq:NP_001162118.1|refseq:NP_001162120.1|ensembl:ENSG00000149970(gene)|ensembl:ENST00000379510(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|rcsb pdb:2EAN|rcsb pdb:3BS5|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|ensembl:ENSP00000368824|ensembl:ENST00000425654|ensembl:ENSP00000397906|ensembl:ENST00000543067|ensembl:ENSP00000444633|ensembl:ENST00000642359|ensembl:ENSP00000496709|dip:DIP-29736N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:KFY1sGM+J+Bwi/LsJHiNvr5vutg7227	rogid:FEIgggNg8LMikG2NZ6LHRD3lKDw9606	rigid:BNE41F2QKrGJPcMhbNUSfScX+8k	false	binding-associated region:21-98	binding-associated region:5-84	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8ML92	uniprotkb:Q8WXI2	intact:EBI-2563975|ensemblmetazoa:FBpp0086569	intact:EBI-1045119|uniprotkb:O94976|uniprotkb:Q5JPK4|uniprotkb:Q8WXI1|uniprotkb:B9EG83|uniprotkb:Q5JPN0|ensembl:ENSP00000368824|uniprotkb:B4DGR4|uniprotkb:B7ZLJ1|uniprotkb:E7ESA4	psi-mi:ave_drome(display_long)|uniprotkb:ave(gene name)|psi-mi:ave(display_short)|uniprotkb:CG30476(orf name)	psi-mi:cnkr2_human(display_long)|uniprotkb:CNKSR2(gene name)|psi-mi:CNKSR2(display_short)|uniprotkb:CNK2(gene name synonym)|uniprotkb:KIAA0902(gene name synonym)|uniprotkb:KSR2(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rajakulendran et al. (2008)	pubmed:18287031|doi:10.1073/pnas.0709705105|imex:IM-9103	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15686725|imex:IM-9103-5|dip:DIP-59203E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725413.1|flybase:FBgn0050476|ensemblmetazoa:FBgn0050476(gene)|ensemblmetazoa:FBtr0087439(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR039144|rcsb pdb:3BS5|rcsb pdb:3BS7|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|dip:DIP-29737N	refseq:NP_001162119.1|refseq:NP_055742.2|refseq:NP_001162118.1|refseq:NP_001162120.1|ensembl:ENSG00000149970(gene)|ensembl:ENST00000379510(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|rcsb pdb:2EAN|rcsb pdb:3BS5|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|ensembl:ENSP00000368824|ensembl:ENST00000425654|ensembl:ENSP00000397906|ensembl:ENST00000543067|ensembl:ENSP00000444633|ensembl:ENST00000642359|ensembl:ENSP00000496709|dip:DIP-29736N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:KFY1sGM+J+Bwi/LsJHiNvr5vutg7227	rogid:FEIgggNg8LMikG2NZ6LHRD3lKDw9606	rigid:BNE41F2QKrGJPcMhbNUSfScX+8k	false	binding-associated region:21-98|tag:n-n	binding-associated region:5-84	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8ML92	uniprotkb:Q8WXI2	intact:EBI-2563975|ensemblmetazoa:FBpp0086569	intact:EBI-1045119|uniprotkb:O94976|uniprotkb:Q5JPK4|uniprotkb:Q8WXI1|uniprotkb:B9EG83|uniprotkb:Q5JPN0|ensembl:ENSP00000368824|uniprotkb:B4DGR4|uniprotkb:B7ZLJ1|uniprotkb:E7ESA4	psi-mi:ave_drome(display_long)|uniprotkb:ave(gene name)|psi-mi:ave(display_short)|uniprotkb:CG30476(orf name)	psi-mi:cnkr2_human(display_long)|uniprotkb:CNKSR2(gene name)|psi-mi:CNKSR2(display_short)|uniprotkb:CNK2(gene name synonym)|uniprotkb:KIAA0902(gene name synonym)|uniprotkb:KSR2(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Rajakulendran et al. (2008)	pubmed:18287031|doi:10.1073/pnas.0709705105|imex:IM-9103	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15686749|imex:IM-9103-2|dip:DIP-59203E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725413.1|flybase:FBgn0050476|ensemblmetazoa:FBgn0050476(gene)|ensemblmetazoa:FBtr0087439(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR039144|rcsb pdb:3BS5|rcsb pdb:3BS7|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|dip:DIP-29737N	refseq:NP_001162119.1|refseq:NP_055742.2|refseq:NP_001162118.1|refseq:NP_001162120.1|ensembl:ENSG00000149970(gene)|ensembl:ENST00000379510(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|rcsb pdb:2EAN|rcsb pdb:3BS5|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|ensembl:ENSP00000368824|ensembl:ENST00000425654|ensembl:ENSP00000397906|ensembl:ENST00000543067|ensembl:ENSP00000444633|ensembl:ENST00000642359|ensembl:ENSP00000496709|dip:DIP-29736N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:KFY1sGM+J+Bwi/LsJHiNvr5vutg7227	rogid:FEIgggNg8LMikG2NZ6LHRD3lKDw9606	rigid:BNE41F2QKrGJPcMhbNUSfScX+8k	false	binding-associated region:21-98	binding-associated region:5-84	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8ML92	uniprotkb:Q8WXI2	intact:EBI-2563975|ensemblmetazoa:FBpp0086569	intact:EBI-1045119|uniprotkb:O94976|uniprotkb:Q5JPK4|uniprotkb:Q8WXI1|uniprotkb:B9EG83|uniprotkb:Q5JPN0|ensembl:ENSP00000368824|uniprotkb:B4DGR4|uniprotkb:B7ZLJ1|uniprotkb:E7ESA4	psi-mi:ave_drome(display_long)|uniprotkb:ave(gene name)|psi-mi:ave(display_short)|uniprotkb:CG30476(orf name)	psi-mi:cnkr2_human(display_long)|uniprotkb:CNKSR2(gene name)|psi-mi:CNKSR2(display_short)|uniprotkb:CNK2(gene name synonym)|uniprotkb:KIAA0902(gene name synonym)|uniprotkb:KSR2(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Rajakulendran et al. (2008)	pubmed:18287031|doi:10.1073/pnas.0709705105|imex:IM-9103	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15686649|imex:IM-9103-1|dip:DIP-59203E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725413.1|flybase:FBgn0050476|ensemblmetazoa:FBgn0050476(gene)|ensemblmetazoa:FBtr0087439(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR039144|rcsb pdb:3BS5|rcsb pdb:3BS7|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|dip:DIP-29737N	refseq:NP_001162119.1|refseq:NP_055742.2|refseq:NP_001162118.1|refseq:NP_001162120.1|ensembl:ENSG00000149970(gene)|ensembl:ENST00000379510(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|rcsb pdb:2EAN|rcsb pdb:3BS5|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|ensembl:ENSP00000368824|ensembl:ENST00000425654|ensembl:ENSP00000397906|ensembl:ENST00000543067|ensembl:ENSP00000444633|ensembl:ENST00000642359|ensembl:ENSP00000496709|dip:DIP-29736N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:KFY1sGM+J+Bwi/LsJHiNvr5vutg7227	rogid:FEIgggNg8LMikG2NZ6LHRD3lKDw9606	rigid:BNE41F2QKrGJPcMhbNUSfScX+8k	false	binding-associated region:21-98	binding-associated region:5-84	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8ML92	uniprotkb:Q24171	intact:EBI-2563975|ensemblmetazoa:FBpp0086569	intact:EBI-15128874|ensemblmetazoa:FBpp0078413|ensemblmetazoa:FBpp0310677|ensemblmetazoa:FBpp0310678|ensemblmetazoa:FBpp0310679	psi-mi:ave_drome(display_long)|uniprotkb:ave(gene name)|psi-mi:ave(display_short)|uniprotkb:CG30476(orf name)	psi-mi:q24171_drome(display_long)|uniprotkb:ksr(gene name)|psi-mi:ksr(display_short)|uniprotkb:CG2899(orf name)|uniprotkb:Dmel\CG2899(gene name synonym)|uniprotkb:EC3-1(gene name synonym)|uniprotkb:EK3-1(gene name synonym)|uniprotkb:KSR(gene name synonym)|uniprotkb:KSR-1(gene name synonym)|uniprotkb:Ksr(gene name synonym)|uniprotkb:Ksr-1(gene name synonym)|uniprotkb:SR3-1(gene name synonym)|uniprotkb:dKsr(gene name synonym)|uniprotkb:"l(3)j5E2"(gene name synonym)|uniprotkb:Dmel_CG2899(orf name)	psi-mi:"MI:0096"(pull down)	Rajakulendran et al. (2008)	pubmed:18287031|doi:10.1073/pnas.0709705105|imex:IM-9103	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15686770|imex:IM-9103-7|dip:DIP-59205E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725413.1|flybase:FBgn0050476|ensemblmetazoa:FBgn0050476(gene)|ensemblmetazoa:FBtr0087439(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR039144|rcsb pdb:3BS5|rcsb pdb:3BS7|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|dip:DIP-29737N	go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0019900"(kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025561|reactome:R-DME-5673000|reactome:R-DME-5674135|reactome:R-DME-5675221|ensemblmetazoa:FBgn0015402(gene)|ensemblmetazoa:FBtr0078766(transcript)|ensemblmetazoa:FBtr0344272(transcript)|ensemblmetazoa:FBtr0344273(transcript)|ensemblmetazoa:FBtr0344274(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|dip:DIP-29739N|flybase:FBgn0015402|refseq:NP_001287177.1|refseq:NP_001287178.1|refseq:NP_001287179.1|refseq:NP_524236.2	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:KFY1sGM+J+Bwi/LsJHiNvr5vutg7227	rogid:Ot+rUJ7C6bPFryVEDodkkIVHn447227	rigid:nZLZR3/dKGZfbwwktg9Xqq+SsXY	false	tag:n-n	binding-associated region:656-966|v5 tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8ML92	uniprotkb:Q7KNQ9	intact:EBI-2563975|ensemblmetazoa:FBpp0086569	intact:EBI-111569|intact:EBI-2564001|ensemblmetazoa:FBpp0086117|ensemblmetazoa:FBpp0309189	psi-mi:ave_drome(display_long)|uniprotkb:ave(gene name)|psi-mi:ave(display_short)|uniprotkb:CG30476(orf name)	psi-mi:q7knq9_drome(display_long)|uniprotkb:cnk(gene name)|psi-mi:cnk(display_short)|uniprotkb:CNK(gene name synonym)|uniprotkb:Cnk(gene name synonym)|uniprotkb:Dmel\CG6556(gene name synonym)|uniprotkb:EC2-3(gene name synonym)|uniprotkb:EK2-3(gene name synonym)|uniprotkb:anon-WO0140519.129(gene name synonym)|uniprotkb:anon-WO0257455.27(gene name synonym)|uniprotkb:"l(2)k16314"(gene name synonym)|uniprotkb:sag(gene name synonym)|uniprotkb:CG6556(orf name)|uniprotkb:Dmel_CG6556(orf name)	psi-mi:"MI:0096"(pull down)	Rajakulendran et al. (2008)	pubmed:18287031|doi:10.1073/pnas.0709705105|imex:IM-9103	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15686770|imex:IM-9103-7|dip:DIP-59205E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725413.1|flybase:FBgn0050476|ensemblmetazoa:FBgn0050476(gene)|ensemblmetazoa:FBtr0087439(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR039144|rcsb pdb:3BS5|rcsb pdb:3BS7|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|dip:DIP-29737N	refseq:NP_725671.1|refseq:NP_001286524.1|dip:DIP-29738N|flybase:FBgn0286070|ensemblmetazoa:FBgn0286070(gene)|ensemblmetazoa:FBtr0086962(transcript)|ensemblmetazoa:FBtr0340214(transcript)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007362"(terminal region determination)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007427"(epithelial cell migration, open tracheal system)|go:"GO:0007474"(imaginal disc-derived wing vein specification)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008293"(torso signaling pathway)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-432553|reactome:R-DME-5674135	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:KFY1sGM+J+Bwi/LsJHiNvr5vutg7227	rogid:luUwzC5ziVQ0R3V3gskb0IrPiG47227	rigid:nZLZR3/dKGZfbwwktg9Xqq+SsXY	false	tag:n-n	binding-associated region:2-549	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)