#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P81122	uniprotkb:P06213-1	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0096"(pull down)	Wu et al. (2008)	pubmed:18278056|doi:10.1038/nsmb.1388|imex:IM-9628	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15685741|dip:DIP-88349E|imex:IM-9628-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:YdUzFfn4InF+c/Oth8Z1wYeAuYI	false	sufficient binding region:602-637|mutation disrupting interaction:621-621|mutation disrupting interaction:624-624|mutation disrupting interaction:627-627|mutation disrupting interaction:628-628|mutation disrupting interaction:629-629|mutation disrupting interaction:631-631|mutation disrupting interaction:633-633|his tag:n-n	binding-associated region:978-1283	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P81122	uniprotkb:P08069	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-475981|uniprotkb:Q14CV2|uniprotkb:B1B5Y2|uniprotkb:Q9UCC0|ensembl:ENSP00000497069	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:igf1r_human(display_long)|uniprotkb:Insulin-like growth factor I receptor(gene name synonym)|uniprotkb:IGF1R(gene name)|psi-mi:IGF1R(display_short)	psi-mi:"MI:0096"(pull down)	Wu et al. (2008)	pubmed:18278056|doi:10.1038/nsmb.1388|imex:IM-9628	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15685833|imex:IM-9628-2|dip:DIP-88350E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704	refseq:NP_000866.1|ensembl:ENSG00000140443(gene)|ensembl:ENST00000650285(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0043560"(insulin receptor substrate binding)|rcsb pdb:1JQH|go:"GO:0006955"(immune response)|refseq:NP_001278787.1|dip:DIP-476N|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0045056"(transcytosis)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051389"(obsolete inactivation of MAPKK activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140318"(protein transporter activity)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904646"(cellular response to amyloid-beta)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|mint:P08069|rcsb pdb:1IGR|rcsb pdb:1K3A|rcsb pdb:1M7N|rcsb pdb:1P4O|rcsb pdb:2OJ9|rcsb pdb:2ZM3|rcsb pdb:3D94|rcsb pdb:3F5P|rcsb pdb:3I81|rcsb pdb:3LVP|rcsb pdb:3LW0|rcsb pdb:3NW5|rcsb pdb:3NW6|rcsb pdb:3NW7|rcsb pdb:3O23|rcsb pdb:3QQU|rcsb pdb:4D2R|rcsb pdb:4XSS|rcsb pdb:5FXQ|rcsb pdb:5FXR|rcsb pdb:5FXS|rcsb pdb:5HZN|rcsb pdb:5U8R|rcsb pdb:6JK8|rcsb pdb:6VWG|rcsb pdb:6VWH|rcsb pdb:6VWI|rcsb pdb:6VWJ|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-9009391|rcsb pdb:5U8Q	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:5RlIkDngFFJ/IO9tyZQnh1Riz0s9606	rigid:Q2KVu38UXCIrJ2bu9I5tiXjlfpI	false	binding-associated region:591-733|mutation disrupting interaction:628-628|his tag:n-n	binding-associated region:956-1256	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P81122	uniprotkb:P06213-1	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wu et al. (2008)	pubmed:18278056|doi:10.1038/nsmb.1388|imex:IM-9628	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15685812|dip:DIP-88349E|imex:IM-9628-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:YdUzFfn4InF+c/Oth8Z1wYeAuYI	false	binding-associated region:620-634	binding-associated region:978-1283	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06213-1	uniprotkb:P06213-1	intact:EBI-15558981|ensembl:ENSP00000303830	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wu et al. (2008)	pubmed:18278056|doi:10.1038/nsmb.1388|imex:IM-9628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15685785|dip:DIP-88351E|imex:IM-9628-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:v9HsWMSiFl0qUxnR+I7j6M2AdSQ	false	binding-associated region:956-1283	binding-associated region:978-1283|mutation:1159-1159	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P81122	uniprotkb:P06213-1	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Wu et al. (2008)	pubmed:18278056|doi:10.1038/nsmb.1388|imex:IM-9628	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15685975|dip:DIP-189211E|imex:IM-9628-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	psi-mi:"MI:0465"(dip)	-	-	dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2012-09-20|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:YdUzFfn4InF+c/Oth8Z1wYeAuYI	false	binding-associated region:620-634	binding-associated region:978-1283	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P81122	uniprotkb:P06213-1	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Wu et al. (2008)	pubmed:18278056|doi:10.1038/nsmb.1388|imex:IM-9628	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15685951|dip:DIP-189211E|imex:IM-9628-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	psi-mi:"MI:0465"(dip)	-	-	dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2012-09-20|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:YdUzFfn4InF+c/Oth8Z1wYeAuYI	false	binding-associated region:620-634	binding-associated region:978-1283	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P81122	uniprotkb:P06213-1	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0096"(pull down)	Wu et al. (2008)	pubmed:18278056|doi:10.1038/nsmb.1388|imex:IM-9628	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15685901|dip:DIP-189211E|imex:IM-9628-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	psi-mi:"MI:0465"(dip)	-	-	dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2012-09-20|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:YdUzFfn4InF+c/Oth8Z1wYeAuYI	false	sufficient binding region:602-637|mutation disrupting interaction:621-621|mutation disrupting interaction:624-624|mutation disrupting interaction:627-627|mutation disrupting interaction:628-628|mutation disrupting interaction:629-629|mutation disrupting interaction:631-631|mutation disrupting interaction:633-633|his tag:n-n	binding-associated region:978-1283	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P81122	uniprotkb:P06213-1	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wu et al. (2008)	pubmed:18278056|doi:10.1038/nsmb.1388|imex:IM-9628	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15685880|dip:DIP-88349E|imex:IM-9628-11	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:YdUzFfn4InF+c/Oth8Z1wYeAuYI	false	binding-associated region:591-733	binding-associated region:978-1283	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P81122	uniprotkb:P06213-1	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wu et al. (2008)	pubmed:18278056|doi:10.1038/nsmb.1388|imex:IM-9628	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15685999|dip:DIP-189211E|imex:IM-9628-19	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	psi-mi:"MI:0465"(dip)	-	-	dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2012-09-20|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:YdUzFfn4InF+c/Oth8Z1wYeAuYI	false	binding-associated region:591-733	binding-associated region:978-1283	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P81122	uniprotkb:P06213-1	intact:EBI-1369862|uniprotkb:B9EJW3|ensembl:ENSMUSP00000038514	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:irs2_mouse(display_long)|uniprotkb:Irs2(gene name)|psi-mi:Irs2(display_short)|uniprotkb:4PS(gene name synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Wu et al. (2008)	pubmed:18278056|doi:10.1038/nsmb.1388|imex:IM-9628	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15685859|dip:DIP-88349E|imex:IM-9628-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074681.1|dip:DIP-39500N|ensembl:ENSMUSG00000038894(gene)|ensembl:ENSMUST00000040514(transcript)|go:"GO:0009749"(response to glucose)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039011|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|reactome:R-MMU-112399|reactome:R-MMU-112412|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-198203|reactome:R-MMU-2428928|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-74713|reactome:R-MMU-74749|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-109704	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:9Yx/YcJZfeRjy4g3peDD5t2pynk10090	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:YdUzFfn4InF+c/Oth8Z1wYeAuYI	false	binding-associated region:620-634	binding-associated region:978-1283	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06213-1	uniprotkb:P06213-1	intact:EBI-15558981|ensembl:ENSP00000303830	intact:EBI-15558981|ensembl:ENSP00000303830	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:p06213-1(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)|uniprotkb:HIR-B(isoform synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wu et al. (2008)	pubmed:18278056|doi:10.1038/nsmb.1388|imex:IM-9628	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15686023|dip:DIP-189212E|imex:IM-9628-21	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	intact:EBI-475899(isoform-parent)|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)	psi-mi:"MI:0465"(dip)	-	-	dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2012-09-20|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rigid:v9HsWMSiFl0qUxnR+I7j6M2AdSQ	false	binding-associated region:956-1283	binding-associated region:978-1283|mutation:1159-1159	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)