#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8VGC3-2 uniprotkb:Q13936 intact:EBI-15685453 intact:EBI-1038838|uniprotkb:Q13917|uniprotkb:Q13918|uniprotkb:Q13919|uniprotkb:Q13920|uniprotkb:Q13921|uniprotkb:Q13922|uniprotkb:Q13923|uniprotkb:Q13924|uniprotkb:Q13925|uniprotkb:Q13926|uniprotkb:Q13927|uniprotkb:Q13928|uniprotkb:Q13929|uniprotkb:Q13930|uniprotkb:Q13932|uniprotkb:Q13933|uniprotkb:Q14743|uniprotkb:Q14744|uniprotkb:Q15877|uniprotkb:Q4VMI7|uniprotkb:Q4VMI8|uniprotkb:Q4VMI9|uniprotkb:Q6PKM7|uniprotkb:Q8N6C0|uniprotkb:Q99025|uniprotkb:Q99241|uniprotkb:Q99875|uniprotkb:B2RUT3|uniprotkb:E9PDJ0 psi-mi:q8vgc3-2(display_long)|uniprotkb:Cacnb2(gene name)|psi-mi:Cacnb2(display_short)|uniprotkb:Cacnlb2(gene name synonym)|uniprotkb:Calcium channel voltage-dependent subunit beta 2(gene name synonym) psi-mi:cac1c_human(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Van et al. (2008) pubmed:18275819|doi:10.1016/j.str.2007.11.010|imex:IM-9149 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15685461|imex:IM-9149-3|dip:DIP-59072E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1038896(isoform-parent) refseq:NP_000710.5|refseq:NP_001123299.1|refseq:NP_001123301.1|refseq:NP_001123303.1|refseq:NP_001123304.1|refseq:NP_001123305.1|refseq:NP_001123306.1|refseq:NP_001123307.1|refseq:NP_001123314.1|refseq:NP_001123315.1|refseq:NP_001123308.1|refseq:NP_001123309.1|refseq:NP_001123310.1|refseq:NP_001123311.1|refseq:NP_001123312.1|refseq:NP_001123313.1|refseq:NP_001123316.1|refseq:NP_001123318.1|refseq:NP_001161095.1|refseq:NP_001161097.1|refseq:NP_001123302.2|refseq:NP_001161096.2|refseq:NP_955630.3|reactome:R-HSA-5576893|reactome:R-HSA-400042|reactome:R-HSA-419037|reactome:R-HSA-422356|go:"GO:0002520"(immune system development)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007507"(heart development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030425"(dendrite)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035585"(calcium-mediated signaling using extracellular calcium source)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070509"(calcium ion import)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086007"(voltage-gated calcium channel activity involved in cardiac muscle cell action potential)|go:"GO:0086012"(membrane depolarization during cardiac muscle cell action potential)|go:"GO:0086045"(membrane depolarization during AV node cell action potential)|go:"GO:0086056"(voltage-gated calcium channel activity involved in AV node cell action potential)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098912"(membrane depolarization during atrial cardiac muscle cell action potential)|go:"GO:1990454"(L-type voltage-gated calcium channel complex)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|rcsb pdb:1T0J|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2LQC|rcsb pdb:3G43|rcsb pdb:3OXQ|rcsb pdb:5V2P|rcsb pdb:5V2Q|rcsb pdb:6C0A|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|go:"GO:0070588"(calcium ion transmembrane transport)|reactome:R-HSA-5576892|dip:DIP-29589N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2019/04/16 rogid:rDSercniN96H3w9KSb01f8yn5B810116 rogid:dhWcWUTulWYd/nQtGorjr481/XA9606 rigid:dkq1hcx+ZmvkjxF1h3pJbAKYNvM false binding-associated region:17-138|binding-associated region:203-425|mutation decreasing interaction:245-245 binding-associated region:428-445|mutation disrupting interaction:440-440|mutation decreasing interaction:437-437|mutation decreasing interaction:441-441 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q05152 uniprotkb:Q8VGC3-2 intact:EBI-15685496 intact:EBI-15685453 psi-mi:cac1b_rabit(display_long)|uniprotkb:CACNA1B(gene name)|psi-mi:CACNA1B(display_short)|uniprotkb:CACH5(gene name synonym)|uniprotkb:CACNL1A5(gene name synonym)|uniprotkb:Brain calcium channel III(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 5(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.2(gene name synonym) psi-mi:q8vgc3-2(display_long)|uniprotkb:Cacnb2(gene name)|psi-mi:Cacnb2(display_short)|uniprotkb:Cacnlb2(gene name synonym)|uniprotkb:Calcium channel voltage-dependent subunit beta 2(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Van et al. (2008) pubmed:18275819|doi:10.1016/j.str.2007.11.010|imex:IM-9149 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15685525|imex:IM-9149-2|dip:DIP-59074E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009986"(cell surface)|go:"GO:0034765"(regulation of ion transmembrane transport)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005447(Voltage-dependent calcium channel, N-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR043203|rcsb pdb:3DVE|rcsb pdb:3DVJ|refseq:NP_001075660.1|dip:DIP-29592N intact:EBI-1038896(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:AgmQVOY/PbaqtAnzBTJEx2K6rgU9986 rogid:rDSercniN96H3w9KSb01f8yn5B810116 rigid:ntTpxS10sASoFytNyA7CBo/jvpo false binding-associated region:379-396 binding-associated region:203-425|binding-associated region:17-138 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P27884 uniprotkb:Q8VGC3-2 intact:EBI-15685548|uniprotkb:P27883 intact:EBI-15685453 psi-mi:cac1a_rabit(display_long)|uniprotkb:CACNA1A(gene name)|psi-mi:CACNA1A(display_short)|uniprotkb:CACH4(gene name synonym)|uniprotkb:CACN3(gene name synonym)|uniprotkb:CACNL1A4(gene name synonym)|uniprotkb:Brain calcium channel I(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide isoform 4(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav2.1(gene name synonym) psi-mi:q8vgc3-2(display_long)|uniprotkb:Cacnb2(gene name)|psi-mi:Cacnb2(display_short)|uniprotkb:Cacnlb2(gene name synonym)|uniprotkb:Calcium channel voltage-dependent subunit beta 2(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Van et al. (2008) pubmed:18275819|doi:10.1016/j.str.2007.11.010|imex:IM-9149 taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15685581|imex:IM-9149-1|dip:DIP-59073E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0070588"(calcium ion transmembrane transport)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|interpro:IPR005448(Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit)|interpro:IPR005821(Ion transport)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|rcsb pdb:3DVM|go:"GO:0046872"(metal ion binding)|refseq:NP_001095163.1|dip:DIP-29591N intact:EBI-1038896(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:P5k43jEFL3aTiGkUx7KYNEPXRmA9986 rogid:rDSercniN96H3w9KSb01f8yn5B810116 rigid:kMMpMqzNx8f/CtnFnu6TiH27km4 false binding-associated region:383-400 binding-associated region:203-425|binding-associated region:17-138 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)