#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q66793 uniprotkb:P01579 intact:EBI-15683787 intact:EBI-1030767|uniprotkb:Q53ZV4|uniprotkb:B5BU88|ensembl:ENSP00000229135 psi-mi:q66793_9poxv(display_long)|uniprotkb:C4R(gene name)|psi-mi:C4R(display_short)|uniprotkb:IFNGR(gene name synonym)|uniprotkb:EVH185(gene name synonym) psi-mi:ifng_human(display_long)|uniprotkb:IFNG(gene name)|psi-mi:IFNG(display_short)|uniprotkb:Immune interferon(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Nuara et al. (2008) pubmed:18252829|doi:10.1073/pnas.0705753105|imex:IM-9081 taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15683801|imex:IM-9081-1|dip:DIP-59181E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR021126|interpro:IPR036116|rcsb pdb:3BES|refseq:NP_671677.1|dip:DIP-29704N refseq:NP_000610.2|ensembl:ENSG00000111537(gene)|ensembl:ENST00000229135(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032834"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0040008"(regulation of growth)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060552"(positive regulation of fructose 1,6-bisphosphate metabolic process)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|interpro:IPR002069(Interferon gamma)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1EKU|rcsb pdb:1FG9|rcsb pdb:1FYH|rcsb pdb:1HIG|rcsb pdb:3BES|rcsb pdb:6E3K|rcsb pdb:6E3L|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8877330|reactome:R-HSA-8950505|dip:DIP-483N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:r56JGDBZDVBc4VsFYOHy1cF49Bg12643 rogid:TI+IepCwKmdJxLSvLmfLJsj50xg9606 rigid:i9/x1dwIsYGMXQ7QthXxvQ4p+3s false binding-associated region:17-266 binding-associated region:24-161 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q66793 uniprotkb:Q66793 intact:EBI-15683787 intact:EBI-15683787 psi-mi:q66793_9poxv(display_long)|uniprotkb:C4R(gene name)|psi-mi:C4R(display_short)|uniprotkb:IFNGR(gene name synonym)|uniprotkb:EVH185(gene name synonym) psi-mi:q66793_9poxv(display_long)|uniprotkb:C4R(gene name)|psi-mi:C4R(display_short)|uniprotkb:IFNGR(gene name synonym)|uniprotkb:EVH185(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Nuara et al. (2008) pubmed:18252829|doi:10.1073/pnas.0705753105|imex:IM-9081 taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus) taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15683840|imex:IM-9081-5|dip:DIP-59182E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR021126|interpro:IPR036116|rcsb pdb:3BES|refseq:NP_671677.1|dip:DIP-29704N go:"GO:0016020"(membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR021126|interpro:IPR036116|rcsb pdb:3BES|refseq:NP_671677.1|dip:DIP-29704N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) - 2017/08/05 2017/08/10 rogid:r56JGDBZDVBc4VsFYOHy1cF49Bg12643 rogid:r56JGDBZDVBc4VsFYOHy1cF49Bg12643 rigid:7dw2C7k3DOpFFf8TKrcBVdrrxCU false binding-associated region:17-266 binding-associated region:17-266 - 0 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q66793 uniprotkb:Q66793 intact:EBI-15683787 intact:EBI-15683787 psi-mi:q66793_9poxv(display_long)|uniprotkb:C4R(gene name)|psi-mi:C4R(display_short)|uniprotkb:IFNGR(gene name synonym)|uniprotkb:EVH185(gene name synonym) psi-mi:q66793_9poxv(display_long)|uniprotkb:C4R(gene name)|psi-mi:C4R(display_short)|uniprotkb:IFNGR(gene name synonym)|uniprotkb:EVH185(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Nuara et al. (2008) pubmed:18252829|doi:10.1073/pnas.0705753105|imex:IM-9081 taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus) taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15683858|imex:IM-9081-4|dip:DIP-59182E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR021126|interpro:IPR036116|rcsb pdb:3BES|refseq:NP_671677.1|dip:DIP-29704N go:"GO:0016020"(membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR021126|interpro:IPR036116|rcsb pdb:3BES|refseq:NP_671677.1|dip:DIP-29704N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/05 2017/08/10 rogid:r56JGDBZDVBc4VsFYOHy1cF49Bg12643 rogid:r56JGDBZDVBc4VsFYOHy1cF49Bg12643 rigid:7dw2C7k3DOpFFf8TKrcBVdrrxCU false binding-associated region:17-266 binding-associated region:17-266 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q66793 uniprotkb:Q66793 intact:EBI-15683787 intact:EBI-15683787 psi-mi:q66793_9poxv(display_long)|uniprotkb:C4R(gene name)|psi-mi:C4R(display_short)|uniprotkb:IFNGR(gene name synonym)|uniprotkb:EVH185(gene name synonym) psi-mi:q66793_9poxv(display_long)|uniprotkb:C4R(gene name)|psi-mi:C4R(display_short)|uniprotkb:IFNGR(gene name synonym)|uniprotkb:EVH185(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Nuara et al. (2008) pubmed:18252829|doi:10.1073/pnas.0705753105|imex:IM-9081 taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus) taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15683822|imex:IM-9081-3|dip:DIP-59182E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR021126|interpro:IPR036116|rcsb pdb:3BES|refseq:NP_671677.1|dip:DIP-29704N go:"GO:0016020"(membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR021126|interpro:IPR036116|rcsb pdb:3BES|refseq:NP_671677.1|dip:DIP-29704N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)") - 2017/08/05 2017/08/10 rogid:r56JGDBZDVBc4VsFYOHy1cF49Bg12643 rogid:r56JGDBZDVBc4VsFYOHy1cF49Bg12643 rigid:7dw2C7k3DOpFFf8TKrcBVdrrxCU false binding-associated region:17-266 binding-associated region:17-266 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q66793 uniprotkb:P01579 intact:EBI-15683787 intact:EBI-1030767|uniprotkb:Q53ZV4|uniprotkb:B5BU88|ensembl:ENSP00000229135 psi-mi:q66793_9poxv(display_long)|uniprotkb:C4R(gene name)|psi-mi:C4R(display_short)|uniprotkb:IFNGR(gene name synonym)|uniprotkb:EVH185(gene name synonym) psi-mi:ifng_human(display_long)|uniprotkb:IFNG(gene name)|psi-mi:IFNG(display_short)|uniprotkb:Immune interferon(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Nuara et al. (2008) pubmed:18252829|doi:10.1073/pnas.0705753105|imex:IM-9081 taxid:12643(ectromelia virus)|taxid:12643(Ectromelia virus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15683877|imex:IM-9081-2|dip:DIP-59181E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016020"(membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR021126|interpro:IPR036116|rcsb pdb:3BES|refseq:NP_671677.1|dip:DIP-29704N refseq:NP_000610.2|ensembl:ENSG00000111537(gene)|ensembl:ENST00000229135(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010835"(regulation of protein ADP-ribosylation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032834"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0040008"(regulation of growth)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060552"(positive regulation of fructose 1,6-bisphosphate metabolic process)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902948"(negative regulation of tau-protein kinase activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000309"("positive regulation of tumor necrosis factor (ligand) superfamily member 11 production")|interpro:IPR002069(Interferon gamma)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1EKU|rcsb pdb:1FG9|rcsb pdb:1FYH|rcsb pdb:1HIG|rcsb pdb:3BES|rcsb pdb:6E3K|rcsb pdb:6E3L|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8877330|reactome:R-HSA-8950505|dip:DIP-483N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:r56JGDBZDVBc4VsFYOHy1cF49Bg12643 rogid:TI+IepCwKmdJxLSvLmfLJsj50xg9606 rigid:i9/x1dwIsYGMXQ7QthXxvQ4p+3s false binding-associated region:17-266 binding-associated region:24-161 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)