#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P24468 uniprotkb:P23769 intact:EBI-2795198|uniprotkb:B6ZGU1|uniprotkb:Q03754|uniprotkb:B4DQJ2|uniprotkb:Q3KQR7|ensembl:ENSP00000377721 intact:EBI-2806671|uniprotkb:Q96BH0|uniprotkb:Q9BUJ6|uniprotkb:Q53YE0|uniprotkb:D3DNB3|uniprotkb:Q96BH8|ensembl:ENSP00000345681|ensembl:ENSP00000417074 psi-mi:cot2_human(display_long)|uniprotkb:NR2F2(gene name)|psi-mi:NR2F2(display_short)|uniprotkb:ARP1(gene name synonym)|uniprotkb:TFCOUP2(gene name synonym)|uniprotkb:COUP transcription factor II(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group F member 2(gene name synonym)|uniprotkb:Apolipoprotein A-I regulatory protein 1(gene name synonym) psi-mi:gata2_human(display_long)|uniprotkb:GATA-binding protein 2(gene name synonym)|uniprotkb:GATA2(gene name)|psi-mi:GATA2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xu et al. (2008) pubmed:18250317|doi:10.1073/pnas.0707082105|imex:IM-9085 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15683593|imex:IM-9085-2|dip:DIP-59185E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_066285.1|refseq:NP_001138627.1|refseq:NP_001138628.1|refseq:NP_001138629.1|ensembl:ENSG00000185551(gene)|ensembl:ENST00000394166(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001764"(neuron migration)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008585"(female gonad development)|go:"GO:0009566"(fertilization)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0009956"(radial pattern formation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0032355"(response to estradiol)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060173"(limb development)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:3CJW|reactome:R-HSA-381340|dip:DIP-29713N refseq:NP_001139133.1|refseq:NP_001139134.1|refseq:NP_116027.2|dip:DIP-29711N|go:"GO:0001764"(neuron migration)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006909"(phagocytosis)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0001709"(cell fate determination)|go:"GO:0010725"(regulation of primitive erythrocyte differentiation)|go:"GO:0021514"(ventral spinal cord interneuron differentiation)|go:"GO:0021533"(cell differentiation in hindbrain)|go:"GO:0021902"(commitment of neuronal cell to specific neuron type in forebrain)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0033993"(response to lipid)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0035854"(eosinophil fate commitment)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045654"(positive regulation of megakaryocyte differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0060872"(semicircular canal development)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097154"(GABAergic neuron differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000977"(regulation of forebrain neuron differentiation)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016374(Transcription factor, GATA-1/2/3)|interpro:IPR029522|interpro:IPR039355|rcsb pdb:5O9B|rcsb pdb:6ZFV|reactome:R-HSA-8939236|reactome:R-HSA-9616222|reactome:R-HSA-983231|ensembl:ENSG00000179348(gene)|ensembl:ENST00000341105(transcript)|ensembl:ENST00000487848(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001655"(urogenital system development) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:XsZyqUr06sQQaD3oXAA3IEa6Dug9606 rogid:tQNHxMqtJhW3+fsILE9055QZoWc9606 rigid:nZmLGPl5vauJ9rSHccDG+wuWugY false - sufficient binding region:377-415|flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P23772 uniprotkb:P24468 intact:EBI-6664905|ensembl:ENSMUSP00000100041 intact:EBI-2795198|uniprotkb:B6ZGU1|uniprotkb:Q03754|uniprotkb:B4DQJ2|uniprotkb:Q3KQR7|ensembl:ENSP00000377721 psi-mi:gata3_mouse(display_long)|uniprotkb:Gata3(gene name)|psi-mi:Gata3(display_short)|uniprotkb:Gata-3(gene name synonym)|uniprotkb:GATA-binding factor 3(gene name synonym) psi-mi:cot2_human(display_long)|uniprotkb:NR2F2(gene name)|psi-mi:NR2F2(display_short)|uniprotkb:ARP1(gene name synonym)|uniprotkb:TFCOUP2(gene name synonym)|uniprotkb:COUP transcription factor II(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group F member 2(gene name synonym)|uniprotkb:Apolipoprotein A-I regulatory protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xu et al. (2008) pubmed:18250317|doi:10.1073/pnas.0707082105|imex:IM-9085 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15683614|imex:IM-9085-1|dip:DIP-59186E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060065"(uterus development)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0060374"(mast cell differentiation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061085"(regulation of histone H3-K27 methylation)|go:"GO:0061290"(canonical Wnt signaling pathway involved in metanephric kidney development)|go:"GO:0070888"(E-box binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072179"(nephric duct formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0090102"(cochlea development)|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000607"(negative regulation of cell proliferation involved in mesonephros development)|go:"GO:2000611"(positive regulation of thyroid hormone generation)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000683"(regulation of cellular response to X-ray)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2000703"(negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation)|go:"GO:2000734"(negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016374(Transcription factor, GATA-1/2/3)|interpro:IPR029521|go:"GO:0048469"(cell maturation)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050728"(negative regulation of inflammatory response)|rcsb pdb:3DFV|rcsb pdb:3DFX|reactome:R-MMU-5689880|reactome:R-MMU-8939236|reactome:R-MMU-9018519|reactome:R-MMU-983231|interpro:IPR039355|ensembl:ENSMUSG00000015619(gene)|ensembl:ENSMUST00000102976(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001764"(neuron migration)|go:"GO:0001775"(cell activation)|go:"GO:0001806"(type IV hypersensitivity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002520"(immune system development)|go:"GO:0002572"(pro-T cell differentiation)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0031929"(TOR signaling)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0035799"(ureter maturation)|go:"GO:0035898"(parathyroid hormone secretion)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043583"(ear development)|go:"GO:0043627"(response to estrogen)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045471"(response to ethanol)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0003281"(ventricular septum development)|refseq:XP_006497417.1|refseq:NP_032117.1|dip:DIP-29712N refseq:NP_066285.1|refseq:NP_001138627.1|refseq:NP_001138628.1|refseq:NP_001138629.1|ensembl:ENSG00000185551(gene)|ensembl:ENST00000394166(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001764"(neuron migration)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008585"(female gonad development)|go:"GO:0009566"(fertilization)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0009956"(radial pattern formation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0032355"(response to estradiol)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0060173"(limb development)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060838"(lymphatic endothelial cell fate commitment)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:3CJW|reactome:R-HSA-381340|dip:DIP-29713N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:DW2mskj2jgiJdOYO6yJxNbBd0Ng10090 rogid:XsZyqUr06sQQaD3oXAA3IEa6Dug9606 rigid:nMf65vJ0Uk9iq0Cq+zIr7FHKiF4 false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)