#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8I0P1	uniprotkb:Q8I0P1	intact:EBI-154500|uniprotkb:Q8T066|uniprotkb:Q8IMX5|ensemblmetazoa:FBpp0083918|ensemblmetazoa:FBpp0083919	intact:EBI-154500|uniprotkb:Q8T066|uniprotkb:Q8IMX5|ensemblmetazoa:FBpp0083918|ensemblmetazoa:FBpp0083919	psi-mi:spast_drome(display_long)|uniprotkb:spas(gene name)|psi-mi:spas(display_short)|uniprotkb:D-Spastin(gene name synonym)|uniprotkb:Dm-Spastin(gene name synonym)|uniprotkb:Dspastin(gene name synonym)|uniprotkb:CG5977(orf name)	psi-mi:spast_drome(display_long)|uniprotkb:spas(gene name)|psi-mi:spas(display_short)|uniprotkb:D-Spastin(gene name synonym)|uniprotkb:Dm-Spastin(gene name synonym)|uniprotkb:Dspastin(gene name synonym)|uniprotkb:CG5977(orf name)	psi-mi:"MI:0067"(light scattering)	Roll-Mecak et al. (2008)	pubmed:18202664|doi:10.1038/nature06482|imex:IM-17986	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15680230|imex:IM-17986-1|dip:DIP-189571E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001303438.1|refseq:NP_651206.3|refseq:NP_732941.2|flybase:FBgn0039141|ensemblmetazoa:FBgn0039141(gene)|ensemblmetazoa:FBtr0084533(transcript)|ensemblmetazoa:FBtr0084534(transcript)|go:"GO:0000022"(mitotic spindle elongation)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008017"(microtubule binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034214"(protein hexamerization)|go:"GO:0035099"(hemocyte migration)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045834"(positive regulation of lipid metabolic process)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:1900074"(negative regulation of neuromuscular synaptic transmission)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:2000331"(regulation of terminal button organization)|dip:DIP-59834N|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR017179(Spastin)|interpro:IPR027417|interpro:IPR041569|rcsb pdb:3B9P|rcsb pdb:6NYV|rcsb pdb:6NYW|rcsb pdb:6P10|rcsb pdb:6P11|rcsb pdb:6P12|rcsb pdb:6P13|rcsb pdb:6P14|reactome:R-DME-9668328	refseq:NP_001303438.1|refseq:NP_651206.3|refseq:NP_732941.2|flybase:FBgn0039141|ensemblmetazoa:FBgn0039141(gene)|ensemblmetazoa:FBtr0084533(transcript)|ensemblmetazoa:FBtr0084534(transcript)|go:"GO:0000022"(mitotic spindle elongation)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008017"(microtubule binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034214"(protein hexamerization)|go:"GO:0035099"(hemocyte migration)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043195"(terminal bouton)|go:"GO:0045834"(positive regulation of lipid metabolic process)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051013"(microtubule severing)|go:"GO:0051301"(cell division)|go:"GO:1900074"(negative regulation of neuromuscular synaptic transmission)|go:"GO:1900075"(positive regulation of neuromuscular synaptic transmission)|go:"GO:2000331"(regulation of terminal button organization)|dip:DIP-59834N|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR017179(Spastin)|interpro:IPR027417|interpro:IPR041569|rcsb pdb:3B9P|rcsb pdb:6NYV|rcsb pdb:6NYW|rcsb pdb:6P10|rcsb pdb:6P11|rcsb pdb:6P12|rcsb pdb:6P13|rcsb pdb:6P14|reactome:R-DME-9668328	psi-mi:"MI:0465"(dip)	caution:This sequence has been withdrawn from Uniprot.|crc64:406D075DCBD2A9CD	caution:This sequence has been withdrawn from Uniprot.|crc64:406D075DCBD2A9CD	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/05	2017/08/10	rogid:E4wXbSFPqBZSakXG10HtoJ9AEz07227	rogid:E4wXbSFPqBZSakXG10HtoJ9AEz07227	rigid:6zGrK8tCuC4rT80qDWoPwAiUYWk	false	binding-associated region:208-696	binding-associated region:208-696	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8MNV0	uniprotkb:Q8MNV0	intact:EBI-15680248|uniprotkb:G5EEF8|uniprotkb:Q7M3K5|uniprotkb:Q8MNU9	intact:EBI-15680248|uniprotkb:G5EEF8|uniprotkb:Q7M3K5|uniprotkb:Q8MNU9	psi-mi:spast_caeel(display_long)|uniprotkb:spas-1(gene name)|psi-mi:spas-1(display_short)|uniprotkb:C24B5.2(orf name)	psi-mi:spast_caeel(display_long)|uniprotkb:spas-1(gene name)|psi-mi:spas-1(display_short)|uniprotkb:C24B5.2(orf name)	psi-mi:"MI:0071"(molecular sieving)	Roll-Mecak et al. (2008)	pubmed:18202664|doi:10.1038/nature06482|imex:IM-17986	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15680282|imex:IM-17986-2|dip:DIP-189570E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040025"(vulval development)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0051013"(microtubule severing)|go:"GO:0051647"(nucleus localization)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR041569|wormbase:C24B5.2c|refseq:NP_001256115.1|refseq:NP_741586.1|wormbase:C24B5.2a|dip:DIP-59833N|reactome:R-CEL-9668328	go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040025"(vulval development)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0051013"(microtubule severing)|go:"GO:0051647"(nucleus localization)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR041569|wormbase:C24B5.2c|refseq:NP_001256115.1|refseq:NP_741586.1|wormbase:C24B5.2a|dip:DIP-59833N|reactome:R-CEL-9668328	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/05	2017/08/10	rogid:Rtd3YD73rDkK4B6OU5pXx0thmPU6239	rogid:Rtd3YD73rDkK4B6OU5pXx0thmPU6239	rigid:DBFdNTgnvRh0sQIP+6+YZBRVWos	false	binding-associated region:15-451	binding-associated region:15-451	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8MNV0	uniprotkb:Q8MNV0	intact:EBI-15680248|uniprotkb:G5EEF8|uniprotkb:Q7M3K5|uniprotkb:Q8MNU9	intact:EBI-15680248|uniprotkb:G5EEF8|uniprotkb:Q7M3K5|uniprotkb:Q8MNU9	psi-mi:spast_caeel(display_long)|uniprotkb:spas-1(gene name)|psi-mi:spas-1(display_short)|uniprotkb:C24B5.2(orf name)	psi-mi:spast_caeel(display_long)|uniprotkb:spas-1(gene name)|psi-mi:spas-1(display_short)|uniprotkb:C24B5.2(orf name)	psi-mi:"MI:0826"(x ray scattering)	Roll-Mecak et al. (2008)	pubmed:18202664|doi:10.1038/nature06482|imex:IM-17986	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15680300|imex:IM-17986-3|dip:DIP-189570E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040025"(vulval development)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0051013"(microtubule severing)|go:"GO:0051647"(nucleus localization)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR041569|wormbase:C24B5.2c|refseq:NP_001256115.1|refseq:NP_741586.1|wormbase:C24B5.2a|dip:DIP-59833N|reactome:R-CEL-9668328	go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040025"(vulval development)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0051013"(microtubule severing)|go:"GO:0051647"(nucleus localization)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR041569|wormbase:C24B5.2c|refseq:NP_001256115.1|refseq:NP_741586.1|wormbase:C24B5.2a|dip:DIP-59833N|reactome:R-CEL-9668328	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/05	2017/08/10	rogid:Rtd3YD73rDkK4B6OU5pXx0thmPU6239	rogid:Rtd3YD73rDkK4B6OU5pXx0thmPU6239	rigid:DBFdNTgnvRh0sQIP+6+YZBRVWos	false	binding-associated region:15-451	binding-associated region:15-451	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8MNV0	uniprotkb:Q8MNV0	intact:EBI-15680248|uniprotkb:G5EEF8|uniprotkb:Q7M3K5|uniprotkb:Q8MNU9	intact:EBI-15680248|uniprotkb:G5EEF8|uniprotkb:Q7M3K5|uniprotkb:Q8MNU9	psi-mi:spast_caeel(display_long)|uniprotkb:spas-1(gene name)|psi-mi:spas-1(display_short)|uniprotkb:C24B5.2(orf name)	psi-mi:spast_caeel(display_long)|uniprotkb:spas-1(gene name)|psi-mi:spas-1(display_short)|uniprotkb:C24B5.2(orf name)	psi-mi:"MI:0067"(light scattering)	Roll-Mecak et al. (2008)	pubmed:18202664|doi:10.1038/nature06482|imex:IM-17986	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15680318|imex:IM-17986-4|dip:DIP-189570E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040025"(vulval development)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0051013"(microtubule severing)|go:"GO:0051647"(nucleus localization)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR041569|wormbase:C24B5.2c|refseq:NP_001256115.1|refseq:NP_741586.1|wormbase:C24B5.2a|dip:DIP-59833N|reactome:R-CEL-9668328	go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031117"(positive regulation of microtubule depolymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040025"(vulval development)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0051013"(microtubule severing)|go:"GO:0051647"(nucleus localization)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR041569|wormbase:C24B5.2c|refseq:NP_001256115.1|refseq:NP_741586.1|wormbase:C24B5.2a|dip:DIP-59833N|reactome:R-CEL-9668328	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/05	2017/08/10	rogid:Rtd3YD73rDkK4B6OU5pXx0thmPU6239	rogid:Rtd3YD73rDkK4B6OU5pXx0thmPU6239	rigid:DBFdNTgnvRh0sQIP+6+YZBRVWos	false	binding-associated region:15-451	binding-associated region:15-451	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)