#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q7Z434-1 uniprotkb:Q86UT6 intact:EBI-15577799|ensembl:ENSP00000401980 intact:EBI-3893071|uniprotkb:A8K6Q1|uniprotkb:B3KPK2|uniprotkb:B3KTA2|uniprotkb:Q7RTR3|uniprotkb:Q96D51|uniprotkb:Q9H724|ensembl:ENSP00000292199|ensembl:ENSP00000386851|ensembl:ENSP00000386858|ensembl:ENSP00000387334 psi-mi:q7z434-1(display_long)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym) psi-mi:nlrx1_human(display_long)|uniprotkb:NLRX1(gene name)|psi-mi:NLRX1(display_short)|uniprotkb:NOD26(gene name synonym)|uniprotkb:NOD5(gene name synonym)|uniprotkb:NOD9(gene name synonym)|uniprotkb:Caterpiller protein 11.3(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 26(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 5(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 9(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Moore et al. (2008) pubmed:18200010|doi:10.1038/nature06501|imex:IM-21999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15679989|imex:IM-21999-1|dip:DIP-195761E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|intact:EBI-995373(isoform-parent) refseq:XP_006718967.1|refseq:XP_011541282.1|refseq:NP_078894.2|dip:DIP-60637N|refseq:NP_001269072.1|refseq:NP_001269073.1|refseq:NP_001269287.1|refseq:XP_005271726.1|ensembl:ENSG00000160703(gene)|ensembl:ENST00000292199(transcript)|ensembl:ENST00000409109(transcript)|ensembl:ENST00000409265(transcript)|ensembl:ENST00000409991(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR027417|interpro:IPR032675|rcsb pdb:3UN9|reactome:R-HSA-168928|reactome:R-HSA-936440|go:"GO:0030054"(cell junction) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rogid:w+BOLVATt2ey/lEP6RY9zP2q/gc9606 rigid:NlafaLL0UfpSEas66mgIV0Cg7no false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95786-1 uniprotkb:Q7Z434-1 intact:EBI-15577823|ensembl:ENSP00000369213 intact:EBI-15577799|ensembl:ENSP00000401980 psi-mi:o95786-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:q7z434-1(display_long)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Moore et al. (2008) pubmed:18200010|doi:10.1038/nature06501|imex:IM-21999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15680039|imex:IM-21999-3|dip:DIP-64254E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|intact:EBI-995350(isoform-parent) ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|intact:EBI-995373(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rigid:obR2EHoHumN9pPBg9pR31HUKako false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7Z434-1 uniprotkb:Q86UT6-1 intact:EBI-15577799|ensembl:ENSP00000401980 intact:EBI-15680006|ensembl:ENSP00000292199|ensembl:ENSP00000386851|ensembl:ENSP00000386858|ensembl:ENSP00000387334 psi-mi:q7z434-1(display_long)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym) psi-mi:q86ut6-1(display_long)|uniprotkb:NLRX1(gene name)|psi-mi:NLRX1(display_short)|uniprotkb:NOD26(gene name synonym)|uniprotkb:NOD5(gene name synonym)|uniprotkb:NOD9(gene name synonym)|uniprotkb:Caterpiller protein 11.3(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 26(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 5(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Moore et al. (2008) pubmed:18200010|doi:10.1038/nature06501|imex:IM-21999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15680058|imex:IM-21999-4|dip:DIP-195761E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|intact:EBI-995373(isoform-parent) intact:EBI-3893071(isoform-parent)|ensembl:ENST00000292199(transcript)|ensembl:ENST00000409109(transcript)|ensembl:ENST00000409265(transcript)|ensembl:ENST00000409991(transcript)|ensembl:ENSG00000160703(gene) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rogid:w+BOLVATt2ey/lEP6RY9zP2q/gc9606 rigid:NlafaLL0UfpSEas66mgIV0Cg7no false flag tag:n-n sufficient binding region:1-556|ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7Z434-1 uniprotkb:Q86UT6-1 intact:EBI-15577799|ensembl:ENSP00000401980 intact:EBI-15680006|ensembl:ENSP00000292199|ensembl:ENSP00000386851|ensembl:ENSP00000386858|ensembl:ENSP00000387334 psi-mi:q7z434-1(display_long)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym) psi-mi:q86ut6-1(display_long)|uniprotkb:NLRX1(gene name)|psi-mi:NLRX1(display_short)|uniprotkb:NOD26(gene name synonym)|uniprotkb:NOD5(gene name synonym)|uniprotkb:NOD9(gene name synonym)|uniprotkb:Caterpiller protein 11.3(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 26(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 5(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 9(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Moore et al. (2008) pubmed:18200010|doi:10.1038/nature06501|imex:IM-21999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15680018|imex:IM-21999-2|dip:DIP-195761E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|intact:EBI-995373(isoform-parent) intact:EBI-3893071(isoform-parent)|ensembl:ENST00000292199(transcript)|ensembl:ENST00000409109(transcript)|ensembl:ENST00000409265(transcript)|ensembl:ENST00000409991(transcript)|ensembl:ENSG00000160703(gene) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rogid:w+BOLVATt2ey/lEP6RY9zP2q/gc9606 rigid:NlafaLL0UfpSEas66mgIV0Cg7no false - ha tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z434-1 uniprotkb:Q86UT6-1 intact:EBI-15577799|ensembl:ENSP00000401980 intact:EBI-15680006|ensembl:ENSP00000292199|ensembl:ENSP00000386851|ensembl:ENSP00000386858|ensembl:ENSP00000387334 psi-mi:q7z434-1(display_long)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym) psi-mi:q86ut6-1(display_long)|uniprotkb:NLRX1(gene name)|psi-mi:NLRX1(display_short)|uniprotkb:NOD26(gene name synonym)|uniprotkb:NOD5(gene name synonym)|uniprotkb:NOD9(gene name synonym)|uniprotkb:Caterpiller protein 11.3(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 26(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 5(gene name synonym)|uniprotkb:Nucleotide-binding oligomerization domain protein 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Moore et al. (2008) pubmed:18200010|doi:10.1038/nature06501|imex:IM-21999 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15680083|imex:IM-21999-5|dip:DIP-195761E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|intact:EBI-995373(isoform-parent) intact:EBI-3893071(isoform-parent)|ensembl:ENST00000292199(transcript)|ensembl:ENST00000409109(transcript)|ensembl:ENST00000409265(transcript)|ensembl:ENST00000409991(transcript)|ensembl:ENSG00000160703(gene) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rogid:w+BOLVATt2ey/lEP6RY9zP2q/gc9606 rigid:NlafaLL0UfpSEas66mgIV0Cg7no false necessary binding region:10-77|flag tag:n-n ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)