#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O15524 uniprotkb:Q77YG1 intact:EBI-968198|ensembl:ENSP00000329418|ensembl:ENSP00000496577|uniprotkb:O15097|uniprotkb:Q9NSA7 intact:EBI-15678227|uniprotkb:A5JP19 psi-mi:socs1_human(display_long)|uniprotkb:SOCS1(gene name)|psi-mi:SOCS1(display_short)|uniprotkb:SSI1(gene name synonym)|uniprotkb:TIP3(gene name synonym)|uniprotkb:JAK-binding protein(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 1(gene name synonym)|uniprotkb:Tec-interacting protein 3(gene name synonym) psi-mi:q77yg1_9hiv1(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ryo et al. (2008) pubmed:18172216|doi:10.1073/pnas.0704831105|imex:IM-9046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15678253|imex:IM-9046-1|dip:DIP-59149E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010533"(regulation of activation of Janus kinase activity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR028411|interpro:IPR035861|interpro:IPR036036|interpro:IPR036860|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|mint:O15524|reactome:R-HSA-1266695|reactome:R-HSA-1433559|reactome:R-HSA-166058|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|ensembl:ENSG00000185338(gene)|ensembl:ENST00000332029(transcript)|ensembl:ENST00000644787(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|refseq:NP_003736.1|dip:DIP-29662N go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:3NTE|refseq:NP_057850.1|interpro:IPR036875 psi-mi:"MI:0465"(dip) - crc64:B74C3858C20EF82C full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:Ybb6XvshFQp4GUNEiBZ41ff/H8I9606 rogid:nGwb9dDgtg+PAOx2OMo606pDync11676 rigid:OFMaxNs5Jz8c+NaHahOsbu+tCmA false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q77YG1 uniprotkb:O15524 intact:EBI-15678227|uniprotkb:A5JP19 intact:EBI-968198|ensembl:ENSP00000329418|ensembl:ENSP00000496577|uniprotkb:O15097|uniprotkb:Q9NSA7 psi-mi:q77yg1_9hiv1(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short) psi-mi:socs1_human(display_long)|uniprotkb:SOCS1(gene name)|psi-mi:SOCS1(display_short)|uniprotkb:SSI1(gene name synonym)|uniprotkb:TIP3(gene name synonym)|uniprotkb:JAK-binding protein(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 1(gene name synonym)|uniprotkb:Tec-interacting protein 3(gene name synonym) psi-mi:"MI:0096"(pull down) Ryo et al. (2008) pubmed:18172216|doi:10.1073/pnas.0704831105|imex:IM-9046 taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15678299|imex:IM-9046-5|dip:DIP-59149E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:3NTE|refseq:NP_057850.1|interpro:IPR036875 go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010533"(regulation of activation of Janus kinase activity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR028411|interpro:IPR035861|interpro:IPR036036|interpro:IPR036860|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|mint:O15524|reactome:R-HSA-1266695|reactome:R-HSA-1433559|reactome:R-HSA-166058|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|ensembl:ENSG00000185338(gene)|ensembl:ENST00000332029(transcript)|ensembl:ENST00000644787(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|refseq:NP_003736.1|dip:DIP-29662N psi-mi:"MI:0465"(dip) crc64:B74C3858C20EF82C - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:nGwb9dDgtg+PAOx2OMo606pDync11676 rogid:Ybb6XvshFQp4GUNEiBZ41ff/H8I9606 rigid:OFMaxNs5Jz8c+NaHahOsbu+tCmA false flag tag:c-c tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O15524 uniprotkb:Q77YG1 intact:EBI-968198|ensembl:ENSP00000329418|ensembl:ENSP00000496577|uniprotkb:O15097|uniprotkb:Q9NSA7 intact:EBI-15678227|uniprotkb:A5JP19 psi-mi:socs1_human(display_long)|uniprotkb:SOCS1(gene name)|psi-mi:SOCS1(display_short)|uniprotkb:SSI1(gene name synonym)|uniprotkb:TIP3(gene name synonym)|uniprotkb:JAK-binding protein(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 1(gene name synonym)|uniprotkb:Tec-interacting protein 3(gene name synonym) psi-mi:q77yg1_9hiv1(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ryo et al. (2008) pubmed:18172216|doi:10.1073/pnas.0704831105|imex:IM-9046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15678320|imex:IM-9046-4|dip:DIP-59149E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010533"(regulation of activation of Janus kinase activity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR028411|interpro:IPR035861|interpro:IPR036036|interpro:IPR036860|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|mint:O15524|reactome:R-HSA-1266695|reactome:R-HSA-1433559|reactome:R-HSA-166058|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|ensembl:ENSG00000185338(gene)|ensembl:ENST00000332029(transcript)|ensembl:ENST00000644787(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|refseq:NP_003736.1|dip:DIP-29662N go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:3NTE|refseq:NP_057850.1|interpro:IPR036875 psi-mi:"MI:0465"(dip) - crc64:B74C3858C20EF82C full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:Ybb6XvshFQp4GUNEiBZ41ff/H8I9606 rogid:nGwb9dDgtg+PAOx2OMo606pDync11676 rigid:OFMaxNs5Jz8c+NaHahOsbu+tCmA false myc tag:n-n flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q77YG1 uniprotkb:O15524 intact:EBI-15678227|uniprotkb:A5JP19 intact:EBI-968198|ensembl:ENSP00000329418|ensembl:ENSP00000496577|uniprotkb:O15097|uniprotkb:Q9NSA7 psi-mi:q77yg1_9hiv1(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short) psi-mi:socs1_human(display_long)|uniprotkb:SOCS1(gene name)|psi-mi:SOCS1(display_short)|uniprotkb:SSI1(gene name synonym)|uniprotkb:TIP3(gene name synonym)|uniprotkb:JAK-binding protein(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 1(gene name synonym)|uniprotkb:Tec-interacting protein 3(gene name synonym) psi-mi:"MI:0096"(pull down) Ryo et al. (2008) pubmed:18172216|doi:10.1073/pnas.0704831105|imex:IM-9046 taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15678272|imex:IM-9046-3|dip:DIP-59149E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:3NTE|refseq:NP_057850.1|interpro:IPR036875 go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010533"(regulation of activation of Janus kinase activity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR028411|interpro:IPR035861|interpro:IPR036036|interpro:IPR036860|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|mint:O15524|reactome:R-HSA-1266695|reactome:R-HSA-1433559|reactome:R-HSA-166058|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|ensembl:ENSG00000185338(gene)|ensembl:ENST00000332029(transcript)|ensembl:ENST00000644787(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|refseq:NP_003736.1|dip:DIP-29662N psi-mi:"MI:0465"(dip) crc64:B74C3858C20EF82C - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:nGwb9dDgtg+PAOx2OMo606pDync11676 rogid:Ybb6XvshFQp4GUNEiBZ41ff/H8I9606 rigid:OFMaxNs5Jz8c+NaHahOsbu+tCmA false tag:n-n|sufficient binding region:2-132|sufficient binding region:379-433 myc tag:n-n|sufficient binding region:1-176 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O15524 uniprotkb:Q77YG1 intact:EBI-968198|ensembl:ENSP00000329418|ensembl:ENSP00000496577|uniprotkb:O15097|uniprotkb:Q9NSA7 intact:EBI-15678227|uniprotkb:A5JP19 psi-mi:socs1_human(display_long)|uniprotkb:SOCS1(gene name)|psi-mi:SOCS1(display_short)|uniprotkb:SSI1(gene name synonym)|uniprotkb:TIP3(gene name synonym)|uniprotkb:JAK-binding protein(gene name synonym)|uniprotkb:STAT-induced STAT inhibitor 1(gene name synonym)|uniprotkb:Tec-interacting protein 3(gene name synonym) psi-mi:q77yg1_9hiv1(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Ryo et al. (2008) pubmed:18172216|doi:10.1073/pnas.0704831105|imex:IM-9046 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15678341|imex:IM-9046-2|dip:DIP-59149E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010533"(regulation of activation of Janus kinase activity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001496(SOCS protein, C-terminal)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR028411|interpro:IPR035861|interpro:IPR036036|interpro:IPR036860|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|mint:O15524|reactome:R-HSA-1266695|reactome:R-HSA-1433559|reactome:R-HSA-166058|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-909733|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983168|ensembl:ENSG00000185338(gene)|ensembl:ENST00000332029(transcript)|ensembl:ENST00000644787(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|refseq:NP_003736.1|dip:DIP-29662N go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0060550"(positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:3NTE|refseq:NP_057850.1|interpro:IPR036875 psi-mi:"MI:0465"(dip) - crc64:B74C3858C20EF82C full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:Ybb6XvshFQp4GUNEiBZ41ff/H8I9606 rogid:nGwb9dDgtg+PAOx2OMo606pDync11676 rigid:OFMaxNs5Jz8c+NaHahOsbu+tCmA false myc tag:n-n flag tag:c-c|sufficient binding region:2-132|sufficient binding region:379-433 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)