#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P26715	uniprotkb:Q13241	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-9018174|ensembl:ENSP00000338130|ensembl:ENSP00000371333|uniprotkb:O43321|uniprotkb:Q9UBE3|uniprotkb:O43773|uniprotkb:Q9UEQ0	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:klrd1_human(display_long)|uniprotkb:KLRD1(gene name)|psi-mi:KLRD1(display_short)|uniprotkb:CD94(gene name synonym)|uniprotkb:KP43(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily D member 1(gene name synonym)|uniprotkb:NK cell receptor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034306|imex:IM-25734-1|wwpdb:3bdw	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	refseq:XP_016874780.1|ensembl:ENSG00000134539(gene)|ensembl:ENST00000336164(transcript)|ensembl:ENST00000381908(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002228"(natural killer cell mediated immunity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0023030"(MHC class Ib protein binding, via antigen binding groove)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|go:"GO:1990405"(protein antigen binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:1B6E|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|refseq:NP_031360.1|refseq:NP_001107868.1|refseq:NP_002253.1	-	-	-	figure legend:Table 1|3d-resolution:2.5A|3d-resolution:RFree =0.27  RWork =0.234|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/03/20	2017/04/26	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:w4CTkGn2+cZbqxfbDb3YZOTurxE9606	rigid:L5BiiAkpJquSJxdl2BE8LS2nsxw	false	sufficient binding region:110-233(IPR033992)	sufficient binding region:40-179(IPR033992)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:P17693	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034325|imex:IM-25734-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:Fig S2, Table S2|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.94x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	sufficient binding region:110-233	sufficient binding region:3-11|mutation with no effect:10-10|mutation decreasing interaction strength:10-10|mutation decreasing interaction strength:10-10|mutation disrupting interaction strength:10-10|mutation disrupting interaction strength:10-10|mutation disrupting interaction strength:10-10	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:P61769-PRO_0000018779	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-13942645	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034325|imex:IM-25734-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:Fig S2, Table S2|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.94x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	sufficient binding region:110-233	sufficient binding region:1-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:P13747	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-726583|uniprotkb:Q30169|uniprotkb:Q9BT83|uniprotkb:Q9GIY7|uniprotkb:Q9GIY8|ensembl:ENSP00000365817|ensembl:ENSP00000373091|ensembl:ENSP00000390707|ensembl:ENSP00000397420|ensembl:ENSP00000400458|ensembl:ENSP00000402694|ensembl:ENSP00000409910|uniprotkb:E2G051|uniprotkb:Q6DU44	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:hlae_human(display_long)|uniprotkb:MHC class I antigen E(gene name synonym)|uniprotkb:HLA-E(gene name)|psi-mi:HLA-E(display_short)|uniprotkb:HLA-6.2(gene name synonym)|uniprotkb:HLAE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034325|imex:IM-25734-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	refseq:NP_005507.3|ensembl:ENSG00000204592(gene)|ensembl:ENSG00000206493(gene)|ensembl:ENSG00000225201(gene)|ensembl:ENSG00000229252(gene)|ensembl:ENSG00000230254(gene)|ensembl:ENSG00000233904(gene)|ensembl:ENSG00000236632(gene)|ensembl:ENST00000376630(transcript)|ensembl:ENST00000383597(transcript)|ensembl:ENST00000415289(transcript)|ensembl:ENST00000415649(transcript)|ensembl:ENST00000425603(transcript)|ensembl:ENST00000427936(transcript)|ensembl:ENST00000444683(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001815"(positive regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002477"(antigen processing and presentation of exogenous peptide antigen via MHC class Ib)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002715"(regulation of natural killer cell mediated immunity)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032398"(MHC class Ib protein complex)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032759"(positive regulation of TRAIL production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:1KPR|rcsb pdb:1KTL|rcsb pdb:1MHE|rcsb pdb:2ESV|rcsb pdb:3AM8|rcsb pdb:3BZE|rcsb pdb:3BZF|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:5W1V|rcsb pdb:5W1W|rcsb pdb:6GGM|rcsb pdb:6GH1|rcsb pdb:6GH4|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|rcsb pdb:6GHN|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|rcsb pdb:6GL1|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|dip:DIP-32N	-	-	-	figure legend:Fig S2, Table S2|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.94x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:JhlO0lcqZm7whCQasHSnQdrA5Tk9606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	sufficient binding region:110-233	sufficient binding region:22..23-200..203	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:Q13241	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-9018174|ensembl:ENSP00000338130|ensembl:ENSP00000371333|uniprotkb:O43321|uniprotkb:Q9UBE3|uniprotkb:O43773|uniprotkb:Q9UEQ0	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:klrd1_human(display_long)|uniprotkb:KLRD1(gene name)|psi-mi:KLRD1(display_short)|uniprotkb:CD94(gene name synonym)|uniprotkb:KP43(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily D member 1(gene name synonym)|uniprotkb:NK cell receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034325|imex:IM-25734-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	refseq:XP_016874780.1|ensembl:ENSG00000134539(gene)|ensembl:ENST00000336164(transcript)|ensembl:ENST00000381908(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002228"(natural killer cell mediated immunity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0023030"(MHC class Ib protein binding, via antigen binding groove)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|go:"GO:1990405"(protein antigen binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:1B6E|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|refseq:NP_031360.1|refseq:NP_001107868.1|refseq:NP_002253.1	-	-	-	figure legend:Fig S2, Table S2|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.94x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:w4CTkGn2+cZbqxfbDb3YZOTurxE9606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	sufficient binding region:110-233	sufficient binding region:40-179	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:P17693	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034363|imex:IM-25734-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:Fig 4A, Table 2|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.94x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	sufficient binding region:110-233	sufficient binding region:3-11	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:P61769-PRO_0000018779	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-13942645	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034363|imex:IM-25734-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:Fig 4A, Table 2|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.94x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	sufficient binding region:110-233	sufficient binding region:1-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:P13747	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-726583|uniprotkb:Q30169|uniprotkb:Q9BT83|uniprotkb:Q9GIY7|uniprotkb:Q9GIY8|ensembl:ENSP00000365817|ensembl:ENSP00000373091|ensembl:ENSP00000390707|ensembl:ENSP00000397420|ensembl:ENSP00000400458|ensembl:ENSP00000402694|ensembl:ENSP00000409910|uniprotkb:E2G051|uniprotkb:Q6DU44	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:hlae_human(display_long)|uniprotkb:MHC class I antigen E(gene name synonym)|uniprotkb:HLA-E(gene name)|psi-mi:HLA-E(display_short)|uniprotkb:HLA-6.2(gene name synonym)|uniprotkb:HLAE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034363|imex:IM-25734-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	refseq:NP_005507.3|ensembl:ENSG00000204592(gene)|ensembl:ENSG00000206493(gene)|ensembl:ENSG00000225201(gene)|ensembl:ENSG00000229252(gene)|ensembl:ENSG00000230254(gene)|ensembl:ENSG00000233904(gene)|ensembl:ENSG00000236632(gene)|ensembl:ENST00000376630(transcript)|ensembl:ENST00000383597(transcript)|ensembl:ENST00000415289(transcript)|ensembl:ENST00000415649(transcript)|ensembl:ENST00000425603(transcript)|ensembl:ENST00000427936(transcript)|ensembl:ENST00000444683(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001815"(positive regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002477"(antigen processing and presentation of exogenous peptide antigen via MHC class Ib)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002715"(regulation of natural killer cell mediated immunity)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032398"(MHC class Ib protein complex)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032759"(positive regulation of TRAIL production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:1KPR|rcsb pdb:1KTL|rcsb pdb:1MHE|rcsb pdb:2ESV|rcsb pdb:3AM8|rcsb pdb:3BZE|rcsb pdb:3BZF|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:5W1V|rcsb pdb:5W1W|rcsb pdb:6GGM|rcsb pdb:6GH1|rcsb pdb:6GH4|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|rcsb pdb:6GHN|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|rcsb pdb:6GL1|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|dip:DIP-32N	-	-	-	figure legend:Fig 4A, Table 2|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.94x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:JhlO0lcqZm7whCQasHSnQdrA5Tk9606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	sufficient binding region:110-233	mutation with no effect:86-86|mutation with no effect:90-90|mutation disrupting interaction strength:93-93|mutation disrupting interaction strength:96-96|mutation decreasing interaction strength:97-97|mutation decreasing interaction strength:100-100|mutation with no effect:110-110|mutation with no effect:129-129|mutation with no effect:170-170|mutation with no effect:175-175|mutation with no effect:176-176|mutation disrupting interaction strength:183-183|mutation with no effect:187-187|mutation with no effect:235-235|sufficient binding region:22..23-200..203|mutation with no effect:83-83	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:Q13241	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-9018174|ensembl:ENSP00000338130|ensembl:ENSP00000371333|uniprotkb:O43321|uniprotkb:Q9UBE3|uniprotkb:O43773|uniprotkb:Q9UEQ0	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:klrd1_human(display_long)|uniprotkb:KLRD1(gene name)|psi-mi:KLRD1(display_short)|uniprotkb:CD94(gene name synonym)|uniprotkb:KP43(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily D member 1(gene name synonym)|uniprotkb:NK cell receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034363|imex:IM-25734-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	refseq:XP_016874780.1|ensembl:ENSG00000134539(gene)|ensembl:ENST00000336164(transcript)|ensembl:ENST00000381908(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002228"(natural killer cell mediated immunity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0023030"(MHC class Ib protein binding, via antigen binding groove)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|go:"GO:1990405"(protein antigen binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:1B6E|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|refseq:NP_031360.1|refseq:NP_001107868.1|refseq:NP_002253.1	-	-	-	figure legend:Fig 4A, Table 2|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.94x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:w4CTkGn2+cZbqxfbDb3YZOTurxE9606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	sufficient binding region:110-233	sufficient binding region:40-179	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:P17693	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034435|imex:IM-25734-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:Fig 4B, Table 3-1|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.23x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	sufficient binding region:110-233	sufficient binding region:3-11	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:P61769-PRO_0000018779	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-13942645	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034435|imex:IM-25734-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:Fig 4B, Table 3-1|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.23x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	sufficient binding region:110-233	sufficient binding region:1-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:P13747	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-726583|uniprotkb:Q30169|uniprotkb:Q9BT83|uniprotkb:Q9GIY7|uniprotkb:Q9GIY8|ensembl:ENSP00000365817|ensembl:ENSP00000373091|ensembl:ENSP00000390707|ensembl:ENSP00000397420|ensembl:ENSP00000400458|ensembl:ENSP00000402694|ensembl:ENSP00000409910|uniprotkb:E2G051|uniprotkb:Q6DU44	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:hlae_human(display_long)|uniprotkb:MHC class I antigen E(gene name synonym)|uniprotkb:HLA-E(gene name)|psi-mi:HLA-E(display_short)|uniprotkb:HLA-6.2(gene name synonym)|uniprotkb:HLAE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034435|imex:IM-25734-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	refseq:NP_005507.3|ensembl:ENSG00000204592(gene)|ensembl:ENSG00000206493(gene)|ensembl:ENSG00000225201(gene)|ensembl:ENSG00000229252(gene)|ensembl:ENSG00000230254(gene)|ensembl:ENSG00000233904(gene)|ensembl:ENSG00000236632(gene)|ensembl:ENST00000376630(transcript)|ensembl:ENST00000383597(transcript)|ensembl:ENST00000415289(transcript)|ensembl:ENST00000415649(transcript)|ensembl:ENST00000425603(transcript)|ensembl:ENST00000427936(transcript)|ensembl:ENST00000444683(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001815"(positive regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002477"(antigen processing and presentation of exogenous peptide antigen via MHC class Ib)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002715"(regulation of natural killer cell mediated immunity)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032398"(MHC class Ib protein complex)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032759"(positive regulation of TRAIL production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:1KPR|rcsb pdb:1KTL|rcsb pdb:1MHE|rcsb pdb:2ESV|rcsb pdb:3AM8|rcsb pdb:3BZE|rcsb pdb:3BZF|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:5W1V|rcsb pdb:5W1W|rcsb pdb:6GGM|rcsb pdb:6GH1|rcsb pdb:6GH4|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|rcsb pdb:6GHN|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|rcsb pdb:6GL1|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|dip:DIP-32N	-	-	-	figure legend:Fig 4B, Table 3-1|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.23x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:JhlO0lcqZm7whCQasHSnQdrA5Tk9606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	sufficient binding region:110-233	sufficient binding region:22..23-200..203	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:Q13241	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-9018174|ensembl:ENSP00000338130|ensembl:ENSP00000371333|uniprotkb:O43321|uniprotkb:Q9UBE3|uniprotkb:O43773|uniprotkb:Q9UEQ0	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:klrd1_human(display_long)|uniprotkb:KLRD1(gene name)|psi-mi:KLRD1(display_short)|uniprotkb:CD94(gene name synonym)|uniprotkb:KP43(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily D member 1(gene name synonym)|uniprotkb:NK cell receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034435|imex:IM-25734-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	refseq:XP_016874780.1|ensembl:ENSG00000134539(gene)|ensembl:ENST00000336164(transcript)|ensembl:ENST00000381908(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002228"(natural killer cell mediated immunity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0023030"(MHC class Ib protein binding, via antigen binding groove)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|go:"GO:1990405"(protein antigen binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:1B6E|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|refseq:NP_031360.1|refseq:NP_001107868.1|refseq:NP_002253.1	-	-	-	figure legend:Fig 4B, Table 3-1|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.23x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:w4CTkGn2+cZbqxfbDb3YZOTurxE9606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	sufficient binding region:110-233	mutation with no effect:79-79|mutation disrupting interaction strength:112-112|mutation disrupting interaction strength:114-114|mutation with no effect:146-146|mutation with no effect:148-148|mutation with no effect:158-158|mutation disrupting interaction strength:160-160|mutation disrupting interaction strength:162-162|mutation disrupting interaction strength:163-163|mutation disrupting interaction strength:164-164|mutation decreasing interaction strength:168-168|sufficient binding region:40-179	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:P17693	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034508|imex:IM-25734-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:Fig 4B, Table 3-2|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.23x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	mutation with no effect:172-172|mutation with no effect:200-200|mutation with no effect:202-202|mutation with no effect:212-212|mutation with no effect:213-213|mutation decreasing interaction strength:215-215|mutation with no effect:217-217|mutation with no effect:220-220|mutation with no effect:223-223|mutation with no effect:163-163|mutation decreasing interaction strength:167-170|mutation decreasing interaction strength:137-137|sufficient binding region:110-233	sufficient binding region:3-11	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:P61769-PRO_0000018779	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-13942645	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034508|imex:IM-25734-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:Fig 4B, Table 3-2|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.23x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	mutation with no effect:172-172|mutation with no effect:200-200|mutation with no effect:202-202|mutation with no effect:212-212|mutation with no effect:213-213|mutation decreasing interaction strength:215-215|mutation with no effect:217-217|mutation with no effect:220-220|mutation with no effect:223-223|mutation with no effect:163-163|mutation decreasing interaction strength:167-170|mutation decreasing interaction strength:137-137|sufficient binding region:110-233	sufficient binding region:1-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:P13747	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-726583|uniprotkb:Q30169|uniprotkb:Q9BT83|uniprotkb:Q9GIY7|uniprotkb:Q9GIY8|ensembl:ENSP00000365817|ensembl:ENSP00000373091|ensembl:ENSP00000390707|ensembl:ENSP00000397420|ensembl:ENSP00000400458|ensembl:ENSP00000402694|ensembl:ENSP00000409910|uniprotkb:E2G051|uniprotkb:Q6DU44	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:hlae_human(display_long)|uniprotkb:MHC class I antigen E(gene name synonym)|uniprotkb:HLA-E(gene name)|psi-mi:HLA-E(display_short)|uniprotkb:HLA-6.2(gene name synonym)|uniprotkb:HLAE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034508|imex:IM-25734-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	refseq:NP_005507.3|ensembl:ENSG00000204592(gene)|ensembl:ENSG00000206493(gene)|ensembl:ENSG00000225201(gene)|ensembl:ENSG00000229252(gene)|ensembl:ENSG00000230254(gene)|ensembl:ENSG00000233904(gene)|ensembl:ENSG00000236632(gene)|ensembl:ENST00000376630(transcript)|ensembl:ENST00000383597(transcript)|ensembl:ENST00000415289(transcript)|ensembl:ENST00000415649(transcript)|ensembl:ENST00000425603(transcript)|ensembl:ENST00000427936(transcript)|ensembl:ENST00000444683(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001815"(positive regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002477"(antigen processing and presentation of exogenous peptide antigen via MHC class Ib)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002715"(regulation of natural killer cell mediated immunity)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032398"(MHC class Ib protein complex)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032759"(positive regulation of TRAIL production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:1KPR|rcsb pdb:1KTL|rcsb pdb:1MHE|rcsb pdb:2ESV|rcsb pdb:3AM8|rcsb pdb:3BZE|rcsb pdb:3BZF|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:5W1V|rcsb pdb:5W1W|rcsb pdb:6GGM|rcsb pdb:6GH1|rcsb pdb:6GH4|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|rcsb pdb:6GHN|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|rcsb pdb:6GL1|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|dip:DIP-32N	-	-	-	figure legend:Fig 4B, Table 3-2|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.23x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:JhlO0lcqZm7whCQasHSnQdrA5Tk9606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	mutation with no effect:172-172|mutation with no effect:200-200|mutation with no effect:202-202|mutation with no effect:212-212|mutation with no effect:213-213|mutation decreasing interaction strength:215-215|mutation with no effect:217-217|mutation with no effect:220-220|mutation with no effect:223-223|mutation with no effect:163-163|mutation decreasing interaction strength:167-170|mutation decreasing interaction strength:137-137|sufficient binding region:110-233	sufficient binding region:22..23-200..203	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26715	uniprotkb:Q13241	intact:EBI-9018187|ensembl:ENSP00000352064|ensembl:ENSP00000438038	intact:EBI-9018174|ensembl:ENSP00000338130|ensembl:ENSP00000371333|uniprotkb:O43321|uniprotkb:Q9UBE3|uniprotkb:O43773|uniprotkb:Q9UEQ0	psi-mi:nkg2a_human(display_long)|uniprotkb:KLRC1(gene name)|psi-mi:KLRC1(display_short)|uniprotkb:CD159 antigen-like family member A(gene name synonym)|uniprotkb:NK cell receptor A(gene name synonym)|uniprotkb:NKG2-A/B-activating NK receptor(gene name synonym)|uniprotkb:NKG2A(gene name synonym)	psi-mi:klrd1_human(display_long)|uniprotkb:KLRD1(gene name)|psi-mi:KLRD1(display_short)|uniprotkb:CD94(gene name synonym)|uniprotkb:KP43(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily D member 1(gene name synonym)|uniprotkb:NK cell receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034508|imex:IM-25734-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000134545(gene)|ensembl:ENST00000359151(transcript)|ensembl:ENST00000544822(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002305"(CD8-positive, gamma-delta intraepithelial T cell differentiation)|go:"GO:0002769"(natural killer cell inhibitory signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2RMX|rcsb pdb:2YU7|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|refseq:NP_002250.1|refseq:NP_015567.1|refseq:NP_998822.1|refseq:NP_998823.1	refseq:XP_016874780.1|ensembl:ENSG00000134539(gene)|ensembl:ENST00000336164(transcript)|ensembl:ENST00000381908(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002228"(natural killer cell mediated immunity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0023030"(MHC class Ib protein binding, via antigen binding groove)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|go:"GO:1990405"(protein antigen binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:1B6E|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|refseq:NP_031360.1|refseq:NP_001107868.1|refseq:NP_002253.1	-	-	-	figure legend:Fig 4B, Table 3-2|comment:HLA-E∗0103 allele|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.23x10^-6(molar)	2017/03/20	2019/01/23	rogid:rSCf7wytGFXA8wxeUdhD34iKTVQ9606	rogid:w4CTkGn2+cZbqxfbDb3YZOTurxE9606	rigid:edhT98azrSv7XoMmln7ued7mcp8	false	mutation with no effect:172-172|mutation with no effect:200-200|mutation with no effect:202-202|mutation with no effect:212-212|mutation with no effect:213-213|mutation decreasing interaction strength:215-215|mutation with no effect:217-217|mutation with no effect:220-220|mutation with no effect:223-223|mutation with no effect:163-163|mutation decreasing interaction strength:167-170|mutation decreasing interaction strength:137-137|sufficient binding region:110-233	sufficient binding region:40-179	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26717	uniprotkb:P17693	intact:EBI-3862171|uniprotkb:O43802|uniprotkb:Q52M74|uniprotkb:Q9NR42|ensembl:ENSP00000371327	intact:EBI-1043063|ensembl:ENSP00000353472|ensembl:ENSP00000388176|ensembl:ENSP00000389522|ensembl:ENSP00000398200|ensembl:ENSP00000373116|ensembl:ENSP00000405238|ensembl:ENSP00000408773|ensembl:ENSP00000412927|ensembl:ENSP00000447762|ensembl:ENSP00000447780|ensembl:ENSP00000448085|ensembl:ENSP00000448363|ensembl:ENSP00000449291|ensembl:ENSP00000449903	psi-mi:nkg2c_human(display_long)|uniprotkb:KLRC2(gene name)|psi-mi:KLRC2(display_short)|uniprotkb:NKG2C(gene name synonym)|uniprotkb:CD159 antigen-like family member C(gene name synonym)|uniprotkb:NK cell receptor C(gene name synonym)|uniprotkb:NKG2-C-activating NK receptor(gene name synonym)	psi-mi:hlag_human(display_long)|uniprotkb:HLAG(gene name synonym)|uniprotkb:HLA-G(gene name)|psi-mi:HLA-G(display_short)|uniprotkb:HLA-6.0(gene name synonym)|uniprotkb:HLA G antigen(gene name synonym)|uniprotkb:MHC class I antigen G(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034576|imex:IM-25734-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002251.2|ensembl:ENSG00000205809(gene)|ensembl:ENST00000381902(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002228"(natural killer cell mediated immunity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062081"(activating MHC class Ib receptor activity)|go:"GO:1990405"(protein antigen binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2L35|reactome:R-HSA-2172127|reactome:R-HSA-2424491|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)	ensembl:ENSG00000204632(gene)|ensembl:ENSG00000206506(gene)|ensembl:ENSG00000230413(gene)|ensembl:ENSG00000233095(gene)|ensembl:ENSG00000235346(gene)|ensembl:ENSG00000235680(gene)|ensembl:ENSG00000237216(gene)|ensembl:ENST00000360323(transcript)|ensembl:ENST00000383621(transcript)|ensembl:ENST00000423011(transcript)|ensembl:ENST00000423373(transcript)|ensembl:ENST00000428701(transcript)|ensembl:ENST00000428952(transcript)|ensembl:ENST00000444098(transcript)|ensembl:ENST00000449127(transcript)|ensembl:ENST00000546545(transcript)|ensembl:ENST00000546634(transcript)|ensembl:ENST00000547241(transcript)|ensembl:ENST00000547931(transcript)|ensembl:ENST00000550897(transcript)|ensembl:ENST00000553052(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002451"(peripheral B cell tolerance induction)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002645"(positive regulation of tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002767"(immune response-inhibiting cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0033106"(cis-Golgi network membrane)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0031527"(filopodium membrane)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070317"(negative regulation of G0 to G1 transition)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|go:"GO:2001199"(negative regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P17693|rcsb pdb:1YDP|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3BZE|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:3KYN|rcsb pdb:3KYO|rcsb pdb:6AEE|rcsb pdb:6K60|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|refseq:NP_002118.1|dip:DIP-46121N	-	-	-	figure legend:Fig 4B, Table 3-3|comment:HLA-E∗0103 allele|comment:"It is stated in the text:- \"we replaced residues 161 and residues 165–168 with the corresponding amino acids from NKG2A\" - but  the corresponding residue in NKG2A is also an \"M\" not an \"I\".  however Figure 3A gives an I/M residue difference at residues 225/223 for NKG2A/C respectively."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.9x10^-6(molar)	2017/03/20	2019/01/23	rogid:Yt6xX/Hf1JDgyDegw2HpHIU9LzA9606	rogid:E3xsP+XcQvU64mCe/05DTS9vHQw9606	rigid:/Uqd9Mlh8pTSW5mh2l7LhDdLdBU	false	mutation increasing interaction strength:165-168|sufficient binding region:94..94-231..231	sufficient binding region:3-11	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26717	uniprotkb:P61769-PRO_0000018779	intact:EBI-3862171|uniprotkb:O43802|uniprotkb:Q52M74|uniprotkb:Q9NR42|ensembl:ENSP00000371327	intact:EBI-13942645	psi-mi:nkg2c_human(display_long)|uniprotkb:KLRC2(gene name)|psi-mi:KLRC2(display_short)|uniprotkb:NKG2C(gene name synonym)|uniprotkb:CD159 antigen-like family member C(gene name synonym)|uniprotkb:NK cell receptor C(gene name synonym)|uniprotkb:NKG2-C-activating NK receptor(gene name synonym)	psi-mi:p61769-pro_0000018779(display_long)|uniprotkb:B2M(gene name)|psi-mi:B2M(display_short)|uniprotkb:CDABP0092(orf name)|uniprotkb:HDCMA22P(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034576|imex:IM-25734-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002251.2|ensembl:ENSG00000205809(gene)|ensembl:ENST00000381902(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002228"(natural killer cell mediated immunity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062081"(activating MHC class Ib receptor activity)|go:"GO:1990405"(protein antigen binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2L35|reactome:R-HSA-2172127|reactome:R-HSA-2424491|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)	intact:EBI-714718(chain-parent)	-	-	chain-seq-start:21|chain-seq-end:119	figure legend:Fig 4B, Table 3-3|comment:HLA-E∗0103 allele|comment:"It is stated in the text:- \"we replaced residues 161 and residues 165–168 with the corresponding amino acids from NKG2A\" - but  the corresponding residue in NKG2A is also an \"M\" not an \"I\".  however Figure 3A gives an I/M residue difference at residues 225/223 for NKG2A/C respectively."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.9x10^-6(molar)	2017/03/20	2019/01/23	rogid:Yt6xX/Hf1JDgyDegw2HpHIU9LzA9606	rogid:PHSGrRweGYBm8t9Sd55DncdrnO49606	rigid:/Uqd9Mlh8pTSW5mh2l7LhDdLdBU	false	mutation increasing interaction strength:165-168|sufficient binding region:94..94-231..231	sufficient binding region:1-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26717	uniprotkb:P13747	intact:EBI-3862171|uniprotkb:O43802|uniprotkb:Q52M74|uniprotkb:Q9NR42|ensembl:ENSP00000371327	intact:EBI-726583|uniprotkb:Q30169|uniprotkb:Q9BT83|uniprotkb:Q9GIY7|uniprotkb:Q9GIY8|ensembl:ENSP00000365817|ensembl:ENSP00000373091|ensembl:ENSP00000390707|ensembl:ENSP00000397420|ensembl:ENSP00000400458|ensembl:ENSP00000402694|ensembl:ENSP00000409910|uniprotkb:E2G051|uniprotkb:Q6DU44	psi-mi:nkg2c_human(display_long)|uniprotkb:KLRC2(gene name)|psi-mi:KLRC2(display_short)|uniprotkb:NKG2C(gene name synonym)|uniprotkb:CD159 antigen-like family member C(gene name synonym)|uniprotkb:NK cell receptor C(gene name synonym)|uniprotkb:NKG2-C-activating NK receptor(gene name synonym)	psi-mi:hlae_human(display_long)|uniprotkb:MHC class I antigen E(gene name synonym)|uniprotkb:HLA-E(gene name)|psi-mi:HLA-E(display_short)|uniprotkb:HLA-6.2(gene name synonym)|uniprotkb:HLAE(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034576|imex:IM-25734-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002251.2|ensembl:ENSG00000205809(gene)|ensembl:ENST00000381902(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002228"(natural killer cell mediated immunity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062081"(activating MHC class Ib receptor activity)|go:"GO:1990405"(protein antigen binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2L35|reactome:R-HSA-2172127|reactome:R-HSA-2424491|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)	refseq:NP_005507.3|ensembl:ENSG00000204592(gene)|ensembl:ENSG00000206493(gene)|ensembl:ENSG00000225201(gene)|ensembl:ENSG00000229252(gene)|ensembl:ENSG00000230254(gene)|ensembl:ENSG00000233904(gene)|ensembl:ENSG00000236632(gene)|ensembl:ENST00000376630(transcript)|ensembl:ENST00000383597(transcript)|ensembl:ENST00000415289(transcript)|ensembl:ENST00000415649(transcript)|ensembl:ENST00000425603(transcript)|ensembl:ENST00000427936(transcript)|ensembl:ENST00000444683(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001815"(positive regulation of antibody-dependent cellular cytotoxicity)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0002477"(antigen processing and presentation of exogenous peptide antigen via MHC class Ib)|go:"GO:0002519"(natural killer cell tolerance induction)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002715"(regulation of natural killer cell mediated immunity)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032398"(MHC class Ib protein complex)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032759"(positive regulation of TRAIL production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:1KPR|rcsb pdb:1KTL|rcsb pdb:1MHE|rcsb pdb:2ESV|rcsb pdb:3AM8|rcsb pdb:3BZE|rcsb pdb:3BZF|rcsb pdb:3CDG|rcsb pdb:3CII|rcsb pdb:5W1V|rcsb pdb:5W1W|rcsb pdb:6GGM|rcsb pdb:6GH1|rcsb pdb:6GH4|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|rcsb pdb:6GHN|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|rcsb pdb:6GL1|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|dip:DIP-32N	-	-	-	figure legend:Fig 4B, Table 3-3|comment:HLA-E∗0103 allele|comment:"It is stated in the text:- \"we replaced residues 161 and residues 165–168 with the corresponding amino acids from NKG2A\" - but  the corresponding residue in NKG2A is also an \"M\" not an \"I\".  however Figure 3A gives an I/M residue difference at residues 225/223 for NKG2A/C respectively."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.9x10^-6(molar)	2017/03/20	2019/01/23	rogid:Yt6xX/Hf1JDgyDegw2HpHIU9LzA9606	rogid:JhlO0lcqZm7whCQasHSnQdrA5Tk9606	rigid:/Uqd9Mlh8pTSW5mh2l7LhDdLdBU	false	mutation increasing interaction strength:165-168|sufficient binding region:94..94-231..231	sufficient binding region:22..23-200..203	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26717	uniprotkb:Q13241	intact:EBI-3862171|uniprotkb:O43802|uniprotkb:Q52M74|uniprotkb:Q9NR42|ensembl:ENSP00000371327	intact:EBI-9018174|ensembl:ENSP00000338130|ensembl:ENSP00000371333|uniprotkb:O43321|uniprotkb:Q9UBE3|uniprotkb:O43773|uniprotkb:Q9UEQ0	psi-mi:nkg2c_human(display_long)|uniprotkb:KLRC2(gene name)|psi-mi:KLRC2(display_short)|uniprotkb:NKG2C(gene name synonym)|uniprotkb:CD159 antigen-like family member C(gene name synonym)|uniprotkb:NK cell receptor C(gene name synonym)|uniprotkb:NKG2-C-activating NK receptor(gene name synonym)	psi-mi:klrd1_human(display_long)|uniprotkb:KLRD1(gene name)|psi-mi:KLRD1(display_short)|uniprotkb:CD94(gene name synonym)|uniprotkb:KP43(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily D member 1(gene name synonym)|uniprotkb:NK cell receptor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sullivan et al. (2007)	pubmed:18083576|imex:IM-25734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-14034576|imex:IM-25734-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002251.2|ensembl:ENSG00000205809(gene)|ensembl:ENST00000381902(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002228"(natural killer cell mediated immunity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0043235"(receptor complex)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062081"(activating MHC class Ib receptor activity)|go:"GO:1990405"(protein antigen binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:2L35|reactome:R-HSA-2172127|reactome:R-HSA-2424491|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0030246"(carbohydrate binding)	refseq:XP_016874780.1|ensembl:ENSG00000134539(gene)|ensembl:ENST00000336164(transcript)|ensembl:ENST00000381908(transcript)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002228"(natural killer cell mediated immunity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0023030"(MHC class Ib protein binding, via antigen binding groove)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0062082"(HLA-E specific inhibitory MHC class Ib receptor activity)|go:"GO:1990405"(protein antigen binding)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|rcsb pdb:1B6E|rcsb pdb:3BDW|rcsb pdb:3CDG|rcsb pdb:3CII|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|refseq:NP_031360.1|refseq:NP_001107868.1|refseq:NP_002253.1	-	-	-	figure legend:Fig 4B, Table 3-3|comment:HLA-E∗0103 allele|comment:"It is stated in the text:- \"we replaced residues 161 and residues 165–168 with the corresponding amino acids from NKG2A\" - but  the corresponding residue in NKG2A is also an \"M\" not an \"I\".  however Figure 3A gives an I/M residue difference at residues 225/223 for NKG2A/C respectively."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.9x10^-6(molar)	2017/03/20	2019/01/23	rogid:Yt6xX/Hf1JDgyDegw2HpHIU9LzA9606	rogid:w4CTkGn2+cZbqxfbDb3YZOTurxE9606	rigid:/Uqd9Mlh8pTSW5mh2l7LhDdLdBU	false	mutation increasing interaction strength:165-168|sufficient binding region:94..94-231..231	sufficient binding region:40-179	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)