#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B intact:EBI-15670677 uniprotkb:O15550 dip:DIP-46193N intact:EBI-4292203|uniprotkb:Q52LL9|uniprotkb:Q5JVQ7|intact:EBI-28988602|ensembl:ENSP00000367203 psi-mi:h3k27me(display_short)|psi-mi:EBI-15670677(display_long) psi-mi:kdm6a_human(display_long)|uniprotkb:KDM6A(gene name)|psi-mi:KDM6A(display_short)|uniprotkb:UTX(gene name synonym)|uniprotkb:Histone demethylase UTX(gene name synonym)|uniprotkb:Ubiquitously-transcribed TPR protein on the X chromosome(gene name synonym)|uniprotkb:Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6A"(gene name synonym) psi-mi:"MI:0415"(enzymatic study) Hong et al. (2007) pubmed:18003914|doi:10.1073/pnas.0707292104|imex:IM-9435 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15670680|imex:IM-9435-1|dip:DIP-88026E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_066963.2|ensembl:ENSG00000147050(gene)|ensembl:ENST00000377967(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O15550|rcsb pdb:3AVR|rcsb pdb:3AVS|rcsb pdb:6FUK|rcsb pdb:6FUL|reactome:R-HSA-3214842|reactome:R-HSA-5617472|ensembl:ENSP00000367203|dip:DIP-46192N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:CLcF0X0dlq40SE0taedCQRq6q84-2 rogid:sqg+Ikkgvz0uT/gMx1wYs9FaDbI9606 rigid:SvfnK32Bw/8rLa5agmDVV4vm4uI false N6,N6-dimethyl-L-lysine:7-7|N6,N6,N6-trimethyl-L-lysine:7-7 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15670677 uniprotkb:O15550 dip:DIP-46193N intact:EBI-4292203|uniprotkb:Q52LL9|uniprotkb:Q5JVQ7|intact:EBI-28988602|ensembl:ENSP00000367203 psi-mi:h3k27me(display_short)|psi-mi:EBI-15670677(display_long) psi-mi:kdm6a_human(display_long)|uniprotkb:KDM6A(gene name)|psi-mi:KDM6A(display_short)|uniprotkb:UTX(gene name synonym)|uniprotkb:Histone demethylase UTX(gene name synonym)|uniprotkb:Ubiquitously-transcribed TPR protein on the X chromosome(gene name synonym)|uniprotkb:Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6A"(gene name synonym) psi-mi:"MI:0415"(enzymatic study) Hong et al. (2007) pubmed:18003914|doi:10.1073/pnas.0707292104|imex:IM-9435 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15670701|imex:IM-9435-2|dip:DIP-88026E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - refseq:NP_066963.2|ensembl:ENSG00000147050(gene)|ensembl:ENST00000377967(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:O15550|rcsb pdb:3AVR|rcsb pdb:3AVS|rcsb pdb:6FUK|rcsb pdb:6FUL|reactome:R-HSA-3214842|reactome:R-HSA-5617472|ensembl:ENSP00000367203|dip:DIP-46192N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:CLcF0X0dlq40SE0taedCQRq6q84-2 rogid:sqg+Ikkgvz0uT/gMx1wYs9FaDbI9606 rigid:SvfnK32Bw/8rLa5agmDVV4vm4uI false N6,N6-dimethyl-L-lysine:7-7|N6,N6,N6-trimethyl-L-lysine:7-7 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5NCY0 intact:EBI-15670677 intact:EBI-1556564|uniprotkb:Q3UWY9|uniprotkb:Q4VC26|uniprotkb:Q6ZQD3|ensembl:ENSMUSP00000091620 dip:DIP-46193N psi-mi:kdm6b_mouse(display_long)|uniprotkb:JmjC domain-containing protein 3(gene name synonym)|uniprotkb:Jumonji domain-containing protein 3(gene name synonym)|uniprotkb:Kdm6b(gene name)|psi-mi:Kdm6b(display_short)|uniprotkb:Kiaa0346(gene name synonym)|uniprotkb:Jmjd3(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6B"(gene name synonym) psi-mi:h3k27me(display_short)|psi-mi:EBI-15670677(display_long) psi-mi:"MI:0415"(enzymatic study) Hong et al. (2007) pubmed:18003914|doi:10.1073/pnas.0707292104|imex:IM-9435 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15670722|imex:IM-9435-3|dip:DIP-88027E - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) refseq:NP_001017426.1|refseq:XP_011247221.1|refseq:XP_011247222.1|refseq:XP_011247223.1|refseq:XP_011247224.1|refseq:XP_011247225.1|refseq:XP_006532961.1|dip:DIP-39160N|ensembl:ENSMUSG00000018476(gene)|ensembl:ENSMUST00000094077(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0016577"(histone demethylation)|go:"GO:0021766"(hippocampus development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060992"(response to fungicide)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR029518|rcsb pdb:4EYU|rcsb pdb:4EZ4|rcsb pdb:4EZH|reactome:R-MMU-2559580|reactome:R-MMU-3214842|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding) - psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:EsQQ2ByEl/bLaegpLDb/n9Q0WIU10090 rogid:CLcF0X0dlq40SE0taedCQRq6q84-2 rigid:IiFtq6EpeKtvOENTByVqGj5o9xU false - N6,N6-dimethyl-L-lysine:0-0|N6,N6,N6-trimethyl-L-lysine:7-7 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)