#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29067	uniprotkb:P29067	intact:EBI-1636616|ensembl:ENSRNOP00000026207	intact:EBI-1636616|ensembl:ENSRNOP00000026207	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Boularan et al. (2007)	pubmed:17984062|doi:10.1073/pnas.0705550104|imex:IM-22904	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668760|imex:IM-22904-1|dip:DIP-197027E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	rigid:O0z1KT/OZ7mQsQSf/E6d01OTvog	false	enhanced green fluorescent protein tag:n-n	mcherry fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29067	uniprotkb:P29067	intact:EBI-1636616|ensembl:ENSRNOP00000026207	intact:EBI-1636616|ensembl:ENSRNOP00000026207	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Boularan et al. (2007)	pubmed:17984062|doi:10.1073/pnas.0705550104|imex:IM-22904	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668781|imex:IM-22904-2|dip:DIP-197027E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/10	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	rigid:O0z1KT/OZ7mQsQSf/E6d01OTvog	false	flag tag:c-c|mutation disrupting interaction strength:162-162,161-161,158-158|mutation disrupting interaction strength:328-328,326-326,252-252,234-234,232-232	myc tag:n-n|mutation disrupting interaction strength:162-162,161-161,158-158|mutation disrupting interaction strength:328-328,326-326,252-252,234-234,232-232	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29067	uniprotkb:P29067	intact:EBI-1636616|ensembl:ENSRNOP00000026207	intact:EBI-1636616|ensembl:ENSRNOP00000026207	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Boularan et al. (2007)	pubmed:17984062|doi:10.1073/pnas.0705550104|imex:IM-22904	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668826|imex:IM-22904-3|dip:DIP-197027E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	rigid:O0z1KT/OZ7mQsQSf/E6d01OTvog	false	renilla luciferase protein tag:c-c	yellow fluorescent protein tag:c-c|mutation disrupting interaction strength:162-162,161-161,158-158|mutation disrupting interaction strength:328-328,326-326,252-252,234-234,232-232	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29067	uniprotkb:Q00987	intact:EBI-1636616|ensembl:ENSRNOP00000026207	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Boularan et al. (2007)	pubmed:17984062|doi:10.1073/pnas.0705550104|imex:IM-22904	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668859|imex:IM-22904-4|dip:DIP-188574E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	rigid:gIHTVC5MKK/0zXN67FIeTcJTty4	false	yellow fluorescent protein tag:c-c|mutation disrupting interaction strength:162-162,161-161,158-158|mutation disrupting interaction strength:328-328,326-326,252-252,234-234,232-232	renilla luciferase protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29067	uniprotkb:Q00987	intact:EBI-1636616|ensembl:ENSRNOP00000026207	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Boularan et al. (2007)	pubmed:17984062|doi:10.1073/pnas.0705550104|imex:IM-22904	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668915|imex:IM-22904-6|dip:DIP-188574E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	rigid:gIHTVC5MKK/0zXN67FIeTcJTty4	false	mcherry fluorescent protein tag:c-c	enhanced green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21333	uniprotkb:P29067	intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45	intact:EBI-1636616|ensembl:ENSRNOP00000026207	psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Boularan et al. (2007)	pubmed:17984062|doi:10.1073/pnas.0705550104|imex:IM-22904	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668892|imex:IM-22904-5|dip:DIP-197028E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/10	rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	rigid:XSoaT9lqzayH95ehHZMMuofif30	false	sufficient binding region:2363-2647|myc tag:n-n	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q00987	uniprotkb:P29067	intact:EBI-389668|intact:EBI-28980679|ensembl:ENSP00000444430|uniprotkb:A6NL51|uniprotkb:Q13226|uniprotkb:Q13297|uniprotkb:Q13298|uniprotkb:Q13299|uniprotkb:Q13300|uniprotkb:Q13301|uniprotkb:Q53XW0|uniprotkb:Q71TW9|uniprotkb:Q8WYJ1|uniprotkb:Q8WYJ2|uniprotkb:Q9UGI3|uniprotkb:Q9UMT8|uniprotkb:A8K2S6	intact:EBI-1636616|ensembl:ENSRNOP00000026207	psi-mi:mdm2_human(display_long)|uniprotkb:MDM2(gene name)|psi-mi:MDM2(display_short)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:arrb2_rat(display_long)|uniprotkb:Arrb2(gene name)|psi-mi:Arrb2(display_short)|uniprotkb:Arrestin beta-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Boularan et al. (2007)	pubmed:17984062|doi:10.1073/pnas.0705550104|imex:IM-22904	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668936|imex:IM-22904-7|dip:DIP-188574E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135679(gene)|ensembl:ENST00000539479(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENST00000258149|ensembl:ENSP00000258149|ensembl:ENST00000299252|ensembl:ENSP00000299252|ensembl:ENST00000360430|ensembl:ENSP00000353611|ensembl:ENST00000393413|ensembl:ENSP00000377065|ensembl:ENSP00000444430|refseq:NP_001138811.1|refseq:NP_001265391.1|refseq:NP_002383.2|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0036369"(transcription factor catabolic process)|refseq:XP_005268929.1|refseq:XP_006719462.1|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|interpro:IPR044080|mint:Q00987|rcsb pdb:1RV1|rcsb pdb:1T4E|rcsb pdb:1T4F|rcsb pdb:1YCR|rcsb pdb:1Z1M|rcsb pdb:2AXI|rcsb pdb:2C6A|rcsb pdb:2C6B|rcsb pdb:2F1Y|rcsb pdb:2FOP|rcsb pdb:2GV2|rcsb pdb:2HDP|rcsb pdb:2LZG|rcsb pdb:2M86|rcsb pdb:2MPS|rcsb pdb:2RUH|rcsb pdb:2VJE|rcsb pdb:2VJF|rcsb pdb:3EQS|rcsb pdb:3G03|rcsb pdb:3IUX|rcsb pdb:3IWY|rcsb pdb:3JZK|rcsb pdb:3JZR|rcsb pdb:3JZS|rcsb pdb:3LBK|rcsb pdb:3LBL|rcsb pdb:3LNJ|rcsb pdb:3LNZ|rcsb pdb:3MQS|rcsb pdb:3TJ2|rcsb pdb:3TPX|rcsb pdb:3TU1|rcsb pdb:3V3B|rcsb pdb:3VBG|rcsb pdb:3VZV|rcsb pdb:3W69|rcsb pdb:4DIJ|rcsb pdb:4ERE|rcsb pdb:4ERF|rcsb pdb:4HBM|rcsb pdb:4HFZ|rcsb pdb:4HG7|rcsb pdb:4JV7|rcsb pdb:4JV9|rcsb pdb:4JVE|rcsb pdb:4JVR|rcsb pdb:4JWR|rcsb pdb:4MDN|rcsb pdb:4MDQ|rcsb pdb:4OAS|rcsb pdb:4OBA|rcsb pdb:4OCC|rcsb pdb:4ODE|rcsb pdb:4ODF|rcsb pdb:4OGN|rcsb pdb:4OGT|rcsb pdb:4OGV|rcsb pdb:4OQ3|rcsb pdb:4QO4|rcsb pdb:4QOC|rcsb pdb:4UD7|rcsb pdb:4UE1|rcsb pdb:4XXB|rcsb pdb:4ZFI|rcsb pdb:4ZGK|rcsb pdb:4ZYC|rcsb pdb:4ZYF|rcsb pdb:4ZYI|rcsb pdb:5AFG|rcsb pdb:5HMH|rcsb pdb:5HMI|rcsb pdb:5HMK|rcsb pdb:5J7F|rcsb pdb:5J7G|rcsb pdb:5LAV|rcsb pdb:5LAW|rcsb pdb:5C5A|rcsb pdb:5LAY|rcsb pdb:5LAZ|rcsb pdb:5LN2|rcsb pdb:5MNJ|rcsb pdb:5OAI|rcsb pdb:5OC8|rcsb pdb:5SWK|rcsb pdb:5TRF|rcsb pdb:5UMM|rcsb pdb:5VK0|rcsb pdb:5WTS|rcsb pdb:5XXK|rcsb pdb:5Z02|rcsb pdb:5ZXF|rcsb pdb:6AAW|rcsb pdb:6GGN|rcsb pdb:6H22|rcsb pdb:6HFA|rcsb pdb:6I29|rcsb pdb:6I3S|rcsb pdb:6IM9|rcsb pdb:6KZU|rcsb pdb:6Q96|rcsb pdb:6Q9H|rcsb pdb:6Q9L|rcsb pdb:6Q9O|rcsb pdb:6SQO|rcsb pdb:6T2D|rcsb pdb:6T2E|rcsb pdb:6T2F|rcsb pdb:6Y4Q|rcsb pdb:7AD0|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BIR|rcsb pdb:7BIT|rcsb pdb:7BIV|rcsb pdb:7BJ0|rcsb pdb:7BJ6|rcsb pdb:7BMG|reactome:R-HSA-198323|reactome:R-HSA-2559580|reactome:R-HSA-2559585|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-399719|reactome:R-HSA-5674400|reactome:R-HSA-5689880|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69541|reactome:R-HSA-8941858|rcsb pdb:4UMN|rcsb pdb:4WT2|dip:DIP-392N	rgd:2157|refseq:NP_037043.1|dip:DIP-40507N|ensembl:ENSRNOG00000019308(gene)|ensembl:ENSRNOT00000026207(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006897"(endocytosis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|rcsb pdb:6K3F|reactome:R-RNO-418555|reactome:R-RNO-456926|reactome:R-RNO-5099900|reactome:R-RNO-5635838|reactome:R-RNO-5674135|reactome:R-RNO-5689880|reactome:R-RNO-8856825|reactome:R-RNO-8856828	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	-	2017/08/05	2017/08/10	rogid:CFy2L9Et1jFtlApOFn2AKiGPWJ89606	rogid:CmLKfjz9uKH8AcfJcGB/SlhkeuE10116	rigid:gIHTVC5MKK/0zXN67FIeTcJTty4	false	renilla luciferase protein tag:n-n	flag tag:c-c|mutation decreasing interaction strength:162-162,161-161,158-158|mutation decreasing interaction strength:328-328,326-326,252-252,234-234,232-232	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)