#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9VVX3	uniprotkb:Q9VVX3	intact:EBI-118222|uniprotkb:A8JNV7|uniprotkb:Q494J1|uniprotkb:Q94916|uniprotkb:Q9VVX2|intact:EBI-3433048|ensemblmetazoa:FBpp0074795|ensemblmetazoa:FBpp0074796|ensemblmetazoa:FBpp0111803|ensemblmetazoa:FBpp0288861|ensemblmetazoa:FBpp0303227|ensemblmetazoa:FBpp0304981	intact:EBI-118222|uniprotkb:A8JNV7|uniprotkb:Q494J1|uniprotkb:Q94916|uniprotkb:Q9VVX2|intact:EBI-3433048|ensemblmetazoa:FBpp0074795|ensemblmetazoa:FBpp0074796|ensemblmetazoa:FBpp0111803|ensemblmetazoa:FBpp0288861|ensemblmetazoa:FBpp0303227|ensemblmetazoa:FBpp0304981	psi-mi:friz2_drome(display_long)|uniprotkb:CG9739(orf name)|uniprotkb:fz2(gene name)|psi-mi:fz2(display_short)	psi-mi:friz2_drome(display_long)|uniprotkb:CG9739(orf name)|uniprotkb:fz2(gene name)|psi-mi:fz2(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Zhao et al. (2007)	pubmed:17960137|doi:10.1038/nature06225|imex:IM-21847	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668259|imex:IM-21847-1|dip:DIP-192271E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001262036.1|refseq:NP_001262038.1|refseq:NP_001097643.1|refseq:NP_001137971.1|refseq:NP_524155.1|refseq:NP_730389.1|flybase:FBgn0016797|ensemblmetazoa:FBgn0016797(gene)|ensemblmetazoa:FBtr0075028(transcript)|ensemblmetazoa:FBtr0075029(transcript)|ensemblmetazoa:FBtr0112890(transcript)|ensemblmetazoa:FBtr0299586(transcript)|ensemblmetazoa:FBtr0330194(transcript)|ensemblmetazoa:FBtr0332735(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0042685"(cardioblast cell fate specification)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048675"(axon extension)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|reactome:R-DME-209387|reactome:R-DME-209440|reactome:R-DME-209472|reactome:R-DME-4086398|reactome:R-DME-4608870|reactome:R-DME-5140745|dip:DIP-17196N	refseq:NP_001262036.1|refseq:NP_001262038.1|refseq:NP_001097643.1|refseq:NP_001137971.1|refseq:NP_524155.1|refseq:NP_730389.1|flybase:FBgn0016797|ensemblmetazoa:FBgn0016797(gene)|ensemblmetazoa:FBtr0075028(transcript)|ensemblmetazoa:FBtr0075029(transcript)|ensemblmetazoa:FBtr0112890(transcript)|ensemblmetazoa:FBtr0299586(transcript)|ensemblmetazoa:FBtr0330194(transcript)|ensemblmetazoa:FBtr0332735(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0042685"(cardioblast cell fate specification)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048675"(axon extension)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|reactome:R-DME-209387|reactome:R-DME-209440|reactome:R-DME-209472|reactome:R-DME-4086398|reactome:R-DME-4608870|reactome:R-DME-5140745|dip:DIP-17196N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/05	2017/08/10	rogid:DONCeTs13fWZaew7Mv060K0qqjg7227	rogid:DONCeTs13fWZaew7Mv060K0qqjg7227	rigid:93eJ8nIZUTcgT/wPZ6fGPGwNH+o	false	yellow fluorescent protein tag:n-n	cyan fluorescent protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91682	uniprotkb:P91682	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhao et al. (2007)	pubmed:17960137|doi:10.1038/nature06225|imex:IM-21847	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668280|imex:IM-21847-2|dip:DIP-192270E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/05	2017/08/10	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:5GM/cWz3DGRdlI136kvpsKXzBv4	false	sufficient binding region:641-1035	sufficient binding region:641-1035	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91682	uniprotkb:P91682	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2007)	pubmed:17960137|doi:10.1038/nature06225|imex:IM-21847	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668301|imex:IM-21847-3|dip:DIP-192270E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/05	2017/08/10	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:5GM/cWz3DGRdlI136kvpsKXzBv4	false	myc tag:n-n	flag tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91682	uniprotkb:P91682	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Zhao et al. (2007)	pubmed:17960137|doi:10.1038/nature06225|imex:IM-21847	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668322|imex:IM-21847-4|dip:DIP-192270E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/05	2017/08/10	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:5GM/cWz3DGRdlI136kvpsKXzBv4	false	yellow fluorescent protein tag:n-n	cyan fluorescent protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91682	uniprotkb:P91682	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhao et al. (2007)	pubmed:17960137|doi:10.1038/nature06225|imex:IM-21847	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668343|imex:IM-21847-5|dip:DIP-192270E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:5GM/cWz3DGRdlI136kvpsKXzBv4	false	sufficient binding region:860-1035|35s radiolabel:?-?	glutathione s tranferase tag:n-n|sufficient binding region:656-755	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P91682	uniprotkb:P91682	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Zhao et al. (2007)	pubmed:17960137|doi:10.1038/nature06225|imex:IM-21847	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668368|imex:IM-21847-6|dip:DIP-192270E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/05	2017/08/10	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:5GM/cWz3DGRdlI136kvpsKXzBv4	false	yellow fluorescent protein tag:c-c	cyan fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91682	uniprotkb:P91682	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhao et al. (2007)	pubmed:17960137|doi:10.1038/nature06225|imex:IM-21847	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668410|imex:IM-21847-8|dip:DIP-192270E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:5GM/cWz3DGRdlI136kvpsKXzBv4	false	flag tag:n-n|sufficient binding region:860-1035	glutathione s tranferase tag:n-n|sufficient binding region:656-755	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9VVX3	uniprotkb:Q9VVX3	intact:EBI-118222|uniprotkb:A8JNV7|uniprotkb:Q494J1|uniprotkb:Q94916|uniprotkb:Q9VVX2|intact:EBI-3433048|ensemblmetazoa:FBpp0074795|ensemblmetazoa:FBpp0074796|ensemblmetazoa:FBpp0111803|ensemblmetazoa:FBpp0288861|ensemblmetazoa:FBpp0303227|ensemblmetazoa:FBpp0304981	intact:EBI-118222|uniprotkb:A8JNV7|uniprotkb:Q494J1|uniprotkb:Q94916|uniprotkb:Q9VVX2|intact:EBI-3433048|ensemblmetazoa:FBpp0074795|ensemblmetazoa:FBpp0074796|ensemblmetazoa:FBpp0111803|ensemblmetazoa:FBpp0288861|ensemblmetazoa:FBpp0303227|ensemblmetazoa:FBpp0304981	psi-mi:friz2_drome(display_long)|uniprotkb:CG9739(orf name)|uniprotkb:fz2(gene name)|psi-mi:fz2(display_short)	psi-mi:friz2_drome(display_long)|uniprotkb:CG9739(orf name)|uniprotkb:fz2(gene name)|psi-mi:fz2(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Zhao et al. (2007)	pubmed:17960137|doi:10.1038/nature06225|imex:IM-21847	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668389|imex:IM-21847-7|dip:DIP-192271E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001262036.1|refseq:NP_001262038.1|refseq:NP_001097643.1|refseq:NP_001137971.1|refseq:NP_524155.1|refseq:NP_730389.1|flybase:FBgn0016797|ensemblmetazoa:FBgn0016797(gene)|ensemblmetazoa:FBtr0075028(transcript)|ensemblmetazoa:FBtr0075029(transcript)|ensemblmetazoa:FBtr0112890(transcript)|ensemblmetazoa:FBtr0299586(transcript)|ensemblmetazoa:FBtr0330194(transcript)|ensemblmetazoa:FBtr0332735(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0042685"(cardioblast cell fate specification)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048675"(axon extension)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|reactome:R-DME-209387|reactome:R-DME-209440|reactome:R-DME-209472|reactome:R-DME-4086398|reactome:R-DME-4608870|reactome:R-DME-5140745|dip:DIP-17196N	refseq:NP_001262036.1|refseq:NP_001262038.1|refseq:NP_001097643.1|refseq:NP_001137971.1|refseq:NP_524155.1|refseq:NP_730389.1|flybase:FBgn0016797|ensemblmetazoa:FBgn0016797(gene)|ensemblmetazoa:FBtr0075028(transcript)|ensemblmetazoa:FBtr0075029(transcript)|ensemblmetazoa:FBtr0112890(transcript)|ensemblmetazoa:FBtr0299586(transcript)|ensemblmetazoa:FBtr0330194(transcript)|ensemblmetazoa:FBtr0332735(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007494"(midgut development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008585"(female gonad development)|go:"GO:0008587"(imaginal disc-derived wing margin morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016201"(synaptic target inhibition)|go:"GO:0016477"(cell migration)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0035206"(regulation of hemocyte proliferation)|go:"GO:0035293"(chitin-based larval cuticle pattern formation)|go:"GO:0042685"(cardioblast cell fate specification)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048675"(axon extension)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060250"(germ-line stem-cell niche homeostasis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|reactome:R-DME-209387|reactome:R-DME-209440|reactome:R-DME-209472|reactome:R-DME-4086398|reactome:R-DME-4608870|reactome:R-DME-5140745|dip:DIP-17196N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/05	2017/08/10	rogid:DONCeTs13fWZaew7Mv060K0qqjg7227	rogid:DONCeTs13fWZaew7Mv060K0qqjg7227	rigid:93eJ8nIZUTcgT/wPZ6fGPGwNH+o	false	yellow fluorescent protein tag:c-c	cyan fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91682	uniprotkb:P91682	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	intact:EBI-142245|uniprotkb:Q9VPM8|uniprotkb:B7FNK1|ensemblmetazoa:FBpp0077788	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:smo_drome(display_long)|uniprotkb:smo(gene name)|psi-mi:smo(display_short)|uniprotkb:CG11561(orf name)|uniprotkb:dSMO(gene name synonym)|uniprotkb:SMOH(gene name synonym)|uniprotkb:Smooth(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2007)	pubmed:17960137|doi:10.1038/nature06225|imex:IM-21847	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15668435|imex:IM-21847-9|dip:DIP-192270E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	refseq:NP_523443.1|flybase:FBgn0003444|dip:DIP-19956N|ensemblmetazoa:FBgn0003444(gene)|ensemblmetazoa:FBtr0078129(transcript)|go:"GO:0001745"(compound eye morphogenesis)|go:"GO:0001746"(Bolwig's organ morphogenesis)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007350"(blastoderm segmentation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0007417"(central nervous system development)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048099"(anterior/posterior lineage restriction, imaginal disc)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:2MAH|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-216119|reactome:R-DME-216217|reactome:R-DME-5610787|reactome:R-DME-5620922|reactome:R-DME-5635838	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/05	2017/08/10	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rogid:B/9O3wxDY6qY2W709uuH3tz1XTY7227	rigid:5GM/cWz3DGRdlI136kvpsKXzBv4	false	myc tag:n-n	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)