#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P52631	uniprotkb:O13097	intact:EBI-10764775|ensembl:ENSRNOP00000026760	intact:EBI-15667006	psi-mi:stat3_rat(display_long)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)	psi-mi:efnb1_xenla(display_long)|uniprotkb:efnb1(gene name)|psi-mi:efnb1(display_short)|uniprotkb:eplg2(gene name synonym)|uniprotkb:lerk2(gene name synonym)|uniprotkb:ELK ligand(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 2(gene name synonym)|uniprotkb:XlERK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667086|imex:IM-22901-3|dip:DIP-197018E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3772|refseq:NP_036879.1|ensembl:ENSRNOG00000019742(gene)|ensembl:ENSRNOT00000026760(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|reactome:R-RNO-1059683|reactome:R-RNO-1266695|reactome:R-RNO-1433557|reactome:R-RNO-186763|reactome:R-RNO-6783783|reactome:R-RNO-6785807|reactome:R-RNO-8849474|reactome:R-RNO-8854691|reactome:R-RNO-8875791|reactome:R-RNO-8983432|reactome:R-RNO-8984722|reactome:R-RNO-8985947|reactome:R-RNO-9008059|reactome:R-RNO-9020933|reactome:R-RNO-9020956|reactome:R-RNO-9020958|dip:DIP-44909N	interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR001799(Ephrin)|interpro:IPR031328|interpro:IPR034255|go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|refseq:NP_001080948.2|dip:DIP-60983N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:GM7blyTFFn5mrHEH3Sp0Hz+zYFQ10116	rogid:Ex76SRY1od+MUpD+NMc1O6Rc3/M8355	rigid:9Zx7BNB2DCH4tYtwaeP4cOyUS9I	false	ha tag:c-c	mutation decreasing interaction strength:312-312,296-296|mutation decreasing interaction strength:312-312,307-307,296-296	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8AW92	uniprotkb:O13097	intact:EBI-15667028	intact:EBI-15667006	psi-mi:lmo4a_xenla(display_long)|uniprotkb:lmo4-a(gene name)|psi-mi:lmo4-a(display_short)|uniprotkb:lmo4(gene name synonym)|uniprotkb:LIM domain only protein 4-A(gene name synonym)|uniprotkb:Xlmo4(gene name synonym)	psi-mi:efnb1_xenla(display_long)|uniprotkb:efnb1(gene name)|psi-mi:efnb1(display_short)|uniprotkb:eplg2(gene name synonym)|uniprotkb:lerk2(gene name synonym)|uniprotkb:ELK ligand(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 2(gene name synonym)|uniprotkb:XlERK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667114|imex:IM-22901-4|dip:DIP-197013E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003712"(transcription coregulator activity)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0007498"(mesoderm development)|go:"GO:0030154"(cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001079179.1|dip:DIP-60984N	interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR001799(Ephrin)|interpro:IPR031328|interpro:IPR034255|go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|refseq:NP_001080948.2|dip:DIP-60983N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:ngW8D1d68256JUOT0naPk5izbGU8355	rogid:Ex76SRY1od+MUpD+NMc1O6Rc3/M8355	rigid:/19uM8ZuBQpyP1yHtgoE9JQgIfQ	false	ha tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8AW92	uniprotkb:O13097	intact:EBI-15667028	intact:EBI-15667006	psi-mi:lmo4a_xenla(display_long)|uniprotkb:lmo4-a(gene name)|psi-mi:lmo4-a(display_short)|uniprotkb:lmo4(gene name synonym)|uniprotkb:LIM domain only protein 4-A(gene name synonym)|uniprotkb:Xlmo4(gene name synonym)	psi-mi:efnb1_xenla(display_long)|uniprotkb:efnb1(gene name)|psi-mi:efnb1(display_short)|uniprotkb:eplg2(gene name synonym)|uniprotkb:lerk2(gene name synonym)|uniprotkb:ELK ligand(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 2(gene name synonym)|uniprotkb:XlERK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667046|imex:IM-22901-1|dip:DIP-197013E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003712"(transcription coregulator activity)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0007498"(mesoderm development)|go:"GO:0030154"(cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001079179.1|dip:DIP-60984N	interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR001799(Ephrin)|interpro:IPR031328|interpro:IPR034255|go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|refseq:NP_001080948.2|dip:DIP-60983N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:ngW8D1d68256JUOT0naPk5izbGU8355	rogid:Ex76SRY1od+MUpD+NMc1O6Rc3/M8355	rigid:/19uM8ZuBQpyP1yHtgoE9JQgIfQ	false	ha tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P52631	uniprotkb:O13097	intact:EBI-10764775|ensembl:ENSRNOP00000026760	intact:EBI-15667006	psi-mi:stat3_rat(display_long)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)	psi-mi:efnb1_xenla(display_long)|uniprotkb:efnb1(gene name)|psi-mi:efnb1(display_short)|uniprotkb:eplg2(gene name synonym)|uniprotkb:lerk2(gene name synonym)|uniprotkb:ELK ligand(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 2(gene name synonym)|uniprotkb:XlERK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667065|imex:IM-22901-2|dip:DIP-197018E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3772|refseq:NP_036879.1|ensembl:ENSRNOG00000019742(gene)|ensembl:ENSRNOT00000026760(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|reactome:R-RNO-1059683|reactome:R-RNO-1266695|reactome:R-RNO-1433557|reactome:R-RNO-186763|reactome:R-RNO-6783783|reactome:R-RNO-6785807|reactome:R-RNO-8849474|reactome:R-RNO-8854691|reactome:R-RNO-8875791|reactome:R-RNO-8983432|reactome:R-RNO-8984722|reactome:R-RNO-8985947|reactome:R-RNO-9008059|reactome:R-RNO-9020933|reactome:R-RNO-9020956|reactome:R-RNO-9020958|dip:DIP-44909N	interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR001799(Ephrin)|interpro:IPR031328|interpro:IPR034255|go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|refseq:NP_001080948.2|dip:DIP-60983N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:GM7blyTFFn5mrHEH3Sp0Hz+zYFQ10116	rogid:Ex76SRY1od+MUpD+NMc1O6Rc3/M8355	rigid:9Zx7BNB2DCH4tYtwaeP4cOyUS9I	false	ha tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P52632	uniprotkb:O13097	intact:EBI-15667283	intact:EBI-15667006	psi-mi:sta5b_rat(display_long)|uniprotkb:Stat5b(gene name)|psi-mi:Stat5b(display_short)	psi-mi:efnb1_xenla(display_long)|uniprotkb:efnb1(gene name)|psi-mi:efnb1(display_short)|uniprotkb:eplg2(gene name synonym)|uniprotkb:lerk2(gene name synonym)|uniprotkb:ELK ligand(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 2(gene name synonym)|uniprotkb:XlERK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667327|imex:IM-22901-9|dip:DIP-197019E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001553"(luteinization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007548"(sex differentiation)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0019218"(regulation of steroid metabolic process)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019530"(taurine metabolic process)|go:"GO:0019915"(lipid storage)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032825"(positive regulation of natural killer cell differentiation)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046543"(development of secondary female sexual characteristics)|go:"GO:0046544"(development of secondary male sexual characteristics)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070672"(response to interleukin-15)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097531"(mast cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035858|interpro:IPR035886|interpro:IPR036535|interpro:IPR036860|reactome:R-RNO-1266695|reactome:R-RNO-1433557|reactome:R-RNO-186763|reactome:R-RNO-512988|reactome:R-RNO-8854691|reactome:R-RNO-8983432|reactome:R-RNO-8985947|reactome:R-RNO-9020558|reactome:R-RNO-9020958|reactome:R-RNO-982772|rgd:3774|refseq:NP_071775.1|dip:DIP-60986N	interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR001799(Ephrin)|interpro:IPR031328|interpro:IPR034255|go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|refseq:NP_001080948.2|dip:DIP-60983N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:woFuoqDAv1scPI6DjZkwe0iZG+s10116	rogid:Ex76SRY1od+MUpD+NMc1O6Rc3/M8355	rigid:4OxWQMtTPLuwdK/qghuujrHZTNE	false	ha tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:F1M9D6	uniprotkb:O13097	intact:EBI-15667209|ensembl:ENSRNOP00000019465	intact:EBI-15667006	psi-mi:f1m9d6_rat(display_long)|uniprotkb:rCG_22495(orf name)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short)	psi-mi:efnb1_xenla(display_long)|uniprotkb:efnb1(gene name)|psi-mi:efnb1(display_short)|uniprotkb:eplg2(gene name synonym)|uniprotkb:lerk2(gene name synonym)|uniprotkb:ELK ligand(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 2(gene name synonym)|uniprotkb:XlERK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667264|imex:IM-22901-8|dip:DIP-197015E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000014079(gene)|ensembl:ENSRNOT00000019465(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|rgd:3771|refseq:NP_116001.2|dip:DIP-60985N	interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR001799(Ephrin)|interpro:IPR031328|interpro:IPR034255|go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|refseq:NP_001080948.2|dip:DIP-60983N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:awUGjbFWL5AWj+XM9ElMoc5FZJQ10116	rogid:Ex76SRY1od+MUpD+NMc1O6Rc3/M8355	rigid:/QqrHxhSdKTPX+6TmGD730v266o	false	ha tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6PF53	uniprotkb:P52631	intact:EBI-15667173	intact:EBI-10764775|ensembl:ENSRNOP00000026760	psi-mi:q6pf53_xenla(display_long)|uniprotkb:efnb2.L(gene name)|psi-mi:efnb2.L(display_short)|uniprotkb:efnb2(gene name synonym)|uniprotkb:efnb2a(gene name synonym)|uniprotkb:XELAEV_18013082mg(orf name)	psi-mi:stat3_rat(display_long)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667190|imex:IM-22901-7|dip:DIP-197020E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|refseq:NP_001079954.1|dip:DIP-60988N	rgd:3772|refseq:NP_036879.1|ensembl:ENSRNOG00000019742(gene)|ensembl:ENSRNOT00000026760(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|reactome:R-RNO-1059683|reactome:R-RNO-1266695|reactome:R-RNO-1433557|reactome:R-RNO-186763|reactome:R-RNO-6783783|reactome:R-RNO-6785807|reactome:R-RNO-8849474|reactome:R-RNO-8854691|reactome:R-RNO-8875791|reactome:R-RNO-8983432|reactome:R-RNO-8984722|reactome:R-RNO-8985947|reactome:R-RNO-9008059|reactome:R-RNO-9020933|reactome:R-RNO-9020956|reactome:R-RNO-9020958|dip:DIP-44909N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:TMok5XQzJOuXlJc4uLoH8JPw2pU8355	rogid:GM7blyTFFn5mrHEH3Sp0Hz+zYFQ10116	rigid:9161w/XlXmsLax3+Pd6Zaa6vcHQ	false	-	ha tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52631	uniprotkb:O13097	intact:EBI-10764775|ensembl:ENSRNOP00000026760	intact:EBI-15667006	psi-mi:stat3_rat(display_long)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)	psi-mi:efnb1_xenla(display_long)|uniprotkb:efnb1(gene name)|psi-mi:efnb1(display_short)|uniprotkb:eplg2(gene name synonym)|uniprotkb:lerk2(gene name synonym)|uniprotkb:ELK ligand(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 2(gene name synonym)|uniprotkb:XlERK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667152|imex:IM-22901-6|dip:DIP-197018E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3772|refseq:NP_036879.1|ensembl:ENSRNOG00000019742(gene)|ensembl:ENSRNOT00000026760(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|reactome:R-RNO-1059683|reactome:R-RNO-1266695|reactome:R-RNO-1433557|reactome:R-RNO-186763|reactome:R-RNO-6783783|reactome:R-RNO-6785807|reactome:R-RNO-8849474|reactome:R-RNO-8854691|reactome:R-RNO-8875791|reactome:R-RNO-8983432|reactome:R-RNO-8984722|reactome:R-RNO-8985947|reactome:R-RNO-9008059|reactome:R-RNO-9020933|reactome:R-RNO-9020956|reactome:R-RNO-9020958|dip:DIP-44909N	interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR001799(Ephrin)|interpro:IPR031328|interpro:IPR034255|go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|refseq:NP_001080948.2|dip:DIP-60983N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:GM7blyTFFn5mrHEH3Sp0Hz+zYFQ10116	rogid:Ex76SRY1od+MUpD+NMc1O6Rc3/M8355	rigid:9Zx7BNB2DCH4tYtwaeP4cOyUS9I	false	ha tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PF53	uniprotkb:F1M9D6	intact:EBI-15667173	intact:EBI-15667209|ensembl:ENSRNOP00000019465	psi-mi:q6pf53_xenla(display_long)|uniprotkb:efnb2.L(gene name)|psi-mi:efnb2.L(display_short)|uniprotkb:efnb2(gene name synonym)|uniprotkb:efnb2a(gene name synonym)|uniprotkb:XELAEV_18013082mg(orf name)	psi-mi:f1m9d6_rat(display_long)|uniprotkb:rCG_22495(orf name)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667346|imex:IM-22901-10|dip:DIP-197022E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|refseq:NP_001079954.1|dip:DIP-60988N	ensembl:ENSRNOG00000014079(gene)|ensembl:ENSRNOT00000019465(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|rgd:3771|refseq:NP_116001.2|dip:DIP-60985N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:TMok5XQzJOuXlJc4uLoH8JPw2pU8355	rogid:awUGjbFWL5AWj+XM9ElMoc5FZJQ10116	rigid:7wBX8HrqQFj82zFNEDWG1XBbaTk	false	-	ha tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52795	uniprotkb:P52631	intact:EBI-8107507|intact:MINT-1793539|ensembl:ENSMUSP00000050716	intact:EBI-10764775|ensembl:ENSRNOP00000026760	psi-mi:efnb1_mouse(display_long)|uniprotkb:Efnb1(gene name)|psi-mi:Efnb1(display_short)|uniprotkb:Epl2(gene name synonym)|uniprotkb:Eplg2(gene name synonym)|uniprotkb:Lerk2(gene name synonym)|uniprotkb:Stra1(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 2(gene name synonym)|uniprotkb:CEK5 receptor ligand(gene name synonym)|uniprotkb:Stimulated by retinoic acid gene 1 protein(gene name synonym)|uniprotkb:ELK ligand(gene name synonym)|uniprotkb:EFL-3(gene name synonym)	psi-mi:stat3_rat(display_long)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667133|imex:IM-22901-5|dip:DIP-197014E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034240.1|dip:DIP-29206N|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|mint:P52795|rcsb pdb:6P7S|reactome:R-MMU-2682334|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|go:"GO:0099054"(presynapse assembly)|ensembl:ENSMUSG00000031217(gene)|ensembl:ENSMUST00000052839(transcript)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0098978"(glutamatergic synapse)	rgd:3772|refseq:NP_036879.1|ensembl:ENSRNOG00000019742(gene)|ensembl:ENSRNOT00000026760(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|reactome:R-RNO-1059683|reactome:R-RNO-1266695|reactome:R-RNO-1433557|reactome:R-RNO-186763|reactome:R-RNO-6783783|reactome:R-RNO-6785807|reactome:R-RNO-8849474|reactome:R-RNO-8854691|reactome:R-RNO-8875791|reactome:R-RNO-8983432|reactome:R-RNO-8984722|reactome:R-RNO-8985947|reactome:R-RNO-9008059|reactome:R-RNO-9020933|reactome:R-RNO-9020956|reactome:R-RNO-9020958|dip:DIP-44909N	psi-mi:"MI:0465"(dip)	function:Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:Js3TO3daJCJdawFl8NX7HMgbpkM10090	rogid:GM7blyTFFn5mrHEH3Sp0Hz+zYFQ10116	rigid:0a/pLNYhGxsFn+NG7GdHJWZZSjE	false	-	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P52631	uniprotkb:O13097	intact:EBI-10764775|ensembl:ENSRNOP00000026760	intact:EBI-15667006	psi-mi:stat3_rat(display_long)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)	psi-mi:efnb1_xenla(display_long)|uniprotkb:efnb1(gene name)|psi-mi:efnb1(display_short)|uniprotkb:eplg2(gene name synonym)|uniprotkb:lerk2(gene name synonym)|uniprotkb:ELK ligand(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 2(gene name synonym)|uniprotkb:XlERK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667415|imex:IM-22901-13|dip:DIP-197018E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3772|refseq:NP_036879.1|ensembl:ENSRNOG00000019742(gene)|ensembl:ENSRNOT00000026760(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|reactome:R-RNO-1059683|reactome:R-RNO-1266695|reactome:R-RNO-1433557|reactome:R-RNO-186763|reactome:R-RNO-6783783|reactome:R-RNO-6785807|reactome:R-RNO-8849474|reactome:R-RNO-8854691|reactome:R-RNO-8875791|reactome:R-RNO-8983432|reactome:R-RNO-8984722|reactome:R-RNO-8985947|reactome:R-RNO-9008059|reactome:R-RNO-9020933|reactome:R-RNO-9020956|reactome:R-RNO-9020958|dip:DIP-44909N	interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR001799(Ephrin)|interpro:IPR031328|interpro:IPR034255|go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|refseq:NP_001080948.2|dip:DIP-60983N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:GM7blyTFFn5mrHEH3Sp0Hz+zYFQ10116	rogid:Ex76SRY1od+MUpD+NMc1O6Rc3/M8355	rigid:9Zx7BNB2DCH4tYtwaeP4cOyUS9I	false	ha tag:c-c|mutation disrupting interaction strength:609-609	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q62120	uniprotkb:O13097	intact:EBI-646604|uniprotkb:Q7TQD0|uniprotkb:Q62124|intact:EBI-16039126|ensembl:ENSMUSP00000025705|ensembl:ENSMUSP00000064394|ensembl:ENSMUSP00000158242|uniprotkb:G5E852	intact:EBI-15667006	psi-mi:jak2_mouse(display_long)|uniprotkb:Janus kinase 2(gene name synonym)|uniprotkb:Jak2(gene name)|psi-mi:Jak2(display_short)	psi-mi:efnb1_xenla(display_long)|uniprotkb:efnb1(gene name)|psi-mi:efnb1(display_short)|uniprotkb:eplg2(gene name synonym)|uniprotkb:lerk2(gene name synonym)|uniprotkb:ELK ligand(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 2(gene name synonym)|uniprotkb:XlERK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667396|imex:IM-22901-12|dip:DIP-197016E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001041642.1|refseq:NP_032439.2|dip:DIP-320N|ensembl:ENSMUSG00000024789(gene)|ensembl:ENSMUST00000025705(transcript)|ensembl:ENSMUST00000065796(transcript)|ensembl:ENSMUST00000238009(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000791"(euchromatin)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097012"(response to granulocyte macrophage colony-stimulating factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0098794"(postsynapse)|interpro:IPR019749|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031959"(mineralocorticoid receptor signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0020037"(heme binding)|interpro:IPR020693|interpro:IPR035588|interpro:IPR035589|interpro:IPR035860|interpro:IPR035963|interpro:IPR036860|interpro:IPR037838|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:Q62120|rcsb pdb:2HDX|rcsb pdb:4GL9|reactome:R-MMU-1059683|reactome:R-MMU-110056|interpro:IPR020635|reactome:R-MMU-112411|reactome:R-MMU-1170546|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035166"(post-embryonic hemopoiesis)|go:"GO:0035401"("histone kinase activity (H3-Y41 specific)")|go:"GO:0035409"(histone H3-Y41 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034050"(programmed cell death induced by symbiont)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|reactome:R-MMU-512988|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-6785807|reactome:R-MMU-6788467|reactome:R-MMU-69231|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-9020591|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912526|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|reactome:R-MMU-983231|reactome:R-MMU-1433557|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0012505"(endomembrane system)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-60238N|refseq:XP_011245457.1	interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR001799(Ephrin)|interpro:IPR031328|interpro:IPR034255|go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|refseq:NP_001080948.2|dip:DIP-60983N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2021/02/11	rogid:pdjCNCHmNTiJ1gGtJyiWoGgtq4I10090	rogid:Ex76SRY1od+MUpD+NMc1O6Rc3/M8355	rigid:rCcQLwc1nALr+3T4h+SnFc6ucA8	false	ha tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9PT69	uniprotkb:P52631	intact:EBI-15667365	intact:EBI-10764775|ensembl:ENSRNOP00000026760	psi-mi:q9pt69_xenla(display_long)|uniprotkb:efnb3.L(gene name)|psi-mi:efnb3.L(display_short)|uniprotkb:efnb3(gene name synonym)	psi-mi:stat3_rat(display_long)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667377|imex:IM-22901-11|dip:DIP-197021E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|refseq:NP_001079311.1|dip:DIP-60987N	rgd:3772|refseq:NP_036879.1|ensembl:ENSRNOG00000019742(gene)|ensembl:ENSRNOT00000026760(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|reactome:R-RNO-1059683|reactome:R-RNO-1266695|reactome:R-RNO-1433557|reactome:R-RNO-186763|reactome:R-RNO-6783783|reactome:R-RNO-6785807|reactome:R-RNO-8849474|reactome:R-RNO-8854691|reactome:R-RNO-8875791|reactome:R-RNO-8983432|reactome:R-RNO-8984722|reactome:R-RNO-8985947|reactome:R-RNO-9008059|reactome:R-RNO-9020933|reactome:R-RNO-9020956|reactome:R-RNO-9020958|dip:DIP-44909N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:5wCU6fW0RDDP5iOI4exlmUV10BA8355	rogid:GM7blyTFFn5mrHEH3Sp0Hz+zYFQ10116	rigid:BtMG0BDaaiLnW4+Xz/+sF/o0SO4	false	-	ha tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9PT69	uniprotkb:F1M9D6	intact:EBI-15667365	intact:EBI-15667209|ensembl:ENSRNOP00000019465	psi-mi:q9pt69_xenla(display_long)|uniprotkb:efnb3.L(gene name)|psi-mi:efnb3.L(display_short)|uniprotkb:efnb3(gene name synonym)	psi-mi:f1m9d6_rat(display_long)|uniprotkb:rCG_22495(orf name)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667437|imex:IM-22901-14|dip:DIP-197023E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|refseq:NP_001079311.1|dip:DIP-60987N	ensembl:ENSRNOG00000014079(gene)|ensembl:ENSRNOT00000019465(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|rgd:3771|refseq:NP_116001.2|dip:DIP-60985N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:5wCU6fW0RDDP5iOI4exlmUV10BA8355	rogid:awUGjbFWL5AWj+XM9ElMoc5FZJQ10116	rigid:RmheUSQlMEyYNjLoQdBp6H/w9lU	false	-	ha tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P52795	uniprotkb:P42227	intact:EBI-8107507|intact:MINT-1793539|ensembl:ENSMUSP00000050716	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:efnb1_mouse(display_long)|uniprotkb:Efnb1(gene name)|psi-mi:Efnb1(display_short)|uniprotkb:Epl2(gene name synonym)|uniprotkb:Eplg2(gene name synonym)|uniprotkb:Lerk2(gene name synonym)|uniprotkb:Stra1(gene name synonym)|uniprotkb:EPH-related receptor tyrosine kinase ligand 2(gene name synonym)|uniprotkb:CEK5 receptor ligand(gene name synonym)|uniprotkb:Stimulated by retinoic acid gene 1 protein(gene name synonym)|uniprotkb:ELK ligand(gene name synonym)|uniprotkb:EFL-3(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bong et al. (2007)	pubmed:17954917|doi:10.1073/pnas.0702337104|imex:IM-22901	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15667456|imex:IM-22901-15|dip:DIP-197017E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034240.1|dip:DIP-29206N|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR001799(Ephrin)|interpro:IPR008972(Cupredoxin)|interpro:IPR019765|interpro:IPR031328|interpro:IPR034255|mint:P52795|rcsb pdb:6P7S|reactome:R-MMU-2682334|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|go:"GO:0099054"(presynapse assembly)|ensembl:ENSMUSG00000031217(gene)|ensembl:ENSMUST00000052839(transcript)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0098978"(glutamatergic synapse)	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	psi-mi:"MI:0465"(dip)	function:Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:Js3TO3daJCJdawFl8NX7HMgbpkM10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	rigid:jmOdkIO6/dQ7MdsFsmNrZpMVIvk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)