#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UQN3-1 uniprotkb:O75351 intact:EBI-15663586|ensembl:ENSP00000263780 intact:EBI-2514459|ensembl:ENSP00000238497|uniprotkb:Q9GZS7|uniprotkb:Q69HW4 psi-mi:q9uqn3-1(display_long)|uniprotkb:CHMP2B(gene name)|psi-mi:CHMP2B(display_short)|uniprotkb:CHMP2.5(gene name synonym)|uniprotkb:Chromatin-modifying protein 2b(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 2-2(gene name synonym)|uniprotkb:CGI-84(orf name) psi-mi:vps4b_human(display_long)|uniprotkb:VPS4B(gene name)|psi-mi:VPS4B(display_short)|uniprotkb:SKD1(gene name synonym)|uniprotkb:VPS42(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 1"(gene name synonym)|uniprotkb:Cell migration-inducing gene 1 protein(gene name synonym)|uniprotkb:MIG1(orf name) psi-mi:"MI:0077"(nuclear magnetic resonance) Stuchell-Brereton et al. (2007) pubmed:17928862|doi:10.1038/nature06172|imex:IM-21151 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15663595|imex:IM-21151-1|dip:DIP-191023E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000083937(gene)|ensembl:ENST00000263780(transcript)|intact:EBI-718324(isoform-parent) ensembl:ENSG00000119541(gene)|ensembl:ENST00000238497(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033993"(response to lipid)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051261"(protein depolymerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903724"(positive regulation of centriole elongation)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR031255|interpro:IPR036181|interpro:IPR041569|rcsb pdb:1WR0|rcsb pdb:1XWI|rcsb pdb:2CPT|rcsb pdb:2JQH|rcsb pdb:2JQK|rcsb pdb:4U7Y|rcsb pdb:7L9X|reactome:R-HSA-162588|reactome:R-HSA-917729|refseq:NP_004860.2|dip:DIP-53790N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:WmtZzxKkbkLsgFov/DJDKKGvIto9606 rogid:BBEuP035ynUSYZcCp76bTduLz589606 rigid:Y9G1lvxC9Eh7zfrfdkvFQDsTPLg false sufficient binding region:195-213 sufficient binding region:1-86 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7LBR1 uniprotkb:O75351 intact:EBI-2118090|uniprotkb:Q96E89|uniprotkb:Q9HD41|ensembl:ENSP00000432279 intact:EBI-2514459|ensembl:ENSP00000238497|uniprotkb:Q9GZS7|uniprotkb:Q69HW4 psi-mi:chm1b_human(display_long)|uniprotkb:CHMP1B(gene name)|psi-mi:CHMP1B(display_short)|uniprotkb:C18orf2(gene name synonym)|uniprotkb:Chromatin-modifying protein 1b(gene name synonym)|uniprotkb:CHMP1.5(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 46-2(gene name synonym) psi-mi:vps4b_human(display_long)|uniprotkb:VPS4B(gene name)|psi-mi:VPS4B(display_short)|uniprotkb:SKD1(gene name synonym)|uniprotkb:VPS42(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 1"(gene name synonym)|uniprotkb:Cell migration-inducing gene 1 protein(gene name synonym)|uniprotkb:MIG1(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Stuchell-Brereton et al. (2007) pubmed:17928862|doi:10.1038/nature06172|imex:IM-21151 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15663637|imex:IM-21151-3|dip:DIP-191021E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065145.2|ensembl:ENSP00000432279|dip:DIP-48534N|ensembl:ENSG00000255112(gene)|ensembl:ENST00000526991(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030496"(midbody)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0051301"(cell division)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090541"(MIT domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:Q7LBR1|rcsb pdb:3EAB|rcsb pdb:3JC1|rcsb pdb:4TXQ|rcsb pdb:4TXR|rcsb pdb:6E8G|rcsb pdb:6TZ4|rcsb pdb:6TZ5|rcsb pdb:6TZ9 ensembl:ENSG00000119541(gene)|ensembl:ENST00000238497(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033993"(response to lipid)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051261"(protein depolymerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903724"(positive regulation of centriole elongation)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR031255|interpro:IPR036181|interpro:IPR041569|rcsb pdb:1WR0|rcsb pdb:1XWI|rcsb pdb:2CPT|rcsb pdb:2JQH|rcsb pdb:2JQK|rcsb pdb:4U7Y|rcsb pdb:7L9X|reactome:R-HSA-162588|reactome:R-HSA-917729|refseq:NP_004860.2|dip:DIP-53790N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:JBzgWtpzZ/td6JuSSCIx5xpZE7M9606 rogid:BBEuP035ynUSYZcCp76bTduLz589606 rigid:Ylc3fIc9e2A5sSitnQD6DuJxh0M false sufficient binding region:180-196|mutation decreasing interaction strength:192-192|mutation decreasing interaction strength:188-188 sufficient binding region:1-86 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQN3-1 uniprotkb:Q9UN37 intact:EBI-15663586|ensembl:ENSP00000263780 intact:EBI-1171942|uniprotkb:Q8TF07|uniprotkb:Q9UI03|uniprotkb:Q9Y582|uniprotkb:B2RCB7|ensembl:ENSP00000254950 psi-mi:q9uqn3-1(display_long)|uniprotkb:CHMP2B(gene name)|psi-mi:CHMP2B(display_short)|uniprotkb:CHMP2.5(gene name synonym)|uniprotkb:Chromatin-modifying protein 2b(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 2-2(gene name synonym)|uniprotkb:CGI-84(orf name) psi-mi:vps4a_human(display_long)|uniprotkb:VPS4-1(gene name synonym)|uniprotkb:Protein SKD2(gene name synonym)|uniprotkb:VPS4A(gene name)|psi-mi:VPS4A(display_short)|uniprotkb:VPS4(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Stuchell-Brereton et al. (2007) pubmed:17928862|doi:10.1038/nature06172|imex:IM-21151 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15663616|imex:IM-21151-2|dip:DIP-191025E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000083937(gene)|ensembl:ENST00000263780(transcript)|intact:EBI-718324(isoform-parent) refseq:NP_037377.1|ensembl:ENSG00000132612(gene)|ensembl:ENST00000254950(transcript)|go:"GO:0000916"(actomyosin contractile ring contraction)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009838"(abscission)|go:"GO:0010008"(endosome membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072319"(vesicle uncoating)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:1904896"(ESCRT complex disassembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR036181|interpro:IPR041569|mint:Q9UN37|rcsb pdb:1YXR|rcsb pdb:2JQ9|rcsb pdb:2K3W|reactome:R-HSA-162588|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9668328|interpro:IPR031255|dip:DIP-44585N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:WmtZzxKkbkLsgFov/DJDKKGvIto9606 rogid:kr3zmre/ELTm2b/fCytp8IlBUhs9606 rigid:kx7awWakdJPEltXmJ4Fl5WFzjSE false sufficient binding region:195-213 sufficient binding region:1-84 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UN37 uniprotkb:Q9HD42-1 intact:EBI-1171942|uniprotkb:Q8TF07|uniprotkb:Q9UI03|uniprotkb:Q9Y582|uniprotkb:B2RCB7|ensembl:ENSP00000254950 intact:EBI-15663713|ensembl:ENSP00000380998 psi-mi:vps4a_human(display_long)|uniprotkb:VPS4-1(gene name synonym)|uniprotkb:Protein SKD2(gene name synonym)|uniprotkb:VPS4A(gene name)|psi-mi:VPS4A(display_short)|uniprotkb:VPS4(gene name synonym) psi-mi:q9hd42-1(display_long)|uniprotkb:CHMP1A(gene name)|psi-mi:CHMP1A(display_short)|uniprotkb:CHMP1(gene name synonym)|uniprotkb:KIAA0047(gene name synonym)|uniprotkb:PCOLN3(gene name synonym)|uniprotkb:PRSM1(gene name synonym)|uniprotkb:Chromatin-modifying protein 1a(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 46-1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Stuchell-Brereton et al. (2007) pubmed:17928862|doi:10.1038/nature06172|imex:IM-21151 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15663746|imex:IM-21151-7|dip:DIP-191024E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037377.1|ensembl:ENSG00000132612(gene)|ensembl:ENST00000254950(transcript)|go:"GO:0000916"(actomyosin contractile ring contraction)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009838"(abscission)|go:"GO:0010008"(endosome membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072319"(vesicle uncoating)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:1904896"(ESCRT complex disassembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR036181|interpro:IPR041569|mint:Q9UN37|rcsb pdb:1YXR|rcsb pdb:2JQ9|rcsb pdb:2K3W|reactome:R-HSA-162588|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9668328|interpro:IPR031255|dip:DIP-44585N ensembl:ENSG00000131165(gene)|ensembl:ENST00000397901(transcript)|intact:EBI-1057156(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:kr3zmre/ELTm2b/fCytp8IlBUhs9606 rogid:w7fMwItYOqS/JXLy+8DWcJBaEPE9606 rigid:ln5myipTb/36uDM16fnjRTYropI false sufficient binding region:1-84 sufficient binding region:180-196 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UN37 uniprotkb:Q9HD42-1 intact:EBI-1171942|uniprotkb:Q8TF07|uniprotkb:Q9UI03|uniprotkb:Q9Y582|uniprotkb:B2RCB7|ensembl:ENSP00000254950 intact:EBI-15663713|ensembl:ENSP00000380998 psi-mi:vps4a_human(display_long)|uniprotkb:VPS4-1(gene name synonym)|uniprotkb:Protein SKD2(gene name synonym)|uniprotkb:VPS4A(gene name)|psi-mi:VPS4A(display_short)|uniprotkb:VPS4(gene name synonym) psi-mi:q9hd42-1(display_long)|uniprotkb:CHMP1A(gene name)|psi-mi:CHMP1A(display_short)|uniprotkb:CHMP1(gene name synonym)|uniprotkb:KIAA0047(gene name synonym)|uniprotkb:PCOLN3(gene name synonym)|uniprotkb:PRSM1(gene name synonym)|uniprotkb:Chromatin-modifying protein 1a(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 46-1(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Stuchell-Brereton et al. (2007) pubmed:17928862|doi:10.1038/nature06172|imex:IM-21151 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15663725|imex:IM-21151-6|dip:DIP-191024E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037377.1|ensembl:ENSG00000132612(gene)|ensembl:ENST00000254950(transcript)|go:"GO:0000916"(actomyosin contractile ring contraction)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009838"(abscission)|go:"GO:0010008"(endosome membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072319"(vesicle uncoating)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:1904896"(ESCRT complex disassembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR036181|interpro:IPR041569|mint:Q9UN37|rcsb pdb:1YXR|rcsb pdb:2JQ9|rcsb pdb:2K3W|reactome:R-HSA-162588|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9668328|interpro:IPR031255|dip:DIP-44585N ensembl:ENSG00000131165(gene)|ensembl:ENST00000397901(transcript)|intact:EBI-1057156(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:kr3zmre/ELTm2b/fCytp8IlBUhs9606 rogid:w7fMwItYOqS/JXLy+8DWcJBaEPE9606 rigid:ln5myipTb/36uDM16fnjRTYropI false sufficient binding region:1-84 sufficient binding region:180-196 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7LBR1 uniprotkb:Q9UN37 intact:EBI-2118090|uniprotkb:Q96E89|uniprotkb:Q9HD41|ensembl:ENSP00000432279 intact:EBI-1171942|uniprotkb:Q8TF07|uniprotkb:Q9UI03|uniprotkb:Q9Y582|uniprotkb:B2RCB7|ensembl:ENSP00000254950 psi-mi:chm1b_human(display_long)|uniprotkb:CHMP1B(gene name)|psi-mi:CHMP1B(display_short)|uniprotkb:C18orf2(gene name synonym)|uniprotkb:Chromatin-modifying protein 1b(gene name synonym)|uniprotkb:CHMP1.5(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 46-2(gene name synonym) psi-mi:vps4a_human(display_long)|uniprotkb:VPS4-1(gene name synonym)|uniprotkb:Protein SKD2(gene name synonym)|uniprotkb:VPS4A(gene name)|psi-mi:VPS4A(display_short)|uniprotkb:VPS4(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Stuchell-Brereton et al. (2007) pubmed:17928862|doi:10.1038/nature06172|imex:IM-21151 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15663685|imex:IM-21151-5|dip:DIP-191026E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065145.2|ensembl:ENSP00000432279|dip:DIP-48534N|ensembl:ENSG00000255112(gene)|ensembl:ENST00000526991(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030496"(midbody)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0051301"(cell division)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090541"(MIT domain binding)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR005024(Snf7)|mint:Q7LBR1|rcsb pdb:3EAB|rcsb pdb:3JC1|rcsb pdb:4TXQ|rcsb pdb:4TXR|rcsb pdb:6E8G|rcsb pdb:6TZ4|rcsb pdb:6TZ5|rcsb pdb:6TZ9 refseq:NP_037377.1|ensembl:ENSG00000132612(gene)|ensembl:ENST00000254950(transcript)|go:"GO:0000916"(actomyosin contractile ring contraction)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009838"(abscission)|go:"GO:0010008"(endosome membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072319"(vesicle uncoating)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:1904896"(ESCRT complex disassembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR036181|interpro:IPR041569|mint:Q9UN37|rcsb pdb:1YXR|rcsb pdb:2JQ9|rcsb pdb:2K3W|reactome:R-HSA-162588|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9668328|interpro:IPR031255|dip:DIP-44585N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:JBzgWtpzZ/td6JuSSCIx5xpZE7M9606 rogid:kr3zmre/ELTm2b/fCytp8IlBUhs9606 rigid:9zoElbU8XlCGvTggvatJ1RtY6bk false sufficient binding region:180-196 sufficient binding region:1-84|mutation disrupting interaction strength:64-64|mutation decreasing interaction strength:64-64 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UQN3-1 uniprotkb:O75351 intact:EBI-15663586|ensembl:ENSP00000263780 intact:EBI-2514459|ensembl:ENSP00000238497|uniprotkb:Q9GZS7|uniprotkb:Q69HW4 psi-mi:q9uqn3-1(display_long)|uniprotkb:CHMP2B(gene name)|psi-mi:CHMP2B(display_short)|uniprotkb:CHMP2.5(gene name synonym)|uniprotkb:Chromatin-modifying protein 2b(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 2-2(gene name synonym)|uniprotkb:CGI-84(orf name) psi-mi:vps4b_human(display_long)|uniprotkb:VPS4B(gene name)|psi-mi:VPS4B(display_short)|uniprotkb:SKD1(gene name synonym)|uniprotkb:VPS42(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 1"(gene name synonym)|uniprotkb:Cell migration-inducing gene 1 protein(gene name synonym)|uniprotkb:MIG1(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Stuchell-Brereton et al. (2007) pubmed:17928862|doi:10.1038/nature06172|imex:IM-21151 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15663664|imex:IM-21151-4|dip:DIP-191023E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000083937(gene)|ensembl:ENST00000263780(transcript)|intact:EBI-718324(isoform-parent) ensembl:ENSG00000119541(gene)|ensembl:ENST00000238497(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033993"(response to lipid)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051261"(protein depolymerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903724"(positive regulation of centriole elongation)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR031255|interpro:IPR036181|interpro:IPR041569|rcsb pdb:1WR0|rcsb pdb:1XWI|rcsb pdb:2CPT|rcsb pdb:2JQH|rcsb pdb:2JQK|rcsb pdb:4U7Y|rcsb pdb:7L9X|reactome:R-HSA-162588|reactome:R-HSA-917729|refseq:NP_004860.2|dip:DIP-53790N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:WmtZzxKkbkLsgFov/DJDKKGvIto9606 rogid:BBEuP035ynUSYZcCp76bTduLz589606 rigid:Y9G1lvxC9Eh7zfrfdkvFQDsTPLg false sufficient binding region:195-213 sufficient binding region:1-86 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HD42-1 uniprotkb:O75351 intact:EBI-15663713|ensembl:ENSP00000380998 intact:EBI-2514459|ensembl:ENSP00000238497|uniprotkb:Q9GZS7|uniprotkb:Q69HW4 psi-mi:q9hd42-1(display_long)|uniprotkb:CHMP1A(gene name)|psi-mi:CHMP1A(display_short)|uniprotkb:CHMP1(gene name synonym)|uniprotkb:KIAA0047(gene name synonym)|uniprotkb:PCOLN3(gene name synonym)|uniprotkb:PRSM1(gene name synonym)|uniprotkb:Chromatin-modifying protein 1a(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 46-1(gene name synonym) psi-mi:vps4b_human(display_long)|uniprotkb:VPS4B(gene name)|psi-mi:VPS4B(display_short)|uniprotkb:SKD1(gene name synonym)|uniprotkb:VPS42(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 1"(gene name synonym)|uniprotkb:Cell migration-inducing gene 1 protein(gene name synonym)|uniprotkb:MIG1(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Stuchell-Brereton et al. (2007) pubmed:17928862|doi:10.1038/nature06172|imex:IM-21151 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15663767|imex:IM-21151-8|dip:DIP-191022E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000131165(gene)|ensembl:ENST00000397901(transcript)|intact:EBI-1057156(isoform-parent) ensembl:ENSG00000119541(gene)|ensembl:ENST00000238497(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033993"(response to lipid)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051261"(protein depolymerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903724"(positive regulation of centriole elongation)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR031255|interpro:IPR036181|interpro:IPR041569|rcsb pdb:1WR0|rcsb pdb:1XWI|rcsb pdb:2CPT|rcsb pdb:2JQH|rcsb pdb:2JQK|rcsb pdb:4U7Y|rcsb pdb:7L9X|reactome:R-HSA-162588|reactome:R-HSA-917729|refseq:NP_004860.2|dip:DIP-53790N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:w7fMwItYOqS/JXLy+8DWcJBaEPE9606 rogid:BBEuP035ynUSYZcCp76bTduLz589606 rigid:KalNblxZ9Mg+1JysXmVO9zZ+Hz8 false sufficient binding region:180-196 sufficient binding region:1-86 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)