#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8AXF4	uniprotkb:P51812	intact:EBI-8609042|uniprotkb:Q9PTL8|intact:MINT-8176781	intact:EBI-1046616|ensembl:ENSP00000368884|uniprotkb:Q4VAP3|uniprotkb:Q59H26|uniprotkb:Q5JPK8|uniprotkb:Q7Z3Z7|uniprotkb:B2R9V4	psi-mi:fbx43_xenla(display_long)|uniprotkb:fbxo43(gene name)|psi-mi:fbxo43(display_short)|uniprotkb:emi2(gene name synonym)|uniprotkb:erp1(gene name synonym)|uniprotkb:fbx26(gene name synonym)|uniprotkb:Early mitotic inhibitor 2(gene name synonym)|uniprotkb:Emi1-related protein 1(gene name synonym)|uniprotkb:F-box protein 26(gene name synonym)|uniprotkb:Xerp1(gene name synonym)	psi-mi:ks6a3_human(display_long)|uniprotkb:Insulin-stimulated protein kinase 1(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1b(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 3(gene name synonym)|uniprotkb:MAPKAPK1B(gene name synonym)|uniprotkb:Ribosomal S6 kinase 2(gene name synonym)|uniprotkb:pp90RSK2(gene name synonym)|uniprotkb:RPS6KA3(gene name)|psi-mi:RPS6KA3(display_short)|uniprotkb:ISPK1(gene name synonym)|uniprotkb:RSK2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Wu et al. (2007)	pubmed:17881560|doi:10.1073/pnas.0707537104|imex:IM-9463	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15659435|imex:IM-9463-1|dip:DIP-88069E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016567"(protein ubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR044064|refseq:NP_001093338.1|refseq:XP_018121628.1|dip:DIP-46217N	go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043555"(regulation of translation in response to stress)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0045202"(synapse)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|ensembl:ENSG00000177189(gene)|ensembl:ENST00000379565(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|refseq:NP_004577.1|interpro:IPR041905|interpro:IPR041906|mint:P51812|rcsb pdb:4D9T|rcsb pdb:4D9U|rcsb pdb:4JG6|rcsb pdb:4JG7|rcsb pdb:4JG8|rcsb pdb:4NUS|rcsb pdb:4NW5|rcsb pdb:4NW6|rcsb pdb:5D9K|rcsb pdb:5D9L|reactome:R-HSA-198753|reactome:R-HSA-199920|reactome:R-HSA-2559582|reactome:R-HSA-437239|reactome:R-HSA-442742|reactome:R-HSA-444257|reactome:R-HSA-881907|dip:DIP-38247N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:/ZtkR0XR14Vbd25kJFWs1OHIfwQ8355	rogid:zkX8NPvSEjVEap7TxboH2SKy9zg9606	rigid:C8lTn+eKmtweztN96/cEJbCOrco	false	binding-associated region:1-350	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8AXF4	uniprotkb:Q6IRD3	intact:EBI-8609042|uniprotkb:Q9PTL8|intact:MINT-8176781	intact:EBI-15659454	psi-mi:fbx43_xenla(display_long)|uniprotkb:fbxo43(gene name)|psi-mi:fbxo43(display_short)|uniprotkb:emi2(gene name synonym)|uniprotkb:erp1(gene name synonym)|uniprotkb:fbx26(gene name synonym)|uniprotkb:Early mitotic inhibitor 2(gene name synonym)|uniprotkb:Emi1-related protein 1(gene name synonym)|uniprotkb:F-box protein 26(gene name synonym)|uniprotkb:Xerp1(gene name synonym)	psi-mi:q6ird3_xenla(display_long)|uniprotkb:ppp2r2a.S(gene name)|psi-mi:ppp2r2a.S(display_short)|uniprotkb:PP2A(gene name synonym)|uniprotkb:ppp2r2a(gene name synonym)|uniprotkb:XELAEV_18020223mg(orf name)	psi-mi:"MI:0096"(pull down)	Wu et al. (2007)	pubmed:17881560|doi:10.1073/pnas.0707537104|imex:IM-9463	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15659470|imex:IM-9463-2|dip:DIP-88070E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016567"(protein ubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR044064|refseq:NP_001093338.1|refseq:XP_018121628.1|dip:DIP-46217N	go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0019888"(protein phosphatase regulator activity)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|refseq:NP_001084138.1|dip:DIP-46218N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:/ZtkR0XR14Vbd25kJFWs1OHIfwQ8355	rogid:6Xul5xn8R+ndkPVgJ0+JgHhW4jE8355	rigid:bntHrlGl5k30SMRCGP7ib01Et4c	false	binding-associated region:1-350|maltose binding protein tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8AXF4	uniprotkb:Q6IRD3	intact:EBI-8609042|uniprotkb:Q9PTL8|intact:MINT-8176781	intact:EBI-15659454	psi-mi:fbx43_xenla(display_long)|uniprotkb:fbxo43(gene name)|psi-mi:fbxo43(display_short)|uniprotkb:emi2(gene name synonym)|uniprotkb:erp1(gene name synonym)|uniprotkb:fbx26(gene name synonym)|uniprotkb:Early mitotic inhibitor 2(gene name synonym)|uniprotkb:Emi1-related protein 1(gene name synonym)|uniprotkb:F-box protein 26(gene name synonym)|uniprotkb:Xerp1(gene name synonym)	psi-mi:q6ird3_xenla(display_long)|uniprotkb:ppp2r2a.S(gene name)|psi-mi:ppp2r2a.S(display_short)|uniprotkb:PP2A(gene name synonym)|uniprotkb:ppp2r2a(gene name synonym)|uniprotkb:XELAEV_18020223mg(orf name)	psi-mi:"MI:0096"(pull down)	Wu et al. (2007)	pubmed:17881560|doi:10.1073/pnas.0707537104|imex:IM-9463	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15659491|imex:IM-9463-3|dip:DIP-88070E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016567"(protein ubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR044064|refseq:NP_001093338.1|refseq:XP_018121628.1|dip:DIP-46217N	go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0019888"(protein phosphatase regulator activity)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018067|interpro:IPR036322|refseq:NP_001084138.1|dip:DIP-46218N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:/ZtkR0XR14Vbd25kJFWs1OHIfwQ8355	rogid:6Xul5xn8R+ndkPVgJ0+JgHhW4jE8355	rigid:bntHrlGl5k30SMRCGP7ib01Et4c	false	binding-associated region:1-350|tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)