#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43741	uniprotkb:P80385	intact:EBI-1053424|uniprotkb:Q5VXY0|uniprotkb:B4DH06|uniprotkb:A8K9V5|ensembl:ENSP00000254101	intact:EBI-918056|uniprotkb:Q4QQW6|ensembl:ENSRNOP00000070458	psi-mi:aakb2_human(display_long)|uniprotkb:PRKAB2(gene name)|psi-mi:PRKAB2(display_short)	psi-mi:aakg1_rat(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)	psi-mi:"MI:0071"(molecular sieving)	Xiao et al. (2007)	pubmed:17851531|doi:10.1038/nature06161|imex:IM-21155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15658259|imex:IM-21155-1|dip:DIP-187264E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005390.1|ensembl:ENSG00000131791(gene)|ensembl:ENST00000254101(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:O43741|rcsb pdb:2F15|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:6B2E|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|interpro:IPR014756(Immunoglobulin E-set)|dip:DIP-39763N	rgd:3388|refseq:NP_037142.1|dip:DIP-37278N|ensembl:ENSRNOG00000061499(gene)|ensembl:ENSRNOT00000083354(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAG|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4EAK|rcsb pdb:4EAL|rcsb pdb:4QFG|rcsb pdb:4QFR|rcsb pdb:4QFS|rcsb pdb:5KQ5|rcsb pdb:5T5T|rcsb pdb:5UFU|rcsb pdb:6E4T|rcsb pdb:6E4U|rcsb pdb:6E4W|reactome:R-RNO-1632852|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:GYLp/VWkcEC1mJcrg0gtIQ99DVg9606	rogid:uryb9rfseg81E/x+FC3Cecf2FnI10116	rigid:n+5l7SVNpbizFYuvbMRjtR2UVXQ	false	sufficient binding region:187-272	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43741	uniprotkb:P54645	intact:EBI-1053424|uniprotkb:Q5VXY0|uniprotkb:B4DH06|uniprotkb:A8K9V5|ensembl:ENSP00000254101	intact:EBI-7596967|intact:MINT-4566241|ensembl:ENSRNOP00000017626	psi-mi:aakb2_human(display_long)|uniprotkb:PRKAB2(gene name)|psi-mi:PRKAB2(display_short)	psi-mi:aapk1_rat(display_long)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)|uniprotkb:Ampk1(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Xiao et al. (2007)	pubmed:17851531|doi:10.1038/nature06161|imex:IM-21155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15658259|imex:IM-21155-1|dip:DIP-187264E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005390.1|ensembl:ENSG00000131791(gene)|ensembl:ENST00000254101(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:O43741|rcsb pdb:2F15|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:6B2E|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|interpro:IPR014756(Immunoglobulin E-set)|dip:DIP-39763N	rgd:3387|refseq:NP_062015.2|ensembl:ENSRNOG00000012799(gene)|ensembl:ENSRNOT00000017626(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042557"(eukaryotic elongation factor-2 kinase activator activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:P54645|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4EAK|rcsb pdb:4EAL|rcsb pdb:4F2L|rcsb pdb:4QFG|rcsb pdb:4QFR|rcsb pdb:4QFS|rcsb pdb:5KQ5|rcsb pdb:5T5T|rcsb pdb:5UFU|rcsb pdb:6E4T|rcsb pdb:6E4U|rcsb pdb:6E4W|reactome:R-RNO-1632852|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756|dip:DIP-57168N	psi-mi:"MI:0465"(dip)	-	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:GYLp/VWkcEC1mJcrg0gtIQ99DVg9606	rogid:6ENmHVb5EI3JOKaf/gUMI7w2aqQ10116	rigid:n+5l7SVNpbizFYuvbMRjtR2UVXQ	false	sufficient binding region:187-272	sufficient binding region:407-559	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43741	uniprotkb:P80385	intact:EBI-1053424|uniprotkb:Q5VXY0|uniprotkb:B4DH06|uniprotkb:A8K9V5|ensembl:ENSP00000254101	intact:EBI-918056|uniprotkb:Q4QQW6|ensembl:ENSRNOP00000070458	psi-mi:aakb2_human(display_long)|uniprotkb:PRKAB2(gene name)|psi-mi:PRKAB2(display_short)	psi-mi:aakg1_rat(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Xiao et al. (2007)	pubmed:17851531|doi:10.1038/nature06161|imex:IM-21155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15658284|imex:IM-21155-2|dip:DIP-187264E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005390.1|ensembl:ENSG00000131791(gene)|ensembl:ENST00000254101(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:O43741|rcsb pdb:2F15|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:6B2E|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|interpro:IPR014756(Immunoglobulin E-set)|dip:DIP-39763N	rgd:3388|refseq:NP_037142.1|dip:DIP-37278N|ensembl:ENSRNOG00000061499(gene)|ensembl:ENSRNOT00000083354(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAG|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4EAK|rcsb pdb:4EAL|rcsb pdb:4QFG|rcsb pdb:4QFR|rcsb pdb:4QFS|rcsb pdb:5KQ5|rcsb pdb:5T5T|rcsb pdb:5UFU|rcsb pdb:6E4T|rcsb pdb:6E4U|rcsb pdb:6E4W|reactome:R-RNO-1632852|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:GYLp/VWkcEC1mJcrg0gtIQ99DVg9606	rogid:uryb9rfseg81E/x+FC3Cecf2FnI10116	rigid:n+5l7SVNpbizFYuvbMRjtR2UVXQ	false	sufficient binding region:187-272	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43741	uniprotkb:P54645	intact:EBI-1053424|uniprotkb:Q5VXY0|uniprotkb:B4DH06|uniprotkb:A8K9V5|ensembl:ENSP00000254101	intact:EBI-7596967|intact:MINT-4566241|ensembl:ENSRNOP00000017626	psi-mi:aakb2_human(display_long)|uniprotkb:PRKAB2(gene name)|psi-mi:PRKAB2(display_short)	psi-mi:aapk1_rat(display_long)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)|uniprotkb:Ampk1(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Xiao et al. (2007)	pubmed:17851531|doi:10.1038/nature06161|imex:IM-21155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15658284|imex:IM-21155-2|dip:DIP-187264E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005390.1|ensembl:ENSG00000131791(gene)|ensembl:ENST00000254101(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:O43741|rcsb pdb:2F15|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:6B2E|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|interpro:IPR014756(Immunoglobulin E-set)|dip:DIP-39763N	rgd:3387|refseq:NP_062015.2|ensembl:ENSRNOG00000012799(gene)|ensembl:ENSRNOT00000017626(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042557"(eukaryotic elongation factor-2 kinase activator activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:P54645|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4EAK|rcsb pdb:4EAL|rcsb pdb:4F2L|rcsb pdb:4QFG|rcsb pdb:4QFR|rcsb pdb:4QFS|rcsb pdb:5KQ5|rcsb pdb:5T5T|rcsb pdb:5UFU|rcsb pdb:6E4T|rcsb pdb:6E4U|rcsb pdb:6E4W|reactome:R-RNO-1632852|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756|dip:DIP-57168N	psi-mi:"MI:0465"(dip)	-	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:GYLp/VWkcEC1mJcrg0gtIQ99DVg9606	rogid:6ENmHVb5EI3JOKaf/gUMI7w2aqQ10116	rigid:n+5l7SVNpbizFYuvbMRjtR2UVXQ	false	sufficient binding region:187-272	sufficient binding region:407-559	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43741	uniprotkb:P80385	intact:EBI-1053424|uniprotkb:Q5VXY0|uniprotkb:B4DH06|uniprotkb:A8K9V5|ensembl:ENSP00000254101	intact:EBI-918056|uniprotkb:Q4QQW6|ensembl:ENSRNOP00000070458	psi-mi:aakb2_human(display_long)|uniprotkb:PRKAB2(gene name)|psi-mi:PRKAB2(display_short)	psi-mi:aakg1_rat(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)	psi-mi:"MI:0067"(light scattering)	Xiao et al. (2007)	pubmed:17851531|doi:10.1038/nature06161|imex:IM-21155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15658306|imex:IM-21155-3|dip:DIP-187264E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005390.1|ensembl:ENSG00000131791(gene)|ensembl:ENST00000254101(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:O43741|rcsb pdb:2F15|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:6B2E|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|interpro:IPR014756(Immunoglobulin E-set)|dip:DIP-39763N	rgd:3388|refseq:NP_037142.1|dip:DIP-37278N|ensembl:ENSRNOG00000061499(gene)|ensembl:ENSRNOT00000083354(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAG|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4EAK|rcsb pdb:4EAL|rcsb pdb:4QFG|rcsb pdb:4QFR|rcsb pdb:4QFS|rcsb pdb:5KQ5|rcsb pdb:5T5T|rcsb pdb:5UFU|rcsb pdb:6E4T|rcsb pdb:6E4U|rcsb pdb:6E4W|reactome:R-RNO-1632852|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:GYLp/VWkcEC1mJcrg0gtIQ99DVg9606	rogid:uryb9rfseg81E/x+FC3Cecf2FnI10116	rigid:n+5l7SVNpbizFYuvbMRjtR2UVXQ	false	sufficient binding region:187-272	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43741	uniprotkb:P54645	intact:EBI-1053424|uniprotkb:Q5VXY0|uniprotkb:B4DH06|uniprotkb:A8K9V5|ensembl:ENSP00000254101	intact:EBI-7596967|intact:MINT-4566241|ensembl:ENSRNOP00000017626	psi-mi:aakb2_human(display_long)|uniprotkb:PRKAB2(gene name)|psi-mi:PRKAB2(display_short)	psi-mi:aapk1_rat(display_long)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)|uniprotkb:Ampk1(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)	psi-mi:"MI:0067"(light scattering)	Xiao et al. (2007)	pubmed:17851531|doi:10.1038/nature06161|imex:IM-21155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15658306|imex:IM-21155-3|dip:DIP-187264E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005390.1|ensembl:ENSG00000131791(gene)|ensembl:ENST00000254101(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:O43741|rcsb pdb:2F15|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:6B2E|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|interpro:IPR014756(Immunoglobulin E-set)|dip:DIP-39763N	rgd:3387|refseq:NP_062015.2|ensembl:ENSRNOG00000012799(gene)|ensembl:ENSRNOT00000017626(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042557"(eukaryotic elongation factor-2 kinase activator activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:P54645|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4EAK|rcsb pdb:4EAL|rcsb pdb:4F2L|rcsb pdb:4QFG|rcsb pdb:4QFR|rcsb pdb:4QFS|rcsb pdb:5KQ5|rcsb pdb:5T5T|rcsb pdb:5UFU|rcsb pdb:6E4T|rcsb pdb:6E4U|rcsb pdb:6E4W|reactome:R-RNO-1632852|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756|dip:DIP-57168N	psi-mi:"MI:0465"(dip)	-	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:GYLp/VWkcEC1mJcrg0gtIQ99DVg9606	rogid:6ENmHVb5EI3JOKaf/gUMI7w2aqQ10116	rigid:n+5l7SVNpbizFYuvbMRjtR2UVXQ	false	sufficient binding region:187-272	sufficient binding region:407-559	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43741	uniprotkb:P80385	intact:EBI-1053424|uniprotkb:Q5VXY0|uniprotkb:B4DH06|uniprotkb:A8K9V5|ensembl:ENSP00000254101	intact:EBI-918056|uniprotkb:Q4QQW6|ensembl:ENSRNOP00000070458	psi-mi:aakb2_human(display_long)|uniprotkb:PRKAB2(gene name)|psi-mi:PRKAB2(display_short)	psi-mi:aakg1_rat(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)	psi-mi:"MI:0226"(ion exchange chromatography)	Xiao et al. (2007)	pubmed:17851531|doi:10.1038/nature06161|imex:IM-21155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15658328|imex:IM-21155-4|dip:DIP-187264E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005390.1|ensembl:ENSG00000131791(gene)|ensembl:ENST00000254101(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:O43741|rcsb pdb:2F15|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:6B2E|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|interpro:IPR014756(Immunoglobulin E-set)|dip:DIP-39763N	rgd:3388|refseq:NP_037142.1|dip:DIP-37278N|ensembl:ENSRNOG00000061499(gene)|ensembl:ENSRNOT00000083354(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAG|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4EAK|rcsb pdb:4EAL|rcsb pdb:4QFG|rcsb pdb:4QFR|rcsb pdb:4QFS|rcsb pdb:5KQ5|rcsb pdb:5T5T|rcsb pdb:5UFU|rcsb pdb:6E4T|rcsb pdb:6E4U|rcsb pdb:6E4W|reactome:R-RNO-1632852|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:GYLp/VWkcEC1mJcrg0gtIQ99DVg9606	rogid:uryb9rfseg81E/x+FC3Cecf2FnI10116	rigid:n+5l7SVNpbizFYuvbMRjtR2UVXQ	false	sufficient binding region:187-272	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43741	uniprotkb:P54645	intact:EBI-1053424|uniprotkb:Q5VXY0|uniprotkb:B4DH06|uniprotkb:A8K9V5|ensembl:ENSP00000254101	intact:EBI-7596967|intact:MINT-4566241|ensembl:ENSRNOP00000017626	psi-mi:aakb2_human(display_long)|uniprotkb:PRKAB2(gene name)|psi-mi:PRKAB2(display_short)	psi-mi:aapk1_rat(display_long)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)|uniprotkb:Ampk1(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)	psi-mi:"MI:0226"(ion exchange chromatography)	Xiao et al. (2007)	pubmed:17851531|doi:10.1038/nature06161|imex:IM-21155	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15658328|imex:IM-21155-4|dip:DIP-187264E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005390.1|ensembl:ENSG00000131791(gene)|ensembl:ENST00000254101(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:O43741|rcsb pdb:2F15|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:6B2E|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|interpro:IPR014756(Immunoglobulin E-set)|dip:DIP-39763N	rgd:3387|refseq:NP_062015.2|ensembl:ENSRNOG00000012799(gene)|ensembl:ENSRNOT00000017626(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042557"(eukaryotic elongation factor-2 kinase activator activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:P54645|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4EAK|rcsb pdb:4EAL|rcsb pdb:4F2L|rcsb pdb:4QFG|rcsb pdb:4QFR|rcsb pdb:4QFS|rcsb pdb:5KQ5|rcsb pdb:5T5T|rcsb pdb:5UFU|rcsb pdb:6E4T|rcsb pdb:6E4U|rcsb pdb:6E4W|reactome:R-RNO-1632852|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756|dip:DIP-57168N	psi-mi:"MI:0465"(dip)	-	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:GYLp/VWkcEC1mJcrg0gtIQ99DVg9606	rogid:6ENmHVb5EI3JOKaf/gUMI7w2aqQ10116	rigid:n+5l7SVNpbizFYuvbMRjtR2UVXQ	false	sufficient binding region:187-272	sufficient binding region:407-559	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54645	uniprotkb:P80385	intact:EBI-7596967|intact:MINT-4566241|ensembl:ENSRNOP00000017626	intact:EBI-918056|uniprotkb:Q4QQW6|ensembl:ENSRNOP00000070458	psi-mi:aapk1_rat(display_long)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)|uniprotkb:Ampk1(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)	psi-mi:aakg1_rat(display_long)|uniprotkb:Prkag1(gene name)|psi-mi:Prkag1(display_short)	psi-mi:"MI:0096"(pull down)	Xiao et al. (2007)	pubmed:17851531|doi:10.1038/nature06161|imex:IM-21155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15658350|imex:IM-21155-5|dip:DIP-187264E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3387|refseq:NP_062015.2|ensembl:ENSRNOG00000012799(gene)|ensembl:ENSRNOT00000017626(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042557"(eukaryotic elongation factor-2 kinase activator activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:P54645|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4EAK|rcsb pdb:4EAL|rcsb pdb:4F2L|rcsb pdb:4QFG|rcsb pdb:4QFR|rcsb pdb:4QFS|rcsb pdb:5KQ5|rcsb pdb:5T5T|rcsb pdb:5UFU|rcsb pdb:6E4T|rcsb pdb:6E4U|rcsb pdb:6E4W|reactome:R-RNO-1632852|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756|dip:DIP-57168N	rgd:3388|refseq:NP_037142.1|dip:DIP-37278N|ensembl:ENSRNOG00000061499(gene)|ensembl:ENSRNOT00000083354(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAG|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4EAK|rcsb pdb:4EAL|rcsb pdb:4QFG|rcsb pdb:4QFR|rcsb pdb:4QFS|rcsb pdb:5KQ5|rcsb pdb:5T5T|rcsb pdb:5UFU|rcsb pdb:6E4T|rcsb pdb:6E4U|rcsb pdb:6E4W|reactome:R-RNO-1632852|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756	psi-mi:"MI:0465"(dip)	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:6ENmHVb5EI3JOKaf/gUMI7w2aqQ10116	rogid:uryb9rfseg81E/x+FC3Cecf2FnI10116	rigid:n+5l7SVNpbizFYuvbMRjtR2UVXQ	false	sufficient binding region:407-559|his tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54645	uniprotkb:O43741	intact:EBI-7596967|intact:MINT-4566241|ensembl:ENSRNOP00000017626	intact:EBI-1053424|uniprotkb:Q5VXY0|uniprotkb:B4DH06|uniprotkb:A8K9V5|ensembl:ENSP00000254101	psi-mi:aapk1_rat(display_long)|uniprotkb:Prkaa1(gene name)|psi-mi:Prkaa1(display_short)|uniprotkb:Ampk1(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)	psi-mi:aakb2_human(display_long)|uniprotkb:PRKAB2(gene name)|psi-mi:PRKAB2(display_short)	psi-mi:"MI:0096"(pull down)	Xiao et al. (2007)	pubmed:17851531|doi:10.1038/nature06161|imex:IM-21155	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15658350|imex:IM-21155-5|dip:DIP-187264E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3387|refseq:NP_062015.2|ensembl:ENSRNOG00000012799(gene)|ensembl:ENSRNOT00000017626(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042557"(eukaryotic elongation factor-2 kinase activator activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046321"(positive regulation of fatty acid oxidation)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:P54645|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4EAK|rcsb pdb:4EAL|rcsb pdb:4F2L|rcsb pdb:4QFG|rcsb pdb:4QFR|rcsb pdb:4QFS|rcsb pdb:5KQ5|rcsb pdb:5T5T|rcsb pdb:5UFU|rcsb pdb:6E4T|rcsb pdb:6E4U|rcsb pdb:6E4W|reactome:R-RNO-1632852|reactome:R-RNO-380972|reactome:R-RNO-5628897|reactome:R-RNO-6804756|dip:DIP-57168N	refseq:NP_005390.1|ensembl:ENSG00000131791(gene)|ensembl:ENST00000254101(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0080090"(regulation of primary metabolic process)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR006828(5-AMP-activated protein kinase, beta subunit, complex-interacting region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032640|interpro:IPR037256|interpro:IPR039160|mint:O43741|rcsb pdb:2F15|rcsb pdb:2V8Q|rcsb pdb:2V92|rcsb pdb:2V9J|rcsb pdb:2Y8L|rcsb pdb:2Y8Q|rcsb pdb:2YA3|rcsb pdb:4CFH|rcsb pdb:4EAI|rcsb pdb:4EAJ|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:6B2E|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|interpro:IPR014756(Immunoglobulin E-set)|dip:DIP-39763N	psi-mi:"MI:0465"(dip)	function:Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:6ENmHVb5EI3JOKaf/gUMI7w2aqQ10116	rogid:GYLp/VWkcEC1mJcrg0gtIQ99DVg9606	rigid:n+5l7SVNpbizFYuvbMRjtR2UVXQ	false	sufficient binding region:407-559|his tag:n-n	sufficient binding region:187-272	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)