#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q3U182	uniprotkb:P62991	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dentin et al. (2007)	pubmed:17805301|doi:10.1038/nature06128|imex:IM-21835	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15656881|imex:IM-21835-1|dip:DIP-192255E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/15	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rigid:Cm/C3hORT9oyIWyB/SH4DSGxffc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3U182	uniprotkb:Q9R1A8	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-15656898|ensembl:ENSMUSP00000076160	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:cop1_mouse(display_long)|uniprotkb:Cop1(gene name)|psi-mi:Cop1(display_short)|uniprotkb:Constitutive photomorphogenesis protein 1 homolog(gene name synonym)|uniprotkb:RING finger and WD repeat domain protein 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RFWD2(gene name synonym)|uniprotkb:RNF200(gene name synonym)|uniprotkb:Rfwd2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dentin et al. (2007)	pubmed:17805301|doi:10.1038/nature06128|imex:IM-21835	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15656948|imex:IM-21835-3|dip:DIP-192256E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	ensembl:ENSMUSG00000040782(gene)|ensembl:ENSMUST00000076894(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017907|interpro:IPR019775|interpro:IPR036322|interpro:IPR042755|reactome:R-MMU-349425|reactome:R-MMU-8951664|refseq:NP_036061.1|dip:DIP-60522N	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:o0OcJlYZdNGthUiUO0cxTzTTcQ010090	rigid:kY9acV97AVA3Y+KYeTE9IlMnoS4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3U182	uniprotkb:Q9R1A8	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-15656898|ensembl:ENSMUSP00000076160	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:cop1_mouse(display_long)|uniprotkb:Cop1(gene name)|psi-mi:Cop1(display_short)|uniprotkb:Constitutive photomorphogenesis protein 1 homolog(gene name synonym)|uniprotkb:RING finger and WD repeat domain protein 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RFWD2(gene name synonym)|uniprotkb:RNF200(gene name synonym)|uniprotkb:Rfwd2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dentin et al. (2007)	pubmed:17805301|doi:10.1038/nature06128|imex:IM-21835	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15656927|imex:IM-21835-2|dip:DIP-192256E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	ensembl:ENSMUSG00000040782(gene)|ensembl:ENSMUST00000076894(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017907|interpro:IPR019775|interpro:IPR036322|interpro:IPR042755|reactome:R-MMU-349425|reactome:R-MMU-8951664|refseq:NP_036061.1|dip:DIP-60522N	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:o0OcJlYZdNGthUiUO0cxTzTTcQ010090	rigid:kY9acV97AVA3Y+KYeTE9IlMnoS4	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3U182	uniprotkb:Q9R1A8	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-15656898|ensembl:ENSMUSP00000076160	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:cop1_mouse(display_long)|uniprotkb:Cop1(gene name)|psi-mi:Cop1(display_short)|uniprotkb:Constitutive photomorphogenesis protein 1 homolog(gene name synonym)|uniprotkb:RING finger and WD repeat domain protein 2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RFWD2(gene name synonym)|uniprotkb:RNF200(gene name synonym)|uniprotkb:Rfwd2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dentin et al. (2007)	pubmed:17805301|doi:10.1038/nature06128|imex:IM-21835	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15656965|imex:IM-21835-4|dip:DIP-192256E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	ensembl:ENSMUSG00000040782(gene)|ensembl:ENSMUST00000076894(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017907|interpro:IPR019775|interpro:IPR036322|interpro:IPR042755|reactome:R-MMU-349425|reactome:R-MMU-8951664|refseq:NP_036061.1|dip:DIP-60522N	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:o0OcJlYZdNGthUiUO0cxTzTTcQ010090	rigid:kY9acV97AVA3Y+KYeTE9IlMnoS4	false	flag tag:n-n|mutation disrupting interaction strength:215-215,214-214	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)