#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O94907	uniprotkb:O88572	intact:EBI-742864|uniprotkb:B2RC19|ensembl:ENSP00000363081	intact:EBI-6169857	psi-mi:dkk1_human(display_long)|uniprotkb:SK(gene name synonym)|uniprotkb:DKK1(gene name)|psi-mi:DKK1(display_short)|uniprotkb:UNQ492/PRO1008(orf name)	psi-mi:lrp6_mouse(display_long)|uniprotkb:Lrp6(gene name)|psi-mi:Lrp6(display_short)	psi-mi:"MI:0071"(molecular sieving)	Binnerts et al. (2007)	pubmed:17804805|doi:10.1073/pnas.0702305104|imex:IM-9704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15656167|imex:IM-9704-1|dip:DIP-88534E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036374.1|interpro:IPR039863|rcsb pdb:3S2K|rcsb pdb:3S8V|rcsb pdb:3SOQ|rcsb pdb:5FWW|rcsb pdb:5GJE|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-5339717|ensembl:ENSG00000107984(gene)|ensembl:ENST00000373970(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007611"(learning or memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042663"(regulation of endodermal cell fate specification)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045813"(positive regulation of Wnt signaling pathway, calcium modulating pathway)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060173"(limb development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0090082"(positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098883"(synapse pruning)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901296"(negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1904723"(negative regulation of Wnt-Frizzled-LRP5/6 complex assembly)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR006796(Dickkopf, N-terminal cysteine-rich)|dip:DIP-46461N	go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003401"(axis elongation)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051593"(response to folic acid)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060284"(regulation of cell development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0060596"(mammary placode formation)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061310"(canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021872"(forebrain generation of neurons)|go:"GO:0021915"(neural tube development)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048699"(generation of neurons)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:2000164"(negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis)|go:"GO:2000166"(negative regulation of planar cell polarity pathway involved in pericardium morphogenesis)|go:"GO:2000168"(negative regulation of planar cell polarity pathway involved in neural tube closure)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000149"(negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis)|go:"GO:2000151"(negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis)|go:"GO:2000162"(negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis)|refseq:NP_032540.2|dip:DIP-46460N|reactome:R-MMU-3772470|reactome:R-MMU-4641262|reactome:R-MMU-4641263	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:OOYhVQDXaaC6AbdFdUKMCjB9L1M9606	rogid:62E3KoylZ2wnvUSiqWjHmW66CvE10090	rigid:hhA4v6TcOi78KDAWa80tmhLdA+s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96MU8	uniprotkb:O88572	intact:EBI-15656184|ensembl:ENSP00000385431|uniprotkb:B0QY46|uniprotkb:B0QY47|uniprotkb:B1AJR5|uniprotkb:Q5TIB9|uniprotkb:Q6P3X6|uniprotkb:Q9BY70|uniprotkb:Q9UGS5|uniprotkb:Q9UGU1	intact:EBI-6169857	psi-mi:krem1_human(display_long)|uniprotkb:KREMEN1(gene name)|psi-mi:KREMEN1(display_short)|uniprotkb:KREMEN(gene name synonym)|uniprotkb:KRM1(gene name synonym)|uniprotkb:Dickkopf receptor(gene name synonym)|uniprotkb:Kringle domain-containing transmembrane protein 1(gene name synonym)|uniprotkb:Kringle-containing protein marking the eye and the nose(gene name synonym)	psi-mi:lrp6_mouse(display_long)|uniprotkb:Lrp6(gene name)|psi-mi:Lrp6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Binnerts et al. (2007)	pubmed:17804805|doi:10.1073/pnas.0702305104|imex:IM-9704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15656236|imex:IM-9704-2|dip:DIP-88535E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183762(gene)|ensembl:ENST00000407188(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007154"(cell communication)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0060173"(limb development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000001(Kringle)|interpro:IPR000859(CUB)|interpro:IPR002889(Carbohydrate-binding WSC)|interpro:IPR013806(Kringle-like fold)|interpro:IPR017076(Kremen)|interpro:IPR018056|interpro:IPR035914|interpro:IPR038178|rcsb pdb:5FWS|rcsb pdb:5FWT|rcsb pdb:5FWU|rcsb pdb:5FWV|rcsb pdb:5FWW|rcsb pdb:7BZT|rcsb pdb:7BZU|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-5339717|refseq:NP_001034659.2|refseq:NP_114434.3|dip:DIP-46462N	go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003401"(axis elongation)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051593"(response to folic acid)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060284"(regulation of cell development)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0060596"(mammary placode formation)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0061310"(canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021872"(forebrain generation of neurons)|go:"GO:0021915"(neural tube development)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048699"(generation of neurons)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:2000164"(negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis)|go:"GO:2000166"(negative regulation of planar cell polarity pathway involved in pericardium morphogenesis)|go:"GO:2000168"(negative regulation of planar cell polarity pathway involved in neural tube closure)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000149"(negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis)|go:"GO:2000151"(negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis)|go:"GO:2000162"(negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis)|refseq:NP_032540.2|dip:DIP-46460N|reactome:R-MMU-3772470|reactome:R-MMU-4641262|reactome:R-MMU-4641263	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:WAnNC1fW5HVSXj0YDpXZOPZB8RM9606	rogid:62E3KoylZ2wnvUSiqWjHmW66CvE10090	rigid:yUFzmzKzcOHBJmKE4Wr5SwJOGco	false	ha tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O94907	uniprotkb:Q96MU8	intact:EBI-742864|uniprotkb:B2RC19|ensembl:ENSP00000363081	intact:EBI-15656184|ensembl:ENSP00000385431|uniprotkb:B0QY46|uniprotkb:B0QY47|uniprotkb:B1AJR5|uniprotkb:Q5TIB9|uniprotkb:Q6P3X6|uniprotkb:Q9BY70|uniprotkb:Q9UGS5|uniprotkb:Q9UGU1	psi-mi:dkk1_human(display_long)|uniprotkb:SK(gene name synonym)|uniprotkb:DKK1(gene name)|psi-mi:DKK1(display_short)|uniprotkb:UNQ492/PRO1008(orf name)	psi-mi:krem1_human(display_long)|uniprotkb:KREMEN1(gene name)|psi-mi:KREMEN1(display_short)|uniprotkb:KREMEN(gene name synonym)|uniprotkb:KRM1(gene name synonym)|uniprotkb:Dickkopf receptor(gene name synonym)|uniprotkb:Kringle domain-containing transmembrane protein 1(gene name synonym)|uniprotkb:Kringle-containing protein marking the eye and the nose(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Binnerts et al. (2007)	pubmed:17804805|doi:10.1073/pnas.0702305104|imex:IM-9704	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15656257|imex:IM-9704-3|dip:DIP-88536E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036374.1|interpro:IPR039863|rcsb pdb:3S2K|rcsb pdb:3S8V|rcsb pdb:3SOQ|rcsb pdb:5FWW|rcsb pdb:5GJE|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-5339717|ensembl:ENSG00000107984(gene)|ensembl:ENST00000373970(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007611"(learning or memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042662"(negative regulation of mesodermal cell fate specification)|go:"GO:0042663"(regulation of endodermal cell fate specification)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045813"(positive regulation of Wnt signaling pathway, calcium modulating pathway)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060173"(limb development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0090082"(positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098883"(synapse pruning)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901296"(negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1904723"(negative regulation of Wnt-Frizzled-LRP5/6 complex assembly)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR006796(Dickkopf, N-terminal cysteine-rich)|dip:DIP-46461N	ensembl:ENSG00000183762(gene)|ensembl:ENST00000407188(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007154"(cell communication)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0060173"(limb development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR000001(Kringle)|interpro:IPR000859(CUB)|interpro:IPR002889(Carbohydrate-binding WSC)|interpro:IPR013806(Kringle-like fold)|interpro:IPR017076(Kremen)|interpro:IPR018056|interpro:IPR035914|interpro:IPR038178|rcsb pdb:5FWS|rcsb pdb:5FWT|rcsb pdb:5FWU|rcsb pdb:5FWV|rcsb pdb:5FWW|rcsb pdb:7BZT|rcsb pdb:7BZU|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-5339717|refseq:NP_001034659.2|refseq:NP_114434.3|dip:DIP-46462N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:OOYhVQDXaaC6AbdFdUKMCjB9L1M9606	rogid:WAnNC1fW5HVSXj0YDpXZOPZB8RM9606	rigid:UrMNk+OP12eEyD2SEtImoIoU7h0	false	-	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)