#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P24063 uniprotkb:P11835 intact:EBI-983966|ensembl:ENSMUSP00000131847 intact:EBI-644501|uniprotkb:Q64482 psi-mi:ital_mouse(display_long)|uniprotkb:Leukocyte adhesion glycoprotein LFA-1 alpha chain(gene name synonym)|uniprotkb:Leukocyte function-associated molecule 1 alpha chain(gene name synonym)|uniprotkb:Lymphocyte antigen 15(gene name synonym)|uniprotkb:CD11 antigen-like family member A(gene name synonym)|uniprotkb:Itgal(gene name)|psi-mi:Itgal(display_short)|uniprotkb:Lfa-1(gene name synonym)|uniprotkb:Ly-15(gene name synonym) psi-mi:itb2_mouse(display_long)|uniprotkb:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta(gene name synonym)|uniprotkb:Complement receptor C3 subunit beta(gene name synonym)|uniprotkb:Itgb2(gene name)|psi-mi:Itgb2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bonasio et al. (2007) pubmed:17785425|doi:10.1073/pnas.0705201104|imex:IM-9700 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15655554|imex:IM-9700-1|dip:DIP-88524E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000030830(gene)|ensembl:ENSMUST00000170971(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0002291"(T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0035683"(memory T cell extravasation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-6798695|dip:DIP-35643N refseq:NP_032430.2|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0043113"(receptor clustering)|go:"GO:0043235"(receptor complex)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990266"(neutrophil migration)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015439(Integrin beta-2 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|reactome:R-MMU-166016|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-6798695|dip:DIP-37428N|mint:P11835 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:+gF/EH5h/001gtCj3z0rC5qtOUc10090 rogid:a6PSt0Keij+/xNNHH2GNomc28SM10090 rigid:iAI/TFqfOQg7MPYLVtx5SLJbrVw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)