#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62600	refseq:XP_001080493	intact:EBI-7052018|uniprotkb:Q75NE4|uniprotkb:Q62734|uniprotkb:O88672|intact:MINT-202608|uniprotkb:O89041|uniprotkb:Q68GV6	intact:EBI-15655491|dip:DIP-46455N	psi-mi:nos3_rat(display_long)|uniprotkb:Nos3(gene name)|psi-mi:Nos3(display_short)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:rsirt1(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mattagajasingh et al. (2007)	pubmed:17785417|doi:10.1073/pnas.0704329104|imex:IM-9699	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15655494|imex:IM-9699-2|dip:DIP-88522E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q62600|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009750"(response to fructose)|go:"GO:0010038"(response to metal ion)|go:"GO:0010181"(FMN binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0014823"(response to activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030324"(lung development)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034097"(response to cytokine)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0036017"(response to erythropoietin)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060348"(bone development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0071000"(response to magnetism)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1901556"(response to candesartan)|go:"GO:1901558"(response to metformin)|go:"GO:1901652"(response to peptide)|go:"GO:1901654"(response to ketone)|go:"GO:1902074"(response to salt)|go:"GO:1903576"(response to L-arginine)|go:"GO:1904648"(cellular response to rotenone)|go:"GO:1990478"(response to ultrasound)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|reactome:R-RNO-1222556|reactome:R-RNO-1474151|reactome:R-RNO-203615|reactome:R-RNO-203641|reactome:R-RNO-203754|reactome:R-RNO-392154|reactome:R-RNO-5218920|reactome:R-RNO-9009391|rgd:3186|refseq:NP_068610.1|dip:DIP-41833N	-	psi-mi:"MI:0465"(dip)	comment:mint|function:"Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/05	2017/08/10	rogid:GAf5Sj7pV//hAQqxd/xnWwW/C1I10116	-	-	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29473	uniprotkb:Q96EB6	intact:EBI-7636493|intact:MINT-1347838	intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015	psi-mi:nos3_bovin(display_long)|uniprotkb:NOS3(gene name)|psi-mi:NOS3(display_short)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym)	psi-mi:"MI:0406"(deacetylase assay)	Mattagajasingh et al. (2007)	pubmed:17785417|doi:10.1073/pnas.0704329104|imex:IM-9699	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15655511|imex:IM-9699-3|dip:DIP-88523E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1ZZT|rcsb pdb:3N5S|rcsb pdb:3N5T|rcsb pdb:3NLD|rcsb pdb:3NLE|rcsb pdb:3NLF|rcsb pdb:3NLG|rcsb pdb:3NLH|rcsb pdb:2G6O|rcsb pdb:3NLI|rcsb pdb:3NLT|rcsb pdb:3NLU|rcsb pdb:2HX2|rcsb pdb:3NSE|rcsb pdb:2NSE|rcsb pdb:3PNH|rcsb pdb:3RQO|rcsb pdb:3RQP|rcsb pdb:4C3A|rcsb pdb:4CAR|rcsb pdb:4CFT|rcsb pdb:4CTY|rcsb pdb:4CTZ|rcsb pdb:3DQS|rcsb pdb:4CU0|rcsb pdb:4CU1|rcsb pdb:4CUL|rcsb pdb:3DQT|rcsb pdb:4CUM|rcsb pdb:4CUN|rcsb pdb:4CVG|rcsb pdb:4CWV|rcsb pdb:4CWW|rcsb pdb:4CWX|rcsb pdb:3E7S|rcsb pdb:4CWY|rcsb pdb:4CWZ|rcsb pdb:4CX0|rcsb pdb:4CX1|rcsb pdb:4CX2|rcsb pdb:4D33|rcsb pdb:4D34|rcsb pdb:4D35|rcsb pdb:4D36|rcsb pdb:4D37|rcsb pdb:4D38|rcsb pdb:4D39|rcsb pdb:4D3A|rcsb pdb:4IMX|rcsb pdb:4JSK|rcsb pdb:4JSL|rcsb pdb:4JSM|rcsb pdb:4K5H|rcsb pdb:4K5I|rcsb pdb:4K5J|rcsb pdb:3JWW|rcsb pdb:4K5K|rcsb pdb:4KCP|rcsb pdb:4KCQ|rcsb pdb:4KCR|rcsb pdb:4KCS|rcsb pdb:4LUW|rcsb pdb:4NSE|rcsb pdb:4UH7|rcsb pdb:4UH8|rcsb pdb:4UH9|rcsb pdb:4UHA|rcsb pdb:4UPQ|rcsb pdb:4UPR|rcsb pdb:4UPS|rcsb pdb:3JWX|rcsb pdb:4UPT|rcsb pdb:3JWY|rcsb pdb:3JWZ|rcsb pdb:5ADJ|rcsb pdb:5ADK|rcsb pdb:5ADL|rcsb pdb:5ADM|rcsb pdb:5ADN|rcsb pdb:5FJ2|rcsb pdb:3N5P|rcsb pdb:5FJ3|rcsb pdb:5FVY|rcsb pdb:5FVZ|rcsb pdb:3N5Q|rcsb pdb:5NSE|rcsb pdb:5UOD|rcsb pdb:5VV6|rcsb pdb:5VV7|rcsb pdb:5VV8|rcsb pdb:5VV9|rcsb pdb:5VVA|rcsb pdb:5VVG|rcsb pdb:5VVN|rcsb pdb:3N5R|rcsb pdb:6NSE|rcsb pdb:7NSE|rcsb pdb:8NSE|rcsb pdb:9NSE|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010181"(FMN binding)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|rcsb pdb:1D0C|rcsb pdb:1D0O|rcsb pdb:1D1V|rcsb pdb:1D1W|rcsb pdb:1D1X|rcsb pdb:1D1Y|rcsb pdb:1DM6|rcsb pdb:1DM7|rcsb pdb:1DM8|rcsb pdb:1DMI|rcsb pdb:1DMJ|rcsb pdb:1DMK|rcsb pdb:1ED4|rcsb pdb:1ED5|rcsb pdb:1ED6|rcsb pdb:1FOI|rcsb pdb:1FOJ|rcsb pdb:1FOL|rcsb pdb:1FOO|rcsb pdb:1FOP|rcsb pdb:1I83|rcsb pdb:1NSE|rcsb pdb:1P6L|rcsb pdb:1P6M|rcsb pdb:1P6N|rcsb pdb:1Q2O|rcsb pdb:1RS8|rcsb pdb:1RS9|rcsb pdb:1ZZS|dip:DIP-42217N	refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)	psi-mi:"MI:0465"(dip)	comment:mint|function:"Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:sAK/x37YPMbuDb8wNCCw31kGXwE9913	rogid:h3zVepuhRhzlINCluVuAn71Btjc9606	rigid:qQH/Hi3EEZ0tfZAYNTZwFGnhlMw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62600	refseq:XP_001080493	intact:EBI-7052018|uniprotkb:Q75NE4|uniprotkb:Q62734|uniprotkb:O88672|intact:MINT-202608|uniprotkb:O89041|uniprotkb:Q68GV6	intact:EBI-15655491|dip:DIP-46455N	psi-mi:nos3_rat(display_long)|uniprotkb:Nos3(gene name)|psi-mi:Nos3(display_short)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:rsirt1(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Mattagajasingh et al. (2007)	pubmed:17785417|doi:10.1073/pnas.0704329104|imex:IM-9699	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15655528|imex:IM-9699-1|dip:DIP-88522E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q62600|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009750"(response to fructose)|go:"GO:0010038"(response to metal ion)|go:"GO:0010181"(FMN binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0014823"(response to activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030324"(lung development)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034097"(response to cytokine)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035094"(response to nicotine)|go:"GO:0036017"(response to erythropoietin)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048678"(response to axon injury)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060348"(bone development)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0071000"(response to magnetism)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071403"(cellular response to high density lipoprotein particle stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1901556"(response to candesartan)|go:"GO:1901558"(response to metformin)|go:"GO:1901652"(response to peptide)|go:"GO:1901654"(response to ketone)|go:"GO:1902074"(response to salt)|go:"GO:1903576"(response to L-arginine)|go:"GO:1904648"(cellular response to rotenone)|go:"GO:1990478"(response to ultrasound)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|reactome:R-RNO-1222556|reactome:R-RNO-1474151|reactome:R-RNO-203615|reactome:R-RNO-203641|reactome:R-RNO-203754|reactome:R-RNO-392154|reactome:R-RNO-5218920|reactome:R-RNO-9009391|rgd:3186|refseq:NP_068610.1|dip:DIP-41833N	-	psi-mi:"MI:0465"(dip)	comment:mint|function:"Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/05	2017/08/10	rogid:GAf5Sj7pV//hAQqxd/xnWwW/C1I10116	-	-	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)