#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q60848	uniprotkb:P30658	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	intact:EBI-360174|uniprotkb:O35731|uniprotkb:A2ABG2|ensembl:ENSMUSP00000026662|uniprotkb:Q8CIA0	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:cbx2_mouse(display_long)|uniprotkb:Cbx2(gene name)|psi-mi:Cbx2(display_short)|uniprotkb:M33(gene name synonym)|uniprotkb:Modifier 3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xi et al. (2007)	pubmed:17726103|doi:10.1073/pnas.0703669104|imex:IM-9708	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654714|imex:IM-9708-1|dip:DIP-88542E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N	ensembl:ENSMUSG00000025577(gene)|ensembl:ENSMUST00000026662(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0016607"(nuclear speck)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035102"(PRC1 complex)|go:"GO:0045137"(development of primary sexual characteristics)|interpro:IPR000953(Chromo domain)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|interpro:IPR033773|interpro:IPR042796|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|refseq:NP_031649.2|dip:DIP-690N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	rogid:nUduKr4Vds3Ta6BDINRY2hFRweU10090	rigid:lJmL2eGE0SFDA8UEop+tZSJ1Q1A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60848	uniprotkb:P23798	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	intact:EBI-926857|ensembl:ENSMUSP00000018681|ensembl:ENSMUSP00000099437|ensembl:ENSMUSP00000126967|ensembl:ENSMUSP00000137517	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:pcgf2_mouse(display_long)|uniprotkb:Pcgf2(gene name)|psi-mi:Pcgf2(display_short)|uniprotkb:Mel18(gene name synonym)|uniprotkb:Mel-18(gene name synonym)|uniprotkb:Rnf110(gene name synonym)|uniprotkb:Zfp144(gene name synonym)|uniprotkb:Znf144(gene name synonym)|uniprotkb:DNA-binding protein Mel-18(gene name synonym)|uniprotkb:Melanoma nuclear protein 18(gene name synonym)|uniprotkb:RING finger protein 110(gene name synonym)|uniprotkb:Zinc finger protein 144(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xi et al. (2007)	pubmed:17726103|doi:10.1073/pnas.0703669104|imex:IM-9708	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654714|imex:IM-9708-1|dip:DIP-88542E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N	refseq:XP_011247274.1|refseq:XP_011247275.1|refseq:XP_011247277.1|refseq:NP_001156779.1|refseq:NP_001156780.1|refseq:NP_033571.1|refseq:XP_017169992.1|dip:DIP-37645N|ensembl:ENSMUSG00000018537(gene)|ensembl:ENSMUST00000018681(transcript)|ensembl:ENSMUST00000103148(transcript)|ensembl:ENSMUST00000169807(transcript)|ensembl:ENSMUST00000179765(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001739"(sex chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8953750	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	rogid:BHDGzWbi1oVLvmehDQ9Wp2x9ZVQ10090	rigid:lJmL2eGE0SFDA8UEop+tZSJ1Q1A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60848	uniprotkb:P25916	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	intact:EBI-927401|ensembl:ENSMUSP00000028071|ensembl:ENSMUSP00000110300	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:bmi1_mouse(display_long)|uniprotkb:Bmi1(gene name)|psi-mi:Bmi1(display_short)|uniprotkb:Pcgf4(gene name synonym)|uniprotkb:Bmi-1(gene name synonym)|uniprotkb:Polycomb group RING finger protein 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xi et al. (2007)	pubmed:17726103|doi:10.1073/pnas.0703669104|imex:IM-9708	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654714|imex:IM-9708-1|dip:DIP-88542E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N	refseq:NP_031578.2|refseq:XP_006497374.1|refseq:XP_006497375.1|ensembl:ENSMUSG00000026739(gene)|ensembl:ENSMUST00000028071(transcript)|ensembl:ENSMUST00000051929(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|dip:DIP-132N|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006959"(humoral immune response)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009987"(cellular process)|go:"GO:0016573"(histone acetylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031519"(PcG protein complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|mint:P25916|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	rogid:xqs8rfZzDnr99TmUEdISjicPiqQ10090	rigid:lJmL2eGE0SFDA8UEop+tZSJ1Q1A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23798	uniprotkb:Q60848	intact:EBI-926857|ensembl:ENSMUSP00000018681|ensembl:ENSMUSP00000099437|ensembl:ENSMUSP00000126967|ensembl:ENSMUSP00000137517	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	psi-mi:pcgf2_mouse(display_long)|uniprotkb:Pcgf2(gene name)|psi-mi:Pcgf2(display_short)|uniprotkb:Mel18(gene name synonym)|uniprotkb:Mel-18(gene name synonym)|uniprotkb:Rnf110(gene name synonym)|uniprotkb:Zfp144(gene name synonym)|uniprotkb:Znf144(gene name synonym)|uniprotkb:DNA-binding protein Mel-18(gene name synonym)|uniprotkb:Melanoma nuclear protein 18(gene name synonym)|uniprotkb:RING finger protein 110(gene name synonym)|uniprotkb:Zinc finger protein 144(gene name synonym)	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xi et al. (2007)	pubmed:17726103|doi:10.1073/pnas.0703669104|imex:IM-9708	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654733|imex:IM-9708-2|dip:DIP-88546E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011247274.1|refseq:XP_011247275.1|refseq:XP_011247277.1|refseq:NP_001156779.1|refseq:NP_001156780.1|refseq:NP_033571.1|refseq:XP_017169992.1|dip:DIP-37645N|ensembl:ENSMUSG00000018537(gene)|ensembl:ENSMUST00000018681(transcript)|ensembl:ENSMUST00000103148(transcript)|ensembl:ENSMUST00000169807(transcript)|ensembl:ENSMUST00000179765(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001739"(sex chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8953750	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:BHDGzWbi1oVLvmehDQ9Wp2x9ZVQ10090	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	rigid:H5849ZaGK/ZK9vKYrFS9hLZdkDg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88509	uniprotkb:P25916	intact:EBI-7987547|intact:MINT-2523761|uniprotkb:O88510|uniprotkb:O88511|ensembl:ENSMUSP00000072761|ensembl:ENSMUSP00000105396	intact:EBI-927401|ensembl:ENSMUSP00000028071|ensembl:ENSMUSP00000110300	psi-mi:dnm3b_mouse(display_long)|uniprotkb:Dnmt3b(gene name)|psi-mi:Dnmt3b(display_short)|uniprotkb:DNA methyltransferase MmuIIIB(gene name synonym)	psi-mi:bmi1_mouse(display_long)|uniprotkb:Bmi1(gene name)|psi-mi:Bmi1(display_short)|uniprotkb:Pcgf4(gene name synonym)|uniprotkb:Bmi-1(gene name synonym)|uniprotkb:Polycomb group RING finger protein 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xi et al. (2007)	pubmed:17726103|doi:10.1073/pnas.0703669104|imex:IM-9708	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654750|imex:IM-9708-3|dip:DIP-88544E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258676.1|refseq:NP_001003961.2|refseq:NP_001258674.1|refseq:NP_001003960.2|refseq:NP_034198.3|refseq:NP_001258673.1|dip:DIP-43736N|ensembl:ENSMUSG00000027478(gene)|ensembl:ENSMUST00000072997(transcript)|ensembl:ENSMUST00000109774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090116"(C-5 methylation of cytosine)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:O88509|rcsb pdb:1KHC|reactome:R-MMU-212300|reactome:R-MMU-4655427	refseq:NP_031578.2|refseq:XP_006497374.1|refseq:XP_006497375.1|ensembl:ENSMUSG00000026739(gene)|ensembl:ENSMUST00000028071(transcript)|ensembl:ENSMUST00000051929(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|dip:DIP-132N|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006959"(humoral immune response)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009987"(cellular process)|go:"GO:0016573"(histone acetylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031519"(PcG protein complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|mint:P25916|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0465"(dip)	comment:mint|function:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:kyLQKXAetZyuwqBYP3+08/cb5JU10090	rogid:xqs8rfZzDnr99TmUEdISjicPiqQ10090	rigid:iDkvoyUy4Gn8MC7wPfU59wxBtdA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30658	uniprotkb:Q60848	intact:EBI-360174|uniprotkb:O35731|uniprotkb:A2ABG2|ensembl:ENSMUSP00000026662|uniprotkb:Q8CIA0	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	psi-mi:cbx2_mouse(display_long)|uniprotkb:Cbx2(gene name)|psi-mi:Cbx2(display_short)|uniprotkb:M33(gene name synonym)|uniprotkb:Modifier 3 protein(gene name synonym)	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xi et al. (2007)	pubmed:17726103|doi:10.1073/pnas.0703669104|imex:IM-9708	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654767|imex:IM-9708-4|dip:DIP-88547E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025577(gene)|ensembl:ENSMUST00000026662(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0016607"(nuclear speck)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035102"(PRC1 complex)|go:"GO:0045137"(development of primary sexual characteristics)|interpro:IPR000953(Chromo domain)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|interpro:IPR033773|interpro:IPR042796|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|refseq:NP_031649.2|dip:DIP-690N	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:nUduKr4Vds3Ta6BDINRY2hFRweU10090	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	rigid:8PrBA2KueeuYvJgyIXpRNT3qxUM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q60848	uniprotkb:P25916	intact:EBI-3043887|ensembl:ENSMUSP00000025965|uniprotkb:Q497T3|uniprotkb:Q8VDZ1|uniprotkb:Q9CYV7	intact:EBI-927401|ensembl:ENSMUSP00000028071|ensembl:ENSMUSP00000110300	psi-mi:hells_mouse(display_long)|uniprotkb:Hells(gene name)|psi-mi:Hells(display_short)|uniprotkb:Lsh(gene name synonym)|uniprotkb:Pasg(gene name synonym)|uniprotkb:Proliferation-associated SNF2-like protein(gene name synonym)	psi-mi:bmi1_mouse(display_long)|uniprotkb:Bmi1(gene name)|psi-mi:Bmi1(display_short)|uniprotkb:Pcgf4(gene name synonym)|uniprotkb:Bmi-1(gene name synonym)|uniprotkb:Polycomb group RING finger protein 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xi et al. (2007)	pubmed:17726103|doi:10.1073/pnas.0703669104|imex:IM-9708	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654784|imex:IM-9708-5|dip:DIP-88545E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000025001(gene)|ensembl:ENSMUST00000025965(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001655"(urogenital system development)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0007275"(multicellular organism development)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0051301"(cell division)|go:"GO:0070615"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR038718|interpro:IPR044753|mint:Q60848|refseq:NP_032260.2|refseq:XP_006526762.1|dip:DIP-43735N	refseq:NP_031578.2|refseq:XP_006497374.1|refseq:XP_006497375.1|ensembl:ENSMUSG00000026739(gene)|ensembl:ENSMUST00000028071(transcript)|ensembl:ENSMUST00000051929(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|dip:DIP-132N|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006959"(humoral immune response)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009987"(cellular process)|go:"GO:0016573"(histone acetylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031519"(PcG protein complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|mint:P25916|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:rxUxEmjFSksq7JWhJEaA4Xeo+XY10090	rogid:xqs8rfZzDnr99TmUEdISjicPiqQ10090	rigid:aEMXlVTLQqA761wkX0IGtRPMlXc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88509	uniprotkb:P30658	intact:EBI-7987547|intact:MINT-2523761|uniprotkb:O88510|uniprotkb:O88511|ensembl:ENSMUSP00000072761|ensembl:ENSMUSP00000105396	intact:EBI-360174|uniprotkb:O35731|uniprotkb:A2ABG2|ensembl:ENSMUSP00000026662|uniprotkb:Q8CIA0	psi-mi:dnm3b_mouse(display_long)|uniprotkb:Dnmt3b(gene name)|psi-mi:Dnmt3b(display_short)|uniprotkb:DNA methyltransferase MmuIIIB(gene name synonym)	psi-mi:cbx2_mouse(display_long)|uniprotkb:Cbx2(gene name)|psi-mi:Cbx2(display_short)|uniprotkb:M33(gene name synonym)|uniprotkb:Modifier 3 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xi et al. (2007)	pubmed:17726103|doi:10.1073/pnas.0703669104|imex:IM-9708	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654801|imex:IM-9708-6|dip:DIP-88543E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258676.1|refseq:NP_001003961.2|refseq:NP_001258674.1|refseq:NP_001003960.2|refseq:NP_034198.3|refseq:NP_001258673.1|dip:DIP-43736N|ensembl:ENSMUSG00000027478(gene)|ensembl:ENSMUST00000072997(transcript)|ensembl:ENSMUST00000109774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090116"(C-5 methylation of cytosine)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:O88509|rcsb pdb:1KHC|reactome:R-MMU-212300|reactome:R-MMU-4655427	ensembl:ENSMUSG00000025577(gene)|ensembl:ENSMUST00000026662(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0016607"(nuclear speck)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035102"(PRC1 complex)|go:"GO:0045137"(development of primary sexual characteristics)|interpro:IPR000953(Chromo domain)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|interpro:IPR033773|interpro:IPR042796|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|refseq:NP_031649.2|dip:DIP-690N	psi-mi:"MI:0465"(dip)	comment:mint|function:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:kyLQKXAetZyuwqBYP3+08/cb5JU10090	rogid:nUduKr4Vds3Ta6BDINRY2hFRweU10090	rigid:9+xtA/NXbWZSpSur9N3B+q+HJYY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88509	uniprotkb:P23798	intact:EBI-7987547|intact:MINT-2523761|uniprotkb:O88510|uniprotkb:O88511|ensembl:ENSMUSP00000072761|ensembl:ENSMUSP00000105396	intact:EBI-926857|ensembl:ENSMUSP00000018681|ensembl:ENSMUSP00000099437|ensembl:ENSMUSP00000126967|ensembl:ENSMUSP00000137517	psi-mi:dnm3b_mouse(display_long)|uniprotkb:Dnmt3b(gene name)|psi-mi:Dnmt3b(display_short)|uniprotkb:DNA methyltransferase MmuIIIB(gene name synonym)	psi-mi:pcgf2_mouse(display_long)|uniprotkb:Pcgf2(gene name)|psi-mi:Pcgf2(display_short)|uniprotkb:Mel18(gene name synonym)|uniprotkb:Mel-18(gene name synonym)|uniprotkb:Rnf110(gene name synonym)|uniprotkb:Zfp144(gene name synonym)|uniprotkb:Znf144(gene name synonym)|uniprotkb:DNA-binding protein Mel-18(gene name synonym)|uniprotkb:Melanoma nuclear protein 18(gene name synonym)|uniprotkb:RING finger protein 110(gene name synonym)|uniprotkb:Zinc finger protein 144(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xi et al. (2007)	pubmed:17726103|doi:10.1073/pnas.0703669104|imex:IM-9708	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654801|imex:IM-9708-6|dip:DIP-88543E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258676.1|refseq:NP_001003961.2|refseq:NP_001258674.1|refseq:NP_001003960.2|refseq:NP_034198.3|refseq:NP_001258673.1|dip:DIP-43736N|ensembl:ENSMUSG00000027478(gene)|ensembl:ENSMUST00000072997(transcript)|ensembl:ENSMUST00000109774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090116"(C-5 methylation of cytosine)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:O88509|rcsb pdb:1KHC|reactome:R-MMU-212300|reactome:R-MMU-4655427	refseq:XP_011247274.1|refseq:XP_011247275.1|refseq:XP_011247277.1|refseq:NP_001156779.1|refseq:NP_001156780.1|refseq:NP_033571.1|refseq:XP_017169992.1|dip:DIP-37645N|ensembl:ENSMUSG00000018537(gene)|ensembl:ENSMUST00000018681(transcript)|ensembl:ENSMUST00000103148(transcript)|ensembl:ENSMUST00000169807(transcript)|ensembl:ENSMUST00000179765(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001739"(sex chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8953750	psi-mi:"MI:0465"(dip)	comment:mint|function:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:kyLQKXAetZyuwqBYP3+08/cb5JU10090	rogid:BHDGzWbi1oVLvmehDQ9Wp2x9ZVQ10090	rigid:9+xtA/NXbWZSpSur9N3B+q+HJYY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88509	uniprotkb:P25916	intact:EBI-7987547|intact:MINT-2523761|uniprotkb:O88510|uniprotkb:O88511|ensembl:ENSMUSP00000072761|ensembl:ENSMUSP00000105396	intact:EBI-927401|ensembl:ENSMUSP00000028071|ensembl:ENSMUSP00000110300	psi-mi:dnm3b_mouse(display_long)|uniprotkb:Dnmt3b(gene name)|psi-mi:Dnmt3b(display_short)|uniprotkb:DNA methyltransferase MmuIIIB(gene name synonym)	psi-mi:bmi1_mouse(display_long)|uniprotkb:Bmi1(gene name)|psi-mi:Bmi1(display_short)|uniprotkb:Pcgf4(gene name synonym)|uniprotkb:Bmi-1(gene name synonym)|uniprotkb:Polycomb group RING finger protein 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xi et al. (2007)	pubmed:17726103|doi:10.1073/pnas.0703669104|imex:IM-9708	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654801|imex:IM-9708-6|dip:DIP-88543E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001258676.1|refseq:NP_001003961.2|refseq:NP_001258674.1|refseq:NP_001003960.2|refseq:NP_034198.3|refseq:NP_001258673.1|dip:DIP-43736N|ensembl:ENSMUSG00000027478(gene)|ensembl:ENSMUST00000072997(transcript)|ensembl:ENSMUST00000109774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051718"("DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates")|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051719"("DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates")|go:"GO:0060821"(obsolete inactivation of X chromosome by DNA methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090116"(C-5 methylation of cytosine)|interpro:IPR000313(PWWP)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR018117|interpro:IPR025766|interpro:IPR029063|interpro:IPR030488|interpro:IPR040552|mint:O88509|rcsb pdb:1KHC|reactome:R-MMU-212300|reactome:R-MMU-4655427	refseq:NP_031578.2|refseq:XP_006497374.1|refseq:XP_006497375.1|ensembl:ENSMUSG00000026739(gene)|ensembl:ENSMUST00000028071(transcript)|ensembl:ENSMUST00000051929(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|dip:DIP-132N|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006959"(humoral immune response)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009987"(cellular process)|go:"GO:0016573"(histone acetylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031519"(PcG protein complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|mint:P25916|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750	psi-mi:"MI:0465"(dip)	comment:mint|function:Required for genome wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/05	2017/08/10	rogid:kyLQKXAetZyuwqBYP3+08/cb5JU10090	rogid:xqs8rfZzDnr99TmUEdISjicPiqQ10090	rigid:9+xtA/NXbWZSpSur9N3B+q+HJYY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)