#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P69924	uniprotkb:P69924	intact:EBI-555196|uniprotkb:P00453|ensemblbacteria:AAC75295|ensemblbacteria:BAA16054	intact:EBI-555196|uniprotkb:P00453|ensemblbacteria:AAC75295|ensemblbacteria:BAA16054	psi-mi:rir2_ecoli(display_long)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:Protein B2(gene name synonym)|uniprotkb:Protein R2(gene name synonym)|uniprotkb:nrdB(gene name)|psi-mi:nrdB(display_short)|uniprotkb:ftsB(gene name synonym)|uniprotkb:b2235(locus name)|uniprotkb:JW2229(locus name)	psi-mi:rir2_ecoli(display_long)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:Protein B2(gene name synonym)|uniprotkb:Protein R2(gene name synonym)|uniprotkb:nrdB(gene name)|psi-mi:nrdB(display_short)|uniprotkb:ftsB(gene name synonym)|uniprotkb:b2235(locus name)|uniprotkb:JW2229(locus name)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2007)	pubmed:17726094|doi:10.1073/pnas.0706803104|imex:IM-22894	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654603|imex:IM-22894-1|dip:DIP-108979E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416738.1|refseq:WP_000332037.1|dip:DIP-36213N|ensemblbacteria:AAC75295(transcript)|ensemblbacteria:b2235(gene)|ensemblbacteria:BAA16054(gene)|ensemblbacteria:BAA16054(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:1AV8|rcsb pdb:1BIQ|rcsb pdb:1JPR|rcsb pdb:1JQC|rcsb pdb:1MRR|rcsb pdb:1MXR|rcsb pdb:1PFR|rcsb pdb:1PIM|rcsb pdb:1PIU|rcsb pdb:1PIY|rcsb pdb:1PIZ|rcsb pdb:1PJ0|rcsb pdb:1PJ1|rcsb pdb:1PM2|rcsb pdb:1R1R|rcsb pdb:1R65|rcsb pdb:1RIB|rcsb pdb:1RNR|rcsb pdb:1RSR|rcsb pdb:1RSV|rcsb pdb:1XIK|rcsb pdb:1YFD|rcsb pdb:2ALX|rcsb pdb:2AV8|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:2XOF|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CI2|rcsb pdb:5CI3|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R	refseq:NP_416738.1|refseq:WP_000332037.1|dip:DIP-36213N|ensemblbacteria:AAC75295(transcript)|ensemblbacteria:b2235(gene)|ensemblbacteria:BAA16054(gene)|ensemblbacteria:BAA16054(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:1AV8|rcsb pdb:1BIQ|rcsb pdb:1JPR|rcsb pdb:1JQC|rcsb pdb:1MRR|rcsb pdb:1MXR|rcsb pdb:1PFR|rcsb pdb:1PIM|rcsb pdb:1PIU|rcsb pdb:1PIY|rcsb pdb:1PIZ|rcsb pdb:1PJ0|rcsb pdb:1PJ1|rcsb pdb:1PM2|rcsb pdb:1R1R|rcsb pdb:1R65|rcsb pdb:1RIB|rcsb pdb:1RNR|rcsb pdb:1RSR|rcsb pdb:1RSV|rcsb pdb:1XIK|rcsb pdb:1YFD|rcsb pdb:2ALX|rcsb pdb:2AV8|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:2XOF|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CI2|rcsb pdb:5CI3|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:42pZa9Gzjeb/xN8QIpmolT+yu0M83333	rogid:42pZa9Gzjeb/xN8QIpmolT+yu0M83333	rigid:ITxa3fzBA0amajYR2K2/jfWTKvw	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P69924	uniprotkb:P00452	intact:EBI-555196|uniprotkb:P00453|ensemblbacteria:AAC75295|ensemblbacteria:BAA16054	intact:EBI-370018|uniprotkb:P78177|uniprotkb:P78088|ensemblbacteria:AAC75294|ensemblbacteria:BAA16053	psi-mi:rir2_ecoli(display_long)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:Protein B2(gene name synonym)|uniprotkb:Protein R2(gene name synonym)|uniprotkb:nrdB(gene name)|psi-mi:nrdB(display_short)|uniprotkb:ftsB(gene name synonym)|uniprotkb:b2235(locus name)|uniprotkb:JW2229(locus name)	psi-mi:rir1_ecoli(display_long)|uniprotkb:nrdA(gene name)|psi-mi:nrdA(display_short)|uniprotkb:dnaF(gene name synonym)|uniprotkb:Protein B1(gene name synonym)|uniprotkb:b2234(locus name)|uniprotkb:Ribonucleoside-diphosphate reductase 1 R1 subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:JW2228(locus name)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2007)	pubmed:17726094|doi:10.1073/pnas.0706803104|imex:IM-22894	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654619|imex:IM-22894-2|dip:DIP-170755E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416738.1|refseq:WP_000332037.1|dip:DIP-36213N|ensemblbacteria:AAC75295(transcript)|ensemblbacteria:b2235(gene)|ensemblbacteria:BAA16054(gene)|ensemblbacteria:BAA16054(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:1AV8|rcsb pdb:1BIQ|rcsb pdb:1JPR|rcsb pdb:1JQC|rcsb pdb:1MRR|rcsb pdb:1MXR|rcsb pdb:1PFR|rcsb pdb:1PIM|rcsb pdb:1PIU|rcsb pdb:1PIY|rcsb pdb:1PIZ|rcsb pdb:1PJ0|rcsb pdb:1PJ1|rcsb pdb:1PM2|rcsb pdb:1R1R|rcsb pdb:1R65|rcsb pdb:1RIB|rcsb pdb:1RNR|rcsb pdb:1RSR|rcsb pdb:1RSV|rcsb pdb:1XIK|rcsb pdb:1YFD|rcsb pdb:2ALX|rcsb pdb:2AV8|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:2XOF|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CI2|rcsb pdb:5CI3|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R	ensemblbacteria:AAC75294(transcript)|ensemblbacteria:b2234(gene)|ensemblbacteria:BAA16053(gene)|ensemblbacteria:BAA16053(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:1QFN|rcsb pdb:1R1R|rcsb pdb:1RLR|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R|refseq:WP_001075164.1|refseq:NP_416737.1|dip:DIP-584N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:42pZa9Gzjeb/xN8QIpmolT+yu0M83333	rogid:XdJE47xPcAa/C7+LU76gQcIMrL083333	rigid:xhs3cusljmEtIUyQmpoYlCn/MbM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23921	uniprotkb:P23921	intact:EBI-717006|uniprotkb:Q9UNN2|ensembl:ENSP00000300738	intact:EBI-717006|uniprotkb:Q9UNN2|ensembl:ENSP00000300738	psi-mi:rir1_human(display_long)|uniprotkb:Ribonucleoside-diphosphate reductase subunit M1(gene name synonym)|uniprotkb:Ribonucleotide reductase large subunit(gene name synonym)|uniprotkb:RRM1(gene name)|psi-mi:RRM1(display_short)|uniprotkb:RR1(gene name synonym)	psi-mi:rir1_human(display_long)|uniprotkb:Ribonucleoside-diphosphate reductase subunit M1(gene name synonym)|uniprotkb:Ribonucleotide reductase large subunit(gene name synonym)|uniprotkb:RRM1(gene name)|psi-mi:RRM1(display_short)|uniprotkb:RR1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2007)	pubmed:17726094|doi:10.1073/pnas.0706803104|imex:IM-22894	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654636|imex:IM-22894-3|dip:DIP-186976E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001024.1|refseq:NP_001304993.1|refseq:NP_001304994.1|ensembl:ENSG00000167325(gene)|ensembl:ENST00000300738(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006206"(pyrimidine nucleobase metabolic process)|go:"GO:0006260"(DNA replication)|go:"GO:0008584"(male gonad development)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061731"(ribonucleoside-diphosphate reductase activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:2WGH|rcsb pdb:3HNC|rcsb pdb:3HND|rcsb pdb:3HNE|rcsb pdb:3HNF|rcsb pdb:4X3V|rcsb pdb:5D1Y|rcsb pdb:5TUS|rcsb pdb:6AUI|rcsb pdb:6L3R|rcsb pdb:6L7L|rcsb pdb:6LKM|reactome:R-HSA-499943|dip:DIP-24233N	refseq:NP_001024.1|refseq:NP_001304993.1|refseq:NP_001304994.1|ensembl:ENSG00000167325(gene)|ensembl:ENST00000300738(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006206"(pyrimidine nucleobase metabolic process)|go:"GO:0006260"(DNA replication)|go:"GO:0008584"(male gonad development)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061731"(ribonucleoside-diphosphate reductase activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:2WGH|rcsb pdb:3HNC|rcsb pdb:3HND|rcsb pdb:3HNE|rcsb pdb:3HNF|rcsb pdb:4X3V|rcsb pdb:5D1Y|rcsb pdb:5TUS|rcsb pdb:6AUI|rcsb pdb:6L3R|rcsb pdb:6L7L|rcsb pdb:6LKM|reactome:R-HSA-499943|dip:DIP-24233N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:3+XYBQzGh1wi495ZTSvHbYvUXZQ9606	rogid:3+XYBQzGh1wi495ZTSvHbYvUXZQ9606	rigid:noS7Fv+pxNwSB4X59F5/LRSUh2A	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31350	uniprotkb:P23921	intact:EBI-2339245|uniprotkb:B2R9B5|uniprotkb:Q5WRU7|uniprotkb:J3KP43|intact:EBI-10973436|ensembl:ENSP00000302955|ensembl:ENSP00000493399	intact:EBI-717006|uniprotkb:Q9UNN2|ensembl:ENSP00000300738	psi-mi:rir2_human(display_long)|uniprotkb:RRM2(gene name)|psi-mi:RRM2(display_short)|uniprotkb:RR2(gene name synonym)|uniprotkb:Ribonucleotide reductase small subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase small chain(gene name synonym)	psi-mi:rir1_human(display_long)|uniprotkb:Ribonucleoside-diphosphate reductase subunit M1(gene name synonym)|uniprotkb:Ribonucleotide reductase large subunit(gene name synonym)|uniprotkb:RRM1(gene name)|psi-mi:RRM1(display_short)|uniprotkb:RR1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2007)	pubmed:17726094|doi:10.1073/pnas.0706803104|imex:IM-22894	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654652|imex:IM-22894-4|dip:DIP-40169E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001025.1|refseq:NP_001159403.1|dip:DIP-24232N|ensembl:ENSG00000171848(gene)|ensembl:ENST00000304567(transcript)|ensembl:ENST00000641198(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:2UW2|rcsb pdb:3OLJ|rcsb pdb:3VPM|rcsb pdb:3VPN|rcsb pdb:3VPO|reactome:R-HSA-499943|reactome:R-HSA-69205|reactome:R-HSA-8953750	refseq:NP_001024.1|refseq:NP_001304993.1|refseq:NP_001304994.1|ensembl:ENSG00000167325(gene)|ensembl:ENST00000300738(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006206"(pyrimidine nucleobase metabolic process)|go:"GO:0006260"(DNA replication)|go:"GO:0008584"(male gonad development)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0061731"(ribonucleoside-diphosphate reductase activity)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:2WGH|rcsb pdb:3HNC|rcsb pdb:3HND|rcsb pdb:3HNE|rcsb pdb:3HNF|rcsb pdb:4X3V|rcsb pdb:5D1Y|rcsb pdb:5TUS|rcsb pdb:6AUI|rcsb pdb:6L3R|rcsb pdb:6L7L|rcsb pdb:6LKM|reactome:R-HSA-499943|dip:DIP-24233N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:vkkD9wGSPnsXX89dIQ53fhLD7uI9606	rogid:3+XYBQzGh1wi495ZTSvHbYvUXZQ9606	rigid:R5b3Xm9TFrnAkfyOxrhsg4D47rI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31350	uniprotkb:P31350	intact:EBI-2339245|uniprotkb:B2R9B5|uniprotkb:Q5WRU7|uniprotkb:J3KP43|intact:EBI-10973436|ensembl:ENSP00000302955|ensembl:ENSP00000493399	intact:EBI-2339245|uniprotkb:B2R9B5|uniprotkb:Q5WRU7|uniprotkb:J3KP43|intact:EBI-10973436|ensembl:ENSP00000302955|ensembl:ENSP00000493399	psi-mi:rir2_human(display_long)|uniprotkb:RRM2(gene name)|psi-mi:RRM2(display_short)|uniprotkb:RR2(gene name synonym)|uniprotkb:Ribonucleotide reductase small subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase small chain(gene name synonym)	psi-mi:rir2_human(display_long)|uniprotkb:RRM2(gene name)|psi-mi:RRM2(display_short)|uniprotkb:RR2(gene name synonym)|uniprotkb:Ribonucleotide reductase small subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase small chain(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2007)	pubmed:17726094|doi:10.1073/pnas.0706803104|imex:IM-22894	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654669|imex:IM-22894-5|dip:DIP-197002E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001025.1|refseq:NP_001159403.1|dip:DIP-24232N|ensembl:ENSG00000171848(gene)|ensembl:ENST00000304567(transcript)|ensembl:ENST00000641198(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:2UW2|rcsb pdb:3OLJ|rcsb pdb:3VPM|rcsb pdb:3VPN|rcsb pdb:3VPO|reactome:R-HSA-499943|reactome:R-HSA-69205|reactome:R-HSA-8953750	refseq:NP_001025.1|refseq:NP_001159403.1|dip:DIP-24232N|ensembl:ENSG00000171848(gene)|ensembl:ENST00000304567(transcript)|ensembl:ENST00000641198(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:2UW2|rcsb pdb:3OLJ|rcsb pdb:3VPM|rcsb pdb:3VPN|rcsb pdb:3VPO|reactome:R-HSA-499943|reactome:R-HSA-69205|reactome:R-HSA-8953750	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:vkkD9wGSPnsXX89dIQ53fhLD7uI9606	rogid:vkkD9wGSPnsXX89dIQ53fhLD7uI9606	rigid:mirfF07JvHrhUX0amrkluh7NpJQ	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00452	uniprotkb:P00452	intact:EBI-370018|uniprotkb:P78177|uniprotkb:P78088|ensemblbacteria:AAC75294|ensemblbacteria:BAA16053	intact:EBI-370018|uniprotkb:P78177|uniprotkb:P78088|ensemblbacteria:AAC75294|ensemblbacteria:BAA16053	psi-mi:rir1_ecoli(display_long)|uniprotkb:nrdA(gene name)|psi-mi:nrdA(display_short)|uniprotkb:dnaF(gene name synonym)|uniprotkb:Protein B1(gene name synonym)|uniprotkb:b2234(locus name)|uniprotkb:Ribonucleoside-diphosphate reductase 1 R1 subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:JW2228(locus name)	psi-mi:rir1_ecoli(display_long)|uniprotkb:nrdA(gene name)|psi-mi:nrdA(display_short)|uniprotkb:dnaF(gene name synonym)|uniprotkb:Protein B1(gene name synonym)|uniprotkb:b2234(locus name)|uniprotkb:Ribonucleoside-diphosphate reductase 1 R1 subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase 1(gene name synonym)|uniprotkb:JW2228(locus name)	psi-mi:"MI:0071"(molecular sieving)	Wang et al. (2007)	pubmed:17726094|doi:10.1073/pnas.0706803104|imex:IM-22894	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654685|imex:IM-22894-6|dip:DIP-50186E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAC75294(transcript)|ensemblbacteria:b2234(gene)|ensemblbacteria:BAA16053(gene)|ensemblbacteria:BAA16053(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:1QFN|rcsb pdb:1R1R|rcsb pdb:1RLR|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R|refseq:WP_001075164.1|refseq:NP_416737.1|dip:DIP-584N	ensemblbacteria:AAC75294(transcript)|ensemblbacteria:b2234(gene)|ensemblbacteria:BAA16053(gene)|ensemblbacteria:BAA16053(transcript)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0015949"(nucleobase-containing small molecule interconversion)|go:"GO:0042802"(identical protein binding)|interpro:IPR000788(Ribonucleotide reductase large subunit, C-terminal)|interpro:IPR005144(ATP-cone)|interpro:IPR008926(Ribonucleotide reductase R1 subunit, N-terminal)|interpro:IPR013346(Ribonucleoside-diphosphate reductase, alpha subunit)|interpro:IPR013509(Ribonucleotide reductase large subunit, N-terminal)|interpro:IPR039718|rcsb pdb:1QFN|rcsb pdb:1R1R|rcsb pdb:1RLR|rcsb pdb:2R1R|rcsb pdb:2X0X|rcsb pdb:2XAK|rcsb pdb:2XAP|rcsb pdb:2XAV|rcsb pdb:2XAW|rcsb pdb:2XAX|rcsb pdb:2XAY|rcsb pdb:2XAZ|rcsb pdb:2XO4|rcsb pdb:2XO5|rcsb pdb:3R1R|rcsb pdb:3UUS|rcsb pdb:4ERM|rcsb pdb:4ERP|rcsb pdb:4R1R|rcsb pdb:5CNS|rcsb pdb:5CNT|rcsb pdb:5CNU|rcsb pdb:5CNV|rcsb pdb:5R1R|rcsb pdb:6R1R|rcsb pdb:6W4X|rcsb pdb:7R1R|refseq:WP_001075164.1|refseq:NP_416737.1|dip:DIP-584N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:XdJE47xPcAa/C7+LU76gQcIMrL083333	rogid:XdJE47xPcAa/C7+LU76gQcIMrL083333	rigid:GgY1R3PibGXVunCsIVYKNIW9E90	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)