#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P09681	uniprotkb:P48546	intact:EBI-8588553|ensembl:ENSP00000350005|uniprotkb:Q6NTD3|uniprotkb:Q4VB42|intact:MINT-8090589	intact:EBI-15653881|ensembl:ENSP00000467494|uniprotkb:B7WP14|uniprotkb:B7ZKQ0|uniprotkb:Q14401|uniprotkb:Q16400|uniprotkb:Q52M04|uniprotkb:Q9UPI1	psi-mi:gip_human(display_long)|uniprotkb:Incretin hormone(gene name synonym)|uniprotkb:GIP(gene name)|psi-mi:GIP(display_short)|uniprotkb:Glucose-dependent insulinotropic polypeptide(gene name synonym)	psi-mi:gipr_human(display_long)|uniprotkb:GIPR(gene name)|psi-mi:GIPR(display_short)|uniprotkb:Glucose-dependent insulinotropic polypeptide receptor(gene name synonym)	psi-mi:"MI:0016"(circular dichroism)	Parthier et al. (2007)	pubmed:17715056|doi:10.1073/pnas.0706404104|imex:IM-9714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15653930|imex:IM-9714-1|dip:DIP-88558E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159224(gene)|ensembl:ENST00000357424(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009749"(response to glucose)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033993"(response to lipid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035640"(exploration behavior)|go:"GO:0038192"(gastric inhibitory peptide signaling pathway)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0042594"(response to starvation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043200"(response to amino acid)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0048678"(response to axon injury)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0055123"(digestive system development)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0070328"(triglyceride homeostasis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR039078|rcsb pdb:1T5Q|rcsb pdb:2B4N|rcsb pdb:2L70|go:"GO:0042493"|rcsb pdb:2L71|rcsb pdb:2OBU|reactome:R-HSA-9660821|rcsb pdb:2QKH|reactome:R-HSA-400511|reactome:R-HSA-418555|reactome:R-HSA-420092|dip:DIP-46469N|refseq:NP_004114.1	go:"GO:0009749"(response to glucose)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016519"(gastric inhibitory peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0038192"(gastric inhibitory peptide signaling pathway)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0048678"(response to axon injury)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070542"(response to fatty acid)|go:"GO:0120022"(glucagon family peptide binding)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001749(GPCR, family 2, gastric inhibitory polypeptide receptor)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:2QKH|rcsb pdb:4HJ0|rcsb pdb:6DKJ|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|ensembl:ENSG00000010310(gene)|ensembl:ENST00000590918(transcript)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|refseq:NP_000155.1|refseq:NP_001295347.1|dip:DIP-46468N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:uDk65FsDVA70YuVfSkYyfbSCFeQ9606	rogid:WR5yk1oC1AaCZDauK4JmV7aUWII9606	rigid:7H8/v4rWggwlsOj7sqZVBsXBAGc	false	binding-associated region:52-93	binding-associated region:24-138	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09681	uniprotkb:P48546	intact:EBI-8588553|ensembl:ENSP00000350005|uniprotkb:Q6NTD3|uniprotkb:Q4VB42|intact:MINT-8090589	intact:EBI-15653881|ensembl:ENSP00000467494|uniprotkb:B7WP14|uniprotkb:B7ZKQ0|uniprotkb:Q14401|uniprotkb:Q16400|uniprotkb:Q52M04|uniprotkb:Q9UPI1	psi-mi:gip_human(display_long)|uniprotkb:Incretin hormone(gene name synonym)|uniprotkb:GIP(gene name)|psi-mi:GIP(display_short)|uniprotkb:Glucose-dependent insulinotropic polypeptide(gene name synonym)	psi-mi:gipr_human(display_long)|uniprotkb:GIPR(gene name)|psi-mi:GIPR(display_short)|uniprotkb:Glucose-dependent insulinotropic polypeptide receptor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Parthier et al. (2007)	pubmed:17715056|doi:10.1073/pnas.0706404104|imex:IM-9714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15653952|imex:IM-9714-2|dip:DIP-88558E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159224(gene)|ensembl:ENST00000357424(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009749"(response to glucose)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033993"(response to lipid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035640"(exploration behavior)|go:"GO:0038192"(gastric inhibitory peptide signaling pathway)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0042594"(response to starvation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043200"(response to amino acid)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0048678"(response to axon injury)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0055123"(digestive system development)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0070328"(triglyceride homeostasis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR039078|rcsb pdb:1T5Q|rcsb pdb:2B4N|rcsb pdb:2L70|go:"GO:0042493"|rcsb pdb:2L71|rcsb pdb:2OBU|reactome:R-HSA-9660821|rcsb pdb:2QKH|reactome:R-HSA-400511|reactome:R-HSA-418555|reactome:R-HSA-420092|dip:DIP-46469N|refseq:NP_004114.1	go:"GO:0009749"(response to glucose)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016519"(gastric inhibitory peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0038192"(gastric inhibitory peptide signaling pathway)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0048678"(response to axon injury)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070542"(response to fatty acid)|go:"GO:0120022"(glucagon family peptide binding)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001749(GPCR, family 2, gastric inhibitory polypeptide receptor)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:2QKH|rcsb pdb:4HJ0|rcsb pdb:6DKJ|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|ensembl:ENSG00000010310(gene)|ensembl:ENST00000590918(transcript)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|refseq:NP_000155.1|refseq:NP_001295347.1|dip:DIP-46468N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:uDk65FsDVA70YuVfSkYyfbSCFeQ9606	rogid:WR5yk1oC1AaCZDauK4JmV7aUWII9606	rigid:7H8/v4rWggwlsOj7sqZVBsXBAGc	false	binding-associated region:52-93	binding-associated region:24-138	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01275	uniprotkb:P48546	intact:EBI-7629173|ensembl:ENSP00000364647|ensembl:ENSP00000387662|uniprotkb:A6NN65|intact:MINT-8090511|uniprotkb:Q53TP6	intact:EBI-15653881|ensembl:ENSP00000467494|uniprotkb:B7WP14|uniprotkb:B7ZKQ0|uniprotkb:Q14401|uniprotkb:Q16400|uniprotkb:Q52M04|uniprotkb:Q9UPI1	psi-mi:gluc_human(display_long)|uniprotkb:GCG(gene name)|psi-mi:GCG(display_short)	psi-mi:gipr_human(display_long)|uniprotkb:GIPR(gene name)|psi-mi:GIPR(display_short)|uniprotkb:Glucose-dependent insulinotropic polypeptide receptor(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Parthier et al. (2007)	pubmed:17715056|doi:10.1073/pnas.0706404104|imex:IM-9714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15653973|imex:IM-9714-3|dip:DIP-88559E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-420092|reactome:R-HSA-422085|reactome:R-HSA-9660821|reactome:R-HSA-418555|ensembl:ENSG00000115263(gene)|ensembl:ENST00000375497(transcript)|ensembl:ENST00000418842(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014823"(response to activity)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015550(Glucagon-like)|mint:P01275|rcsb pdb:1BH0|rcsb pdb:1D0R|rcsb pdb:1NAU|rcsb pdb:2G49|rcsb pdb:2L63|rcsb pdb:2L64|rcsb pdb:2M5P|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|rcsb pdb:2M5Q|rcsb pdb:3IOL|rcsb pdb:4APD|rcsb pdb:4ZGM|rcsb pdb:5OTU|rcsb pdb:5OTV|rcsb pdb:5OTW|rcsb pdb:5OTX|rcsb pdb:5VAI|rcsb pdb:5YQZ|rcsb pdb:6EDS|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6NZN|rcsb pdb:6PHI|rcsb pdb:6PHJ|rcsb pdb:6PHK|rcsb pdb:6PHL|rcsb pdb:6PHO|rcsb pdb:6PHP|rcsb pdb:6VCB|rcsb pdb:6X18|rcsb pdb:7D68|reactome:R-HSA-163359|reactome:R-HSA-381676|reactome:R-HSA-381771|reactome:R-HSA-416476|refseq:NP_002045.1|dip:DIP-46470N	go:"GO:0009749"(response to glucose)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016519"(gastric inhibitory peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0038192"(gastric inhibitory peptide signaling pathway)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0048678"(response to axon injury)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070542"(response to fatty acid)|go:"GO:0120022"(glucagon family peptide binding)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001749(GPCR, family 2, gastric inhibitory polypeptide receptor)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:2QKH|rcsb pdb:4HJ0|rcsb pdb:6DKJ|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|ensembl:ENSG00000010310(gene)|ensembl:ENST00000590918(transcript)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|refseq:NP_000155.1|refseq:NP_001295347.1|dip:DIP-46468N	psi-mi:"MI:0465"(dip)	comment:mint|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:lZLjmf6wPVM15tLWwCJkDwY3CSw9606	rogid:WR5yk1oC1AaCZDauK4JmV7aUWII9606	rigid:iHCo3QhnL86NoDIzikAzZGw4VTI	false	polyprotein fragment:98-127	binding-associated region:24-138	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01275	uniprotkb:P48546	intact:EBI-7629173|ensembl:ENSP00000364647|ensembl:ENSP00000387662|uniprotkb:A6NN65|intact:MINT-8090511|uniprotkb:Q53TP6	intact:EBI-15653881|ensembl:ENSP00000467494|uniprotkb:B7WP14|uniprotkb:B7ZKQ0|uniprotkb:Q14401|uniprotkb:Q16400|uniprotkb:Q52M04|uniprotkb:Q9UPI1	psi-mi:gluc_human(display_long)|uniprotkb:GCG(gene name)|psi-mi:GCG(display_short)	psi-mi:gipr_human(display_long)|uniprotkb:GIPR(gene name)|psi-mi:GIPR(display_short)|uniprotkb:Glucose-dependent insulinotropic polypeptide receptor(gene name synonym)	psi-mi:"MI:0016"(circular dichroism)	Parthier et al. (2007)	pubmed:17715056|doi:10.1073/pnas.0706404104|imex:IM-9714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15653994|imex:IM-9714-4|dip:DIP-88559E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-420092|reactome:R-HSA-422085|reactome:R-HSA-9660821|reactome:R-HSA-418555|ensembl:ENSG00000115263(gene)|ensembl:ENST00000375497(transcript)|ensembl:ENST00000418842(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014823"(response to activity)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR015550(Glucagon-like)|mint:P01275|rcsb pdb:1BH0|rcsb pdb:1D0R|rcsb pdb:1NAU|rcsb pdb:2G49|rcsb pdb:2L63|rcsb pdb:2L64|rcsb pdb:2M5P|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|rcsb pdb:2M5Q|rcsb pdb:3IOL|rcsb pdb:4APD|rcsb pdb:4ZGM|rcsb pdb:5OTU|rcsb pdb:5OTV|rcsb pdb:5OTW|rcsb pdb:5OTX|rcsb pdb:5VAI|rcsb pdb:5YQZ|rcsb pdb:6EDS|rcsb pdb:6LMK|rcsb pdb:6LML|rcsb pdb:6NZN|rcsb pdb:6PHI|rcsb pdb:6PHJ|rcsb pdb:6PHK|rcsb pdb:6PHL|rcsb pdb:6PHO|rcsb pdb:6PHP|rcsb pdb:6VCB|rcsb pdb:6X18|rcsb pdb:7D68|reactome:R-HSA-163359|reactome:R-HSA-381676|reactome:R-HSA-381771|reactome:R-HSA-416476|refseq:NP_002045.1|dip:DIP-46470N	go:"GO:0009749"(response to glucose)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016519"(gastric inhibitory peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0038192"(gastric inhibitory peptide signaling pathway)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0048678"(response to axon injury)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070542"(response to fatty acid)|go:"GO:0120022"(glucagon family peptide binding)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001749(GPCR, family 2, gastric inhibitory polypeptide receptor)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:2QKH|rcsb pdb:4HJ0|rcsb pdb:6DKJ|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|ensembl:ENSG00000010310(gene)|ensembl:ENST00000590918(transcript)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|refseq:NP_000155.1|refseq:NP_001295347.1|dip:DIP-46468N	psi-mi:"MI:0465"(dip)	comment:mint|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:lZLjmf6wPVM15tLWwCJkDwY3CSw9606	rogid:WR5yk1oC1AaCZDauK4JmV7aUWII9606	rigid:iHCo3QhnL86NoDIzikAzZGw4VTI	false	polyprotein fragment:98-127	binding-associated region:24-138	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09681	uniprotkb:P48546	intact:EBI-8588553|ensembl:ENSP00000350005|uniprotkb:Q6NTD3|uniprotkb:Q4VB42|intact:MINT-8090589	intact:EBI-15653881|ensembl:ENSP00000467494|uniprotkb:B7WP14|uniprotkb:B7ZKQ0|uniprotkb:Q14401|uniprotkb:Q16400|uniprotkb:Q52M04|uniprotkb:Q9UPI1	psi-mi:gip_human(display_long)|uniprotkb:Incretin hormone(gene name synonym)|uniprotkb:GIP(gene name)|psi-mi:GIP(display_short)|uniprotkb:Glucose-dependent insulinotropic polypeptide(gene name synonym)	psi-mi:gipr_human(display_long)|uniprotkb:GIPR(gene name)|psi-mi:GIPR(display_short)|uniprotkb:Glucose-dependent insulinotropic polypeptide receptor(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Parthier et al. (2007)	pubmed:17715056|doi:10.1073/pnas.0706404104|imex:IM-9714	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15654015|imex:IM-9714-5|dip:DIP-88558E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000159224(gene)|ensembl:ENST00000357424(transcript)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007613"(memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009749"(response to glucose)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031767"(gastric inhibitory polypeptide receptor binding)|go:"GO:0031769"(glucagon receptor binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0033993"(response to lipid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035640"(exploration behavior)|go:"GO:0038192"(gastric inhibitory peptide signaling pathway)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0042594"(response to starvation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043200"(response to amino acid)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0048678"(response to axon injury)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0055123"(digestive system development)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070094"(positive regulation of glucagon secretion)|go:"GO:0070328"(triglyceride homeostasis)|interpro:IPR000532(Glucagon/GIP/secretin/VIP)|interpro:IPR039078|rcsb pdb:1T5Q|rcsb pdb:2B4N|rcsb pdb:2L70|go:"GO:0042493"|rcsb pdb:2L71|rcsb pdb:2OBU|reactome:R-HSA-9660821|rcsb pdb:2QKH|reactome:R-HSA-400511|reactome:R-HSA-418555|reactome:R-HSA-420092|dip:DIP-46469N|refseq:NP_004114.1	go:"GO:0009749"(response to glucose)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016519"(gastric inhibitory peptide receptor activity)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0038192"(gastric inhibitory peptide signaling pathway)|go:"GO:0043950"(positive regulation of cAMP-mediated signaling)|go:"GO:0048678"(response to axon injury)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070542"(response to fatty acid)|go:"GO:0120022"(glucagon family peptide binding)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001749(GPCR, family 2, gastric inhibitory polypeptide receptor)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:2QKH|rcsb pdb:4HJ0|rcsb pdb:6DKJ|reactome:R-HSA-418555|reactome:R-HSA-420092|reactome:R-HSA-9660821|ensembl:ENSG00000010310(gene)|ensembl:ENST00000590918(transcript)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|refseq:NP_000155.1|refseq:NP_001295347.1|dip:DIP-46468N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:uDk65FsDVA70YuVfSkYyfbSCFeQ9606	rogid:WR5yk1oC1AaCZDauK4JmV7aUWII9606	rigid:7H8/v4rWggwlsOj7sqZVBsXBAGc	false	binding-associated region:52-93	binding-associated region:24-138	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)