#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9CWR8 uniprotkb:O88508-1 intact:EBI-3043871|ensembl:ENSMUSP00000000746|ensembl:ENSMUSP00000116970|ensembl:ENSMUSP00000121562 intact:EBI-15650457|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009 psi-mi:dnm3l_mouse(display_long)|uniprotkb:Dnmt3l(gene name)|psi-mi:Dnmt3l(display_short) psi-mi:o88508-1(display_long)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym) psi-mi:"MI:0096"(pull down) Jia et al. (2007) pubmed:17713477|doi:10.1038/nature06146|imex:IM-21161 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15653481|imex:IM-21161-1|dip:DIP-191034E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271126.1|ensembl:ENSMUSG00000000730(gene)|ensembl:ENSMUST00000000746(transcript)|ensembl:ENSMUST00000138785(transcript)|ensembl:ENSMUST00000151242(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019899"(enzyme binding)|go:"GO:0032259"(methylation)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071514"(genomic imprinting)|go:"GO:0006306"(DNA methylation)|go:"GO:1905642"(negative regulation of DNA methylation)|go:"GO:1905643"(positive regulation of DNA methylation)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR025766|interpro:IPR030486|interpro:IPR040552|refseq:NP_001075164.1|refseq:NP_062321.1|dip:DIP-49029N ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000174817(transcript)|ensembl:ENSMUST00000020991(transcript)|intact:EBI-995154(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:5eTaaJeCQTpKh5Wd2MZP25DSexM10090 rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090 rigid:N7HD971s9sdYm89ZKE/INjejdlo false sufficient binding region:160-386|glutathione s tranferase tag:n-n sufficient binding region:623-908|his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9CWR8 uniprotkb:Q9CWR8 intact:EBI-3043871|ensembl:ENSMUSP00000000746|ensembl:ENSMUSP00000116970|ensembl:ENSMUSP00000121562 intact:EBI-3043871|ensembl:ENSMUSP00000000746|ensembl:ENSMUSP00000116970|ensembl:ENSMUSP00000121562 psi-mi:dnm3l_mouse(display_long)|uniprotkb:Dnmt3l(gene name)|psi-mi:Dnmt3l(display_short) psi-mi:dnm3l_mouse(display_long)|uniprotkb:Dnmt3l(gene name)|psi-mi:Dnmt3l(display_short) psi-mi:"MI:0071"(molecular sieving) Jia et al. (2007) pubmed:17713477|doi:10.1038/nature06146|imex:IM-21161 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15653527|imex:IM-21161-3|dip:DIP-191035E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271126.1|ensembl:ENSMUSG00000000730(gene)|ensembl:ENSMUST00000000746(transcript)|ensembl:ENSMUST00000138785(transcript)|ensembl:ENSMUST00000151242(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019899"(enzyme binding)|go:"GO:0032259"(methylation)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071514"(genomic imprinting)|go:"GO:0006306"(DNA methylation)|go:"GO:1905642"(negative regulation of DNA methylation)|go:"GO:1905643"(positive regulation of DNA methylation)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR025766|interpro:IPR030486|interpro:IPR040552|refseq:NP_001075164.1|refseq:NP_062321.1|dip:DIP-49029N refseq:NP_001271126.1|ensembl:ENSMUSG00000000730(gene)|ensembl:ENSMUST00000000746(transcript)|ensembl:ENSMUST00000138785(transcript)|ensembl:ENSMUST00000151242(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019899"(enzyme binding)|go:"GO:0032259"(methylation)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071514"(genomic imprinting)|go:"GO:0006306"(DNA methylation)|go:"GO:1905642"(negative regulation of DNA methylation)|go:"GO:1905643"(positive regulation of DNA methylation)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR025766|interpro:IPR030486|interpro:IPR040552|refseq:NP_001075164.1|refseq:NP_062321.1|dip:DIP-49029N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:5eTaaJeCQTpKh5Wd2MZP25DSexM10090 rogid:5eTaaJeCQTpKh5Wd2MZP25DSexM10090 rigid:mKWpPUnrliXEg59bQfbgpgj5IoQ false mutation disrupting interaction strength:297-297 mutation disrupting interaction strength:297-297 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88508-1 uniprotkb:O88508-1 intact:EBI-15650457|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009 intact:EBI-15650457|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009 psi-mi:o88508-1(display_long)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym) psi-mi:o88508-1(display_long)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Jia et al. (2007) pubmed:17713477|doi:10.1038/nature06146|imex:IM-21161 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15653545|imex:IM-21161-4|dip:DIP-191036E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000174817(transcript)|ensembl:ENSMUST00000020991(transcript)|intact:EBI-995154(isoform-parent) ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000174817(transcript)|ensembl:ENSMUST00000020991(transcript)|intact:EBI-995154(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090 rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090 rigid:rigUPTz6u9jUnHE5qy0v6BhKPN4 false mutation decreasing interaction strength:728-728|sufficient binding region:220-908 mutation decreasing interaction strength:728-728|sufficient binding region:220-908 - 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9CWR8 uniprotkb:O88508-1 intact:EBI-3043871|ensembl:ENSMUSP00000000746|ensembl:ENSMUSP00000116970|ensembl:ENSMUSP00000121562 intact:EBI-15650457|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009 psi-mi:dnm3l_mouse(display_long)|uniprotkb:Dnmt3l(gene name)|psi-mi:Dnmt3l(display_short) psi-mi:o88508-1(display_long)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Jia et al. (2007) pubmed:17713477|doi:10.1038/nature06146|imex:IM-21161 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15653567|imex:IM-21161-5|dip:DIP-191034E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271126.1|ensembl:ENSMUSG00000000730(gene)|ensembl:ENSMUST00000000746(transcript)|ensembl:ENSMUST00000138785(transcript)|ensembl:ENSMUST00000151242(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019899"(enzyme binding)|go:"GO:0032259"(methylation)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071514"(genomic imprinting)|go:"GO:0006306"(DNA methylation)|go:"GO:1905642"(negative regulation of DNA methylation)|go:"GO:1905643"(positive regulation of DNA methylation)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR025766|interpro:IPR030486|interpro:IPR040552|refseq:NP_001075164.1|refseq:NP_062321.1|dip:DIP-49029N ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000174817(transcript)|ensembl:ENSMUST00000020991(transcript)|intact:EBI-995154(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:5eTaaJeCQTpKh5Wd2MZP25DSexM10090 rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090 rigid:N7HD971s9sdYm89ZKE/INjejdlo false sufficient binding region:160-386 sufficient binding region:623-908 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9CWR8 uniprotkb:O88508-1 intact:EBI-3043871|ensembl:ENSMUSP00000000746|ensembl:ENSMUSP00000116970|ensembl:ENSMUSP00000121562 intact:EBI-15650457|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009 psi-mi:dnm3l_mouse(display_long)|uniprotkb:Dnmt3l(gene name)|psi-mi:Dnmt3l(display_short) psi-mi:o88508-1(display_long)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Jia et al. (2007) pubmed:17713477|doi:10.1038/nature06146|imex:IM-21161 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15653506|imex:IM-21161-2|dip:DIP-191034E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271126.1|ensembl:ENSMUSG00000000730(gene)|ensembl:ENSMUST00000000746(transcript)|ensembl:ENSMUST00000138785(transcript)|ensembl:ENSMUST00000151242(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019899"(enzyme binding)|go:"GO:0032259"(methylation)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071514"(genomic imprinting)|go:"GO:0006306"(DNA methylation)|go:"GO:1905642"(negative regulation of DNA methylation)|go:"GO:1905643"(positive regulation of DNA methylation)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR025766|interpro:IPR030486|interpro:IPR040552|refseq:NP_001075164.1|refseq:NP_062321.1|dip:DIP-49029N ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000174817(transcript)|ensembl:ENSMUST00000020991(transcript)|intact:EBI-995154(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:5eTaaJeCQTpKh5Wd2MZP25DSexM10090 rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090 rigid:N7HD971s9sdYm89ZKE/INjejdlo false sufficient binding region:160-386 sufficient binding region:623-908 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9CWR8 uniprotkb:O88508-1 intact:EBI-3043871|ensembl:ENSMUSP00000000746|ensembl:ENSMUSP00000116970|ensembl:ENSMUSP00000121562 intact:EBI-15650457|ensembl:ENSMUSP00000020991|ensembl:ENSMUSP00000134009 psi-mi:dnm3l_mouse(display_long)|uniprotkb:Dnmt3l(gene name)|psi-mi:Dnmt3l(display_short) psi-mi:o88508-1(display_long)|uniprotkb:Cysteine methyltransferase DNMT3A(gene name synonym)|uniprotkb:Dnmt3a(gene name)|psi-mi:Dnmt3a(display_short)|uniprotkb:DNA methyltransferase MmuIIIA(gene name synonym) psi-mi:"MI:0096"(pull down) Jia et al. (2007) pubmed:17713477|doi:10.1038/nature06146|imex:IM-21161 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15653588|imex:IM-21161-6|dip:DIP-191034E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001271126.1|ensembl:ENSMUSG00000000730(gene)|ensembl:ENSMUST00000000746(transcript)|ensembl:ENSMUST00000138785(transcript)|ensembl:ENSMUST00000151242(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0019899"(enzyme binding)|go:"GO:0032259"(methylation)|go:"GO:0032776"(DNA methylation on cytosine)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071514"(genomic imprinting)|go:"GO:0006306"(DNA methylation)|go:"GO:1905642"(negative regulation of DNA methylation)|go:"GO:1905643"(positive regulation of DNA methylation)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR025766|interpro:IPR030486|interpro:IPR040552|refseq:NP_001075164.1|refseq:NP_062321.1|dip:DIP-49029N ensembl:ENSMUSG00000020661(gene)|ensembl:ENSMUST00000174817(transcript)|ensembl:ENSMUST00000020991(transcript)|intact:EBI-995154(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/05 2017/08/10 rogid:5eTaaJeCQTpKh5Wd2MZP25DSexM10090 rogid:ZLqyo0sbBdWAlvbJ25rm+p58o5810090 rigid:N7HD971s9sdYm89ZKE/INjejdlo false sufficient binding region:160-386|glutathione s tranferase tag:n-n sufficient binding region:623-908|his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)