#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O95786-1 uniprotkb:Q9H1Y0 intact:EBI-15577823|ensembl:ENSP00000369213 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:o95786-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15653225|imex:IM-9712-1|dip:DIP-88555E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|intact:EBI-995350(isoform-parent) refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 rigid:u0DzwwDXf+UuR8dR+LWx8fmKvxw false sufficient binding region:1-604|flag tag:n-n ha tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95786-1 uniprotkb:O94817 intact:EBI-15577823|ensembl:ENSP00000369213 intact:EBI-746742|uniprotkb:Q6PJV2|ensembl:ENSP00000425107 psi-mi:o95786-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:atg12_human(display_long)|uniprotkb:Autophagy-related protein 12(gene name synonym)|uniprotkb:ATG12(gene name)|psi-mi:ATG12(display_short)|uniprotkb:APG12(gene name synonym)|uniprotkb:APG12L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15653271|imex:IM-9712-3|dip:DIP-88550E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|intact:EBI-995350(isoform-parent) reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|refseq:NP_004698.3|ensembl:ENSG00000145782(gene)|ensembl:ENST00000509910(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|refseq:NP_001264712.1|dip:DIP-46466N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606 rogid:V+K93xoWUNtOTJk4k03IP+Q+HfA9606 rigid:FDq9cHbr0hloAjkYaemBilPeC3U false sufficient binding region:1-604|flag tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O95786-1 uniprotkb:Q9H1Y0 intact:EBI-15577823|ensembl:ENSP00000369213 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:o95786-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15653271|imex:IM-9712-3|dip:DIP-88550E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|intact:EBI-995350(isoform-parent) refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 rigid:FDq9cHbr0hloAjkYaemBilPeC3U false sufficient binding region:1-604|flag tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7Z434-1 uniprotkb:Q9H1Y0 intact:EBI-15577799|ensembl:ENSP00000401980 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:q7z434-1(display_long)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0096"(pull down) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15653248|imex:IM-9712-2|dip:DIP-88551E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|intact:EBI-995373(isoform-parent) refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 rigid:q+WzViUkJN05GZ5B35pUHzH+pLU false sufficient binding region:1-100|ha tag:n-n tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9BYX4 uniprotkb:O94817 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 intact:EBI-746742|uniprotkb:Q6PJV2|ensembl:ENSP00000425107 psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:atg12_human(display_long)|uniprotkb:Autophagy-related protein 12(gene name synonym)|uniprotkb:ATG12(gene name)|psi-mi:ATG12(display_short)|uniprotkb:APG12(gene name synonym)|uniprotkb:APG12L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15653297|imex:IM-9712-4|dip:DIP-88552E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|refseq:NP_004698.3|ensembl:ENSG00000145782(gene)|ensembl:ENST00000509910(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|refseq:NP_001264712.1|dip:DIP-46466N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 rogid:V+K93xoWUNtOTJk4k03IP+Q+HfA9606 rigid:dW/P/xARt8GXSVrWFEw5A0TQ8Ho false sufficient binding region:1-575|flag tag:n-n ha tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BYX4 uniprotkb:Q9H1Y0 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15653297|imex:IM-9712-4|dip:DIP-88552E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 rigid:dW/P/xARt8GXSVrWFEw5A0TQ8Ho false sufficient binding region:1-575|flag tag:n-n ha tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z434-1 uniprotkb:O95786-1 intact:EBI-15577799|ensembl:ENSP00000401980 intact:EBI-15577823|ensembl:ENSP00000369213 psi-mi:q7z434-1(display_long)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym) psi-mi:o95786-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15653323|imex:IM-9712-5|dip:DIP-64254E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|intact:EBI-995373(isoform-parent) ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|intact:EBI-995350(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606 rigid:obR2EHoHumN9pPBg9pR31HUKako false ha tag:n-n sufficient binding region:1-604|flag tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7Z434-1 uniprotkb:Q9H1Y0 intact:EBI-15577799|ensembl:ENSP00000401980 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:q7z434-1(display_long)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15653346|imex:IM-9712-6|dip:DIP-88551E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|intact:EBI-995373(isoform-parent) refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 rigid:q+WzViUkJN05GZ5B35pUHzH+pLU false flag tag:n-n ha tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z434-1 uniprotkb:O94817 intact:EBI-15577799|ensembl:ENSP00000401980 intact:EBI-746742|uniprotkb:Q6PJV2|ensembl:ENSP00000425107 psi-mi:q7z434-1(display_long)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym) psi-mi:atg12_human(display_long)|uniprotkb:Autophagy-related protein 12(gene name synonym)|uniprotkb:ATG12(gene name)|psi-mi:ATG12(display_short)|uniprotkb:APG12(gene name synonym)|uniprotkb:APG12L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15653407|imex:IM-9712-9|dip:DIP-88553E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|intact:EBI-995373(isoform-parent) reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|refseq:NP_004698.3|ensembl:ENSG00000145782(gene)|ensembl:ENST00000509910(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|refseq:NP_001264712.1|dip:DIP-46466N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rogid:V+K93xoWUNtOTJk4k03IP+Q+HfA9606 rigid:Y1lX704n8E2epChYg3QcdO3l6o8 false sufficient binding region:1-100|mutation disrupting interaction:54-54|flag tag:n-n ha tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z434-1 uniprotkb:Q9H1Y0 intact:EBI-15577799|ensembl:ENSP00000401980 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:q7z434-1(display_long)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15653407|imex:IM-9712-9|dip:DIP-88553E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|intact:EBI-995373(isoform-parent) refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 rigid:Y1lX704n8E2epChYg3QcdO3l6o8 false sufficient binding region:1-100|mutation disrupting interaction:54-54|flag tag:n-n ha tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9H1Y0 uniprotkb:Q7Z434-1 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 intact:EBI-15577799|ensembl:ENSP00000401980 psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:q7z434-1(display_long)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15653390|imex:IM-9712-8|dip:DIP-88551E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|intact:EBI-995373(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rigid:q+WzViUkJN05GZ5B35pUHzH+pLU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95786-1 uniprotkb:Q9H1Y0 intact:EBI-15577823|ensembl:ENSP00000369213 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:o95786-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0096"(pull down) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15653367|imex:IM-9712-7|dip:DIP-88555E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|intact:EBI-995350(isoform-parent) refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 rigid:u0DzwwDXf+UuR8dR+LWx8fmKvxw false binding-associated region:1-172|ha tag:n-n tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O95786-1 uniprotkb:Q7Z434-1 intact:EBI-15577823|ensembl:ENSP00000369213 intact:EBI-15577799|ensembl:ENSP00000401980 psi-mi:o95786-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:q7z434-1(display_long)|uniprotkb:MAVS(gene name)|psi-mi:MAVS(display_short)|uniprotkb:IPS1(gene name synonym)|uniprotkb:KIAA1271(gene name synonym)|uniprotkb:VISA(gene name synonym)|uniprotkb:CARD adapter inducing interferon beta(gene name synonym)|uniprotkb:Interferon beta promoter stimulator protein 1(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 031N(gene name synonym)|uniprotkb:Virus-induced-signaling adapter(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15653436|imex:IM-9712-10|dip:DIP-88554E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|intact:EBI-995350(isoform-parent) ensembl:ENSG00000088888(gene)|ensembl:ENST00000428216(transcript)|intact:EBI-995373(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606 rogid:NUZJ/I/rKEG17NeqQS067haIDhY9606 rigid:hiHyl3R4iPT3cZl1FJVQEj3M6mI false sufficient binding region:1-604|flag tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O95786-1 uniprotkb:O94817 intact:EBI-15577823|ensembl:ENSP00000369213 intact:EBI-746742|uniprotkb:Q6PJV2|ensembl:ENSP00000425107 psi-mi:o95786-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:atg12_human(display_long)|uniprotkb:Autophagy-related protein 12(gene name synonym)|uniprotkb:ATG12(gene name)|psi-mi:ATG12(display_short)|uniprotkb:APG12(gene name synonym)|uniprotkb:APG12L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15653436|imex:IM-9712-10|dip:DIP-88554E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|intact:EBI-995350(isoform-parent) reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|refseq:NP_004698.3|ensembl:ENSG00000145782(gene)|ensembl:ENST00000509910(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006501"(C-terminal protein lipidation)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0044804"(autophagy of nucleus)|interpro:IPR007242(Autophagy protein 12)|interpro:IPR029071|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|refseq:NP_001264712.1|dip:DIP-46466N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606 rogid:V+K93xoWUNtOTJk4k03IP+Q+HfA9606 rigid:hiHyl3R4iPT3cZl1FJVQEj3M6mI false sufficient binding region:1-604|flag tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O95786-1 uniprotkb:Q9H1Y0 intact:EBI-15577823|ensembl:ENSP00000369213 intact:EBI-1047414|uniprotkb:O60875|uniprotkb:Q5JVR2|uniprotkb:Q68DI4|uniprotkb:Q9H2B8|uniprotkb:Q9HCZ7|ensembl:ENSP00000343313|ensembl:ENSP00000358072 psi-mi:o95786-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:atg5_human(display_long)|uniprotkb:APG5-like(gene name synonym)|uniprotkb:Apoptosis-specific protein(gene name synonym)|uniprotkb:ATG5(gene name)|psi-mi:ATG5(display_short)|uniprotkb:APG5L(gene name synonym)|uniprotkb:ASP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jounai et al. (2007) pubmed:17709747|doi:10.1073/pnas.0704014104|imex:IM-9712 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15653436|imex:IM-9712-10|dip:DIP-88554E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|intact:EBI-995350(isoform-parent) refseq:NP_001273035.1|refseq:NP_001273036.1|refseq:NP_001273037.1|refseq:NP_001273040.1|refseq:NP_004840.1|dip:DIP-29758N|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0009620"(response to fungus)|go:"GO:0016020"(membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034274"(Atg12-Atg5-Atg16 complex)|go:"GO:0035973"(aggrephagy)|go:"GO:0039689"(negative stranded viral RNA replication)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044804"(autophagy of nucleus)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0048840"(otolith development)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060047"(heart contraction)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061739"(protein lipidation involved in autophagosome assembly)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0075044"(positive regulation by symbiont of host autophagy)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|interpro:IPR007239(Autophagy protein 5)|interpro:IPR042526|interpro:IPR042527|rcsb pdb:4GDK|rcsb pdb:4GDL|rcsb pdb:4NAW|rcsb pdb:4TQ0|rcsb pdb:4TQ1|rcsb pdb:5D7G|rcsb pdb:5NPV|rcsb pdb:5NPW|reactome:R-HSA-1632852|reactome:R-HSA-5205685|reactome:R-HSA-8934903|reactome:R-HSA-936440|ensembl:ENSG00000057663(gene)|ensembl:ENST00000343245(transcript)|ensembl:ENST00000369076(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006501"(C-terminal protein lipidation) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606 rogid:YqK4btJDQmY/dGxrmYxQmL+iAzc9606 rigid:hiHyl3R4iPT3cZl1FJVQEj3M6mI false sufficient binding region:1-604|flag tag:n-n ha tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)