#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15120	uniprotkb:P10515	intact:EBI-1383915|uniprotkb:B4DXG6|ensembl:ENSP00000368460|ensembl:ENSP00000497727	intact:EBI-2959723|ensembl:ENSP00000280346|uniprotkb:Q16783|uniprotkb:Q53EP3	psi-mi:pdk3_human(display_long)|uniprotkb:Pyruvate dehydrogenase kinase isoform 3(gene name synonym)|uniprotkb:PDK3(gene name)|psi-mi:PDK3(display_short)|uniprotkb:PDHK3(gene name synonym)	psi-mi:odp2_human(display_long)|uniprotkb:DLAT(gene name)|psi-mi:DLAT(display_short)|uniprotkb:DLTA(gene name synonym)|uniprotkb:70 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)|uniprotkb:Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex(gene name synonym)|uniprotkb:M2 antigen complex 70 kDa subunit(gene name synonym)|uniprotkb:Pyruvate dehydrogenase complex component E2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kato et al. (2007)	pubmed:17683942|doi:10.1016/j.str.2007.07.001|imex:IM-8801	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15650071|imex:IM-8801-1|dip:DIP-58928E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005382.1|refseq:NP_001135858.1|dip:DIP-29498N|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR018955|interpro:IPR036784|interpro:IPR036890|interpro:IPR039028|mint:Q15120|rcsb pdb:1Y8N|rcsb pdb:1Y8O|rcsb pdb:1Y8P|rcsb pdb:2PNR|rcsb pdb:2Q8I|reactome:R-HSA-204174|reactome:R-HSA-5362517|ensembl:ENSG00000067992(gene)|ensembl:ENST00000379162(transcript)|ensembl:ENST00000648777(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010510"(regulation of acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0071333"(cellular response to glucose stimulus)	refseq:NP_001922.2|ensembl:ENSG00000150768(gene)|ensembl:ENST00000280346(transcript)|go:"GO:0004742"(dihydrolipoyllysine-residue acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0030431"(sleep)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045254"(pyruvate dehydrogenase complex)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR006257(Dihydrolipoamide acetyltransferase, long form)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:P10515|rcsb pdb:1FYC|rcsb pdb:1Y8N|rcsb pdb:1Y8O|rcsb pdb:1Y8P|rcsb pdb:2DNE|rcsb pdb:2PNR|rcsb pdb:2Q8I|rcsb pdb:3B8K|rcsb pdb:3CRK|rcsb pdb:3CRL|rcsb pdb:6CT0|rcsb pdb:6H55|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-29496N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:Q+/L48rFsQ7HDy8zDZWSfHzVghU9606	rogid:Owh80Cm4CXvo2rPKUhLGc/U47co9606	rigid:LTrg9VOAqP263cQ9o5eS7S+FQmo	false	-	sufficient binding region:179-286	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15118	uniprotkb:Q15118	intact:EBI-7016221|uniprotkb:B7Z937|uniprotkb:E9PD65|uniprotkb:Q308M4|ensembl:ENSP00000282077|ensembl:ENSP00000386985|uniprotkb:B2R6T1|intact:MINT-2881420|uniprotkb:D3DPD8	intact:EBI-7016221|uniprotkb:B7Z937|uniprotkb:E9PD65|uniprotkb:Q308M4|ensembl:ENSP00000282077|ensembl:ENSP00000386985|uniprotkb:B2R6T1|intact:MINT-2881420|uniprotkb:D3DPD8	psi-mi:pdk1_human(display_long)|uniprotkb:PDK1(gene name)|psi-mi:PDK1(display_short)|uniprotkb:PDHK1(gene name synonym)|uniprotkb:Pyruvate dehydrogenase kinase isoform 1(gene name synonym)	psi-mi:pdk1_human(display_long)|uniprotkb:PDK1(gene name)|psi-mi:PDK1(display_short)|uniprotkb:PDHK1(gene name synonym)|uniprotkb:Pyruvate dehydrogenase kinase isoform 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kato et al. (2007)	pubmed:17683942|doi:10.1016/j.str.2007.07.001|imex:IM-8801	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15650093|imex:IM-8801-2|dip:DIP-58929E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-29497N|ensembl:ENSG00000152256(gene)|ensembl:ENST00000282077(transcript)|ensembl:ENST00000410055(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010510"(regulation of acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR018955|interpro:IPR036784|interpro:IPR036890|interpro:IPR039028|mint:Q15118|rcsb pdb:2Q8F|rcsb pdb:2Q8G|rcsb pdb:2Q8H|reactome:R-HSA-204174|reactome:R-HSA-5362517|refseq:NP_002601.1|refseq:NP_001265478.1	dip:DIP-29497N|ensembl:ENSG00000152256(gene)|ensembl:ENST00000282077(transcript)|ensembl:ENST00000410055(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0010510"(regulation of acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR018955|interpro:IPR036784|interpro:IPR036890|interpro:IPR039028|mint:Q15118|rcsb pdb:2Q8F|rcsb pdb:2Q8G|rcsb pdb:2Q8H|reactome:R-HSA-204174|reactome:R-HSA-5362517|refseq:NP_002601.1|refseq:NP_001265478.1	psi-mi:"MI:0465"(dip)	comment:mint|comment:homomint|function:Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism	comment:mint|comment:homomint|function:Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:bGVYvRnjKgE4fa6X5wY5SveeIUM9606	rogid:bGVYvRnjKgE4fa6X5wY5SveeIUM9606	rigid:9lt9EAex5EJEKeqIPWWHeLPLCFY	false	sufficient binding region:30-436	sufficient binding region:30-436	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)