#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9ET75 uniprotkb:Q62599 intact:EBI-15649593 intact:EBI-349237|uniprotkb:Q9Z0N8 psi-mi:q9et75_rat(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short) psi-mi:mta1_rat(display_long)|uniprotkb:Mta1(gene name)|psi-mi:Mta1(display_short)|uniprotkb:Zg29(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Manavathi et al. (2007) pubmed:17666527|doi:10.1073/pnas.0705878104|imex:IM-9735 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15649612|imex:IM-9735-1|dip:DIP-88589E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949|refseq:NP_076480.1|rgd:620909|dip:DIP-46497N rgd:621018|refseq:NP_072110.1|go:"GO:0005874"(microtubule)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007565"(female pregnancy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033363"(secretory granule organization)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0005634"(nucleus)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001025(Bromo adjacent region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|interpro:IPR017884|interpro:IPR017930|interpro:IPR035170|interpro:IPR040138|interpro:IPR009057(Homeodomain-like)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|dip:DIP-33254N|reactome:R-RNO-3232118|reactome:R-RNO-73762|reactome:R-RNO-8943724|reactome:R-RNO-3214815 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/05 2017/08/10 rogid:PuuYJuZKhc1Y5HyEnpfYSxuEc1410116 rogid:KevNBIb4NJucSfmX2zkb60f4Ax810116 rigid:fGt2eChPh1OHT0WhGZD3Rwa1bSs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P70288 uniprotkb:Q62233 intact:EBI-302251|uniprotkb:B2RRP3 intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677 psi-mi:hdac2_mouse(display_long)|uniprotkb:Hdac2(gene name)|psi-mi:Hdac2(display_short)|uniprotkb:Yy1bp(gene name synonym)|uniprotkb:YY1 transcription factor-binding protein(gene name synonym) psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Manavathi et al. (2007) pubmed:17666527|doi:10.1073/pnas.0705878104|imex:IM-9735 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15649629|imex:IM-9735-2|dip:DIP-88592E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-4551638|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-9022692|reactome:R-MMU-983231|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|refseq:NP_032255.2|dip:DIP-32854N|mint:P70288 refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:bGLIDKTlyhBz40NViC8calRacZ010090 rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090 rigid:DWVeaXAR0tRTW4c1CBWXY+LqPKw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P70288 uniprotkb:Q62233 intact:EBI-302251|uniprotkb:B2RRP3 intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677 psi-mi:hdac2_mouse(display_long)|uniprotkb:Hdac2(gene name)|psi-mi:Hdac2(display_short)|uniprotkb:Yy1bp(gene name synonym)|uniprotkb:YY1 transcription factor-binding protein(gene name synonym) psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym) psi-mi:"MI:0096"(pull down) Manavathi et al. (2007) pubmed:17666527|doi:10.1073/pnas.0705878104|imex:IM-9735 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15649646|imex:IM-9735-4|dip:DIP-88592E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|reactome:R-MMU-3214815|reactome:R-MMU-350054|reactome:R-MMU-4551638|reactome:R-MMU-6804758|reactome:R-MMU-73762|reactome:R-MMU-8943724|reactome:R-MMU-9022692|reactome:R-MMU-983231|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016358"(dendrite development)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061198"(fungiform papilla formation)|refseq:NP_032255.2|dip:DIP-32854N|mint:P70288 refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:bGLIDKTlyhBz40NViC8calRacZ010090 rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090 rigid:DWVeaXAR0tRTW4c1CBWXY+LqPKw false glutathione s tranferase tag:n-n sufficient binding region:120-333 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99PA1 uniprotkb:Q9ET75 intact:EBI-15649667 intact:EBI-15649593 psi-mi:q99pa1_rat(display_long) psi-mi:q9et75_rat(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Manavathi et al. (2007) pubmed:17666527|doi:10.1073/pnas.0705878104|imex:IM-9735 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15649713|imex:IM-9735-5|dip:DIP-88590E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005654"(nucleoplasm)|go:"GO:0016787"(hydrolase activity)|interpro:IPR023696|interpro:IPR037138|dip:DIP-46498N go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949|refseq:NP_076480.1|rgd:620909|dip:DIP-46497N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/05 2017/08/10 rogid:2JwBEfU+SJ+6KWkHSQVBqeqBv3U10116 rogid:PuuYJuZKhc1Y5HyEnpfYSxuEc1410116 rigid:h6TR3335liUeW8MI6tEFXNdVlZ0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q62599 uniprotkb:Q9ET75 intact:EBI-349237|uniprotkb:Q9Z0N8 intact:EBI-15649593 psi-mi:mta1_rat(display_long)|uniprotkb:Mta1(gene name)|psi-mi:Mta1(display_short)|uniprotkb:Zg29(gene name synonym) psi-mi:q9et75_rat(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Manavathi et al. (2007) pubmed:17666527|doi:10.1073/pnas.0705878104|imex:IM-9735 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15649751|imex:IM-9735-7|dip:DIP-88589E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:621018|refseq:NP_072110.1|go:"GO:0005874"(microtubule)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007565"(female pregnancy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033363"(secretory granule organization)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0005634"(nucleus)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001025(Bromo adjacent region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|interpro:IPR017884|interpro:IPR017930|interpro:IPR035170|interpro:IPR040138|interpro:IPR009057(Homeodomain-like)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|dip:DIP-33254N|reactome:R-RNO-3232118|reactome:R-RNO-73762|reactome:R-RNO-8943724|reactome:R-RNO-3214815 go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949|refseq:NP_076480.1|rgd:620909|dip:DIP-46497N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/05 2017/08/10 rogid:KevNBIb4NJucSfmX2zkb60f4Ax810116 rogid:PuuYJuZKhc1Y5HyEnpfYSxuEc1410116 rigid:fGt2eChPh1OHT0WhGZD3Rwa1bSs false - flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8K4B0 uniprotkb:Q62233 intact:EBI-1216353|uniprotkb:Q80UI1|uniprotkb:Q8K4D4|uniprotkb:Q924K9|ensembl:ENSMUSP00000009099 intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677 psi-mi:mta1_mouse(display_long)|uniprotkb:Mta1(gene name)|psi-mi:Mta1(display_short) psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym) psi-mi:"MI:0096"(pull down) Manavathi et al. (2007) pubmed:17666527|doi:10.1073/pnas.0705878104|imex:IM-9735 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15649730|imex:IM-9735-6|dip:DIP-88591E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006515485.1|dip:DIP-38226N|ensembl:ENSMUSG00000021144(gene)|ensembl:ENSMUST00000009099(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|reactome:R-MMU-3214815|reactome:R-MMU-3232118|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006302"(double-strand break repair)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033363"(secretory granule organization)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR035170|interpro:IPR040138|mint:Q8K4B0|reactome:R-MMU-73762|reactome:R-MMU-8943724 refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:5DvgpUkohteacGjUvdFq7C+fU2w10090 rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090 rigid:H2IAqxuODgE+SmdSXrMmc8ZYr4w false glutathione s tranferase tag:n-n necessary binding region:184-333 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q62233 uniprotkb:Q8K4B0 intact:EBI-2297327|uniprotkb:P70176|uniprotkb:P70177|uniprotkb:Q4QQQ3|ensembl:ENSMUSP00000135312|ensembl:ENSMUSP00000135677 intact:EBI-1216353|uniprotkb:Q80UI1|uniprotkb:Q8K4D4|uniprotkb:Q924K9|ensembl:ENSMUSP00000009099 psi-mi:six3_mouse(display_long)|uniprotkb:Six3(gene name)|psi-mi:Six3(display_short)|uniprotkb:Sine oculis homeobox homolog 3(gene name synonym) psi-mi:mta1_mouse(display_long)|uniprotkb:Mta1(gene name)|psi-mi:Mta1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Manavathi et al. (2007) pubmed:17666527|doi:10.1073/pnas.0705878104|imex:IM-9735 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15649770|imex:IM-9735-3|dip:DIP-88591E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035511.2|dip:DIP-46499N|ensembl:ENSMUSG00000038805(gene)|ensembl:ENSMUST00000175898(transcript)|ensembl:ENSMUST00000176081(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001654"(eye development)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003404"(optic vesicle morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007420"(brain development)|go:"GO:0008406"(gonad development)|go:"GO:0009946"(proximal/distal axis specification)|go:"GO:0014016"(neuroblast differentiation)|go:"GO:0021536"(diencephalon development)|go:"GO:0021537"(telencephalon development)|go:"GO:0021797"(forebrain anterior/posterior pattern specification)|go:"GO:0021798"(forebrain dorsal/ventral pattern formation)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048512"(circadian behavior)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0097402"(neuroblast migration)|go:"GO:1901987"(regulation of cell cycle phase transition)|go:"GO:1902692"(regulation of neuroblast proliferation)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR031701|interpro:IPR032949 refseq:XP_006515485.1|dip:DIP-38226N|ensembl:ENSMUSG00000021144(gene)|ensembl:ENSMUST00000009099(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|reactome:R-MMU-3214815|reactome:R-MMU-3232118|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006302"(double-strand break repair)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033363"(secretory granule organization)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR035170|interpro:IPR040138|mint:Q8K4B0|reactome:R-MMU-73762|reactome:R-MMU-8943724 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:2L0pSyki8qB2GWxiSfs9M1ruwXM10090 rogid:5DvgpUkohteacGjUvdFq7C+fU2w10090 rigid:H2IAqxuODgE+SmdSXrMmc8ZYr4w false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)