#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P42703	uniprotkb:P15018	intact:EBI-8376843|intact:MINT-4100386|uniprotkb:Q5I0Y2|ensembl:ENSMUSP00000064551|ensembl:ENSMUSP00000126137|ensembl:ENSMUSP00000154750	intact:EBI-1037189|uniprotkb:Q52LZ2|uniprotkb:B2RCW7|ensembl:ENSP00000249075|uniprotkb:B5MC23	psi-mi:lifr_mouse(display_long)|uniprotkb:Lifr(gene name)|psi-mi:Lifr(display_short)|uniprotkb:D-factor/LIF receptor(gene name synonym)	psi-mi:lif_human(display_long)|uniprotkb:LIF(gene name)|psi-mi:LIF(display_short)|uniprotkb:HILDA(gene name synonym)|uniprotkb:Differentiation-stimulating factor(gene name synonym)|uniprotkb:Melanoma-derived LPL inhibitor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Huyton et al. (2007)	pubmed:17652170|doi:10.1073/pnas.0705577104|imex:IM-9738	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15649351|imex:IM-9738-1|dip:DIP-88598E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011243628.1|refseq:NP_001106857.1|refseq:NP_038612.1|refseq:XP_006520030.1|refseq:XP_006520032.1|refseq:XP_006520033.1|refseq:XP_006520034.1|dip:DIP-5772N|ensembl:ENSMUSG00000054263(gene)|ensembl:ENSMUST00000067190(transcript)|ensembl:ENSMUST00000171588(transcript)|ensembl:ENSMUST00000226471(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004923"(leukemia inhibitory factor receptor activity)|go:"GO:0004924"(oncostatin-M receptor activity)|go:"GO:0005127"(ciliary neurotrophic factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019838"(growth factor binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034097"(response to cytokine)|go:"GO:0038165"(oncostatin-M-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR040817|interpro:IPR040901|mint:P42703|rcsb pdb:2Q7N|reactome:R-MMU-6788467	refseq:NP_002300.1|refseq:NP_001244064.1|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072108"(positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901676"(positive regulation of histone H3-K27 acetylation)|go:"GO:1903025"(regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR001581(LIF/OSM)|interpro:IPR003624(Leukemia inhibitory factor)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR019827|rcsb pdb:1EMR|rcsb pdb:1PVH|rcsb pdb:2Q7N|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-6788467|ensembl:ENSG00000128342(gene)|ensembl:ENST00000249075(transcript)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005146"(leukemia inhibitory factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006955"(immune response)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0007275"(multicellular organism development)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0007566"(embryo implantation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033141"(positive regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0048644"(muscle organ morphogenesis)|go:"GO:0048666"(neuron development)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048861"(leukemia inhibitory factor signaling pathway)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060426"(lung vasculature development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0060707"(trophoblast giant cell differentiation)|dip:DIP-5769N	psi-mi:"MI:0465"(dip)	comment:mint|function:Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:suNAINyC0j/aezB+NCa0/bnA8ME10090	rogid:2d7GyGfcJX8JuAWYA3ZIcmwzTbY9606	rigid:sCxJLdAso8zAjn3/6LC+7/ulPzc	false	binding-associated region:7-486	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)