#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29972	uniprotkb:P29972	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Buck et al. (2007)	pubmed:17632520|doi:10.1038/nsmb1275|imex:IM-8976	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15647000|imex:IM-8976-1|dip:DIP-59088E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rigid:0QK6xv4AFyXqI2GTa+99tnQoYyU	false	mutation disrupting interaction strength:51-51,49-49|mutation disrupting interaction strength:51-51,49-49,185-185	mutation disrupting interaction strength:51-51,49-49|mutation disrupting interaction strength:51-51,49-49,185-185	-	0	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P29972	uniprotkb:P29972	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Buck et al. (2007)	pubmed:17632520|doi:10.1038/nsmb1275|imex:IM-8976	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15647023|imex:IM-8976-2|dip:DIP-59088E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2017/08/05	2017/08/10	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rigid:2wgT+vT6dHn2cGUN6U7GoFJ609M	false	-	myc tag:120-120|mutation disrupting interaction strength:49-49|mutation disrupting interaction strength:51-51,49-49,185-185	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)