#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10233	uniprotkb:P06492	intact:EBI-7490002|uniprotkb:B9VQH7|uniprotkb:Q09I85|intact:MINT-6732747	intact:EBI-7489933|uniprotkb:Q09I86|intact:MINT-275736|uniprotkb:B9VQH6	psi-mi:vp22_hhv11(display_long)|uniprotkb:UL49(orf name)	psi-mi:vp16_hhv11(display_long)|uniprotkb:Vmw65(gene name synonym)|uniprotkb:ICP25(gene name synonym)|uniprotkb:Alpha-TIF(gene name synonym)|uniprotkb:Alpha trans-inducing protein(gene name synonym)|uniprotkb:UL48(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Taddeo et al. (2007)	pubmed:17620619|doi:10.1073/pnas.0705245104|imex:IM-22888	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15646823|imex:IM-22888-1|dip:DIP-143735E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137124.1|mint:P10233|go:"GO:0019033"(viral tegument)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044177"(host cell Golgi apparatus)|interpro:IPR006908(Herpesvirus UL49 tegument protein)|rcsb pdb:4XAL|dip:DIP-57160N	refseq:YP_009137123.1|mint:P06492|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0046809"(replication compartment)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003174("Alpha trans-inducing protein (Alpha-TIF)")|interpro:IPR021051|interpro:IPR036538|rcsb pdb:16VP|rcsb pdb:2PHE|rcsb pdb:2PHG|dip:DIP-41776N	psi-mi:"MI:0465"(dip)	comment:mint	comment:mint|function:"Responsible for transcriptional activation of immediate early promoters (alpha genes). Activation requires the formation of a heteromeric complex with the host cell factor. These two proteins then assemble with the octamer motif-binding protein Oct-1 on the cis-acting target sequence: 5'-TAATGARAT-3'"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:DM3Zmc28xl4p1fOVo8YqkCjc3OU10299	rogid:8rAT+y7LSTotMP4XcD+eSyMpff010299	rigid:/3tgpwlj1J6s24DPu0flyraZ23A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10225	uniprotkb:P10233	intact:EBI-6148417|uniprotkb:Q82170|uniprotkb:Q09I92	intact:EBI-7490002|uniprotkb:B9VQH7|uniprotkb:Q09I85|intact:MINT-6732747	psi-mi:shut_hhv11(display_long)|uniprotkb:UL41(gene name)|psi-mi:UL41(display_short)	psi-mi:vp22_hhv11(display_long)|uniprotkb:UL49(orf name)	psi-mi:"MI:0096"(pull down)	Taddeo et al. (2007)	pubmed:17620619|doi:10.1073/pnas.0705245104|imex:IM-22888	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15646840|imex:IM-22888-2|dip:DIP-196999E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-57855N|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|interpro:IPR006086(XPG I)|interpro:IPR029060	refseq:YP_009137124.1|mint:P10233|go:"GO:0019033"(viral tegument)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044177"(host cell Golgi apparatus)|interpro:IPR006908(Herpesvirus UL49 tegument protein)|rcsb pdb:4XAL|dip:DIP-57160N	psi-mi:"MI:0465"(dip)	-	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:WTLHj+wKggCJsTkRWqliyRjHmuk10299	rogid:DM3Zmc28xl4p1fOVo8YqkCjc3OU10299	rigid:+WhSnYLu30BEH4LrnO/zBzxb+PM	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10225	uniprotkb:P06492	intact:EBI-6148417|uniprotkb:Q82170|uniprotkb:Q09I92	intact:EBI-7489933|uniprotkb:Q09I86|intact:MINT-275736|uniprotkb:B9VQH6	psi-mi:shut_hhv11(display_long)|uniprotkb:UL41(gene name)|psi-mi:UL41(display_short)	psi-mi:vp16_hhv11(display_long)|uniprotkb:Vmw65(gene name synonym)|uniprotkb:ICP25(gene name synonym)|uniprotkb:Alpha-TIF(gene name synonym)|uniprotkb:Alpha trans-inducing protein(gene name synonym)|uniprotkb:UL48(orf name)	psi-mi:"MI:0096"(pull down)	Taddeo et al. (2007)	pubmed:17620619|doi:10.1073/pnas.0705245104|imex:IM-22888	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15646840|imex:IM-22888-2|dip:DIP-196999E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-57855N|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|interpro:IPR006086(XPG I)|interpro:IPR029060	refseq:YP_009137123.1|mint:P06492|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0046809"(replication compartment)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003174("Alpha trans-inducing protein (Alpha-TIF)")|interpro:IPR021051|interpro:IPR036538|rcsb pdb:16VP|rcsb pdb:2PHE|rcsb pdb:2PHG|dip:DIP-41776N	psi-mi:"MI:0465"(dip)	-	comment:mint|function:"Responsible for transcriptional activation of immediate early promoters (alpha genes). Activation requires the formation of a heteromeric complex with the host cell factor. These two proteins then assemble with the octamer motif-binding protein Oct-1 on the cis-acting target sequence: 5'-TAATGARAT-3'"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:WTLHj+wKggCJsTkRWqliyRjHmuk10299	rogid:8rAT+y7LSTotMP4XcD+eSyMpff010299	rigid:+WhSnYLu30BEH4LrnO/zBzxb+PM	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10225	uniprotkb:P10233	intact:EBI-6148417|uniprotkb:Q82170|uniprotkb:Q09I92	intact:EBI-7490002|uniprotkb:B9VQH7|uniprotkb:Q09I85|intact:MINT-6732747	psi-mi:shut_hhv11(display_long)|uniprotkb:UL41(gene name)|psi-mi:UL41(display_short)	psi-mi:vp22_hhv11(display_long)|uniprotkb:UL49(orf name)	psi-mi:"MI:0096"(pull down)	Taddeo et al. (2007)	pubmed:17620619|doi:10.1073/pnas.0705245104|imex:IM-22888	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15646860|imex:IM-22888-3|dip:DIP-196999E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-57855N|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|interpro:IPR006086(XPG I)|interpro:IPR029060	refseq:YP_009137124.1|mint:P10233|go:"GO:0019033"(viral tegument)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044177"(host cell Golgi apparatus)|interpro:IPR006908(Herpesvirus UL49 tegument protein)|rcsb pdb:4XAL|dip:DIP-57160N	psi-mi:"MI:0465"(dip)	-	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:WTLHj+wKggCJsTkRWqliyRjHmuk10299	rogid:DM3Zmc28xl4p1fOVo8YqkCjc3OU10299	rigid:+WhSnYLu30BEH4LrnO/zBzxb+PM	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10225	uniprotkb:P06492	intact:EBI-6148417|uniprotkb:Q82170|uniprotkb:Q09I92	intact:EBI-7489933|uniprotkb:Q09I86|intact:MINT-275736|uniprotkb:B9VQH6	psi-mi:shut_hhv11(display_long)|uniprotkb:UL41(gene name)|psi-mi:UL41(display_short)	psi-mi:vp16_hhv11(display_long)|uniprotkb:Vmw65(gene name synonym)|uniprotkb:ICP25(gene name synonym)|uniprotkb:Alpha-TIF(gene name synonym)|uniprotkb:Alpha trans-inducing protein(gene name synonym)|uniprotkb:UL48(orf name)	psi-mi:"MI:0096"(pull down)	Taddeo et al. (2007)	pubmed:17620619|doi:10.1073/pnas.0705245104|imex:IM-22888	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15646860|imex:IM-22888-3|dip:DIP-196999E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-57855N|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|interpro:IPR006086(XPG I)|interpro:IPR029060	refseq:YP_009137123.1|mint:P06492|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0046809"(replication compartment)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003174("Alpha trans-inducing protein (Alpha-TIF)")|interpro:IPR021051|interpro:IPR036538|rcsb pdb:16VP|rcsb pdb:2PHE|rcsb pdb:2PHG|dip:DIP-41776N	psi-mi:"MI:0465"(dip)	-	comment:mint|function:"Responsible for transcriptional activation of immediate early promoters (alpha genes). Activation requires the formation of a heteromeric complex with the host cell factor. These two proteins then assemble with the octamer motif-binding protein Oct-1 on the cis-acting target sequence: 5'-TAATGARAT-3'"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:WTLHj+wKggCJsTkRWqliyRjHmuk10299	rogid:8rAT+y7LSTotMP4XcD+eSyMpff010299	rigid:+WhSnYLu30BEH4LrnO/zBzxb+PM	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06492	uniprotkb:P10225	intact:EBI-7489933|uniprotkb:Q09I86|intact:MINT-275736|uniprotkb:B9VQH6	intact:EBI-6148417|uniprotkb:Q82170|uniprotkb:Q09I92	psi-mi:vp16_hhv11(display_long)|uniprotkb:Vmw65(gene name synonym)|uniprotkb:ICP25(gene name synonym)|uniprotkb:Alpha-TIF(gene name synonym)|uniprotkb:Alpha trans-inducing protein(gene name synonym)|uniprotkb:UL48(orf name)	psi-mi:shut_hhv11(display_long)|uniprotkb:UL41(gene name)|psi-mi:UL41(display_short)	psi-mi:"MI:0096"(pull down)	Taddeo et al. (2007)	pubmed:17620619|doi:10.1073/pnas.0705245104|imex:IM-22888	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15646880|imex:IM-22888-4|dip:DIP-151756E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137123.1|mint:P06492|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0046809"(replication compartment)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003174("Alpha trans-inducing protein (Alpha-TIF)")|interpro:IPR021051|interpro:IPR036538|rcsb pdb:16VP|rcsb pdb:2PHE|rcsb pdb:2PHG|dip:DIP-41776N	dip:DIP-57855N|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039595"(induction by virus of catabolism of host mRNA)|go:"GO:0039657"(suppression by virus of host gene expression)|interpro:IPR006086(XPG I)|interpro:IPR029060	psi-mi:"MI:0465"(dip)	comment:mint|function:"Responsible for transcriptional activation of immediate early promoters (alpha genes). Activation requires the formation of a heteromeric complex with the host cell factor. These two proteins then assemble with the octamer motif-binding protein Oct-1 on the cis-acting target sequence: 5'-TAATGARAT-3'"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:8rAT+y7LSTotMP4XcD+eSyMpff010299	rogid:WTLHj+wKggCJsTkRWqliyRjHmuk10299	rigid:fexIJHrfuDkGB/gLCn2ZsGFdQTQ	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)