#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O08675	uniprotkb:P19221	intact:EBI-8627044|ensembl:ENSMUSP00000022182|uniprotkb:Q3UXV3|intact:MINT-261941|uniprotkb:B9EIT2	intact:EBI-8375972|intact:MINT-4137721|ensembl:ENSMUSP00000028681	psi-mi:par3_mouse(display_long)|uniprotkb:F2rl2(gene name)|psi-mi:F2rl2(display_short)|uniprotkb:Par3(gene name synonym)|uniprotkb:Thrombin receptor-like 2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 2(gene name synonym)	psi-mi:thrb_mouse(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Cf2(gene name synonym)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Bah et al. (2007)	pubmed:17606903|doi:10.1073/pnas.0704409104|imex:IM-22878	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15645544|imex:IM-22878-1|dip:DIP-196969E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR003943(Protease-activated receptor 3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2PUX|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|ensembl:ENSMUSG00000021675(gene)|ensembl:ENSMUST00000022182(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032991"(protein-containing complex)|refseq:NP_034300.3|dip:DIP-41474N	refseq:NP_034298.1|dip:DIP-60968N|ensembl:ENSMUSG00000027249(gene)|ensembl:ENSMUST00000028681(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|interpro:IPR035972|interpro:IPR037111|interpro:IPR038178|interpro:IPR043504|mint:P19221|rcsb pdb:2OCV|rcsb pdb:2PUX|rcsb pdb:2PV9|rcsb pdb:3EDX|rcsb pdb:3HK3|rcsb pdb:3HK6|rcsb pdb:3HKI|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-159740|reactome:R-MMU-159763|reactome:R-MMU-159782|reactome:R-MMU-202733|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926|reactome:R-MMU-76009|reactome:R-MMU-977606	psi-mi:"MI:0465"(dip)	comment:mint|function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation	comment:mint|function:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:t+DHNtXUukndXO9sR25FtOXzvm010090	rogid:amZ+Pl0pNliSHuykYcjQLfqb1vw10090	rigid:bz3+pXL3Q/DOOt+yZAODi5aR/sk	false	sufficient binding region:38-56	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88634	uniprotkb:P19221	intact:EBI-8507883|intact:MINT-2737730|uniprotkb:Q8BZ77|ensembl:ENSMUSP00000054426	intact:EBI-8375972|intact:MINT-4137721|ensembl:ENSMUSP00000028681	psi-mi:par4_mouse(display_long)|uniprotkb:F2rl3(gene name)|psi-mi:F2rl3(display_short)|uniprotkb:Par4(gene name synonym)|uniprotkb:Thrombin receptor-like 3(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 3(gene name synonym)	psi-mi:thrb_mouse(display_long)|uniprotkb:F2(gene name)|psi-mi:F2(display_short)|uniprotkb:Cf2(gene name synonym)|uniprotkb:Coagulation factor II(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Bah et al. (2007)	pubmed:17606903|doi:10.1073/pnas.0704409104|imex:IM-22878	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15645564|imex:IM-22878-2|dip:DIP-196970E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032001.2|dip:DIP-42480N|ensembl:ENSMUSG00000050147(gene)|ensembl:ENSMUST00000058099(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR003944(Protease-activated receptor 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:O88634|rcsb pdb:2PV9|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926	refseq:NP_034298.1|dip:DIP-60968N|ensembl:ENSMUSG00000027249(gene)|ensembl:ENSMUST00000028681(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030168"(platelet activation)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070493"(thrombin-activated receptor signaling pathway)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0090218"(positive regulation of lipid kinase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900738"(positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000001(Kringle)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003966(Peptidase S1A, prothrombin/thrombin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR018114|interpro:IPR018992|interpro:IPR033116|interpro:IPR035972|interpro:IPR037111|interpro:IPR038178|interpro:IPR043504|mint:P19221|rcsb pdb:2OCV|rcsb pdb:2PUX|rcsb pdb:2PV9|rcsb pdb:3EDX|rcsb pdb:3HK3|rcsb pdb:3HK6|rcsb pdb:3HKI|reactome:R-MMU-140837|reactome:R-MMU-140875|reactome:R-MMU-159740|reactome:R-MMU-159763|reactome:R-MMU-159782|reactome:R-MMU-202733|reactome:R-MMU-375276|reactome:R-MMU-416476|reactome:R-MMU-456926|reactome:R-MMU-76009|reactome:R-MMU-977606	psi-mi:"MI:0465"(dip)	comment:mint|function:Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation	comment:mint|function:Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:rtkvJPLXA8/c4X3wixVRFWXBFpo10090	rogid:amZ+Pl0pNliSHuykYcjQLfqb1vw10090	rigid:sO/P2g7iIbhjsAJ4K0w3WCc4C7w	false	sufficient binding region:51-81	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)