#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q6B0I6 intact:EBI-15643864 intact:EBI-4311651|uniprotkb:Q9NW76|uniprotkb:B3KPC4|uniprotkb:Q9NT41|uniprotkb:Q0VF39|ensembl:ENSP00000334181|ensembl:ENSP00000460897|ensembl:ENSP00000482224 dip:DIP-29604N psi-mi:kdm4d_human(display_long)|uniprotkb:KDM4D(gene name)|psi-mi:KDM4D(display_short)|uniprotkb:JHDM3D(gene name synonym)|uniprotkb:JMJD2D(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3D(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2D(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4D"(gene name synonym) psi-mi:h3k9-1(display_short)|psi-mi:EBI-15643864(display_long) psi-mi:"MI:0515"(methyltransferase assay) Couture et al. (2007) pubmed:17589523|doi:10.1038/nsmb1273|imex:IM-9146 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0871"(demethylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15643886|imex:IM-9146-3|dip:DIP-59087E - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0327"(peptide) refseq:NP_060509.2|rcsb pdb:5PI6|rcsb pdb:5PI7|rcsb pdb:5PI8|rcsb pdb:5PI9|rcsb pdb:5PIA|rcsb pdb:5PIB|rcsb pdb:5PIC|rcsb pdb:5PID|rcsb pdb:5PIE|rcsb pdb:5PIF|rcsb pdb:5PIG|rcsb pdb:5PIH|rcsb pdb:5PII|rcsb pdb:5PIJ|rcsb pdb:5PIK|rcsb pdb:5PIL|rcsb pdb:5PIM|rcsb pdb:5PIN|rcsb pdb:5PIO|rcsb pdb:5PIP|rcsb pdb:5PIQ|rcsb pdb:5PIR|rcsb pdb:5PIS|rcsb pdb:5PIT|rcsb pdb:5PIU|rcsb pdb:5PIV|rcsb pdb:5PIW|rcsb pdb:5PIX|rcsb pdb:5PIY|rcsb pdb:5PIZ|rcsb pdb:5PJ0|rcsb pdb:5PI5|rcsb pdb:5PJ1|rcsb pdb:5PJ2|rcsb pdb:5PJ3|rcsb pdb:5PJ4|rcsb pdb:5PJ6|rcsb pdb:5PJ7|rcsb pdb:5PJ8|rcsb pdb:5PJ9|rcsb pdb:5PJA|rcsb pdb:5PJB|rcsb pdb:5PJC|rcsb pdb:5PJD|rcsb pdb:5PJE|rcsb pdb:5PJF|rcsb pdb:5PJG|rcsb pdb:5PJ5|rcsb pdb:5PJH|rcsb pdb:5PJI|rcsb pdb:5PJJ|rcsb pdb:5PJK|rcsb pdb:5PJL|rcsb pdb:5PJM|rcsb pdb:5PJN|rcsb pdb:5PJO|rcsb pdb:5PJP|rcsb pdb:5PJQ|rcsb pdb:5PJR|rcsb pdb:5PJS|rcsb pdb:6ETT|rcsb pdb:6ETU|rcsb pdb:5PJT|rcsb pdb:6ETV|rcsb pdb:6ETW|rcsb pdb:6F5Q|rcsb pdb:6F5R|rcsb pdb:6F5S|rcsb pdb:6F5T|rcsb pdb:6H0W|rcsb pdb:6H0X|rcsb pdb:6H0Y|rcsb pdb:6H0Z|rcsb pdb:6H10|rcsb pdb:6H11|reactome:R-HSA-3214842|ensembl:ENSG00000186280(gene)|ensembl:ENST00000335080(transcript)|ensembl:ENST00000536741(transcript)|ensembl:ENST00000610872(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|rcsb pdb:5PJV|rcsb pdb:5PJW|rcsb pdb:5PJX|rcsb pdb:5PJY|rcsb pdb:5PJZ|rcsb pdb:5PK0|rcsb pdb:5PK1|rcsb pdb:5PK2|rcsb pdb:5PJU|rcsb pdb:5PK3|rcsb pdb:5PK4|rcsb pdb:5PK5|rcsb pdb:5PK6|rcsb pdb:5PK7|rcsb pdb:5PK8|rcsb pdb:5PK9|rcsb pdb:5PKA|rcsb pdb:5PKB|rcsb pdb:5PKC|rcsb pdb:5PKD|rcsb pdb:5PKE|rcsb pdb:5PKF|rcsb pdb:5PKG|rcsb pdb:5PKH|rcsb pdb:5PKI|rcsb pdb:5PKJ|rcsb pdb:5PKK|rcsb pdb:5PKL|rcsb pdb:5PKM|rcsb pdb:5PKN|rcsb pdb:5PKO|rcsb pdb:5PKP|rcsb pdb:5PKQ|rcsb pdb:5PKR|rcsb pdb:5PKS|rcsb pdb:5PKT|rcsb pdb:5PKU|rcsb pdb:5PKV|rcsb pdb:5PKW|rcsb pdb:5PKX|rcsb pdb:5PKY|rcsb pdb:5PKZ|rcsb pdb:5PL0|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0072562"(blood microparticle)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|mint:Q6B0I6|rcsb pdb:3DXT|rcsb pdb:3DXU|rcsb pdb:4D6Q|rcsb pdb:4D6R|rcsb pdb:4D6S|rcsb pdb:4HON|rcsb pdb:5PL2|rcsb pdb:5PL3|rcsb pdb:5PL1|rcsb pdb:5PL4|rcsb pdb:5PL5|rcsb pdb:5PL6|rcsb pdb:5PL7|rcsb pdb:5PL8|rcsb pdb:5PL9|rcsb pdb:5PLA|rcsb pdb:5PLB|rcsb pdb:5PLC|rcsb pdb:5PLD|rcsb pdb:5PLE|rcsb pdb:5PLF|rcsb pdb:5PLG|rcsb pdb:5PLH|rcsb pdb:5PLI|rcsb pdb:5PLJ|rcsb pdb:5PLK|rcsb pdb:5PLL|rcsb pdb:5PLM|rcsb pdb:5PLN|rcsb pdb:5PLO|rcsb pdb:5PLP|rcsb pdb:5PLQ|rcsb pdb:5PLR|rcsb pdb:5PLS|rcsb pdb:5F5A|rcsb pdb:5F5C|rcsb pdb:5FP4|rcsb pdb:5FP7|rcsb pdb:5FP8|rcsb pdb:5FP9|rcsb pdb:5FPA|rcsb pdb:5FPB|rcsb pdb:5PH0|rcsb pdb:5PH1|rcsb pdb:5PH2|rcsb pdb:5PH3|rcsb pdb:5PH4|rcsb pdb:4HOO|rcsb pdb:5PH5|rcsb pdb:5PH6|rcsb pdb:5PH7|rcsb pdb:5PH8|rcsb pdb:5PH9|rcsb pdb:5PHA|rcsb pdb:5PHB|rcsb pdb:5PHC|rcsb pdb:5PHD|rcsb pdb:5PHE|rcsb pdb:5PLU|rcsb pdb:5PLV|rcsb pdb:5PLW|rcsb pdb:5PLX|rcsb pdb:5PLY|rcsb pdb:5PLZ|rcsb pdb:5PM0|rcsb pdb:5PM1|rcsb pdb:5PM2|rcsb pdb:5PM3|rcsb pdb:5PM4|rcsb pdb:5PM5|rcsb pdb:5PM6|rcsb pdb:5PM7|rcsb pdb:5PM8|rcsb pdb:5PM9|rcsb pdb:5PMA|rcsb pdb:5PMB|rcsb pdb:5PMC|rcsb pdb:5PMD|rcsb pdb:5PME|rcsb pdb:5PMF|rcsb pdb:5PMG|rcsb pdb:5PMH|rcsb pdb:5PMI|rcsb pdb:5PMJ|rcsb pdb:5PMK|rcsb pdb:5PML|rcsb pdb:5PMM|rcsb pdb:5PMN|rcsb pdb:5PMO|rcsb pdb:5PMP|rcsb pdb:5PMQ|rcsb pdb:5PMR|rcsb pdb:5PMS|rcsb pdb:5PMT|rcsb pdb:5PMU|rcsb pdb:5PMV|rcsb pdb:5PMW|rcsb pdb:5PMX|rcsb pdb:5PMY|rcsb pdb:5PMZ|rcsb pdb:5PN0|rcsb pdb:5PN1|rcsb pdb:5PN2|rcsb pdb:5PN3|rcsb pdb:5PN4|rcsb pdb:5PN5|rcsb pdb:5PN6|rcsb pdb:5PN7|rcsb pdb:5PN8|rcsb pdb:5PN9|rcsb pdb:5PNA|rcsb pdb:5PNB|rcsb pdb:5PNC|rcsb pdb:5PND|rcsb pdb:5PNE|rcsb pdb:5PNF|rcsb pdb:5PNG|rcsb pdb:5PNH|rcsb pdb:5PNI|rcsb pdb:5PNJ|rcsb pdb:5PNK|rcsb pdb:5PNL|rcsb pdb:5PNM|rcsb pdb:5PLT|rcsb pdb:5PNN|rcsb pdb:5PNO|rcsb pdb:5PNP|rcsb pdb:5PNQ|rcsb pdb:5PNR|rcsb pdb:5PNS|rcsb pdb:5PNU|rcsb pdb:5PNV|rcsb pdb:5PNW|rcsb pdb:6ETE|rcsb pdb:6ETG|rcsb pdb:6ETS|rcsb pdb:5PHJ|rcsb pdb:5PHK|rcsb pdb:5PHL|rcsb pdb:5PHM|rcsb pdb:5PHN|rcsb pdb:5PHO|rcsb pdb:5PHP|rcsb pdb:5PHQ|rcsb pdb:5PHR|rcsb pdb:5PHS|rcsb pdb:5PHT|rcsb pdb:5PHU|rcsb pdb:5PHV|rcsb pdb:5PHF|rcsb pdb:5PHG|rcsb pdb:5PHH|rcsb pdb:5PHI|rcsb pdb:5PHW|rcsb pdb:5PHX|rcsb pdb:5PHY|rcsb pdb:5PHZ|rcsb pdb:5PI0|rcsb pdb:5PI1|rcsb pdb:5PI2|rcsb pdb:5PI3|rcsb pdb:5PI4|dip:DIP-29606N - psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:svQfKWBCSAPSGFAV5YPZXFvcqkk9606 rogid:UueKuoNTI6/lxV4J2Sp5goJ/4Ic-2 rigid:PQeHApAW2F5wO80AysdEw3iLyzE false sufficient binding region:3-354|mutation decreasing interaction:292-292 N6,N6,N6-trimethyl-L-lysine:9-9|N6,N6-dimethyl-L-lysine:9-9 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15643864 uniprotkb:O75164-1 dip:DIP-29604N intact:EBI-15643640|ensembl:ENSP00000361473 psi-mi:h3k9-1(display_short)|psi-mi:EBI-15643864(display_long) psi-mi:o75164-1(display_long)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Couture et al. (2007) pubmed:17589523|doi:10.1038/nsmb1273|imex:IM-9146 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15643867|imex:IM-9146-4|dip:DIP-59085E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - intact:EBI-936709(isoform-parent)|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:UueKuoNTI6/lxV4J2Sp5goJ/4Ic-2 rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606 rigid:COJa3UDOKHid64Lle7js7wLVhLg false - sufficient binding region:1-350 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15643913 uniprotkb:O75164-1 dip:DIP-29605N intact:EBI-15643640|ensembl:ENSP00000361473 psi-mi:h3k36-1(display_short)|psi-mi:EBI-15643913(display_long) psi-mi:o75164-1(display_long)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym) psi-mi:"MI:0515"(methyltransferase assay) Couture et al. (2007) pubmed:17589523|doi:10.1038/nsmb1273|imex:IM-9146 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0871"(demethylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15643935|imex:IM-9146-2|dip:DIP-59086E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - intact:EBI-936709(isoform-parent)|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:gBNhc4934hYkYYkCgz69JDD4AoU-2 rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606 rigid:OLh8JJCbLdQoL7T9MCk+L55+sxw false N6,N6,N6-trimethyl-L-lysine:12-12 sufficient binding region:1-350 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15643913 uniprotkb:O75164-1 dip:DIP-29605N intact:EBI-15643640|ensembl:ENSP00000361473 psi-mi:h3k36-1(display_short)|psi-mi:EBI-15643913(display_long) psi-mi:o75164-1(display_long)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Couture et al. (2007) pubmed:17589523|doi:10.1038/nsmb1273|imex:IM-9146 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15643916|imex:IM-9146-5|dip:DIP-59086E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - intact:EBI-936709(isoform-parent)|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:gBNhc4934hYkYYkCgz69JDD4AoU-2 rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606 rigid:OLh8JJCbLdQoL7T9MCk+L55+sxw false - sufficient binding region:1-350 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) intact:EBI-15643864 uniprotkb:O75164-1 dip:DIP-29604N intact:EBI-15643640|ensembl:ENSP00000361473 psi-mi:h3k9-1(display_short)|psi-mi:EBI-15643864(display_long) psi-mi:o75164-1(display_long)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym) psi-mi:"MI:0515"(methyltransferase assay) Couture et al. (2007) pubmed:17589523|doi:10.1038/nsmb1273|imex:IM-9146 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0871"(demethylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-15643956|imex:IM-9146-1|dip:DIP-59085E - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0327"(peptide) psi-mi:"MI:0326"(protein) - intact:EBI-936709(isoform-parent)|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:UueKuoNTI6/lxV4J2Sp5goJ/4Ic-2 rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606 rigid:COJa3UDOKHid64Lle7js7wLVhLg false mutation decreasing interaction:12-12|N6,N6-dimethyl-L-lysine:9-9|N6,N6,N6-trimethyl-L-lysine:9-9|mutation decreasing interaction:7-7 mutation decreasing interaction:288-288|sufficient binding region:1-350 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)