#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01236	uniprotkb:P13497	intact:EBI-6903064|ensembl:ENSP00000302150|uniprotkb:Q15199|uniprotkb:Q92996	intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714	psi-mi:prl_human(display_long)|uniprotkb:PRL(gene name)|psi-mi:PRL(display_short)	psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ge et al. (2007)	pubmed:17548836|doi:10.1073/pnas.0704179104|imex:IM-22856	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15640992|imex:IM-22856-1|dip:DIP-196907E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172179(gene)|ensembl:ENST00000306482(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005148"(prolactin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007595"(lactation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030879"(mammary gland development)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031904"(endosome lumen)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:1902895"(positive regulation of miRNA transcription)|interpro:IPR001400(Somatotropin hormone)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018116|rcsb pdb:1RW5|rcsb pdb:2Q98|rcsb pdb:3D48|rcsb pdb:3EW3|rcsb pdb:3MZG|rcsb pdb:3N06|rcsb pdb:3N0P|rcsb pdb:3NCB|rcsb pdb:3NCC|rcsb pdb:3NCE|rcsb pdb:3NCF|rcsb pdb:3NPZ|reactome:R-HSA-1170546|reactome:R-HSA-977225|reactome:R-HSA-982772|go:"GO:1903489"(positive regulation of lactation)|refseq:NP_000939.1|refseq:NP_001157030.1|dip:DIP-59635N	refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:4ojucvdmaBrTTrB4ee/BsXLlv1U9606	rogid:IS39foZyMR0650AjBaf1gA8YD/k9606	rigid:TyK/q2xI5CAGzm0nf3vUl1p/gmA	false	-	mutation disrupting interaction strength:214-214|flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01241	uniprotkb:P13497	intact:EBI-1026046|uniprotkb:Q9HBZ1|uniprotkb:Q9UMJ7|uniprotkb:Q9UNL5|uniprotkb:Q14405|uniprotkb:Q16631|uniprotkb:Q5EB53|uniprotkb:A6NEF6|ensembl:ENSP00000312673	intact:EBI-489827|uniprotkb:Q13292|uniprotkb:Q13872|uniprotkb:Q14874|uniprotkb:Q99421|uniprotkb:Q99422|uniprotkb:Q99423|uniprotkb:Q9UL38|uniprotkb:A8K6F5|uniprotkb:B2RN46|uniprotkb:D3DSR0|ensembl:ENSP00000305714	psi-mi:soma_human(display_long)|uniprotkb:GH1(gene name)|psi-mi:GH1(display_short)|uniprotkb:Growth hormone(gene name synonym)|uniprotkb:Pituitary growth hormone(gene name synonym)|uniprotkb:Growth hormone 1(gene name synonym)	psi-mi:bmp1_human(display_long)|uniprotkb:Procollagen C-proteinase(gene name synonym)|uniprotkb:Mammalian tolloid protein(gene name synonym)|uniprotkb:BMP1(gene name)|psi-mi:BMP1(display_short)|uniprotkb:PCOLC(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ge et al. (2007)	pubmed:17548836|doi:10.1073/pnas.0704179104|imex:IM-22856	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15641014|imex:IM-22856-2|dip:DIP-196908E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000506.2|refseq:NP_072053.1|ensembl:ENSG00000259384(gene)|ensembl:ENST00000323322(transcript)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005148"(prolactin receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008083"(growth factor activity)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010828"(positive regulation of glucose transmembrane transport)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031904"(endosome lumen)|go:"GO:0032355"(response to estradiol)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0048513"(animal organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0070195"(growth hormone receptor complex)|go:"GO:0070977"(bone maturation)|interpro:IPR001400(Somatotropin hormone)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018116|rcsb pdb:1A22|rcsb pdb:1AXI|rcsb pdb:1BP3|rcsb pdb:1HGU|rcsb pdb:1HUW|rcsb pdb:1HWG|rcsb pdb:1HWH|rcsb pdb:1KF9|rcsb pdb:3HHR|rcsb pdb:6QIO|reactome:R-HSA-1170546|reactome:R-HSA-422085|reactome:R-HSA-982772|refseq:NP_072054.1|dip:DIP-1022N	refseq:NP_001190.1|refseq:NP_006120.1|refseq:XP_011542919.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031982"(vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0061036"(positive regulation of cartilage development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR001881(EGF-like calcium-binding)|ensembl:ENSG00000168487(gene)|ensembl:ENST00000306385(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005125"(cytokine activity)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR018097|interpro:IPR024079|interpro:IPR029837|interpro:IPR034036|interpro:IPR035914|mint:P13497|rcsb pdb:3EDG|rcsb pdb:3EDH|rcsb pdb:6BSL|rcsb pdb:6BSM|rcsb pdb:6BTN|rcsb pdb:6BTO|rcsb pdb:6BTP|rcsb pdb:6BTQ|reactome:R-HSA-1474228|reactome:R-HSA-1650814|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-8963896|refseq:XP_016869227.1|dip:DIP-33403N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:/wwYm28XFv1neYQcngRSejIdWFQ9606	rogid:IS39foZyMR0650AjBaf1gA8YD/k9606	rigid:GGCH5q47b8tmIkw8rUDLLd+zTtM	false	-	mutation disrupting interaction strength:214-214|flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)