#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9HBL0 uniprotkb:Q96QB1-1 intact:EBI-3389814|uniprotkb:Q6IPI5|ensembl:ENSP00000171887|uniprotkb:Q4ZG71 intact:EBI-15638708|ensembl:ENSP00000351797 psi-mi:tens1_human(display_long)|uniprotkb:TNS1(gene name)|psi-mi:TNS1(display_short)|uniprotkb:TNS(gene name synonym) psi-mi:q96qb1-1(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:HP protein(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym) psi-mi:"MI:0018"(two hybrid) Qian et al. (2007) pubmed:17517630|doi:10.1073/pnas.0703033104|imex:IM-22834 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15638722|imex:IM-22834-1|dip:DIP-196868E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000079308(gene)|ensembl:ENST00000171887(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|go:"GO:0003779"(actin binding)|refseq:NP_001294951.1|refseq:NP_072174.3|dip:DIP-60948N intact:EBI-2608428(isoform-parent)|ensembl:ENSG00000164741(gene)|ensembl:ENST00000358919(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/05 2017/08/10 rogid:xyE5fHGhuORnau3rX2Nfpi1LCvg9606 rogid:DMqvStUzVPPnwVj4RvMKUS330TU9606 rigid:czVRZe4rmkYiSFNP8yTJ2G/wj7o false sufficient binding region:?-? sufficient binding region:210-460 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P05106 uniprotkb:Q04205 intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786 intact:EBI-2607590|uniprotkb:Q91007|uniprotkb:Q92011 psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym) psi-mi:tens_chick(display_long)|uniprotkb:TNS(gene name)|psi-mi:TNS(display_short) psi-mi:"MI:0096"(pull down) Qian et al. (2007) pubmed:17517630|doi:10.1073/pnas.0703033104|imex:IM-22834 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15638791|imex:IM-22834-4|dip:DIP-196871E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223 refseq:NP_990786.1|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0009986"(cell surface)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|rcsb pdb:1WVH|rcsb pdb:2GJY|dip:DIP-56927N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606 rogid:NudDX/CO+8lqFexMsW43PM4AznU9031 rigid:BpKNKThqYo3kylvpKfKlkvKahfQ false - glutathione s tranferase tag:n-n|sufficient binding region:1583-1658 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96QB1-1 uniprotkb:Q04205 intact:EBI-15638708|ensembl:ENSP00000351797 intact:EBI-2607590|uniprotkb:Q91007|uniprotkb:Q92011 psi-mi:q96qb1-1(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:HP protein(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym) psi-mi:tens_chick(display_long)|uniprotkb:TNS(gene name)|psi-mi:TNS(display_short) psi-mi:"MI:0096"(pull down) Qian et al. (2007) pubmed:17517630|doi:10.1073/pnas.0703033104|imex:IM-22834 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15638764|imex:IM-22834-3|dip:DIP-196869E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2608428(isoform-parent)|ensembl:ENSG00000164741(gene)|ensembl:ENST00000358919(transcript) refseq:NP_990786.1|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0009986"(cell surface)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|rcsb pdb:1WVH|rcsb pdb:2GJY|dip:DIP-56927N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:DMqvStUzVPPnwVj4RvMKUS330TU9606 rogid:NudDX/CO+8lqFexMsW43PM4AznU9031 rigid:RpD8bZMyLbbDVjTotST3jCDcQ4E false green fluorescent protein tag:?-?|sufficient binding region:1-400 sufficient binding region:1583-1739|glutathione s tranferase tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96QB1-1 uniprotkb:Q04205 intact:EBI-15638708|ensembl:ENSP00000351797 intact:EBI-2607590|uniprotkb:Q91007|uniprotkb:Q92011 psi-mi:q96qb1-1(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:HP protein(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym) psi-mi:tens_chick(display_long)|uniprotkb:TNS(gene name)|psi-mi:TNS(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Qian et al. (2007) pubmed:17517630|doi:10.1073/pnas.0703033104|imex:IM-22834 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15638745|imex:IM-22834-2|dip:DIP-196869E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2608428(isoform-parent)|ensembl:ENSG00000164741(gene)|ensembl:ENST00000358919(transcript) refseq:NP_990786.1|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0009986"(cell surface)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|rcsb pdb:1WVH|rcsb pdb:2GJY|dip:DIP-56927N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:DMqvStUzVPPnwVj4RvMKUS330TU9606 rogid:NudDX/CO+8lqFexMsW43PM4AznU9031 rigid:RpD8bZMyLbbDVjTotST3jCDcQ4E false - green fluorescent protein tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92502 uniprotkb:Q04205 intact:EBI-11792291|uniprotkb:A8K6T2|uniprotkb:D3DVT9|uniprotkb:Q5JST0|uniprotkb:Q68DG7|intact:EBI-28984506|ensembl:ENSP00000252336|ensembl:ENSP00000363725 intact:EBI-2607590|uniprotkb:Q91007|uniprotkb:Q92011 psi-mi:star8_human(display_long)|uniprotkb:STARD8(gene name)|psi-mi:STARD8(display_short)|uniprotkb:DLC3(gene name synonym)|uniprotkb:KIAA0189(gene name synonym)|uniprotkb:Deleted in liver cancer 3 protein(gene name synonym)|uniprotkb:START domain-containing protein 8(gene name synonym)|uniprotkb:START-GAP3(gene name synonym) psi-mi:tens_chick(display_long)|uniprotkb:TNS(gene name)|psi-mi:TNS(display_short) psi-mi:"MI:0096"(pull down) Qian et al. (2007) pubmed:17517630|doi:10.1073/pnas.0703033104|imex:IM-22834 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15638812|imex:IM-22834-5|dip:DIP-196870E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001135975.1|refseq:NP_001135976.1|refseq:NP_055540.2|refseq:XP_011529371.1|ensembl:ENSP00000252336|ensembl:ENSP00000363725|ensembl:ENST00000374599|ensembl:ENSP00000363727|ensembl:ENSG00000130052(gene)|ensembl:ENST00000252336(transcript)|ensembl:ENST00000374597(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008289"(lipid binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023393|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013148|dip:DIP-60949N refseq:NP_990786.1|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0009986"(cell surface)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|rcsb pdb:1WVH|rcsb pdb:2GJY|dip:DIP-56927N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:6mTMYwAgbbJ04nk4GmSlub5hPFU9606 rogid:NudDX/CO+8lqFexMsW43PM4AznU9031 rigid:k3+Dbza69QjhQMsEbFrGj8yWxdo false green fluorescent protein tag:n-n glutathione s tranferase tag:n-n|sufficient binding region:1460-1584|sufficient binding region:1583-1739 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96QB1-1 uniprotkb:Q04205 intact:EBI-15638708|ensembl:ENSP00000351797 intact:EBI-2607590|uniprotkb:Q91007|uniprotkb:Q92011 psi-mi:q96qb1-1(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:HP protein(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym) psi-mi:tens_chick(display_long)|uniprotkb:TNS(gene name)|psi-mi:TNS(display_short) psi-mi:"MI:0096"(pull down) Qian et al. (2007) pubmed:17517630|doi:10.1073/pnas.0703033104|imex:IM-22834 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15638837|imex:IM-22834-6|dip:DIP-196869E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2608428(isoform-parent)|ensembl:ENSG00000164741(gene)|ensembl:ENST00000358919(transcript) refseq:NP_990786.1|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0009986"(cell surface)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|rcsb pdb:1WVH|rcsb pdb:2GJY|dip:DIP-56927N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:DMqvStUzVPPnwVj4RvMKUS330TU9606 rogid:NudDX/CO+8lqFexMsW43PM4AznU9031 rigid:RpD8bZMyLbbDVjTotST3jCDcQ4E false green fluorescent protein tag:?-?|mutation disrupting interaction strength:442-442 sufficient binding region:1460-1584|glutathione s tranferase tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96QB1-1 uniprotkb:Q04205 intact:EBI-15638708|ensembl:ENSP00000351797 intact:EBI-2607590|uniprotkb:Q91007|uniprotkb:Q92011 psi-mi:q96qb1-1(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:HP protein(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym) psi-mi:tens_chick(display_long)|uniprotkb:TNS(gene name)|psi-mi:TNS(display_short) psi-mi:"MI:0096"(pull down) Qian et al. (2007) pubmed:17517630|doi:10.1073/pnas.0703033104|imex:IM-22834 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15638922|imex:IM-22834-10|dip:DIP-196869E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2608428(isoform-parent)|ensembl:ENSG00000164741(gene)|ensembl:ENST00000358919(transcript) refseq:NP_990786.1|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0009986"(cell surface)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|rcsb pdb:1WVH|rcsb pdb:2GJY|dip:DIP-56927N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:DMqvStUzVPPnwVj4RvMKUS330TU9606 rogid:NudDX/CO+8lqFexMsW43PM4AznU9031 rigid:RpD8bZMyLbbDVjTotST3jCDcQ4E false green fluorescent protein tag:?-? sufficient binding region:1460-1584|glutathione s tranferase tag:n-n|sufficient binding region:1583-1739 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96QB1-1 uniprotkb:Q04205 intact:EBI-15638708|ensembl:ENSP00000351797 intact:EBI-2607590|uniprotkb:Q91007|uniprotkb:Q92011 psi-mi:q96qb1-1(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:HP protein(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym) psi-mi:tens_chick(display_long)|uniprotkb:TNS(gene name)|psi-mi:TNS(display_short) psi-mi:"MI:0096"(pull down) Qian et al. (2007) pubmed:17517630|doi:10.1073/pnas.0703033104|imex:IM-22834 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15638901|imex:IM-22834-9|dip:DIP-196869E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2608428(isoform-parent)|ensembl:ENSG00000164741(gene)|ensembl:ENST00000358919(transcript) refseq:NP_990786.1|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0009986"(cell surface)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|rcsb pdb:1WVH|rcsb pdb:2GJY|dip:DIP-56927N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:DMqvStUzVPPnwVj4RvMKUS330TU9606 rogid:NudDX/CO+8lqFexMsW43PM4AznU9031 rigid:RpD8bZMyLbbDVjTotST3jCDcQ4E false - sufficient binding region:1583-1658|glutathione s tranferase tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96QB1-1 uniprotkb:Q04205 intact:EBI-15638708|ensembl:ENSP00000351797 intact:EBI-2607590|uniprotkb:Q91007|uniprotkb:Q92011 psi-mi:q96qb1-1(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:HP protein(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym) psi-mi:tens_chick(display_long)|uniprotkb:TNS(gene name)|psi-mi:TNS(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Qian et al. (2007) pubmed:17517630|doi:10.1073/pnas.0703033104|imex:IM-22834 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15638882|imex:IM-22834-8|dip:DIP-196869E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2608428(isoform-parent)|ensembl:ENSG00000164741(gene)|ensembl:ENST00000358919(transcript) refseq:NP_990786.1|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0009986"(cell surface)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|rcsb pdb:1WVH|rcsb pdb:2GJY|dip:DIP-56927N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:DMqvStUzVPPnwVj4RvMKUS330TU9606 rogid:NudDX/CO+8lqFexMsW43PM4AznU9031 rigid:RpD8bZMyLbbDVjTotST3jCDcQ4E false - green fluorescent protein tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96QB1 uniprotkb:Q9HBL0 intact:EBI-2608428|uniprotkb:B4DR10|uniprotkb:E9PGY9|uniprotkb:O14868|uniprotkb:O43199|uniprotkb:Q7Z5R8|uniprotkb:Q9C0E0|uniprotkb:Q9H7A2|ensembl:ENSP00000276297|uniprotkb:B8PTI0|uniprotkb:E9PDZ8|uniprotkb:E9PF76|uniprotkb:Q86UC6 intact:EBI-3389814|uniprotkb:Q6IPI5|ensembl:ENSP00000171887|uniprotkb:Q4ZG71 psi-mi:rhg07_human(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:HP protein(gene name synonym) psi-mi:tens1_human(display_long)|uniprotkb:TNS1(gene name)|psi-mi:TNS1(display_short)|uniprotkb:TNS(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Qian et al. (2007) pubmed:17517630|doi:10.1073/pnas.0703033104|imex:IM-22834 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15638865|imex:IM-22834-7|dip:DIP-196868E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079043.3|refseq:NP_001157743.1|refseq:NP_006085.2|refseq:NP_872584.2|refseq:XP_005273431.1|refseq:NP_001303597.1|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR023393|interpro:IPR028854|mint:Q96QB1|rcsb pdb:2DKY|rcsb pdb:2GYT|rcsb pdb:2KAP|rcsb pdb:2LOZ|rcsb pdb:3KUQ|rcsb pdb:5FZT|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|refseq:NP_001335013.1|refseq:NP_001335010.1|refseq:NP_001335011.1|refseq:NP_001335012.1|ensembl:ENSG00000164741(gene)|ensembl:ENST00000276297(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0021575"(hindbrain morphogenesis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0030900"(forebrain development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|interpro:IPR000198(RhoGAP)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002913(Lipid-binding START)|interpro:IPR008936(Rho GTPase activation protein)|dip:DIP-56928N ensembl:ENSG00000079308(gene)|ensembl:ENST00000171887(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|go:"GO:0003779"(actin binding)|refseq:NP_001294951.1|refseq:NP_072174.3|dip:DIP-60948N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/05 2017/08/10 rogid:ZTy7Vk68AF6g9TSChz7j8Qxzs7c9606 rogid:xyE5fHGhuORnau3rX2Nfpi1LCvg9606 rigid:jq5dcmSpjUupOPAkyN1qecrLxIs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96QB1-1 uniprotkb:Q04205 intact:EBI-15638708|ensembl:ENSP00000351797 intact:EBI-2607590|uniprotkb:Q91007|uniprotkb:Q92011 psi-mi:q96qb1-1(display_long)|uniprotkb:DLC1(gene name)|psi-mi:DLC1(display_short)|uniprotkb:ARHGAP7(gene name synonym)|uniprotkb:KIAA1723(gene name synonym)|uniprotkb:STARD12(gene name synonym)|uniprotkb:Deleted in liver cancer 1 protein(gene name synonym)|uniprotkb:HP protein(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 7(gene name synonym)|uniprotkb:START domain-containing protein 12(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 12(gene name synonym) psi-mi:tens_chick(display_long)|uniprotkb:TNS(gene name)|psi-mi:TNS(display_short) psi-mi:"MI:0096"(pull down) Qian et al. (2007) pubmed:17517630|doi:10.1073/pnas.0703033104|imex:IM-22834 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15638949|imex:IM-22834-11|dip:DIP-196869E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-2608428(isoform-parent)|ensembl:ENSG00000164741(gene)|ensembl:ENST00000358919(transcript) refseq:NP_990786.1|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0009986"(cell surface)|interpro:IPR000980(SH2 motif)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR033929|interpro:IPR035012|interpro:IPR035892|interpro:IPR036860|rcsb pdb:1WVH|rcsb pdb:2GJY|dip:DIP-56927N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/05 2017/08/10 rogid:DMqvStUzVPPnwVj4RvMKUS330TU9606 rogid:NudDX/CO+8lqFexMsW43PM4AznU9031 rigid:RpD8bZMyLbbDVjTotST3jCDcQ4E false mutation disrupting interaction strength:442-442 glutathione s tranferase tag:n-n|sufficient binding region:1460-1584 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)