#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O70260	uniprotkb:P19490	intact:EBI-7974636|intact:UNK-5365098|ensembl:ENSRNOP00000028814	intact:EBI-371642	psi-mi:pias3_rat(display_long)|uniprotkb:Pias3(gene name)|psi-mi:Pias3(display_short)|uniprotkb:Protein inhibitor of activated STAT protein 3(gene name synonym)|uniprotkb:Potassium channel-associated protein(gene name synonym)|uniprotkb:KChAP(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS3(gene name synonym)	psi-mi:gria1_rat(display_long)|uniprotkb:Gria1(gene name)|psi-mi:Gria1(display_short)|uniprotkb:GluR-A(gene name synonym)|uniprotkb:GluR-K1(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 1(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 1(gene name synonym)|uniprotkb:Glur1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Martin et al. (2007)	pubmed:17486098|doi:10.1038/nature05736|imex:IM-21848	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15636127|imex:IM-21848-2|dip:DIP-192272E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:708413|refseq:NP_113972.2|dip:DIP-47656N|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O70260|reactome:R-RNO-3232118|reactome:R-RNO-3899300|reactome:R-RNO-4090294|reactome:R-RNO-4615885|reactome:R-RNO-4755510|reactome:R-RNO-5696395|ensembl:ENSRNOG00000021218(gene)|ensembl:ENSRNOT00000028814(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009725"(response to hormone)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)	rgd:621531|refseq:NP_113796.1|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044297"(cell body)|go:"GO:0044308"(axonal spine)|go:"GO:0044309"(neuron spine)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060992"(response to fungicide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071418"(cellular response to amine stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0010226"(response to lithium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:2AWW|rcsb pdb:2G2L|rcsb pdb:3SAJ|go:"GO:0097060"(synaptic membrane)|rcsb pdb:6NJL|rcsb pdb:6NJN|rcsb pdb:6QKC|rcsb pdb:6QKZ|rcsb pdb:7OCA|rcsb pdb:7OCC|rcsb pdb:7OCD|rcsb pdb:7OCE|rcsb pdb:7OCF|reactome:R-RNO-204005|reactome:R-RNO-399710|reactome:R-RNO-399719|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|reactome:R-RNO-438066|reactome:R-RNO-5694530|reactome:R-RNO-8849932|reactome:R-RNO-416993|mint:P19490|dip:DIP-30929N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/05	2017/08/10	rogid:J7ttG9hUULFAIs8ybnii6v1lMRk10116	rogid:Bdkl7msqLXWZxd8172jZFghg6BI10116	rigid:XI/AOGeYlkUQuskRjqgNmcG/MM4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5I0H3	uniprotkb:Q66H32	intact:EBI-7253100|intact:MINT-4651872|ensembl:ENSRNOP00000022048	intact:EBI-15636078|ensembl:ENSRNOP00000073525	psi-mi:sumo1_rat(display_long)|uniprotkb:Sumo1(gene name)|psi-mi:Sumo1(display_short)	psi-mi:q66h32_rat(display_long)|uniprotkb:Rangap1(gene name)|psi-mi:Rangap1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Martin et al. (2007)	pubmed:17486098|doi:10.1038/nature05736|imex:IM-21848	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15636110|imex:IM-21848-1|dip:DIP-192276E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1306919|refseq:NP_001009672.1|ensembl:ENSRNOG00000016133(gene)|ensembl:ENSRNOT00000022047(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001741"(XY body)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030578"(PML body organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:Q5I0H3|reactome:R-RNO-3065676|reactome:R-RNO-3065678|reactome:R-RNO-3065679|reactome:R-RNO-3108214|reactome:R-RNO-3108232|reactome:R-RNO-3232118|reactome:R-RNO-3232142|reactome:R-RNO-3899300|reactome:R-RNO-4085377|reactome:R-RNO-4090294|reactome:R-RNO-4551638|reactome:R-RNO-4570464|reactome:R-RNO-4615885|reactome:R-RNO-4655427|reactome:R-RNO-4755510|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-5696395|reactome:R-RNO-69473|reactome:R-RNO-877312|reactome:R-RNO-8866904|reactome:R-RNO-9615933|dip:DIP-46501N	ensembl:ENSRNOG00000031789(gene)|ensembl:ENSRNOT00000090208(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|rgd:1310380	psi-mi:"MI:0465"(dip)	comment:mint|function:Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4	crc64:9FD50F2DBEAC57CA	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/05	2017/08/10	rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ10116	rogid:L3AUcSCNhYWq8SS+W1v3V1mhMhQ10116	rigid:Dc4xNUphbArG3VLi1T8fzm7PYjM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63281	uniprotkb:P42260	intact:EBI-7974723|intact:MINT-4568236|uniprotkb:P50550|uniprotkb:Q15698|uniprotkb:Q86VB3|ensembl:ENSRNOP00000024406	intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884	psi-mi:ubc9_rat(display_long)|uniprotkb:Ube2i(gene name)|psi-mi:Ube2i(display_short)|uniprotkb:Ubce9(gene name synonym)|uniprotkb:SUMO-protein ligase(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 I(gene name synonym)|uniprotkb:Ubiquitin-protein ligase I(gene name synonym)|uniprotkb:Ubiquitin carrier protein I(gene name synonym)|uniprotkb:Ubiquitin carrier protein 9(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme UbcE2A(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase UBC9(gene name synonym)	psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Martin et al. (2007)	pubmed:17486098|doi:10.1038/nature05736|imex:IM-21848	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15636144|imex:IM-21848-3|dip:DIP-192275E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006245981.1|refseq:XP_006245982.1|rgd:3926|refseq:NP_037182.1|refseq:XP_006245980.2|refseq:XP_008765771.2|refseq:XP_017452533.1|dip:DIP-47657N|ensembl:ENSRNOG00000017907(gene)|ensembl:ENSRNOT00000024406(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033145"(positive regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051301"(cell division)|go:"GO:0061656"(SUMO conjugating enzyme activity)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:1903755"(positive regulation of SUMO transferase activity)|go:"GO:1990234"(transferase complex)|go:"GO:1990356"(sumoylated E2 ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P63281|reactome:R-RNO-196791|reactome:R-RNO-3065678|reactome:R-RNO-3108214|reactome:R-RNO-3108232|reactome:R-RNO-3232118|reactome:R-RNO-3232142|reactome:R-RNO-3899300|reactome:R-RNO-4085377|reactome:R-RNO-4090294|reactome:R-RNO-4551638|reactome:R-RNO-4570464|reactome:R-RNO-4615885|reactome:R-RNO-4655427|reactome:R-RNO-4755510|reactome:R-RNO-5693565|reactome:R-RNO-5693607|reactome:R-RNO-5696395|reactome:R-RNO-8866904|reactome:R-RNO-9615933	ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N	psi-mi:"MI:0465"(dip)	comment:mint|function:Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/05	2017/08/10	rogid:VV8ByrWqarJUmpoBqQ9EPZiGpFo10116	rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116	rigid:daSZ+rxucnZpHydi4aDMbaiPYVE	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63281	uniprotkb:P42260	intact:EBI-7974723|intact:MINT-4568236|uniprotkb:P50550|uniprotkb:Q15698|uniprotkb:Q86VB3|ensembl:ENSRNOP00000024406	intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884	psi-mi:ubc9_rat(display_long)|uniprotkb:Ube2i(gene name)|psi-mi:Ube2i(display_short)|uniprotkb:Ubce9(gene name synonym)|uniprotkb:SUMO-protein ligase(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 I(gene name synonym)|uniprotkb:Ubiquitin-protein ligase I(gene name synonym)|uniprotkb:Ubiquitin carrier protein I(gene name synonym)|uniprotkb:Ubiquitin carrier protein 9(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme UbcE2A(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase UBC9(gene name synonym)	psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Martin et al. (2007)	pubmed:17486098|doi:10.1038/nature05736|imex:IM-21848	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15636161|imex:IM-21848-4|dip:DIP-192275E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006245981.1|refseq:XP_006245982.1|rgd:3926|refseq:NP_037182.1|refseq:XP_006245980.2|refseq:XP_008765771.2|refseq:XP_017452533.1|dip:DIP-47657N|ensembl:ENSRNOG00000017907(gene)|ensembl:ENSRNOT00000024406(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033145"(positive regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051301"(cell division)|go:"GO:0061656"(SUMO conjugating enzyme activity)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:1903755"(positive regulation of SUMO transferase activity)|go:"GO:1990234"(transferase complex)|go:"GO:1990356"(sumoylated E2 ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P63281|reactome:R-RNO-196791|reactome:R-RNO-3065678|reactome:R-RNO-3108214|reactome:R-RNO-3108232|reactome:R-RNO-3232118|reactome:R-RNO-3232142|reactome:R-RNO-3899300|reactome:R-RNO-4085377|reactome:R-RNO-4090294|reactome:R-RNO-4551638|reactome:R-RNO-4570464|reactome:R-RNO-4615885|reactome:R-RNO-4655427|reactome:R-RNO-4755510|reactome:R-RNO-5693565|reactome:R-RNO-5693607|reactome:R-RNO-5696395|reactome:R-RNO-8866904|reactome:R-RNO-9615933	ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N	psi-mi:"MI:0465"(dip)	comment:mint|function:Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/05	2017/08/10	rogid:VV8ByrWqarJUmpoBqQ9EPZiGpFo10116	rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116	rigid:daSZ+rxucnZpHydi4aDMbaiPYVE	false	-	sufficient binding region:882-895	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q5I0H3	uniprotkb:P42260	intact:EBI-7253100|intact:MINT-4651872|ensembl:ENSRNOP00000022048	intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884	psi-mi:sumo1_rat(display_long)|uniprotkb:Sumo1(gene name)|psi-mi:Sumo1(display_short)	psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Martin et al. (2007)	pubmed:17486098|doi:10.1038/nature05736|imex:IM-21848	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15636180|imex:IM-21848-5|dip:DIP-191517E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1306919|refseq:NP_001009672.1|ensembl:ENSRNOG00000016133(gene)|ensembl:ENSRNOT00000022047(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001741"(XY body)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030578"(PML body organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:Q5I0H3|reactome:R-RNO-3065676|reactome:R-RNO-3065678|reactome:R-RNO-3065679|reactome:R-RNO-3108214|reactome:R-RNO-3108232|reactome:R-RNO-3232118|reactome:R-RNO-3232142|reactome:R-RNO-3899300|reactome:R-RNO-4085377|reactome:R-RNO-4090294|reactome:R-RNO-4551638|reactome:R-RNO-4570464|reactome:R-RNO-4615885|reactome:R-RNO-4655427|reactome:R-RNO-4755510|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-5696395|reactome:R-RNO-69473|reactome:R-RNO-877312|reactome:R-RNO-8866904|reactome:R-RNO-9615933|dip:DIP-46501N	ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N	psi-mi:"MI:0465"(dip)	comment:mint|function:Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/05	2017/08/10	rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ10116	rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116	rigid:PGpL1DSJfRRgGdYeS5QR0dDAN5Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O70260	uniprotkb:P19491	intact:EBI-7974636|intact:UNK-5365098|ensembl:ENSRNOP00000028814	intact:EBI-77718|uniprotkb:Q9R174	psi-mi:pias3_rat(display_long)|uniprotkb:Pias3(gene name)|psi-mi:Pias3(display_short)|uniprotkb:Protein inhibitor of activated STAT protein 3(gene name synonym)|uniprotkb:Potassium channel-associated protein(gene name synonym)|uniprotkb:KChAP(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS3(gene name synonym)	psi-mi:gria2_rat(display_long)|uniprotkb:Gria2(gene name)|psi-mi:Gria2(display_short)|uniprotkb:Glur2(gene name synonym)|uniprotkb:GluR-B(gene name synonym)|uniprotkb:GluR-K2(gene name synonym)|uniprotkb:Glutamate receptor ionotropic, AMPA 2(gene name synonym)|uniprotkb:AMPA-selective glutamate receptor 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Martin et al. (2007)	pubmed:17486098|doi:10.1038/nature05736|imex:IM-21848	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15636197|imex:IM-21848-6|dip:DIP-192273E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:708413|refseq:NP_113972.2|dip:DIP-47656N|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O70260|reactome:R-RNO-3232118|reactome:R-RNO-3899300|reactome:R-RNO-4090294|reactome:R-RNO-4615885|reactome:R-RNO-4755510|reactome:R-RNO-5696395|ensembl:ENSRNOG00000021218(gene)|ensembl:ENSRNOT00000028814(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009725"(response to hormone)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)	go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|interpro:IPR028082|rcsb pdb:1FTJ|rcsb pdb:1FTK|rcsb pdb:1FTL|rcsb pdb:1FTM|rcsb pdb:1FTO|rcsb pdb:1FW0|rcsb pdb:1GR2|rcsb pdb:1LB8|rcsb pdb:1LB9|rcsb pdb:1LBB|rcsb pdb:1LBC|rcsb pdb:1M5B|rcsb pdb:1M5C|rcsb pdb:1M5D|rcsb pdb:1M5E|rcsb pdb:1M5F|rcsb pdb:1MM6|rcsb pdb:1MM7|rcsb pdb:1MQD|rcsb pdb:1MQG|rcsb pdb:1MQH|rcsb pdb:1MQI|rcsb pdb:1MQJ|rcsb pdb:1MS7|rcsb pdb:1MXU|rcsb pdb:1MXV|rcsb pdb:1MXW|rcsb pdb:1MXX|rcsb pdb:1MXY|rcsb pdb:1MXZ|rcsb pdb:1MY0|rcsb pdb:1MY1|rcsb pdb:1MY2|rcsb pdb:1MY3|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051117"(ATPase binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060992"(response to fungicide)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099544"(perisynaptic space)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004971"(AMPA glutamate receptor activity)|go:"GO:0000149"(SNARE binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0009986"(cell surface)|go:"GO:0010226"(response to lithium ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019865"(immunoglobulin binding)|rcsb pdb:1MY4|rcsb pdb:1N0T|rcsb pdb:1NNK|rcsb pdb:1NNP|rcsb pdb:1P1N|rcsb pdb:1P1O|rcsb pdb:1P1Q|rcsb pdb:1P1U|rcsb pdb:1P1W|rcsb pdb:1SYH|rcsb pdb:1SYI|rcsb pdb:1WVJ|rcsb pdb:1XHY|rcsb pdb:2AIX|rcsb pdb:2AL4|rcsb pdb:2AL5|rcsb pdb:2ANJ|rcsb pdb:2CMO|rcsb pdb:2GFE|rcsb pdb:2I3V|rcsb pdb:2I3W|rcsb pdb:2P2A|rcsb pdb:2UXA|rcsb pdb:2XX7|rcsb pdb:2XX8|rcsb pdb:2XX9|rcsb pdb:2XXH|rcsb pdb:2XXI|rcsb pdb:3B6Q|rcsb pdb:5NIH|rcsb pdb:5NS9|rcsb pdb:5O9A|rcsb pdb:5OEW|rcsb pdb:5VHW|rcsb pdb:5VHX|rcsb pdb:5VHY|rcsb pdb:5VHZ|rcsb pdb:5VOT|rcsb pdb:5VOU|rcsb pdb:5VOV|rcsb pdb:5WEK|rcsb pdb:5WEL|rcsb pdb:5WEM|rcsb pdb:5WEN|rcsb pdb:5WEO|rcsb pdb:6DLZ|rcsb pdb:6DM0|rcsb pdb:6DM1|rcsb pdb:6FAZ|rcsb pdb:6FQG|rcsb pdb:6FQH|rcsb pdb:6FQI|rcsb pdb:6FQJ|rcsb pdb:6FQK|rcsb pdb:6GIV|rcsb pdb:6GL4|rcsb pdb:6HC9|rcsb pdb:6HCA|rcsb pdb:6HCB|rcsb pdb:6HCC|rcsb pdb:6HCH|rcsb pdb:6NJL|rcsb pdb:6NJM|rcsb pdb:6NJN|rcsb pdb:6O9G|rcsb pdb:6PEQ|rcsb pdb:6Q54|rcsb pdb:6Q60|rcsb pdb:6QKC|rcsb pdb:6QKZ|rcsb pdb:3B6T|rcsb pdb:3B6W|rcsb pdb:3B7D|rcsb pdb:3BBR|rcsb pdb:3BFT|rcsb pdb:3BFU|rcsb pdb:3BKI|rcsb pdb:3DP6|rcsb pdb:3H03|rcsb pdb:3H06|rcsb pdb:3H5V|rcsb pdb:3H5W|rcsb pdb:3H6T|rcsb pdb:3H6U|rcsb pdb:3H6V|rcsb pdb:3H6W|rcsb pdb:3HSY|rcsb pdb:3IJO|rcsb pdb:3IJX|rcsb pdb:3IK6|rcsb pdb:3IL1|rcsb pdb:3ILT|rcsb pdb:3ILU|rcsb pdb:3KG2|rcsb pdb:3KGC|rcsb pdb:3LSF|rcsb pdb:3LSL|rcsb pdb:3M3L|rcsb pdb:3N6V|rcsb pdb:3O28|rcsb pdb:3O29|rcsb pdb:3O2A|rcsb pdb:3O2J|rcsb pdb:3O6G|rcsb pdb:3O6H|rcsb pdb:3O6I|rcsb pdb:3PD8|rcsb pdb:3PD9|rcsb pdb:3PMV|rcsb pdb:3PMW|rcsb pdb:3PMX|rcsb pdb:6RUQ|rcsb pdb:6U5S|rcsb pdb:6U6I|rcsb pdb:6UCB|rcsb pdb:6UD4|rcsb pdb:6UD8|rcsb pdb:6XSR|rcsb pdb:6YK2|rcsb pdb:6YK3|rcsb pdb:6YK4|rcsb pdb:6YK5|rcsb pdb:6YK6|rcsb pdb:7OCA|rcsb pdb:7OCC|rcsb pdb:7OCD|rcsb pdb:7OCE|rcsb pdb:7OCF|reactome:R-RNO-399710|reactome:R-RNO-416993|reactome:R-RNO-438066|rcsb pdb:3RTF|rcsb pdb:3RTW|rcsb pdb:3T93|rcsb pdb:3T96|rcsb pdb:3T9H|rcsb pdb:3T9U|rcsb pdb:3T9V|rcsb pdb:3T9X|rcsb pdb:3TDJ|rcsb pdb:3TKD|rcsb pdb:3TZA|rcsb pdb:4FAT|rcsb pdb:4G8M|rcsb pdb:4GXS|rcsb pdb:4H8J|rcsb pdb:4IGT|rcsb pdb:4ISU|rcsb pdb:4IY5|rcsb pdb:4IY6|rcsb pdb:4L17|rcsb pdb:4LZ5|rcsb pdb:4LZ7|rcsb pdb:4LZ8|rcsb pdb:4N07|rcsb pdb:4O3A|rcsb pdb:4O3B|rcsb pdb:4O3C|rcsb pdb:4Q30|rcsb pdb:4U1O|rcsb pdb:4U1W|rcsb pdb:4U1X|rcsb pdb:4U1Y|rcsb pdb:4U1Z|rcsb pdb:4U21|rcsb pdb:4U22|rcsb pdb:4U23|rcsb pdb:4U2P|rcsb pdb:4U2Q|rcsb pdb:4U2R|rcsb pdb:4U4F|rcsb pdb:4U4G|rcsb pdb:4U4S|rcsb pdb:4U4X|rcsb pdb:4U5B|rcsb pdb:4U5C|rcsb pdb:4U5D|rcsb pdb:4U5E|rcsb pdb:4U5F|rcsb pdb:4UQ6|rcsb pdb:4UQJ|rcsb pdb:4UQK|rcsb pdb:4X48|rcsb pdb:4YMA|rcsb pdb:4YU0|rcsb pdb:4Z0I|rcsb pdb:5BUU|rcsb pdb:5CBR|rcsb pdb:5CBS|rcsb pdb:5ELV|rcsb pdb:5FHM|rcsb pdb:5FHN|rcsb pdb:5FHO|rcsb pdb:5FTH|rcsb pdb:5FTI|rcsb pdb:5FWX|rcsb pdb:5FWY|rcsb pdb:5IDE|rcsb pdb:5IDF|rcsb pdb:5JEI|rcsb pdb:5KBS|rcsb pdb:5KBT|rcsb pdb:5KBU|rcsb pdb:5KBV|rcsb pdb:5KK2|rcsb pdb:5L1B|rcsb pdb:5L1E|rcsb pdb:5L1F|rcsb pdb:5L1G|rcsb pdb:5L1H|rcsb pdb:5N6P|rcsb pdb:5NG9|refseq:NP_001077280.1|refseq:NP_058957.1|rgd:61862|mint:P19491|dip:DIP-30952N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/05	2017/08/10	rogid:J7ttG9hUULFAIs8ybnii6v1lMRk10116	rogid:zeQRRvspsIuRyA9kKA7kyIr8HqE10116	rigid:2gbcdzbTSI+pmmGqUPxM+altajc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42260	uniprotkb:O70260	intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884	intact:EBI-7974636|intact:UNK-5365098|ensembl:ENSRNOP00000028814	psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)	psi-mi:pias3_rat(display_long)|uniprotkb:Pias3(gene name)|psi-mi:Pias3(display_short)|uniprotkb:Protein inhibitor of activated STAT protein 3(gene name synonym)|uniprotkb:Potassium channel-associated protein(gene name synonym)|uniprotkb:KChAP(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Martin et al. (2007)	pubmed:17486098|doi:10.1038/nature05736|imex:IM-21848	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15636214|imex:IM-21848-7|dip:DIP-192274E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N	rgd:708413|refseq:NP_113972.2|dip:DIP-47656N|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O70260|reactome:R-RNO-3232118|reactome:R-RNO-3899300|reactome:R-RNO-4090294|reactome:R-RNO-4615885|reactome:R-RNO-4755510|reactome:R-RNO-5696395|ensembl:ENSRNOG00000021218(gene)|ensembl:ENSRNOT00000028814(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009725"(response to hormone)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)	psi-mi:"MI:0465"(dip)	comment:mint	comment:mint|function:"Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/05	2017/08/10	rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116	rogid:J7ttG9hUULFAIs8ybnii6v1lMRk10116	rigid:hyNoHD0TsFJq3sKvMlS79Al9HBQ	false	sufficient binding region:882-895	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P63281	uniprotkb:P42260	intact:EBI-7974723|intact:MINT-4568236|uniprotkb:P50550|uniprotkb:Q15698|uniprotkb:Q86VB3|ensembl:ENSRNOP00000024406	intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884	psi-mi:ubc9_rat(display_long)|uniprotkb:Ube2i(gene name)|psi-mi:Ube2i(display_short)|uniprotkb:Ubce9(gene name synonym)|uniprotkb:SUMO-protein ligase(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 I(gene name synonym)|uniprotkb:Ubiquitin-protein ligase I(gene name synonym)|uniprotkb:Ubiquitin carrier protein I(gene name synonym)|uniprotkb:Ubiquitin carrier protein 9(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme UbcE2A(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase UBC9(gene name synonym)	psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Martin et al. (2007)	pubmed:17486098|doi:10.1038/nature05736|imex:IM-21848	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15636233|imex:IM-21848-8|dip:DIP-192275E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006245981.1|refseq:XP_006245982.1|rgd:3926|refseq:NP_037182.1|refseq:XP_006245980.2|refseq:XP_008765771.2|refseq:XP_017452533.1|dip:DIP-47657N|ensembl:ENSRNOG00000017907(gene)|ensembl:ENSRNOT00000024406(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033145"(positive regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051301"(cell division)|go:"GO:0061656"(SUMO conjugating enzyme activity)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:1903755"(positive regulation of SUMO transferase activity)|go:"GO:1990234"(transferase complex)|go:"GO:1990356"(sumoylated E2 ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P63281|reactome:R-RNO-196791|reactome:R-RNO-3065678|reactome:R-RNO-3108214|reactome:R-RNO-3108232|reactome:R-RNO-3232118|reactome:R-RNO-3232142|reactome:R-RNO-3899300|reactome:R-RNO-4085377|reactome:R-RNO-4090294|reactome:R-RNO-4551638|reactome:R-RNO-4570464|reactome:R-RNO-4615885|reactome:R-RNO-4655427|reactome:R-RNO-4755510|reactome:R-RNO-5693565|reactome:R-RNO-5693607|reactome:R-RNO-5696395|reactome:R-RNO-8866904|reactome:R-RNO-9615933	ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N	psi-mi:"MI:0465"(dip)	comment:mint|function:Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/05	2017/08/10	rogid:VV8ByrWqarJUmpoBqQ9EPZiGpFo10116	rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116	rigid:daSZ+rxucnZpHydi4aDMbaiPYVE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42260	uniprotkb:O70260	intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884	intact:EBI-7974636|intact:UNK-5365098|ensembl:ENSRNOP00000028814	psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)	psi-mi:pias3_rat(display_long)|uniprotkb:Pias3(gene name)|psi-mi:Pias3(display_short)|uniprotkb:Protein inhibitor of activated STAT protein 3(gene name synonym)|uniprotkb:Potassium channel-associated protein(gene name synonym)|uniprotkb:KChAP(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Martin et al. (2007)	pubmed:17486098|doi:10.1038/nature05736|imex:IM-21848	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15636267|imex:IM-21848-10|dip:DIP-192274E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N	rgd:708413|refseq:NP_113972.2|dip:DIP-47656N|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O70260|reactome:R-RNO-3232118|reactome:R-RNO-3899300|reactome:R-RNO-4090294|reactome:R-RNO-4615885|reactome:R-RNO-4755510|reactome:R-RNO-5696395|ensembl:ENSRNOG00000021218(gene)|ensembl:ENSRNOT00000028814(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009725"(response to hormone)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)	psi-mi:"MI:0465"(dip)	comment:mint	comment:mint|function:"Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context"	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/05	2017/08/10	rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116	rogid:J7ttG9hUULFAIs8ybnii6v1lMRk10116	rigid:hyNoHD0TsFJq3sKvMlS79Al9HBQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O70260	uniprotkb:P42260	intact:EBI-7974636|intact:UNK-5365098|ensembl:ENSRNOP00000028814	intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884	psi-mi:pias3_rat(display_long)|uniprotkb:Pias3(gene name)|psi-mi:Pias3(display_short)|uniprotkb:Protein inhibitor of activated STAT protein 3(gene name synonym)|uniprotkb:Potassium channel-associated protein(gene name synonym)|uniprotkb:KChAP(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS3(gene name synonym)	psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Martin et al. (2007)	pubmed:17486098|doi:10.1038/nature05736|imex:IM-21848	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15636250|imex:IM-21848-9|dip:DIP-192274E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:708413|refseq:NP_113972.2|dip:DIP-47656N|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O70260|reactome:R-RNO-3232118|reactome:R-RNO-3899300|reactome:R-RNO-4090294|reactome:R-RNO-4615885|reactome:R-RNO-4755510|reactome:R-RNO-5696395|ensembl:ENSRNOG00000021218(gene)|ensembl:ENSRNOT00000028814(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009725"(response to hormone)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)	ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context"	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/05	2017/08/10	rogid:J7ttG9hUULFAIs8ybnii6v1lMRk10116	rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116	rigid:hyNoHD0TsFJq3sKvMlS79Al9HBQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5I0H3	uniprotkb:P42260	intact:EBI-7253100|intact:MINT-4651872|ensembl:ENSRNOP00000022048	intact:EBI-7809795|ensembl:ENSRNOP00000068172|intact:MINT-8359884	psi-mi:sumo1_rat(display_long)|uniprotkb:Sumo1(gene name)|psi-mi:Sumo1(display_short)	psi-mi:grik2_rat(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Martin et al. (2007)	pubmed:17486098|doi:10.1038/nature05736|imex:IM-21848	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15636284|imex:IM-21848-11|dip:DIP-191517E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1306919|refseq:NP_001009672.1|ensembl:ENSRNOG00000016133(gene)|ensembl:ENSRNOT00000022047(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001741"(XY body)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008134"(transcription factor binding)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0030578"(PML body organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0060021"(roof of mouth development)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090204"(protein localization to nuclear pore)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:Q5I0H3|reactome:R-RNO-3065676|reactome:R-RNO-3065678|reactome:R-RNO-3065679|reactome:R-RNO-3108214|reactome:R-RNO-3108232|reactome:R-RNO-3232118|reactome:R-RNO-3232142|reactome:R-RNO-3899300|reactome:R-RNO-4085377|reactome:R-RNO-4090294|reactome:R-RNO-4551638|reactome:R-RNO-4570464|reactome:R-RNO-4615885|reactome:R-RNO-4655427|reactome:R-RNO-4755510|reactome:R-RNO-5693565|reactome:R-RNO-5693571|reactome:R-RNO-5693607|reactome:R-RNO-5696395|reactome:R-RNO-69473|reactome:R-RNO-877312|reactome:R-RNO-8866904|reactome:R-RNO-9615933|dip:DIP-46501N	ensembl:ENSRNOG00000000368(gene)|ensembl:ENSRNOT00000076234(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|rcsb pdb:1S50|rcsb pdb:1S7Y|rcsb pdb:1S9T|rcsb pdb:1SD3|rcsb pdb:1TT1|rcsb pdb:1YAE|rcsb pdb:2I0B|rcsb pdb:2I0C|rcsb pdb:2XXR|rcsb pdb:2XXT|rcsb pdb:2XXU|rcsb pdb:2XXV|rcsb pdb:2XXW|rcsb pdb:2XXX|rcsb pdb:2XXY|rcsb pdb:3G3F|rcsb pdb:3G3G|rcsb pdb:3G3H|rcsb pdb:3G3I|rcsb pdb:3G3J|rcsb pdb:3G3K|rcsb pdb:3H6G|rcsb pdb:3H6H|rcsb pdb:3QLT|rcsb pdb:3QLU|rcsb pdb:3QLV|rcsb pdb:4BDL|rcsb pdb:4BDM|rcsb pdb:4BDN|rcsb pdb:4BDO|rcsb pdb:4BDQ|rcsb pdb:4BDR|rcsb pdb:4H8I|rcsb pdb:4UQQ|rcsb pdb:5CMK|rcsb pdb:5CMM|rcsb pdb:5KUF|rcsb pdb:5KUH|rcsb pdb:7KS0|rcsb pdb:7KS3|reactome:R-RNO-451307|reactome:R-RNO-451308|refseq:NP_062182.1|rgd:2733|dip:DIP-29256N	psi-mi:"MI:0465"(dip)	comment:mint|function:Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/05	2017/08/10	rogid:mflrn+v4fHL8UdmLodfZBZA6eAQ10116	rogid:0Eh9oL6GX10ePstSVMv0PpRnFWQ10116	rigid:PGpL1DSJfRRgGdYeS5QR0dDAN5Y	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)